Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.005 0.063 -9999.0 0.0 -0.215 24.0 24.0 epithelial cell differentiation 0.002 0.065 -9999.0 0.0 -0.216 24.0 24.0 CYFIP2 0.008 0.026 -9999.0 0.0 -0.44 1.0 1.0 ENAH 0.002 0.043 -9999.0 0.0 -9999.0 0.0 0.0 EGFR 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EPHA2 0.01 0.001 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.006 0.06 -9999.0 0.0 -0.205 24.0 24.0 CTNNB1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.019 0.016 -9999.0 0.0 -0.259 1.0 1.0 AQP5 -0.05 0.148 -9999.0 0.0 -0.435 33.0 33.0 CTNND1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.006 0.059 -9999.0 0.0 -0.202 24.0 24.0 regulation of calcium-dependent cell-cell adhesion -0.024 0.089 -9999.0 0.0 -0.226 44.0 44.0 EGF -0.395 0.135 -9999.0 0.0 -0.44 261.0 261.0 NCKAP1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.159 0.223 -9999.0 0.0 -0.443 107.0 107.0 cortical microtubule organization 0.002 0.065 -9999.0 0.0 -0.216 24.0 24.0 GO:0000145 -0.008 0.056 -9999.0 0.0 -0.193 24.0 24.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.003 0.066 -9999.0 0.0 -0.217 24.0 24.0 MLLT4 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.015 0.049 -9999.0 0.0 -0.176 24.0 24.0 ARF6 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.025 0.001 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.003 0.056 -9999.0 0.0 -0.191 24.0 24.0 PVRL2 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.006 0.06 -9999.0 0.0 -0.205 24.0 24.0 ARF6/GTP 0.028 0.002 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.027 0.124 -9999.0 0.0 -0.44 24.0 24.0 EGFR/EGFR/EGF/EGF -0.194 0.08 -9999.0 0.0 -0.213 266.0 266.0 RhoA/GDP 0.003 0.062 -9999.0 0.0 -0.203 24.0 24.0 actin cytoskeleton organization -0.006 0.059 -9999.0 0.0 -0.201 24.0 24.0 IGF-1R heterotetramer 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.0 0.064 -9999.0 0.0 -0.44 6.0 6.0 DIAPH1 0.019 0.035 -9999.0 0.0 -0.549 1.0 1.0 Wnt receptor signaling pathway -0.002 0.065 0.216 24.0 -9999.0 0.0 24.0 RHOA 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.015 0.049 -9999.0 0.0 -0.178 24.0 24.0 CTNNA1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.006 0.06 -9999.0 0.0 -0.205 24.0 24.0 EFNA1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.006 0.057 -9999.0 0.0 -0.195 24.0 24.0 Ephrin A1/EPHA2 0.001 0.059 -9999.0 0.0 -0.197 24.0 24.0 SEC6/SEC8 -0.015 0.051 -9999.0 0.0 -0.185 24.0 24.0 MGAT3 -0.024 0.09 -9999.0 0.0 -0.23 44.0 44.0 HGF/MET -0.012 0.077 -9999.0 0.0 -0.214 33.0 33.0 HGF -0.017 0.106 -9999.0 0.0 -0.44 17.0 17.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.005 0.064 -9999.0 0.0 -0.217 24.0 24.0 actin cable formation 0.011 0.041 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 -0.006 0.058 -9999.0 0.0 -0.195 25.0 25.0 KIFC3 -0.006 0.06 -9999.0 0.0 -0.205 24.0 24.0 NCK1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.006 0.06 -9999.0 0.0 -0.205 24.0 24.0 NCK1/GIT1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.002 0.065 -9999.0 0.0 -0.216 24.0 24.0 EXOC4 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.006 0.06 -9999.0 0.0 -0.205 24.0 24.0 PIP5K1C -0.006 0.06 -9999.0 0.0 -0.205 24.0 24.0 LIMA1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.001 0.049 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.0 0.056 -9999.0 0.0 -0.216 1.0 1.0 IGF-1R heterotetramer/IGF1 -0.004 0.066 -9999.0 0.0 -0.198 30.0 30.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.009 0.003 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 -0.006 0.061 -9999.0 0.0 -0.205 25.0 25.0 mol:GTP 0.024 0.001 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity 0.0 0.054 -9999.0 0.0 -0.178 24.0 24.0 cortical actin cytoskeleton stabilization -0.005 0.063 -9999.0 0.0 -0.215 24.0 24.0 regulation of cell-cell adhesion -0.006 0.059 -9999.0 0.0 -0.201 24.0 24.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.005 0.064 -9999.0 0.0 -0.217 24.0 24.0