Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Nephrin/Neph1 signaling in the kidney podocyte	129.0	4394.0	34.0	-0.453	0.028	1000.0	-1000.0	-0.035	-1000.0
Angiopoietin receptor Tie2-mediated signaling	98.0	8710.0	88.0	-0.897	0.094	1000.0	-1000.0	-0.065	-1000.0
EGFR-dependent Endothelin signaling events	88.0	1866.0	21.0	-0.56	0.038	1000.0	-1000.0	-0.051	-1000.0
FOXA2 and FOXA3 transcription factor networks	81.0	3741.0	46.0	-1.08	0.031	1000.0	-1000.0	-0.101	-1000.0
PDGFR-alpha signaling pathway	63.0	2803.0	44.0	-0.252	0.038	1000.0	-1000.0	-0.057	-1000.0
Thromboxane A2 receptor signaling	48.0	5102.0	105.0	-0.56	0.097	1000.0	-1000.0	-0.049	-1000.0
Signaling mediated by p38-alpha and p38-beta	40.0	1775.0	44.0	-0.172	0.027	1000.0	-1000.0	-0.036	-1000.0
Glypican 1 network	38.0	1854.0	48.0	-0.325	0.051	1000.0	-1000.0	-0.028	-1000.0
BMP receptor signaling	33.0	2714.0	81.0	-0.371	0.055	1000.0	-1000.0	-0.048	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	33.0	2613.0	78.0	-0.271	0.064	1000.0	-1000.0	-0.052	-1000.0
Endothelins	30.0	2974.0	96.0	-0.609	0.034	1000.0	-1000.0	-0.072	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	29.0	3683.0	125.0	-0.136	0.062	1000.0	-1000.0	-0.072	-1000.0
Arf6 signaling events	27.0	1691.0	62.0	-0.56	0.059	1000.0	-1000.0	-0.045	-1000.0
IL4-mediated signaling events	26.0	2410.0	91.0	-0.868	0.522	1000.0	-1000.0	-0.125	-1000.0
Integrins in angiogenesis	23.0	1939.0	84.0	-0.407	0.058	1000.0	-1000.0	-0.053	-1000.0
Signaling events mediated by PTP1B	22.0	1683.0	76.0	-0.563	0.084	1000.0	-1000.0	-0.044	-1000.0
S1P1 pathway	22.0	820.0	36.0	-0.163	0.027	1000.0	-1000.0	-0.055	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	22.0	1541.0	68.0	-0.481	0.087	1000.0	-1000.0	-0.088	-1000.0
Ceramide signaling pathway	21.0	1651.0	76.0	-0.56	0.197	1000.0	-1000.0	-0.043	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	21.0	2527.0	120.0	-0.23	0.114	1000.0	-1000.0	-0.057	-1000.0
amb2 Integrin signaling	20.0	1715.0	82.0	-0.369	0.035	1000.0	-1000.0	-0.044	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	20.0	1503.0	74.0	-0.56	0.064	1000.0	-1000.0	-0.075	-1000.0
FoxO family signaling	17.0	1134.0	64.0	-0.859	0.063	1000.0	-1000.0	-0.05	-1000.0
Ephrin A  reverse signaling	15.0	105.0	7.0	-0.032	-0.0	1000.0	-1000.0	-0.018	-1000.0
Glucocorticoid receptor regulatory network	15.0	1750.0	114.0	-0.575	0.146	1000.0	-1000.0	-0.056	-1000.0
Plasma membrane estrogen receptor signaling	15.0	1340.0	86.0	-0.135	0.048	1000.0	-1000.0	-0.061	-1000.0
Signaling events regulated by Ret tyrosine kinase	14.0	1175.0	82.0	-0.064	0.028	1000.0	-1000.0	-0.071	-1000.0
LPA4-mediated signaling events	13.0	158.0	12.0	-0.14	0.007	1000.0	-1000.0	-0.024	-1000.0
Coregulation of Androgen receptor activity	13.0	1002.0	76.0	-0.643	0.05	1000.0	-1000.0	-0.02	-1000.0
TCR signaling in naïve CD8+ T cells	13.0	1225.0	93.0	-0.196	0.107	1000.0	-1000.0	-0.052	-1000.0
E-cadherin signaling events	13.0	65.0	5.0	-0.025	0.027	1000.0	-1000.0	-0.0	-1000.0
