Clinical Features MRNA_CNMF MRNA_CHIERARCHICAL CN_CNMF METHLYATION_CNMF RPPA_CNMF RPPA_CHIERARCHICAL MRNASEQ_CNMF MRNASEQ_CHIERARCHICAL MIRSEQ_CNMF MIRSEQ_CHIERARCHICAL MIRSEQ_MATURE_CNMF MIRSEQ_MATURE_CHIERARCHICAL nMutated (%) nWild-Type Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q IDH1 398 (78%) 115 0.22425 0.732 0.88277 1 9.9999e-06 0.00019 9.9999e-06 0.00019 0.00178 0.0211 0.00060999 0.00842 9.9999e-06 0.00019 9.9999e-06 0.00019 2e-05 0.000354 9.9999e-06 0.00019 9.9999e-06 0.00019 9.9999e-06 0.00019 TP53 248 (48%) 265 0.096009 0.461 0.0062799 0.0615 9.9999e-06 0.00019 9.9999e-06 0.00019 0.00359 0.0382 0.00338 0.037 9.9999e-06 0.00019 9.9999e-06 0.00019 9.9999e-06 0.00019 2e-05 0.000354 0.053149 0.307 9.9999e-06 0.00019 ATRX 195 (38%) 318 0.0264 0.193 0.11782 0.516 9.9999e-06 0.00019 9.9999e-06 0.00019 0.090349 0.444 0.03857 0.248 9.9999e-06 0.00019 9.9999e-06 0.00019 9.9999e-06 0.00019 3e-05 0.000513 0.26216 0.791 9.9999e-06 0.00019 CIC 108 (21%) 405 0.050259 0.301 0.00313 0.0351 9.9999e-06 0.00019 9.9999e-06 0.00019 0.04859 0.293 0.3753 0.905 9.9999e-06 0.00019 9.9999e-06 0.00019 9.9999e-06 0.00019 9.9999e-06 0.00019 9.9999e-06 0.00019 9.9999e-06 0.00019 NOTCH1 42 (8%) 471 0.61515 1 0.27951 0.806 2e-04 0.00305 9.9999e-06 0.00019 0.60824 1 0.62111 1 9.9999e-06 0.00019 9.9999e-06 0.00019 2e-04 0.00305 0.00479 0.0491 0.00157 0.0188 0.00013 0.00208 IDH2 20 (4%) 493 NA NA NA NA 0.00132 0.0162 0.00036 0.00526 0.24649 0.764 0.089069 0.44 0.0078399 0.0718 0.00023 0.00341 0.0096499 0.0859 0.00058999 0.00826 0.00297 0.0336 0.04646 0.284 PIK3R1 22 (4%) 491 0.61416 1 0.58007 1 0.0195 0.149 0.00193 0.0226 0.94742 1 0.83095 1 0.1269 0.54 0.03679 0.241 0.086239 0.428 0.58702 1 0.96112 1 0.62851 1 FUBP1 47 (9%) 466 0.02358 0.177 0.0069899 0.0658 9.9999e-06 0.00019 9.9999e-06 0.00019 0.62398 1 0.68248 1 9.9999e-06 0.00019 9.9999e-06 0.00019 9.9999e-06 0.00019 0.00112 0.0141 0.0082899 0.0753 9.9999e-06 0.00019 NF1 33 (6%) 480 NA NA NA NA 0.00115 0.0143 9.9999e-06 0.00019 0.03649 0.24 0.18452 0.671 9.9999e-06 0.00019 9.9999e-06 0.00019 0.33788 0.843 0.00018 0.00283 0.0052999 0.0529 9.9999e-06 0.00019 ARID1A 20 (4%) 493 NA NA NA NA 0.69348 1 0.080009 0.407 0.25495 0.772 0.6353 1 0.03236 0.22 0.14011 0.584 0.31534 0.832 0.60764 1 0.084369 0.423 0.0288 0.203 PTEN 24 (5%) 489 NA NA NA NA 9.9999e-06 0.00019 9.9999e-06 0.00019 0.01286 0.107 0.00211 0.0244 9.9999e-06 0.00019 9.9999e-06 0.00019 0.00354 0.0382 9.9999e-06 0.00019 2e-05 0.000354 9.9999e-06 0.00019 EGFR 35 (7%) 478 NA NA NA NA 9.9999e-06 0.00019 9.9999e-06 0.00019 0.30375 0.83 0.055739 0.316 9.9999e-06 0.00019 9.9999e-06 