E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.036 0.144 -9999.0 0.0 -0.609 22.0 22.0 KLHL20 -0.026 0.069 -9999.0 0.0 -0.249 15.0 15.0 CYFIP2 -0.051 0.203 -9999.0 0.0 -0.86 22.0 22.0 Rac1/GDP 0.026 0.099 -9999.0 0.0 -0.368 21.0 21.0 ENAH -0.035 0.145 -9999.0 0.0 -0.609 22.0 22.0 AP1M1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.018 0.073 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.027 0.061 -9999.0 0.0 -0.198 26.0 26.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.035 0.142 -9999.0 0.0 -0.531 27.0 27.0 RAPGEF1 0.012 0.131 -9999.0 0.0 -0.509 22.0 22.0 CTNND1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.038 0.149 -9999.0 0.0 -0.633 22.0 22.0 CRK 0.003 0.142 -9999.0 0.0 -0.562 22.0 22.0 E-cadherin/gamma catenin/alpha catenin -0.034 0.137 -9999.0 0.0 -0.58 22.0 22.0 alphaE/beta7 Integrin -0.005 0.083 -9999.0 0.0 -0.667 5.0 5.0 IQGAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.036 0.144 -9999.0 0.0 -0.609 22.0 22.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.015 0.056 -9999.0 0.0 -0.366 1.0 1.0 MLLT4 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 -0.028 0.123 -9999.0 0.0 -0.538 20.0 20.0 PI3K -0.019 0.074 -9999.0 0.0 -0.509 1.0 1.0 ARF6 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.04 0.157 -9999.0 0.0 -0.667 22.0 22.0 TIAM1 -0.046 0.194 -9999.0 0.0 -0.86 20.0 20.0 E-cadherin(dimer)/Ca2+ -0.03 0.119 -9999.0 0.0 -0.505 22.0 22.0 AKT1 -0.011 0.041 -9999.0 0.0 -0.256 1.0 1.0 PIK3R1 -0.005 0.063 -9999.0 0.0 -0.86 2.0 2.0 CDH1 -0.051 0.203 -9999.0 0.0 -0.86 22.0 22.0 RhoA/GDP 0.026 0.099 -9999.0 0.0 -0.368 21.0 21.0 actin cytoskeleton organization -0.019 0.051 0.109 1.0 -0.235 5.0 6.0 CDC42/GDP 0.026 0.099 -9999.0 0.0 -0.368 21.0 21.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.021 0.085 -9999.0 0.0 -0.361 22.0 22.0 ITGB7 -0.012 0.099 -9999.0 0.0 -0.86 5.0 5.0 RAC1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.031 0.125 -9999.0 0.0 -0.531 22.0 22.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.03 0.121 -9999.0 0.0 -0.511 22.0 22.0 mol:GDP 0.022 0.116 -9999.0 0.0 -0.438 22.0 22.0 CDC42/GTP/IQGAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP -0.022 0.088 -9999.0 0.0 -9999.0 0.0 0.0 RAC1/GTP/IQGAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.018 0.058 0.199 1.0 -0.279 14.0 15.0 NME1 0.002 0.023 0.316 2.0 -9999.0 0.0 2.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.036 0.144 -9999.0 0.0 -0.609 22.0 22.0 regulation of cell-cell adhesion -0.016 0.064 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 -0.014 0.031 -9999.0 0.0 -0.143 1.0 1.0 Rap1/GTP -0.021 0.084 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.033 0.133 -9999.0 0.0 -0.498 27.0 27.0 CCND1 -0.022 0.074 0.226 1.0 -0.357 14.0 15.0 VAV2 0.007 0.137 -9999.0 0.0 -0.537 22.0 22.0 RAP1/GDP -0.021 0.084 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly -0.035 0.138 -9999.0 0.0 -0.585 22.0 22.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.031 0.127 -9999.0 0.0 -0.475 27.0 27.0 E-cadherin/beta catenin -0.031 0.124 -9999.0 0.0 -0.526 22.0 22.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.035 0.144 -9999.0 0.0 -0.609 22.0 22.0 PIK3CA -0.002 0.045 -9999.0 0.0 -0.86 1.0 1.0 Rac1/GTP -0.043 0.116 0.21 1.0 -0.427 15.0 16.0 E-cadherin/beta catenin/alpha catenin -0.034 0.137 -9999.0 0.0 -0.58 22.0 22.0 ITGAE 0.006 0.043 0.316 7.0 -9999.0 0.0 7.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.039 0.154 -9999.0 0.0 -0.651 22.0 22.0