Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.044 0.191 -9999.0 0.0 -0.581 53.0 53.0 IHH 0.012 0.056 -9999.0 0.0 -0.203 6.0 6.0 SHH Np/Cholesterol/GAS1 -0.011 0.084 0.155 12.0 -0.236 53.0 65.0 LRPAP1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.011 0.083 0.235 53.0 -0.154 12.0 65.0 SMO/beta Arrestin2 -0.005 0.115 -9999.0 0.0 -0.405 18.0 18.0 SMO -0.02 0.111 -9999.0 0.0 -0.412 20.0 20.0 AKT1 -0.003 0.106 -9999.0 0.0 -0.478 17.0 17.0 ARRB2 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.023 0.036 -9999.0 0.0 -0.31 5.0 5.0 ADRBK1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.019 0.11 -9999.0 0.0 -0.407 20.0 20.0 STIL -0.012 0.133 0.231 3.0 -0.297 38.0 41.0 DHH N/PTCH2 0.004 0.085 -9999.0 0.0 -0.307 31.0 31.0 DHH N/PTCH1 -0.02 0.122 -9999.0 0.0 -0.305 56.0 56.0 PIK3CA 0.025 0.02 -9999.0 0.0 -0.428 1.0 1.0 DHH -0.007 0.105 -9999.0 0.0 -0.428 27.0 27.0 PTHLH -0.061 0.255 -9999.0 0.0 -0.775 53.0 53.0 determination of left/right symmetry -0.019 0.11 -9999.0 0.0 -0.407 20.0 20.0 PIK3R1 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.06 0.252 -9999.0 0.0 -0.766 53.0 53.0 IHH N/Hhip -0.04 0.136 -9999.0 0.0 -0.34 76.0 76.0 DHH N/Hhip -0.049 0.14 -9999.0 0.0 -0.312 101.0 101.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.019 0.11 -9999.0 0.0 -0.407 20.0 20.0 pancreas development -0.058 0.159 -9999.0 0.0 -0.292 135.0 135.0 HHAT 0.012 0.077 -9999.0 0.0 -0.393 17.0 17.0 PI3K 0.038 0.007 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.016 0.047 -9999.0 0.0 -0.166 26.0 26.0 somite specification -0.019 0.11 -9999.0 0.0 -0.407 20.0 20.0 SHH Np/Cholesterol/PTCH1 -0.036 0.113 -9999.0 0.0 -0.279 68.0 68.0 SHH Np/Cholesterol/PTCH2 -0.016 0.082 0.153 2.0 -0.238 56.0 58.0 SHH Np/Cholesterol/Megalin -0.059 0.124 0.153 8.0 -0.269 115.0 123.0 SHH -0.03 0.097 -9999.0 0.0 -0.307 52.0 52.0 catabolic process -0.018 0.117 -9999.0 0.0 -0.342 52.0 52.0 SMO/Vitamin D3 -0.032 0.117 0.287 2.0 -0.335 34.0 36.0 SHH Np/Cholesterol/Hhip -0.048 0.119 0.154 8.0 -0.264 102.0 110.0 LRP2 -0.093 0.181 -9999.0 0.0 -0.428 108.0 108.0 receptor-mediated endocytosis -0.066 0.143 -9999.0 0.0 -0.403 47.0 47.0 SHH Np/Cholesterol/BOC -0.014 0.08 -9999.0 0.0 -0.236 54.0 54.0 SHH Np/Cholesterol/CDO -0.02 0.089 0.172 1.0 -0.25 59.0 60.0 mesenchymal cell differentiation 0.048 0.118 0.263 102.0 -0.153 8.0 110.0 mol:Vitamin D3 -0.001 0.145 0.263 6.0 -0.281 67.0 73.0 IHH N/PTCH2 0.023 0.051 -9999.0 0.0 -0.37 5.0 5.0 CDON 0.001 0.095 -9999.0 0.0 -0.428 23.0 23.0 IHH N/PTCH1 -0.011 0.121 -9999.0 0.0 -0.344 52.0 52.0 Megalin/LRPAP1 -0.052 0.137 -9999.0 0.0 -0.303 108.0 108.0 PTCH2 0.016 0.048 -9999.0 0.0 -0.28 10.0 10.0 SHH Np/Cholesterol -0.019 0.075 0.202 1.0 -0.233 52.0 53.0 PTCH1 -0.019 0.118 -9999.0 0.0 -0.343 52.0 52.0 HHIP -0.058 0.159 -9999.0 0.0 -0.292 135.0 135.0