Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.002 0.109 -9999.0 0.0 -9999.0 0.0 0.0 IHH -0.032 0.208 -9999.0 0.0 -0.664 28.0 28.0 SHH Np/Cholesterol/GAS1 -0.002 0.086 -9999.0 0.0 -0.317 18.0 18.0 LRPAP1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.002 0.085 0.315 18.0 -9999.0 0.0 18.0 SMO/beta Arrestin2 -0.007 0.133 -9999.0 0.0 -0.508 4.0 4.0 SMO -0.015 0.13 -9999.0 0.0 -0.432 20.0 20.0 AKT1 -0.01 0.13 -9999.0 0.0 -0.622 7.0 7.0 ARRB2 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.028 0.002 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.016 0.128 -9999.0 0.0 -0.424 21.0 21.0 STIL 0.021 0.121 -9999.0 0.0 -0.369 1.0 1.0 DHH N/PTCH2 0.004 0.125 -9999.0 0.0 -0.478 18.0 18.0 DHH N/PTCH1 -0.019 0.15 -9999.0 0.0 -0.364 42.0 42.0 PIK3CA 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.018 0.161 -9999.0 0.0 -0.639 18.0 18.0 PTHLH -0.014 0.136 -9999.0 0.0 -9999.0 0.0 0.0 determination of left/right symmetry -0.016 0.128 -9999.0 0.0 -0.424 21.0 21.0 PIK3R1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.013 0.135 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/Hhip -0.026 0.17 -9999.0 0.0 -0.45 39.0 39.0 DHH N/Hhip -0.015 0.165 -9999.0 0.0 -0.523 26.0 26.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.016 0.128 -9999.0 0.0 -0.424 21.0 21.0 pancreas development -0.004 0.128 -9999.0 0.0 -0.638 11.0 11.0 HHAT 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.04 0.009 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.008 0.146 -9999.0 0.0 -0.6 16.0 16.0 somite specification -0.016 0.128 -9999.0 0.0 -0.424 21.0 21.0 SHH Np/Cholesterol/PTCH1 -0.006 0.097 -9999.0 0.0 -0.338 6.0 6.0 SHH Np/Cholesterol/PTCH2 0.015 0.043 -9999.0 0.0 -0.374 3.0 3.0 SHH Np/Cholesterol/Megalin -0.021 0.125 -9999.0 0.0 -0.393 28.0 28.0 SHH 0.005 0.051 -9999.0 0.0 -0.481 3.0 3.0 catabolic process -0.007 0.123 -9999.0 0.0 -0.379 28.0 28.0 SMO/Vitamin D3 -0.009 0.114 -9999.0 0.0 -0.423 7.0 7.0 SHH Np/Cholesterol/Hhip -0.0 0.083 -9999.0 0.0 -0.381 12.0 12.0 LRP2 -0.034 0.192 -9999.0 0.0 -0.627 27.0 27.0 receptor-mediated endocytosis -0.037 0.157 -9999.0 0.0 -0.598 12.0 12.0 SHH Np/Cholesterol/BOC 0.016 0.043 -9999.0 0.0 -0.38 3.0 3.0 SHH Np/Cholesterol/CDO 0.015 0.044 -9999.0 0.0 -0.38 3.0 3.0 mesenchymal cell differentiation 0.0 0.082 0.378 12.0 -9999.0 0.0 12.0 mol:Vitamin D3 0.029 0.127 -9999.0 0.0 -0.34 6.0 6.0 IHH N/PTCH2 -0.005 0.138 -9999.0 0.0 -0.421 28.0 28.0 CDON 0.026 0.012 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.001 0.127 -9999.0 0.0 -0.383 28.0 28.0 Megalin/LRPAP1 -0.007 0.149 -9999.0 0.0 -0.468 27.0 27.0 PTCH2 0.025 0.013 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol 0.008 0.041 -9999.0 0.0 -0.378 3.0 3.0 PTCH1 -0.007 0.124 -9999.0 0.0 -0.38 28.0 28.0 HHIP -0.004 0.128 -9999.0 0.0 -0.639 11.0 11.0