GS SIZE SOURCE ES NES NOM p-val FDR q-val FWER p-val Tag % Gene % Signal FDR (median) glob.p.val BIOCARTA_NO1_PATHWAY 28 CAV1 0.57684 1.2535 0.2105 0.23659 0.985 0.464 0.19 0.377 0.20179 0 BIOCARTA_AT1R_PATHWAY 32 MEF2C 0.44613 1.6544 0.03704 0.054678 0.582 0.562 0.409 0.333 0.028177 0 BIOCARTA_BCR_PATHWAY 33 HRAS 0.69768 1.9028 0 0.018187 0.135 0.424 0.183 0.347 0 0 BIOCARTA_HDAC_PATHWAY 26 MEF2C 0.64464 2.0194 0 0.022605 0.047 0.154 0.0481 0.147 0 0.003 BIOCARTA_EGF_PATHWAY 30 HRAS 0.50447 1.5956 0.03165 0.075153 0.687 0.733 0.409 0.434 0.042834 0 BIOCARTA_ERK_PATHWAY 27 HRAS 0.49276 1.4645 0.09182 0.11805 0.877 0.185 0.147 0.158 0.086413 0 BIOCARTA_FAS_PATHWAY 29 LMNB1 0.47666 1.6558 0.03711 0.054925 0.58 0.379 0.328 0.255 0.028252 0 BIOCARTA_FCER1_PATHWAY 37 HRAS 0.69033 1.9145 0.002101 0.017033 0.118 0.405 0.183 0.332 0 0 BIOCARTA_FMLP_PATHWAY 35 GNA15 0.57719 1.9284 0.002105 0.019655 0.105 0.343 0.241 0.261 0 0 BIOCARTA_GH_PATHWAY 25 HRAS 0.56088 1.7336 0.01417 0.03548 0.416 0.4 0.242 0.304 0 0 BIOCARTA_HIVNEF_PATHWAY 57 FASLG 0.47863 2.0762 0.004098 0.032021 0.026 0.439 0.34 0.29 0 0.011 BIOCARTA_IL2RB_PATHWAY 37 E2F1 0.64421 1.8049 0.006452 0.027897 0.279 0.27 0.109 0.241 0 0 BIOCARTA_GSK3_PATHWAY 26 TOLLIP 0.60892 1.8278 0 0.027169 0.238 0.231 0.0741 0.214 0 0 BIOCARTA_DEATH_PATHWAY 32 BID 0.44543 1.6849 0.02595 0.045848 0.515 0.5 0.375 0.313 0.021277 0 BIOCARTA_INTEGRIN_PATHWAY 37 TLN1 0.42471 1.5503 0.06724 0.086214 0.765 0.568 0.35 0.37 0.053644 0 BIOCARTA_KERATINOCYTE_PATHWAY 45 TRAF2 0.57265 1.9355 0.002132 0.019027 0.094 0.422 0.254 0.316 0 0 BIOCARTA_PYK2_PATHWAY 27 HRAS 0.43122 1.7242 0.01613 0.036724 0.434 0.444 0.363 0.284 0 0 BIOCARTA_MAPK_PATHWAY 86 MEF2C 0.43727 1.9685 0.006224 0.019118 0.073 0.593 0.41 0.352 0 0.001 BIOCARTA_PPARA_PATHWAY 54 ACOX1 0.46888 1.5505 0.04027 0.087195 0.763 0.389 0.274 0.283 0.054359 0 BIOCARTA_NFAT_PATHWAY 48 MEF2C 0.55637 1.7407 0 0.034459 0.392 0.417 0.243 0.316 0 0 BIOCARTA_P38MAPK_PATHWAY 39 HMGN1 0.47839 1.7327 0.01423 0.035103 0.416 0.692 0.409 0.41 0 0 BIOCARTA_PDGF_PATHWAY 31 HRAS 0.58229 1.802 0 0.027727 0.285 0.452 0.281 0.325 0 0 BIOCARTA_EDG1_PATHWAY 25 ADCY1 0.59338 1.7477 0.005941 0.032985 0.375 0.28 0.153 0.237 0 0 BIOCARTA_MYOSIN_PATHWAY 28 GNA13 0.44896 1.4419 0.06426 0.1271 0.898 0.607 0.341 0.401 0.092014 0 BIOCARTA_RHO_PATHWAY 30 TLN1 0.40439 1.5815 0.0404 0.07984 0.717 0.667 0.445 0.37 0.047463 0 BIOCARTA_NKT_PATHWAY 25 CSF2 0.79492 1.5076 0.0194 0.098291 0.824 0.68 0.0916 0.619 0.064427 0 BIOCARTA_IL1R_PATHWAY 31 