Signaling events mediated by the Hedgehog family	12.0	625.0	52.0	-0.037	0.04	1000.0	-1000.0	-0.047	-1000.0
Nongenotropic Androgen signaling	12.0	659.0	52.0	-0.107	0.045	1000.0	-1000.0	-0.041	-1000.0
Syndecan-3-mediated signaling events	11.0	385.0	35.0	-0.096	0.075	1000.0	-1000.0	-0.036	-1000.0
TCGA08_rtk_signaling	11.0	295.0	26.0	-0.22	0.062	1000.0	-1000.0	-0.011	-1000.0
E-cadherin signaling in keratinocytes	11.0	492.0	43.0	-0.219	0.043	1000.0	-1000.0	-0.047	-1000.0
Caspase cascade in apoptosis	10.0	800.0	74.0	-0.414	0.066	1000.0	-1000.0	-0.045	-1000.0
p75(NTR)-mediated signaling	10.0	1350.0	125.0	-0.358	0.075	1000.0	-1000.0	-0.083	-1000.0
IL6-mediated signaling events	10.0	755.0	75.0	-0.222	0.041	1000.0	-1000.0	-0.059	-1000.0
Regulation of nuclear SMAD2/3 signaling	9.0	1234.0	136.0	-0.479	0.096	1000.0	-1000.0	-0.048	-1000.0
Calcium signaling in the CD4+ TCR pathway	9.0	298.0	31.0	-0.106	0.028	1000.0	-1000.0	-0.051	-1000.0
IL27-mediated signaling events	9.0	491.0	51.0	-1.006	0.249	1000.0	-1000.0	-0.057	-1000.0
IL23-mediated signaling events	9.0	594.0	60.0	-0.062	0.04	1000.0	-1000.0	-0.084	-1000.0
S1P3 pathway	9.0	416.0	42.0	-0.109	0.039	1000.0	-1000.0	-0.036	-1000.0
Osteopontin-mediated events	8.0	330.0	38.0	-0.065	0.048	1000.0	-1000.0	-0.048	-1000.0
HIF-1-alpha transcription factor network	8.0	656.0	76.0	-0.104	0.086	1000.0	-1000.0	-0.084	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	8.0	690.0	85.0	-0.1	0.109	1000.0	-1000.0	-0.059	-1000.0
Presenilin action in Notch and Wnt signaling	8.0	525.0	61.0	-0.153	0.083	1000.0	-1000.0	-0.052	-1000.0
Reelin signaling pathway	8.0	503.0	56.0	-0.12	0.071	1000.0	-1000.0	-0.056	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	8.0	453.0	52.0	-0.239	0.084	1000.0	-1000.0	-0.047	-1000.0
EPHB forward signaling	8.0	751.0	85.0	-0.151	0.075	1000.0	-1000.0	-0.081	-1000.0
Effects of Botulinum toxin	8.0	229.0	26.0	-0.168	0.045	1000.0	-1000.0	-0.01	-1000.0
E-cadherin signaling in the nascent adherens junction	8.0	622.0	76.0	-0.033	0.048	1000.0	-1000.0	-0.068	-1000.0
Regulation of Telomerase	8.0	894.0	102.0	-0.56	0.068	1000.0	-1000.0	-0.053	-1000.0
PDGFR-beta signaling pathway	8.0	795.0	97.0	-0.032	0.059	1000.0	-1000.0	-0.062	-1000.0
Visual signal transduction: Rods	8.0	429.0	52.0	-0.15	0.053	1000.0	-1000.0	-0.047	-1000.0
Regulation of Androgen receptor activity	8.0	582.0	70.0	-0.754	0.044	1000.0	-1000.0	-0.049	-1000.0
Syndecan-1-mediated signaling events	7.0	260.0	34.0	-0.037	0.028	1000.0	-1000.0	-0.046	-1000.0
ceramide signaling pathway	7.0	368.0	49.0	0.0	0.041	1000.0	-1000.0	-0.049	-1000.0
Regulation of p38-alpha and p38-beta	7.0	398.0	54.0	-0.139	0.065	1000.0	-1000.0	-0.053	-1000.0
ErbB4 signaling events	6.0	476.0	69.0	-0.225	0.087	1000.0	-1000.0	-0.055	-1000.0
Sphingosine 1-phosphate (S1P) pathway	6.0	194.0	28.0	-0.109	0.044	1000.0	-1000.0	-0.031	-1000.0
Cellular roles of Anthrax toxin	6.0	243.0	39.0	-0.146	0.036	1000.0	-1000.0	-0.026	-1000.0
IFN-gamma pathway	6.0	420.0	68.0	-0.249	0.066	1000.0	-1000.0	-0.064	-1000.0