0.00019 0.01055 0.0917 9.9999e-06 0.00019 9.9999e-06 0.00019 9.9999e-06 0.00019 GAGE2A 8 (2%) 505 NA NA NA NA 0.81479 1 1 1 0.96222 1 1 1 0.72402 1 0.62077 1 0.65478 1 0.90096 1 0.82083 1 0.92349 1 NUDT11 11 (2%) 502 NA NA NA NA 1 1 0.84782 1 0.45551 0.964 0.85415 1 0.20348 0.714 0.15635 0.628 0.02547 0.189 0.91908 1 0.16964 0.65 0.29578 0.83 PIK3CA 44 (9%) 469 NA NA NA NA 6.9999e-05 0.00116 2e-05 0.000354 0.32912 0.832 0.56584 1 0.00111 0.0141 3e-05 0.000513 0.0103 0.0903 0.03856 0.248 0.32903 0.832 0.00090999 0.0119 STK19 10 (2%) 503 NA NA NA NA 0.42176 0.947 0.11128 0.505 0.39551 0.914 0.69047 1 0.29944 0.83 0.71899 1 0.16935 0.65 0.54469 1 0.92231 1 0.84331 1 EMG1 6 (1%) 507 NA NA NA NA 1 1 0.8562 1 0.64081 1 0.42431 0.948 0.40764 0.934 0.28467 0.811 0.40916 0.935 0.43084 0.954 0.52989 1 0.72347 1 SMARCA4 26 (5%) 487 NA NA NA NA 0.0114 0.0974 0.10334 0.484 0.18658 0.674 0.9559 1 0.32689 0.832 0.45181 0.964 0.30529 0.83 0.2452 0.764 0.8726 1 0.16422 0.644 NIPBL 18 (4%) 495 NA NA NA NA 0.03738 0.243 0.00076999 0.0102 0.38761 0.914 0.22948 0.737 0.00373 0.0392 0.00482 0.0491 0.4502 0.964 0.17196 0.651 0.01076 0.0927 0.059059 0.331 TCF12 15 (3%) 498 NA NA NA NA 0.67096 1 0.57854 1 0.76103 1 0.50807 1 0.8167 1 0.47677 0.973 0.69848 1 0.517 1 1 1 0.51585 1 DNMT3A 10 (2%) 503 NA NA NA NA 0.66233 1 0.64647 1 0.52431 1 0.47566 0.973 0.63091 1 0.94159 1 0.48041 0.976 0.04418 0.273 0.92223 1 0.97186 1 TRERF1 6 (1%) 507 NA NA NA NA 0.2435 0.764 0.12314 0.531 0.56045 1 0.35132 0.866 0.39193 0.914 0.57493 1 0.39014 0.914 0.75685 1 0.101 0.476 0.35358 0.867 CREBZF 7 (1%) 506 NA NA NA NA 0.052509 0.307 0.0075799 0.0701 0.22464 0.732 0.03526 0.234 0.28117 0.806 0.0226 0.171 0.20238 0.713 0.01367 0.112 0.11568 0.514 0.053549 0.307 FAM47C 18 (4%) 495 NA NA NA NA 0.30717 0.83 0.81827 1 0.46339 0.965 0.25206 0.768 0.27771 0.804 0.01188 0.101 0.61752 1 0.092629 0.449 0.0085099 0.0766 0.00332 0.0368 MYST4 11 (2%) 502 NA NA NA NA 0.02443 0.182 0.12535 0.538 0.12755 0.54 0.70297 1 0.26809 0.796 0.34292 0.853 0.20084 0.71 1 1 0.062449 0.344 0.61091 1 MED9 3 (1%) 510 NA NA NA NA 0.1748 0.653 0.36751 0.894 0.33581 0.84 0.22876 0.737 0.21818 0.728 0.84988 1 0.87716 1 0.79406 1 0.64971 1 0.51129 1 IRS4 7 (1%) 506 NA NA NA NA 0.082379 0.417 0.37705 0.905 0.67195 1 0.57911 1 0.60264 1 0.13691 0.575 0.41465 0.941 0.69196 1 0.26921 0.796 1 1 HTRA2 5 (1%) 508 NA NA NA NA 0.02978 0.207 0.42007 0.946 1 1 1 1 0.95338 1 0.63858 1 0.34835 0.861 0.72437 1 0.55927 1 0.47252 0.973 NRAS 4 (1%) 509 NA NA NA NA 0.56484 1 0.50815 1 1 1 0.32468 0.832 0.418 0.945 0.1072 0.496 0.30455 0.83 0.68335 1 0.33443 0.839 0.75893 1 