IL1R1 0.67801 1.8151 0.002212 0.026393 0.258 0.548 0.221 0.428 0 0 BIOCARTA_MET_PATHWAY 36 HRAS 0.57021 1.826 0.01035 0.026755 0.243 0.639 0.36 0.41 0 0 BIOCARTA_GPCR_PATHWAY 32 HRAS 0.53535 1.7597 0.008048 0.032303 0.351 0.344 0.201 0.275 0 0 BIOCARTA_TCR_PATHWAY 43 HRAS 0.73606 1.8911 0.004237 0.019392 0.145 0.279 0.0504 0.266 0 0 BIOCARTA_PAR1_PATHWAY 36 GNA13 0.4482 1.4059 0.09388 0.14576 0.93 0.611 0.341 0.404 0.11245 0 BIOCARTA_TNFR1_PATHWAY 28 TRAF2 0.48756 1.7373 0.02182 0.034666 0.403 0.393 0.327 0.265 0 0 BIOCARTA_TOLL_PATHWAY 36 PPARA 0.64992 1.8893 0 0.018926 0.148 0.444 0.221 0.347 0 0 BIOCARTA_CREB_PATHWAY 25 ADCY1 0.46791 1.4536 0.07828 0.12402 0.885 0.56 0.37 0.354 0.091183 0 BIOCARTA_WNT_PATHWAY 25 PPARD 0.3854 1.4011 0.1071 0.14632 0.933 0.12 0.136 0.104 0.11375 0 KEGG_PURINE_METABOLISM 153 ADCY3 0.29602 1.2621 0.1062 0.23426 0.983 0.176 0.195 0.143 0.20212 0 KEGG_N_GLYCAN_BIOSYNTHESIS 45 RFT1 0.44275 1.5676 0.0535 0.084918 0.739 0.311 0.281 0.224 0.052974 0 KEGG_O_GLYCAN_BIOSYNTHESIS 28 GALNT3 0.60397 1.6885 0.01075 0.045514 0.51 0.5 0.234 0.384 0.021161 0 KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM 43 CYB5R3 0.42864 1.377 0.1513 0.15645 0.946 0.093 0.059 0.0877 0.12419 0 KEGG_ETHER_LIPID_METABOLISM 26 ENPP6 0.55154 1.5676 0.0245 0.083705 0.739 0.269 0.186 0.22 0.052217 0 KEGG_ARACHIDONIC_ACID_METABOLISM 49 CYP2J2 0.49098 1.2733 0.1509 0.22552 0.977 0.286 0.117 0.253 0.19414 0 KEGG_SPHINGOLIPID_METABOLISM 36 ENPP7 0.42432 1.3037 0.1475 0.20561 0.974 0.667 0.389 0.408 0.17362 0 KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES 25 FUT9 0.54433 1.4774 0.04375 0.1125 0.86 0.4 0.158 0.337 0.079699 0 KEGG_MAPK_SIGNALING_PATHWAY 243 MEF2C 0.45051 1.6731 0.002169 0.048921 0.548 0.276 0.19 0.226 0.024091 0 KEGG_ERBB_SIGNALING_PATHWAY 86 HRAS 0.41423 1.5495 0.02911 0.085558 0.766 0.337 0.28 0.244 0.052947 0 KEGG_CALCIUM_SIGNALING_PATHWAY 165 SLC8A3 0.4748 1.3996 0.04478 0.14595 0.933 0.303 0.149 0.26 0.11325 0 KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 230 IL9R 0.74782 1.8574 0 0.020553 0.186 0.587 0.132 0.516 0 0 KEGG_CHEMOKINE_SIGNALING_PATHWAY 182 ADCY3 0.73874 1.9986 0 0.021489 0.054 0.412 0.112 0.37 0 0.003 KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM 74 PLCZ1 0.35568 1.2528 0.1772 0.23519 0.985 0.149 0.162 0.125 0.20102 0 KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 215 CGA 0.52974 1.4511 0.01354 0.12419 0.889 0.433 0.201 0.35 0.090778 0 KEGG_LYSOSOME 119 HGSNAT 0.48866 1.7499 0.05797 0.033549 0.368 0.555 0.394 0.338 0 0 