Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.038 0.283 0.535 13.0 -0.886 23.0 36.0 IHH 0.013 0.183 0.367 17.0 -0.876 11.0 28.0 SHH Np/Cholesterol/GAS1 -0.12 0.24 -9999.0 0.0 -0.569 79.0 79.0 LRPAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.119 0.238 0.564 79.0 -9999.0 0.0 79.0 SMO/beta Arrestin2 -0.023 0.246 0.344 1.0 -0.795 28.0 29.0 SMO -0.024 0.266 0.385 1.0 -0.84 29.0 30.0 AKT1 0.001 0.14 0.253 1.0 -0.403 21.0 22.0 ARRB2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.009 0.054 0.316 11.0 -9999.0 0.0 11.0 ADRBK1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.022 0.258 0.384 1.0 -0.814 29.0 30.0 STIL -0.004 0.235 0.348 8.0 -0.689 28.0 36.0 DHH N/PTCH2 -0.002 0.053 -9999.0 0.0 -0.667 2.0 2.0 DHH N/PTCH1 -0.016 0.232 0.359 2.0 -0.757 26.0 28.0 PIK3CA -0.002 0.045 -9999.0 0.0 -0.86 1.0 1.0 DHH 0.001 0.016 0.316 1.0 -9999.0 0.0 1.0 PTHLH 0.045 0.287 0.515 13.0 -0.879 23.0 36.0 determination of left/right symmetry -0.022 0.258 0.384 1.0 -0.814 29.0 30.0 PIK3R1 -0.005 0.063 -9999.0 0.0 -0.86 2.0 2.0 skeletal system development 0.046 0.284 0.514 13.0 -0.867 23.0 36.0 IHH N/Hhip -0.34 0.376 0.272 1.0 -0.722 179.0 180.0 DHH N/Hhip -0.31 0.335 -9999.0 0.0 -0.668 173.0 173.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.022 0.258 0.384 1.0 -0.814 29.0 30.0 pancreas development -0.399 0.429 0.316 1.0 -0.858 173.0 174.0 HHAT -0.001 0.05 0.316 2.0 -0.86 1.0 3.0 PI3K -0.005 0.071 -9999.0 0.0 -0.935 2.0 2.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.161 0.337 0.316 1.0 -0.86 70.0 71.0 somite specification -0.022 0.258 0.384 1.0 -0.814 29.0 30.0 SHH Np/Cholesterol/PTCH1 -0.029 0.239 0.329 1.0 -0.686 34.0 35.0 SHH Np/Cholesterol/PTCH2 -0.021 0.116 -9999.0 0.0 -0.57 15.0 15.0 SHH Np/Cholesterol/Megalin -0.081 0.224 -9999.0 0.0 -0.553 64.0 64.0 SHH -0.007 0.137 -9999.0 0.0 -0.71 13.0 13.0 catabolic process 0.012 0.258 0.455 1.0 -0.743 32.0 33.0 SMO/Vitamin D3 -0.025 0.264 0.425 1.0 -0.721 36.0 37.0 SHH Np/Cholesterol/Hhip -0.27 0.283 -9999.0 0.0 -0.552 182.0 182.0 LRP2 -0.099 0.317 0.316 25.0 -0.86 52.0 77.0 receptor-mediated endocytosis -0.07 0.27 -9999.0 0.0 -0.76 33.0 33.0 SHH Np/Cholesterol/BOC -0.014 0.114 -9999.0 0.0 -0.573 13.0 13.0 SHH Np/Cholesterol/CDO -0.02 0.109 -9999.0 0.0 -0.575 13.0 13.0 mesenchymal cell differentiation 0.267 0.28 0.547 182.0 -9999.0 0.0 182.0 mol:Vitamin D3 0.007 0.251 0.425 1.0 -0.688 34.0 35.0 IHH N/PTCH2 -0.0 0.131 0.272 1.0 -0.606 13.0 14.0 CDON 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.002 0.269 0.406 17.0 -0.751 32.0 49.0 Megalin/LRPAP1 -0.079 0.244 -9999.0 0.0 -0.667 52.0 52.0 PTCH2 -0.003 0.067 0.316 2.0 -0.86 2.0 4.0 SHH Np/Cholesterol -0.019 0.111 -9999.0 0.0 -0.583 13.0 13.0 PTCH1 0.012 0.26 0.456 1.0 -0.747 32.0 33.0 HHIP -0.4 0.43 0.316 1.0 -0.86 173.0 174.0