TNRC18 9 (2%) 504 NA NA NA NA 0.9076 1 0.23237 0.741 0.44443 0.964 0.54218 1 0.19077 0.684 0.57719 1 0.6803 1 0.37342 0.903 0.82234 1 0.57819 1 ZNF709 4 (1%) 509 NA NA NA NA 0.6901 1 1 1 1 1 0.67752 1 0.21891 0.728 0.23047 0.737 1 1 0.68225 1 0.27163 0.796 1 1 PLXNA3 9 (2%) 504 NA NA NA NA 0.21111 0.716 0.27158 0.796 0.158 0.629 0.21674 0.728 0.19862 0.705 0.31042 0.832 0.35311 0.867 0.22667 0.732 0.482 0.977 0.87654 1 ROBO3 5 (1%) 508 NA NA NA NA 0.62155 1 0.90417 1 0.84664 1 0.53824 1 0.82785 1 0.70624 1 0.4035 0.929 0.28707 0.815 1 1 0.92577 1 RB1 6 (1%) 507 NA NA NA NA 0.00022 0.00331 0.00076999 0.0102 0.87182 1 0.84611 1 0.01662 0.132 0.096839 0.463 0.60098 1 0.03271 0.22 0.78113 1 0.24635 0.764 SRPX 4 (1%) 509 NA NA NA NA 0.22436 0.732 0.10544 0.49 0.67485 1 0.2515 0.768 0.20591 0.714 0.14369 0.596 0.2757 0.803 0.19787 0.705 0.39502 0.914 0.062489 0.344 PDGFRA 10 (2%) 503 NA NA NA NA 0.32033 0.832 0.062979 0.345 0.12668 0.54 0.22672 0.732 0.0065399 0.0622 0.00011 0.00179 0.00055999 0.00795 0.00155 0.0188 0.85368 1 0.18442 0.671 ZNF512B 5 (1%) 508 NA NA NA NA 0.45255 0.964 0.81677 1 0.93194 1 0.42894 0.954 1 1 0.85098 1 1 1 1 1 0.45647 0.964 0.24764 0.766 ZMIZ1 9 (2%) 504 NA NA NA NA 0.051259 0.303 0.32902 0.832 0.18055 0.667 0.24219 0.763 0.53033 1 0.29817 0.83 0.4777 0.973 0.67804 1 0.01881 0.147 0.42056 0.946 TMEM216 3 (1%) 510 NA NA NA NA 0.25086 0.768 1 1 0.70785 1 0.59706 1 1 1 0.44305 0.964 0.51959 1 0.60438 1 0.30034 0.83 0.66736 1 ARID2 11 (2%) 502 NA NA NA NA 0.85894 1 0.2641 0.791 0.78348 1 0.64446 1 0.4633 0.965 0.65072 1 0.60319 1 0.34761 0.861 0.48364 0.977 0.45786 0.964 RBPJ 7 (1%) 506 NA NA NA NA 1 1 0.18069 0.667 0.1082 0.498 0.051379 0.303 0.43511 0.96 6.9999e-05 0.00116 0.33016 0.832 0.0282 0.201 0.11385 0.51 0.44609 0.964 CUL4B 10 (2%) 503 NA NA NA NA 0.29578 0.83 0.04637 0.284 0.27696 0.804 0.3682 0.894 0.091499 0.446 0.070769 0.375 0.19 0.684 0.0071499 0.0667 1 1 0.3786 0.906 SLC6A3 9 (2%) 504 NA NA NA NA 0.69974 1 0.87701 1 0.32336 0.832 0.0097199 0.0859 0.74015 1 0.48709 0.977 0.17341 0.651 0.50564 1 0.70569 1 0.53694 1 SETD2 10 (2%) 503 NA NA NA NA 0.03944 0.252 0.064049 0.349 1 1 0.89779 1 0.00050999 0.00734 0.053109 0.307 0.60529 1 0.094779 0.457 0.8532 1 0.3769 0.905 KRT3 4 (1%) 509 NA NA NA NA 0.82048 1 0.8804 1 0.79166 1 0.30726 0.83 0.64237 1 0.73812 1 0.2737 0.8 0.1963 0.702 0.39515 0.914 0.21076 0.716 MYT1 6 (1%) 507 NA NA NA NA 0.01517 0.123 0.20765 0.714 NA NA NA NA 0.44812 0.964 0.03242 0.22 0.43042 0.954 0.75678 1 0.45397 0.964 0.94108 1 SMOC1 3 (1%) 510 NA NA NA NA 1 1 1 1 NA NA NA NA 1 1 0.81785 1 0.59781 1 1 1 0.65224 1 0.18275 0.671 