KEGG_ENDOCYTOSIS 179 HRAS 0.4684 2.1137 0 0.033421 0.016 0.33 0.291 0.236 0 0.014 KEGG_MTOR_SIGNALING_PATHWAY 49 PGF 0.44749 1.7623 0.01432 0.032522 0.348 0.163 0.166 0.137 0 0 KEGG_APOPTOSIS 83 FASLG 0.52693 2.0266 0 0.024508 0.039 0.337 0.245 0.256 0 0.005 KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 106 ADCY3 0.48828 1.4499 0.04516 0.12331 0.889 0.302 0.211 0.24 0.089983 0 KEGG_WNT_SIGNALING_PATHWAY 144 PPP2R5B 0.43171 1.5433 0.02396 0.087667 0.776 0.229 0.172 0.191 0.055094 0 KEGG_HEDGEHOG_SIGNALING_PATHWAY 53 WNT3A 0.4776 1.2791 0.1247 0.2247 0.977 0.434 0.242 0.33 0.1924 0 KEGG_AXON_GUIDANCE 126 HRAS 0.46828 1.5249 0.01747 0.093584 0.799 0.413 0.247 0.313 0.062299 0 KEGG_VEGF_SIGNALING_PATHWAY 68 HRAS 0.49147 1.6143 0.02009 0.066843 0.65 0.206 0.142 0.177 0.037252 0 KEGG_FOCAL_ADHESION 193 HRAS 0.49447 1.618 0.01688 0.066244 0.647 0.316 0.228 0.247 0.037167 0 KEGG_ECM_RECEPTOR_INTERACTION 80 VTN 0.59182 1.5247 0.02537 0.092512 0.799 0.45 0.181 0.37 0.061548 0 KEGG_CELL_ADHESION_MOLECULES_CAMS 128 PVR 0.69873 1.8748 0 0.019378 0.168 0.523 0.161 0.442 0 0 KEGG_ADHERENS_JUNCTION 73 LOC646821 0.38218 1.42 0.09731 0.13691 0.916 0.548 0.38 0.341 0.1037 0 KEGG_TIGHT_JUNCTION 124 HRAS 0.35562 1.3964 0.05229 0.14663 0.935 0.419 0.351 0.274 0.11462 0 KEGG_GAP_JUNCTION 85 ADCY3 0.42145 1.4285 0.03198 0.13375 0.912 0.506 0.35 0.33 0.099334 0 KEGG_COMPLEMENT_AND_COAGULATION_CASCADES 63 A2M 0.65779 1.6297 0.01307 0.061377 0.632 0.667 0.19 0.542 0.033634 0 KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION 68 HSP90AB1 0.67082 1.6746 0.006652 0.049194 0.545 0.632 0.262 0.468 0.023747 0 KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY 89 TBK1 0.65899 1.8605 0 0.020847 0.181 0.506 0.224 0.395 0 0 KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY 59 HSP90AB1 0.75812 1.964 0 0.016944 0.076 0.424 0.106 0.38 0 0 KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY 57 IFNA21 0.49323 1.876 0.004082 0.019852 0.164 0.386 0.287 0.276 0 0 KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY 43 IFNA21 0.65187 1.7981 0.00641 0.027838 0.294 0.326 0.147 0.279 0 0 KEGG_JAK_STAT_SIGNALING_PATHWAY 123 IL9R 0.63779 1.8865 0 0.018393 0.15 0.602 0.25 0.455 0 0 KEGG_HEMATOPOIETIC_CELL_LINEAGE 79 IL9R 0.7849 1.7657 0 0.033406 0.342 0.633 0.0984 0.573 0 0 KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY 117 MICB 0.64592 1.7629 0.004386 0.033307 0.348 0.573 0.255 0.43 0 0 KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 104 HRAS 0.67552 1.9242 0.002141 0.017538 0.107 0.317 0.105 