Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.021 0.083 -9999.0 0.0 -0.353 22.0 22.0 epithelial cell differentiation -0.03 0.118 -9999.0 0.0 -0.499 22.0 22.0 CYFIP2 -0.051 0.203 -9999.0 0.0 -0.86 22.0 22.0 ENAH 0.016 0.124 -9999.0 0.0 -0.507 7.0 7.0 EGFR -0.023 0.139 -9999.0 0.0 -0.86 10.0 10.0 EPHA2 -0.053 0.207 -9999.0 0.0 -0.86 23.0 23.0 MYO6 -0.031 0.127 -9999.0 0.0 -0.518 22.0 22.0 CTNNB1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.034 0.137 -9999.0 0.0 -0.58 22.0 22.0 AQP5 -0.016 0.105 -9999.0 0.0 -9999.0 0.0 0.0 CTNND1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.028 0.11 -9999.0 0.0 -0.466 22.0 22.0 regulation of calcium-dependent cell-cell adhesion -0.017 0.128 -9999.0 0.0 -0.465 24.0 24.0 EGF 0.075 0.134 0.316 88.0 -9999.0 0.0 88.0 NCKAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.074 0.204 -9999.0 0.0 -0.683 30.0 30.0 cortical microtubule organization -0.03 0.118 -9999.0 0.0 -0.499 22.0 22.0 GO:0000145 0.003 0.112 -9999.0 0.0 -0.445 22.0 22.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.03 0.119 -9999.0 0.0 -0.505 22.0 22.0 MLLT4 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.051 0.153 -9999.0 0.0 -0.78 7.0 7.0 ARF6 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.037 0.136 -9999.0 0.0 -0.531 26.0 26.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.027 0.104 -9999.0 0.0 -0.438 22.0 22.0 PVRL2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.028 0.112 -9999.0 0.0 -0.475 22.0 22.0 ARF6/GTP -0.034 0.125 -9999.0 0.0 -0.49 26.0 26.0 CDH1 -0.051 0.203 -9999.0 0.0 -0.86 22.0 22.0 EGFR/EGFR/EGF/EGF -0.013 0.158 -9999.0 0.0 -0.518 28.0 28.0 RhoA/GDP -0.028 0.111 -9999.0 0.0 -0.469 22.0 22.0 actin cytoskeleton organization -0.029 0.118 -9999.0 0.0 -0.484 22.0 22.0 IGF-1R heterotetramer -0.015 0.129 0.316 4.0 -0.858 8.0 12.0 GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R -0.015 0.13 0.316 4.0 -0.86 8.0 12.0 IGF1 -0.336 0.42 -9999.0 0.0 -0.86 145.0 145.0 DIAPH1 -0.05 0.179 -9999.0 0.0 -0.742 23.0 23.0 Wnt receptor signaling pathway 0.03 0.118 0.499 22.0 -9999.0 0.0 22.0 RHOA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.051 0.153 -9999.0 0.0 -0.781 7.0 7.0 CTNNA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.03 0.122 -9999.0 0.0 -0.499 22.0 22.0 EFNA1 -0.007 0.077 -9999.0 0.0 -0.86 3.0 3.0 LPP -0.028 0.108 -9999.0 0.0 -0.447 23.0 23.0 Ephrin A1/EPHA2 -0.059 0.178 -9999.0 0.0 -0.537 41.0 41.0 SEC6/SEC8 -0.025 0.099 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.018 0.13 -9999.0 0.0 -0.474 24.0 24.0 HGF/MET -0.278 0.267 -9999.0 0.0 -0.501 206.0 206.0 HGF -0.465 0.43 0.316 1.0 -0.86 201.0 202.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.021 0.084 -9999.0 0.0 -0.355 22.0 22.0 actin cable formation 0.026 0.114 -9999.0 0.0 -0.402 12.0 12.0 KIAA1543 -0.035 0.134 -9999.0 0.0 -0.501 26.0 26.0 KIFC3 -0.028 0.112 -9999.0 0.0 -0.475 22.0 22.0 NCK1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.028 0.112 -9999.0 0.0 -0.475 22.0 22.0 NCK1/GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.03 0.118 -9999.0 0.0 -0.499 22.0 22.0 EXOC4 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.028 0.112 -9999.0 0.0 -0.475 22.0 22.0 PIP5K1C -0.028 0.112 -9999.0 0.0 -0.475 22.0 22.0 LIMA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.044 0.129 -9999.0 0.0 -0.638 7.0 7.0 adherens junction assembly 0.012 0.137 -9999.0 0.0 -0.468 26.0 26.0 IGF-1R heterotetramer/IGF1 -0.217 0.249 -9999.0 0.0 -0.482 167.0 167.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.001 0.048 0.316 1.0 -0.86 1.0 2.0 PLEKHA7 -0.032 0.119 -9999.0 0.0 -0.476 25.0 25.0 mol:GTP -0.037 0.134 -9999.0 0.0 -0.527 26.0 26.0 establishment of epithelial cell apical/basal polarity -0.024 0.094 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.021 0.083 -9999.0 0.0 -0.353 22.0 22.0 regulation of cell-cell adhesion -0.029 0.118 -9999.0 0.0 -0.484 22.0 22.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.021 0.084 -9999.0 0.0 -0.355 22.0 22.0