ZBTB20 21 (4%) 492 NA NA NA NA 0.01265 0.106 0.00061999 0.00845 0.83703 1 0.29514 0.83 0.01325 0.109 0.0038 0.0395 0.159 0.631 0.01945 0.149 0.04061 0.257 0.03289 0.22 PPL 6 (1%) 507 NA NA NA NA 0.76965 1 1 1 0.21076 0.716 0.57602 1 0.84274 1 0.24893 0.767 0.14604 0.602 0.75801 1 0.32871 0.832 0.72588 1 PTPN11 7 (1%) 506 NA NA NA NA 0.54894 1 0.01875 0.147 0.50049 0.997 0.84653 1 0.053399 0.307 0.22635 0.732 0.22006 0.73 0.0051599 0.052 0.01659 0.132 0.00244 0.0279 RET 7 (1%) 506 NA NA NA NA 0.55135 1 0.31946 0.832 0.62347 1 0.8361 1 0.37293 0.903 0.44565 0.964 0.70663 1 0.15248 0.615 0.15016 0.612 0.25379 0.771 ANKRD36 7 (1%) 506 NA NA NA NA 0.02612 0.192 0.11223 0.507 0.44083 0.964 0.17062 0.651 0.60119 1 0.44873 0.964 0.73852 1 1 1 0.89543 1 0.94797 1 NEU2 5 (1%) 508 NA NA NA NA 0.52933 1 0.81622 1 0.87017 1 1 1 0.078129 0.4 0.86873 1 0.30315 0.83 1 1 0.4587 0.964 0.71283 1 PRX 10 (2%) 503 NA NA NA NA 0.11432 0.51 0.03296 0.22 0.83647 1 0.83737 1 0.38889 0.914 0.059969 0.334 0.5355 1 0.00104 0.0134 0.18543 0.672 0.074219 0.387 RBBP6 6 (1%) 507 NA NA NA NA 0.58306 1 0.32117 0.832 1 1 0.097359 0.463 0.02753 0.198 0.0061399 0.0607 0.28063 0.806 0.065619 0.354 0.085249 0.425 0.17854 0.664 CIB1 4 (1%) 509 NA NA NA NA 0.82235 1 1 1 0.62264 1 0.53916 1 0.60765 1 0.17342 0.651 0.2188 0.728 0.04391 0.273 0.12024 0.525 0.31995 0.832 DDX5 5 (1%) 508 NA NA NA NA 1 1 1 1 1 1 0.61296 1 0.61464 1 0.48535 0.977 0.26391 0.791 0.439 0.963 0.02826 0.201 0.31685 0.832 NAP1L2 4 (1%) 509 NA NA NA NA 0.68906 1 1 1 0.89367 1 0.04797 0.291 0.38113 0.908 0.068359 0.365 1 1 0.83037 1 1 1 1 1 SCN4A 6 (1%) 507 NA NA NA NA 0.11283 0.508 0.34661 0.861 0.56665 1 0.8673 1 0.48736 0.977 0.11053 0.504 0.57123 1 0.86602 1 0.067999 0.365 0.41542 0.941 AGBL1 5 (1%) 508 NA NA NA NA 0.16292 0.641 0.11684 0.514 0.1623 0.641 0.050539 0.301 0.03119 0.215 0.0436 0.273 0.20797 0.714 0.0064599 0.062 0.13616 0.574 0.0036 0.0382 TPX2 5 (1%) 508 NA NA NA NA 1 1 0.81946 1 1 1 1 1 0.82888 1 0.38796 0.914 0.48778 0.977 0.074409 0.387 0.16591 0.648 0.31997 0.832 KRT15 6 (1%) 507 NA NA NA NA 0.32977 0.832 1 1 1 1 0.78715 1 0.48885 0.978 0.46571 0.966 0.51776 1 0.86807 1 1 1 1 1 HTR3A 7 (1%) 506 NA NA NA NA 0.62028 1 0.15187 0.615 0.84599 1 1 1 0.66123 1 0.38297 0.908 0.16882 0.65 0.24504 0.764 0.57187 1 0.87166 1 C14ORF4 3 (1%) 510 NA NA NA NA 0.46743 0.966 0.67699 1 NA NA NA NA 1 1 0.84978 1 1 1 0.79299 1 0.64937 1 0.43967 0.963 R3HDM1 7 (1%) 506 NA NA NA NA 1 1 0.82593 1 0.26967 0.796 0.72986 1 0.85564 1 0.62487 1 0.73835 1 0.78384 1 0.074549 0.387 0.94817 1 G6PC 6 (1%) 507 NA NA NA NA 0.3291 0.832 0.14626 0.602 0.9003 1 1 