0.286 0 0 KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY 73 HRAS 0.65137 1.9256 0 0.01841 0.106 0.397 0.174 0.33 0 0 KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY 68 HRAS 0.65272 1.9955 0 0.019008 0.054 0.265 0.104 0.238 0 0.003 KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS 93 RPS6KB2 0.57497 1.9555 0.00211 0.016905 0.081 0.204 0.1 0.185 0 0 KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 109 OCLN 0.5616 1.7503 0.004367 0.034299 0.368 0.312 0.158 0.264 0 0 KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION 43 HLA-DQB1 0.79697 1.724 0 0.036037 0.435 0.674 0.104 0.606 0 0 KEGG_LONG_TERM_POTENTIATION 66 ADCY1 0.36753 1.3214 0.08214 0.19318 0.966 0.242 0.21 0.192 0.1605 0 KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 123 HRAS 0.45529 1.915 0 0.01784 0.117 0.528 0.363 0.339 0 0 KEGG_LONG_TERM_DEPRESSION 61 GNAZ 0.48481 1.5229 0.006726 0.092547 0.801 0.279 0.204 0.223 0.062402 0 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 195 HRAS 0.40939 1.5623 0.01293 0.083039 0.744 0.282 0.221 0.222 0.052484 0 KEGG_INSULIN_SIGNALING_PATHWAY 128 HRAS 0.3594 1.6428 0.01499 0.058223 0.605 0.25 0.252 0.188 0.03046 0 KEGG_GNRH_SIGNALING_PATHWAY 89 ADCY3 0.35039 1.3214 0.06332 0.19487 0.966 0.393 0.338 0.261 0.16194 0 KEGG_MELANOGENESIS 97 ADCY3 0.39887 1.3066 0.09091 0.20462 0.97 0.34 0.272 0.249 0.17345 0 KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY 63 PRKAG3 0.54469 1.965 0 0.018639 0.076 0.397 0.254 0.297 0 0.001 KEGG_TYPE_II_DIABETES_MELLITUS 41 PRKCZ 0.47566 1.4055 0.05983 0.14465 0.93 0.439 0.249 0.331 0.11202 0 KEGG_TYPE_I_DIABETES_MELLITUS 38 HLA-DQB1 0.76607 1.6339 0.004301 0.060784 0.625 0.605 0.0941 0.549 0.033022 0 KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION 37 FXYD2 0.55807 1.5206 0.03854 0.091528 0.803 0.297 0.16 0.25 0.061085 0 KEGG_VASOPRESSIN_REGULATED_WATER_REABSORPTION 42 ADCY3 0.3826 1.5641 0.03648 0.083332 0.744 0.214 0.28 0.155 0.052372 0 KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS 51 ALS2 0.38389 1.259 0.1716 0.23348 0.983 0.176 0.107 0.158 0.20059 0 KEGG_PRION_DISEASES 31 C7 0.64107 1.749 0.006316 0.033157 0.371 0.387 0.115 0.343 0 0 KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION 66 ATP6V0E1 0.49079 1.8195 0.002028 0.02646 0.255 0.167 0.109 0.149 0 0 KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION 55 LOC646821 0.43018 1.5692 0.02614 0.085102 0.735 0.473 0.351 0.308 0.053142 0 KEGG_LEISHMANIA_INFECTION 68 PTGS2 0.73708 1.7734 0.002083 0.032561 0.333 0.515 0.104 0.463 0 0 