E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.028 0.141 -9999.0 0.0 -0.424 55.0 55.0 KLHL20 0.011 0.07 0.159 6.0 -0.219 6.0 12.0 CYFIP2 0.022 0.037 -9999.0 0.0 -0.28 6.0 6.0 Rac1/GDP -0.004 0.095 0.261 4.0 -0.259 48.0 52.0 ENAH -0.032 0.145 -9999.0 0.0 -0.418 61.0 61.0 AP1M1 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.021 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.004 0.065 -9999.0 0.0 -0.236 1.0 1.0 ABI1/Sra1/Nap1 -0.014 0.035 -9999.0 0.0 -0.154 6.0 6.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.021 0.116 -9999.0 0.0 -0.259 70.0 70.0 RAPGEF1 -0.02 0.135 0.245 4.0 -0.374 55.0 59.0 CTNND1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.028 0.151 -9999.0 0.0 -0.428 62.0 62.0 CRK -0.03 0.135 0.224 1.0 -0.397 57.0 58.0 E-cadherin/gamma catenin/alpha catenin 0.014 0.105 -9999.0 0.0 -0.262 63.0 63.0 alphaE/beta7 Integrin 0.019 0.069 -9999.0 0.0 -0.304 19.0 19.0 IQGAP1 0.02 0.043 -9999.0 0.0 -0.25 10.0 10.0 NCKAP1 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.037 0.025 -9999.0 0.0 -0.232 1.0 1.0 DLG1 -0.031 0.144 -9999.0 0.0 -0.419 60.0 60.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.014 0.044 -9999.0 0.0 -0.179 1.0 1.0 MLLT4 0.024 0.021 -9999.0 0.0 -0.428 1.0 1.0 ARF6/GTP/NME1/Tiam1 0.048 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.015 0.057 -9999.0 0.0 -0.229 1.0 1.0 ARF6 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.02 0.116 -9999.0 0.0 -0.309 63.0 63.0 TIAM1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.029 0.088 -9999.0 0.0 -0.219 55.0 55.0 AKT1 -0.003 0.043 0.122 2.0 -0.136 1.0 3.0 PIK3R1 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.046 0.147 -9999.0 0.0 -0.275 122.0 122.0 RhoA/GDP 0.004 0.103 0.255 8.0 -0.259 51.0 59.0 actin cytoskeleton organization 0.014 0.06 0.163 18.0 -0.16 6.0 24.0 CDC42/GDP -0.0 0.099 0.254 5.0 -0.254 51.0 56.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.014 0.078 -9999.0 0.0 -0.222 60.0 60.0 ITGB7 0.001 0.091 -9999.0 0.0 -0.26 44.0 44.0 RAC1 0.023 0.009 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.031 0.095 -9999.0 0.0 -0.234 55.0 55.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.015 0.085 -9999.0 0.0 -0.217 59.0 59.0 mol:GDP -0.011 0.112 0.258 9.0 -0.297 52.0 61.0 CDC42/GTP/IQGAP1 0.027 0.028 -9999.0 0.0 -0.232 4.0 4.0 JUP 0.02 0.049 -9999.0 0.0 -0.428 6.0 6.0 p120 catenin/RhoA/GDP 0.009 0.104 0.26 6.0 -0.265 50.0 56.0 RAC1/GTP/IQGAP1 0.027 0.029 -9999.0 0.0 -0.255 4.0 4.0 PIP5K1C/AP1M1 0.037 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.022 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.012 0.051 0.139 19.0 -0.165 14.0 33.0 NME1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.031 0.146 -9999.0 0.0 -0.417 62.0 62.0 regulation of cell-cell adhesion -0.009 0.055 -9999.0 0.0 -0.209 1.0 1.0 WASF2 0.009 0.029 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.001 0.081 0.214 3.0 -0.262 1.0 4.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.027 0.12 -9999.0 0.0 -0.25 74.0 74.0 CCND1 0.012 0.06 0.161 15.0 -0.204 14.0 29.0 VAV2 -0.013 0.152 -9999.0 0.0 -0.639 5.0 5.0 RAP1/GDP 0.004 0.091 0.27 4.0 -0.231 22.0 26.0 adherens junction assembly -0.03 0.141 -9999.0 0.0 -0.404 62.0 62.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.023 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.016 0.113 -9999.0 0.0 -0.241 74.0 74.0 E-cadherin/beta catenin -0.028 0.104 -9999.0 0.0 -0.32 57.0 57.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.032 0.144 -9999.0 0.0 -0.415 60.0 60.0 PIK3CA 0.025 0.02 -9999.0 0.0 -0.428 1.0 1.0 Rac1/GTP -0.016 0.084 -9999.0 0.0 -0.338 7.0 7.0 E-cadherin/beta catenin/alpha catenin 0.016 0.1 -9999.0 0.0 -0.257 59.0 59.0 ITGAE 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.029 0.154 -9999.0 0.0 -0.437 62.0 62.0