BCR signaling pathway	6.0	603.0	99.0	-0.043	0.062	1000.0	-1000.0	-0.064	-1000.0
Syndecan-4-mediated signaling events	6.0	445.0	67.0	-0.348	0.092	1000.0	-1000.0	-0.062	-1000.0
Class IB PI3K non-lipid kinase events	6.0	18.0	3.0	-0.012	0.012	1000.0	-1000.0	-0.006	-1000.0
Ras signaling in the CD4+ TCR pathway	6.0	107.0	17.0	-0.006	0.042	1000.0	-1000.0	-0.03	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	5.0	322.0	54.0	-0.059	0.047	1000.0	-1000.0	-0.057	-1000.0
Noncanonical Wnt signaling pathway	5.0	141.0	26.0	-0.136	0.027	1000.0	-1000.0	-0.051	-1000.0
Syndecan-2-mediated signaling events	5.0	365.0	69.0	-0.369	0.054	1000.0	-1000.0	-0.036	-1000.0
Fc-epsilon receptor I signaling in mast cells	5.0	562.0	97.0	-0.065	0.05	1000.0	-1000.0	-0.065	-1000.0
PLK1 signaling events	5.0	433.0	85.0	-0.008	0.054	1000.0	-1000.0	-0.025	-1000.0
Class I PI3K signaling events mediated by Akt	5.0	398.0	68.0	-0.03	0.056	1000.0	-1000.0	-0.045	-1000.0
IL1-mediated signaling events	5.0	336.0	62.0	-0.143	0.072	1000.0	-1000.0	-0.051	-1000.0
Ephrin B reverse signaling	5.0	267.0	48.0	-0.019	0.039	1000.0	-1000.0	-0.039	-1000.0
TCGA08_p53	5.0	39.0	7.0	-0.035	0.028	1000.0	-1000.0	-0.011	-1000.0
Canonical Wnt signaling pathway	5.0	271.0	51.0	-0.153	0.078	1000.0	-1000.0	-0.058	-1000.0
Wnt signaling	5.0	41.0	7.0	-0.003	0.027	1000.0	-1000.0	-0.027	-1000.0
ErbB2/ErbB3 signaling events	4.0	267.0	65.0	-0.059	0.048	1000.0	-1000.0	-0.074	-1000.0
IL12-mediated signaling events	4.0	378.0	87.0	-0.164	0.06	1000.0	-1000.0	-0.08	-1000.0
Nectin adhesion pathway	4.0	265.0	63.0	-0.025	0.055	1000.0	-1000.0	-0.058	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	4.0	353.0	83.0	-0.233	0.048	1000.0	-1000.0	-0.045	-1000.0
LPA receptor mediated events	4.0	480.0	102.0	-0.07	0.062	1000.0	-1000.0	-0.056	-1000.0
IGF1 pathway	4.0	230.0	57.0	-0.023	0.065	1000.0	-1000.0	-0.05	-1000.0
BARD1 signaling events	3.0	175.0	57.0	-0.049	0.06	1000.0	-1000.0	-0.058	-1000.0
mTOR signaling pathway	3.0	200.0	53.0	-0.017	0.048	1000.0	-1000.0	-0.045	-1000.0
S1P5 pathway	3.0	60.0	17.0	-0.012	0.027	1000.0	-1000.0	-0.024	-1000.0
HIF-2-alpha transcription factor network	3.0	132.0	43.0	-0.176	0.096	1000.0	-1000.0	-0.062	-1000.0
FAS signaling pathway (CD95)	3.0	150.0	47.0	-0.118	0.04	1000.0	-1000.0	-0.039	-1000.0
Class I PI3K signaling events	3.0	247.0	73.0	-0.021	0.048	1000.0	-1000.0	-0.049	-1000.0
Signaling events mediated by PRL	3.0	120.0	34.0	-0.037	0.04	1000.0	-1000.0	-0.054	-1000.0
FOXM1 transcription factor network	3.0	156.0	51.0	-0.093	0.046	1000.0	-1000.0	-0.124	-1000.0
S1P4 pathway	3.0	89.0	25.0	-0.012	0.053	1000.0	-1000.0	-0.035	-1000.0
Aurora B signaling	3.0	226.0	67.0	-0.247	0.049	1000.0	-1000.0	-0.05	-1000.0
Signaling events mediated by HDAC Class II	2.0	157.0	75.0	-0.105	0.071	1000.0	-1000.0	-0.031	-1000.0
Hedgehog signaling events mediated by Gli proteins	2.0	187.0	65.0	-0.012	0.066	1000.0	-1000.0	-0.053	-1000.0
EPO signaling pathway	2.0	160.0	55.0	-0.003	0.075	1000.0	-1000.0	-0.053	-1000.0
