Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.058 0.125 -9999.0 0.0 -0.22 9.0 9.0 epithelial cell differentiation -0.044 0.11 -9999.0 0.0 -0.192 9.0 9.0 CYFIP2 0.013 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.027 0.085 -9999.0 0.0 -0.316 1.0 1.0 EGFR -0.016 0.103 -9999.0 0.0 -0.378 2.0 2.0 EPHA2 0.013 0.003 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.051 0.122 -9999.0 0.0 -0.2 9.0 9.0 CTNNB1 -0.016 0.102 -9999.0 0.0 -0.378 2.0 2.0 ABI1/Sra1/Nap1 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.035 0.097 -9999.0 0.0 -0.343 1.0 1.0 CTNND1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.045 0.1 -9999.0 0.0 -0.179 9.0 9.0 regulation of calcium-dependent cell-cell adhesion -0.045 0.1 -9999.0 0.0 -0.179 9.0 9.0 EGF 0.014 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.035 0.097 -9999.0 0.0 -0.343 1.0 1.0 cortical microtubule organization -0.044 0.11 -9999.0 0.0 -0.192 9.0 9.0 GO:0000145 -0.045 0.094 -9999.0 0.0 -0.171 9.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.043 0.112 -9999.0 0.0 -0.194 9.0 9.0 MLLT4 -0.002 0.074 -9999.0 0.0 -0.378 1.0 1.0 ARF6/GDP -0.05 0.075 -9999.0 0.0 -0.278 1.0 1.0 ARF6 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.033 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.037 0.095 -9999.0 0.0 -0.31 1.0 1.0 PVRL2 -0.002 0.074 -9999.0 0.0 -0.378 1.0 1.0 ZYX -0.045 0.101 -9999.0 0.0 -0.181 9.0 9.0 ARF6/GTP 0.036 0.002 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.1 0.181 -9999.0 0.0 -0.378 8.0 8.0 EGFR/EGFR/EGF/EGF -0.053 0.1 -9999.0 0.0 -0.168 11.0 11.0 RhoA/GDP -0.046 0.124 -9999.0 0.0 -0.198 9.0 9.0 actin cytoskeleton organization -0.049 0.118 -9999.0 0.0 -0.194 9.0 9.0 IGF-1R heterotetramer 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.002 0.074 -9999.0 0.0 -0.378 1.0 1.0 DIAPH1 0.027 0.014 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway 0.044 0.11 0.192 9.0 -9999.0 0.0 9.0 RHOA -0.002 0.074 -9999.0 0.0 -0.378 1.0 1.0 RhoA/GTP -0.056 0.095 -9999.0 0.0 -0.43 1.0 1.0 CTNNA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.05 0.121 -9999.0 0.0 -0.199 9.0 9.0 EFNA1 0.013 0.003 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.041 0.096 -9999.0 0.0 -0.17 9.0 9.0 Ephrin A1/EPHA2 -0.04 0.098 -9999.0 0.0 -0.172 9.0 9.0 SEC6/SEC8 -0.063 0.101 -9999.0 0.0 -0.171 10.0 10.0 MGAT3 -0.045 0.101 -9999.0 0.0 -0.181 9.0 9.0 HGF/MET -0.039 0.098 -9999.0 0.0 -0.171 9.0 9.0 HGF 0.014 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.058 0.126 -9999.0 0.0 -0.221 9.0 9.0 actin cable formation -0.012 0.079 -9999.0 0.0 -0.268 1.0 1.0 KIAA1543 -0.067 0.126 -9999.0 0.0 -0.197 11.0 11.0 KIFC3 -0.045 0.101 -9999.0 0.0 -0.181 9.0 9.0 NCK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.045 0.101 -9999.0 0.0 -0.181 9.0 9.0 NCK1/GIT1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.044 0.11 -9999.0 0.0 -0.192 9.0 9.0 EXOC4 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.045 0.101 -9999.0 0.0 -0.181 9.0 9.0 PIP5K1C -0.045 0.101 -9999.0 0.0 -0.181 9.0 9.0 LIMA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.028 0.096 -9999.0 0.0 -0.375 1.0 1.0 adherens junction assembly -0.06 0.131 -9999.0 0.0 -0.415 2.0 2.0 IGF-1R heterotetramer/IGF1 -0.046 0.119 -9999.0 0.0 -0.191 9.0 9.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin -0.002 0.073 -9999.0 0.0 -0.259 2.0 2.0 MET 0.013 0.003 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 -0.045 0.101 -9999.0 0.0 -0.181 9.0 9.0 mol:GTP 0.032 0.002 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.041 0.109 -9999.0 0.0 -0.435 1.0 1.0 cortical actin cytoskeleton stabilization -0.058 0.125 -9999.0 0.0 -0.22 9.0 9.0 regulation of cell-cell adhesion -0.049 0.118 -9999.0 0.0 -0.194 9.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.058 0.126 -9999.0 0.0 -0.221 9.0 9.0