KEGG_PATHWAYS_IN_CANCER 315 HRAS 0.47032 1.7197 0 0.03673 0.442 0.273 0.191 0.225 0 0 KEGG_COLORECTAL_CANCER 61 TGFB3 0.40084 1.5372 0.03363 0.088989 0.786 0.197 0.172 0.163 0.058456 0 KEGG_RENAL_CELL_CARCINOMA 69 HRAS 0.46472 1.7121 0.02537 0.038485 0.458 0.522 0.36 0.335 0 0 KEGG_PANCREATIC_CANCER 69 E2F1 0.36962 1.3925 0.1229 0.14788 0.938 0.493 0.363 0.315 0.11538 0 KEGG_ENDOMETRIAL_CANCER 51 HRAS 0.36073 1.2773 0.19 0.22416 0.977 0.098 0.0912 0.0894 0.19329 0 KEGG_GLIOMA 63 E2F1 0.41005 1.4824 0.04009 0.11083 0.857 0.0794 0.0305 0.0772 0.078673 0 KEGG_PROSTATE_CANCER 87 HSP90AB1 0.35472 1.3616 0.1183 0.16659 0.951 0.322 0.299 0.227 0.13675 0 KEGG_THYROID_CANCER 28 HRAS 0.4206 1.2591 0.2215 0.23536 0.983 0.464 0.35 0.302 0.20227 0 KEGG_BASAL_CELL_CARCINOMA 53 WNT3A 0.51303 1.3871 0.08889 0.15028 0.941 0.434 0.23 0.335 0.11731 0 KEGG_MELANOMA 62 E2F1 0.45503 1.4725 0.03171 0.11436 0.867 0.242 0.186 0.198 0.081268 0 KEGG_BLADDER_CANCER 41 E2F1 0.44914 1.3407 0.1283 0.18158 0.959 0.195 0.117 0.173 0.1507 0 KEGG_CHRONIC_MYELOID_LEUKEMIA 72 E2F1 0.47031 1.9734 0.00421 0.021056 0.072 0.5 0.352 0.325 0 0.002 KEGG_ACUTE_MYELOID_LEUKEMIA 56 PPARD 0.59085 2.0581 0 0.024641 0.029 0.25 0.142 0.215 0 0.006 KEGG_SMALL_CELL_LUNG_CANCER 83 E2F1 0.4442 1.5252 0.05616 0.094592 0.799 0.446 0.333 0.299 0.063068 0 KEGG_NON_SMALL_CELL_LUNG_CANCER 53 E2F1 0.40603 1.5222 0.04301 0.091872 0.801 0.0755 0.0531 0.0717 0.061668 0 KEGG_AUTOIMMUNE_THYROID_DISEASE 35 IFNA21 0.78288 1.6344 0.002183 0.061354 0.621 0.686 0.0941 0.622 0.033271 0 KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS 108 HIST2H2AA3 0.58728 1.4835 0.05353 0.11133 0.856 0.343 0.115 0.305 0.078557 0 KEGG_ALLOGRAFT_REJECTION 32 HLA-DQB1 0.80002 1.5908 0.01277 0.075584 0.696 0.688 0.0941 0.624 0.043802 0 KEGG_GRAFT_VERSUS_HOST_DISEASE 36 HLA-DQB1 0.77635 1.5419 0.01535 0.087218 0.777 0.694 0.113 0.617 0.055141 0 KEGG_PRIMARY_IMMUNODEFICIENCY 34 CD8A 0.76624 1.595 0.006652 0.074246 0.687 0.471 0.0546 0.446 0.042728 0 KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM 74 PRKAG3 0.55666 1.552 0.008493 0.087542 0.762 0.554 0.28 0.4 0.055094 0 KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC 68 LOC646821 0.52366 1.424 0.05794 0.1353 0.914 0.544 0.28 0.393 0.10181 0 KEGG_DILATED_CARDIOMYOPATHY 80 ADCY3 0.57051 1.5643 0.008511 0.084368 0.743 0.575 0.28 0.416 0.0529 0 KEGG_VIRAL_MYOCARDITIS 66 LOC646821 0.67428 1.8206 0 0.027221 0.254 0.439 0.133 0.382 0 0 WNT_SIGNALING 84 WNT3A 0.4485 1.4336 0.06458 0.13116 0.904 0.298 0.232 0.23 0.095552 0