Insulin-mediated glucose transport	2.0	73.0	32.0	-0.03	0.049	1000.0	-1000.0	-0.036	-1000.0
Signaling mediated by p38-gamma and p38-delta	2.0	44.0	15.0	-0.01	0.028	1000.0	-1000.0	-0.036	-1000.0
Retinoic acid receptors-mediated signaling	2.0	142.0	58.0	-0.033	0.058	1000.0	-1000.0	-0.029	-1000.0
IL2 signaling events mediated by PI3K	2.0	156.0	58.0	-0.015	0.062	1000.0	-1000.0	-0.043	-1000.0
Arf6 trafficking events	2.0	167.0	71.0	-0.249	0.047	1000.0	-1000.0	-0.037	-1000.0
Insulin Pathway	2.0	188.0	74.0	-0.024	0.071	1000.0	-1000.0	-0.055	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	2.0	92.0	33.0	-0.054	0.068	1000.0	-1000.0	-0.037	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	1.0	26.0	23.0	-0.01	0.048	1000.0	-1000.0	-0.039	-1000.0
JNK signaling in the CD4+ TCR pathway	1.0	24.0	17.0	0.014	0.045	1000.0	-1000.0	-0.046	-1000.0
Arf6 downstream pathway	1.0	76.0	43.0	-0.044	0.045	1000.0	-1000.0	-0.042	-1000.0
Signaling events mediated by HDAC Class I	1.0	175.0	104.0	-0.105	0.067	1000.0	-1000.0	-0.039	-1000.0
Atypical NF-kappaB pathway	1.0	33.0	31.0	-0.0	0.04	1000.0	-1000.0	-0.024	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	64.0	45.0	0.0	0.077	1000.0	-1000.0	-0.052	-1000.0
TCGA08_retinoblastoma	1.0	9.0	8.0	-0.053	0.032	1000.0	-1000.0	-0.003	-1000.0
VEGFR1 specific signals	1.0	89.0	56.0	-0.012	0.064	1000.0	-1000.0	-0.05	-1000.0
Canonical NF-kappaB pathway	0.0	18.0	39.0	-0.0	0.061	1000.0	-1000.0	-0.042	-1000.0
PLK2 and PLK4 events	0.0	0.0	3.0	0.009	0.026	1000.0	-1000.0	-0.016	-1000.0
Visual signal transduction: Cones	0.0	29.0	38.0	-0.018	0.055	1000.0	-1000.0	-0.02	-1000.0
Circadian rhythm pathway	0.0	6.0	22.0	-0.009	0.059	1000.0	-1000.0	-0.046	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	0.0	5.0	0.027	0.04	1000.0	-1000.0	0.002	-1000.0
Aurora A signaling	0.0	20.0	60.0	-0.009	0.062	1000.0	-1000.0	-0.025	-1000.0
Aurora C signaling	0.0	0.0	7.0	-0.02	0.028	1000.0	-1000.0	-0.021	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	0.0	5.0	37.0	-0.01	0.063	1000.0	-1000.0	-0.046	-1000.0
Signaling events mediated by HDAC Class III	0.0	22.0	40.0	-0.049	0.05	1000.0	-1000.0	-0.017	-1000.0
TRAIL signaling pathway	0.0	8.0	48.0	-0.0	0.07	1000.0	-1000.0	-0.05	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	1.0	36.0	-0.054	0.057	1000.0	-1000.0	-0.051	-1000.0
Glypican 2 network	0.0	0.0	4.0	-0.005	-0.001	1000.0	-1000.0	-0.005	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	2.0	27.0	0.0	0.062	1000.0	-1000.0	-0.039	-1000.0
IL2 signaling events mediated by STAT5	0.0	15.0	22.0	0.007	0.041	1000.0	-1000.0	-0.048	-1000.0
Rapid glucocorticoid signaling	0.0	9.0	20.0	-0.004	0.034	1000.0	-1000.0	-0.006	-1000.0
p38 MAPK signaling pathway	0.0	33.0	44.0	-0.0	0.055	1000.0	-1000.0	-0.039	-1000.0
Arf1 pathway	0.0	26.0	54.0	-0.001	0.048	1000.0	-1000.0	-0.025	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.075	1000.0	-1000.0	-0.0	-1000.0
Total	1504	95807	7203	-23.7482864554	7.96877244006	131000	-131000	-6.05370947262	-131000