E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.035 0.164 -9999.0 0.0 -0.459 60.0 60.0 KLHL20 -0.026 0.056 -9999.0 0.0 -0.266 9.0 9.0 CYFIP2 0.008 0.06 -9999.0 0.0 -0.541 6.0 6.0 Rac1/GDP 0.008 0.111 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.035 0.165 -9999.0 0.0 -0.459 60.0 60.0 AP1M1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.013 0.022 -9999.0 0.0 -0.489 1.0 1.0 RAP1A 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.035 0.066 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.017 0.038 -9999.0 0.0 -0.176 11.0 11.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.092 0.151 -9999.0 0.0 -0.375 74.0 74.0 RAPGEF1 -0.014 0.145 -9999.0 0.0 -0.388 60.0 60.0 CTNND1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.073 0.155 -9999.0 0.0 -0.48 60.0 60.0 CRK -0.024 0.156 -9999.0 0.0 -0.426 60.0 60.0 E-cadherin/gamma catenin/alpha catenin -0.083 0.146 -9999.0 0.0 -0.372 66.0 66.0 alphaE/beta7 Integrin -0.033 0.108 -9999.0 0.0 -0.38 45.0 45.0 IQGAP1 0.004 0.075 -9999.0 0.0 -0.531 10.0 10.0 NCKAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin -0.001 0.018 -9999.0 0.0 -0.326 1.0 1.0 DLG1 -0.035 0.165 -9999.0 0.0 -0.458 61.0 61.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.026 0.048 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.013 0.027 -9999.0 0.0 -0.593 1.0 1.0 ARF6/GTP/NME1/Tiam1 0.0 0.015 -9999.0 0.0 -0.326 1.0 1.0 PI3K -0.032 0.061 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.1 0.175 -9999.0 0.0 -0.393 132.0 132.0 TIAM1 0.013 0.027 -9999.0 0.0 -0.593 1.0 1.0 E-cadherin(dimer)/Ca2+ -0.064 0.114 -9999.0 0.0 -0.299 60.0 60.0 AKT1 -0.018 0.035 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.12 0.238 -9999.0 0.0 -0.539 125.0 125.0 RhoA/GDP 0.008 0.111 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.02 0.041 -9999.0 0.0 -0.191 9.0 9.0 CDC42/GDP 0.008 0.111 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.032 0.108 -9999.0 0.0 -0.273 66.0 66.0 ITGB7 -0.034 0.156 -9999.0 0.0 -0.535 45.0 45.0 RAC1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.041 0.136 -9999.0 0.0 -0.317 60.0 60.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.066 0.117 -9999.0 0.0 -0.27 125.0 125.0 mol:GDP -0.002 0.125 -9999.0 0.0 -0.325 8.0 8.0 CDC42/GTP/IQGAP1 -0.006 0.044 -9999.0 0.0 -0.32 10.0 10.0 JUP 0.003 0.081 -9999.0 0.0 -0.572 10.0 10.0 p120 catenin/RhoA/GDP -0.042 0.086 -9999.0 0.0 -9999.0 0.0 0.0 RAC1/GTP/IQGAP1 -0.006 0.044 -9999.0 0.0 -0.319 10.0 10.0 PIP5K1C/AP1M1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.01 0.063 -9999.0 0.0 -0.209 29.0 29.0 NME1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.035 0.164 -9999.0 0.0 -0.459 60.0 60.0 regulation of cell-cell adhesion -0.032 0.059 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 -0.008 0.02 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.041 0.077 -9999.0 0.0 -0.322 1.0 1.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.09 0.148 -9999.0 0.0 -0.578 19.0 19.0 CCND1 0.011 0.077 -9999.0 0.0 -0.262 29.0 29.0 VAV2 -0.018 0.154 -9999.0 0.0 -0.416 60.0 60.0 RAP1/GDP -0.039 0.081 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly -0.033 0.16 -9999.0 0.0 -0.445 60.0 60.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.051 0.16 -9999.0 0.0 -0.55 19.0 19.0 E-cadherin/beta catenin -0.067 0.132 -9999.0 0.0 -0.386 60.0 60.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.036 0.164 -9999.0 0.0 -0.46 60.0 60.0 PIK3CA 0.013 0.027 -9999.0 0.0 -0.593 1.0 1.0 Rac1/GTP -0.042 0.089 -9999.0 0.0 -0.453 9.0 9.0 E-cadherin/beta catenin/alpha catenin -0.077 0.137 -9999.0 0.0 -0.317 125.0 125.0 ITGAE 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.075 0.158 -9999.0 0.0 -0.491 60.0 60.0