1 0.60773 1 0.083189 0.419 0.43248 0.956 0.14853 0.609 0.29659 0.83 0.76484 1 DLC1 6 (1%) 507 NA NA NA NA 0.072269 0.381 0.23587 0.745 0.6712 1 0.83698 1 0.44843 0.964 0.52669 1 0.88896 1 0.15045 0.612 0.78268 1 0.13929 0.583 SLC12A7 7 (1%) 506 NA NA NA NA 0.16726 0.65 0.40501 0.93 0.38269 0.908 0.32101 0.832 0.92212 1 0.86337 1 0.87123 1 0.78614 1 0.89579 1 1 1 SMARCB1 4 (1%) 509 NA NA NA NA 0.82168 1 0.88001 1 0.064479 0.349 0.31015 0.832 0.92515 1 0.59231 1 0.43853 0.963 0.68098 1 0.076029 0.393 0.39485 0.914 WRN 5 (1%) 508 NA NA NA NA 0.20804 0.714 0.076339 0.393 0.9071 1 0.53694 1 0.0296 0.207 0.01602 0.129 0.057039 0.321 1 1 0.04343 0.273 0.45175 0.964 LAMA4 4 (1%) 509 NA NA NA NA 0.4523 0.964 0.30441 0.83 1 1 0.32441 0.832 0.10448 0.488 0.51867 1 0.69963 1 1 1 0.47559 0.973 0.83939 1 MAST2 5 (1%) 508 NA NA NA NA 0.72758 1 0.46307 0.965 0.68637 1 0.2825 0.807 0.72286 1 0.215 0.725 0.01915 0.148 0.52936 1 0.86965 1 0.71679 1 ZMYM2 7 (1%) 506 NA NA NA NA 0.62057 1 0.66533 1 0.58727 1 0.2816 0.806 0.62599 1 0.32076 0.832 0.12308 0.531 0.20839 0.714 0.27064 0.796 0.36462 0.892 SLFN11 4 (1%) 509 NA NA NA NA 0.8237 1 0.88012 1 1 1 0.41505 0.941 0.31076 0.832 0.71288 1 0.59052 1 0.26488 0.791 0.47457 0.973 0.75915 1 C4BPA 6 (1%) 507 NA NA NA NA 0.32877 0.832 0.29695 0.83 0.31348 0.832 0.53623 1 0.90058 1 0.38222 0.908 0.72979 1 0.50517 1 1 1 1 1 TMEM184A 3 (1%) 510 NA NA NA NA 0.46765 0.966 0.29957 0.83 0.89315 1 1 1 0.58431 1 0.17373 0.651 0.87798 1 0.23414 0.742 0.4137 0.941 0.50987 1 KTELC1 5 (1%) 508 NA NA NA NA 1 1 0.66786 1 0.31153 0.832 0.53682 1 0.9527 1 0.78786 1 0.11618 0.514 0.0063699 0.0617 1 1 0.10867 0.498 ASXL2 3 (1%) 510 NA NA NA NA 0.46499 0.966 0.30141 0.83 0.62851 1 0.59728 1 0.82927 1 0.3175 0.832 0.52367 1 0.79498 1 0.20621 0.714 1 1 CCDC135 7 (1%) 506 NA NA NA NA 0.70088 1 1 1 0.39692 0.916 0.42616 0.95 0.48734 0.977 0.02723 0.197 0.65834 1 1 1 0.80179 1 0.73297 1 SLC25A5 4 (1%) 509 NA NA NA NA 0.45608 0.964 0.22614 0.732 NA NA NA NA 0.92647 1 0.42321 0.948 0.8321 1 0.68053 1 0.47364 0.973 0.52019 1 ABCA7 9 (2%) 504 NA NA NA NA 0.70218 1 0.38751 0.914 0.22498 0.732 0.17103 0.651 0.26519 0.791 0.21256 0.719 1 1 0.055339 0.315 0.098909 0.468 0.25194 0.768 NKD2 4 (1%) 509 NA NA NA NA 1 1 0.87816 1 NA NA NA NA 0.64179 1 0.46251 0.965 0.36784 0.894 1 1 1 1 0.83877 1 MAX 4 (1%) 509 NA NA NA NA 0.12318 0.531 0.090659 0.444 0.23345 0.742 0.53718 1 0.18429 0.671 0.15745 0.629 0.30592 0.83 0.82969 1 0.33454 0.839 0.76092 1 VSIG4 6 (1%) 507 NA NA NA NA 0.20703 0.714 0.1691 0.65 0.45901 0.964 0.74924 1 0.76911 1 0.50068 0.997 0.76448 1 0.58338 1 0.69386 1 0.39187 0.914