Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.005 0.075 -9999.0 0.0 -9999.0 0.0 0.0 IHH -0.03 0.143 -9999.0 0.0 -0.466 28.0 28.0 SHH Np/Cholesterol/GAS1 -0.004 0.062 -9999.0 0.0 -0.23 20.0 20.0 LRPAP1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.004 0.061 0.229 20.0 -9999.0 0.0 20.0 SMO/beta Arrestin2 -0.003 0.103 -9999.0 0.0 -0.321 23.0 23.0 SMO -0.01 0.107 -9999.0 0.0 -0.334 25.0 25.0 AKT1 0.008 0.053 -9999.0 0.0 -0.265 1.0 1.0 ARRB2 0.01 0.001 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.009 0.105 -9999.0 0.0 -0.33 25.0 25.0 STIL 0.001 0.063 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH2 -0.007 0.08 -9999.0 0.0 -0.31 19.0 19.0 DHH N/PTCH1 -0.014 0.097 -9999.0 0.0 -0.239 43.0 43.0 PIK3CA 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.02 0.111 -9999.0 0.0 -0.44 19.0 19.0 PTHLH -0.006 0.097 -9999.0 0.0 -9999.0 0.0 0.0 determination of left/right symmetry -0.009 0.105 -9999.0 0.0 -0.33 25.0 25.0 PIK3R1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.006 0.096 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/Hhip -0.023 0.105 -9999.0 0.0 -0.287 39.0 39.0 DHH N/Hhip -0.02 0.105 -9999.0 0.0 -0.339 27.0 27.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.009 0.105 -9999.0 0.0 -0.33 25.0 25.0 pancreas development -0.008 0.086 -9999.0 0.0 -0.439 11.0 11.0 HHAT 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.017 0.106 -9999.0 0.0 -0.44 17.0 17.0 somite specification -0.009 0.105 -9999.0 0.0 -0.33 25.0 25.0 SHH Np/Cholesterol/PTCH1 0.002 0.068 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/PTCH2 0.01 0.025 -9999.0 0.0 -0.233 3.0 3.0 SHH Np/Cholesterol/Megalin -0.012 0.077 -9999.0 0.0 -0.239 29.0 29.0 SHH 0.006 0.032 -9999.0 0.0 -0.31 3.0 3.0 catabolic process -0.003 0.085 -9999.0 0.0 -0.268 25.0 25.0 SMO/Vitamin D3 -0.001 0.087 -9999.0 0.0 -0.264 23.0 23.0 SHH Np/Cholesterol/Hhip 0.0 0.053 -9999.0 0.0 -0.234 14.0 14.0 LRP2 -0.032 0.131 -9999.0 0.0 -0.44 27.0 27.0 receptor-mediated endocytosis -0.018 0.109 -9999.0 0.0 -0.437 10.0 10.0 SHH Np/Cholesterol/BOC 0.01 0.025 -9999.0 0.0 -0.233 3.0 3.0 SHH Np/Cholesterol/CDO 0.01 0.025 -9999.0 0.0 -0.233 3.0 3.0 mesenchymal cell differentiation 0.0 0.052 0.232 14.0 -9999.0 0.0 14.0 mol:Vitamin D3 0.004 0.07 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH2 -0.01 0.085 -9999.0 0.0 -0.269 28.0 28.0 CDON 0.01 0.001 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.001 0.087 -9999.0 0.0 -0.27 25.0 25.0 Megalin/LRPAP1 -0.016 0.094 -9999.0 0.0 -0.31 27.0 27.0 PTCH2 0.01 0.001 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol 0.005 0.025 -9999.0 0.0 -0.235 3.0 3.0 PTCH1 -0.003 0.085 -9999.0 0.0 -0.269 25.0 25.0 HHIP -0.008 0.086 -9999.0 0.0 -0.44 11.0 11.0