E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.028 0.122 -9999.0 0.0 -0.327 49.0 49.0 KLHL20 -0.009 0.07 0.571 1.0 -0.232 7.0 8.0 CYFIP2 0.007 0.091 -9999.0 0.0 -0.37 20.0 20.0 Rac1/GDP -0.01 0.084 -9999.0 0.0 -0.248 21.0 21.0 ENAH -0.02 0.106 -9999.0 0.0 -0.31 40.0 40.0 AP1M1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.03 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.03 0.05 0.125 7.0 -0.183 22.0 29.0 ABI1/Sra1/Nap1 -0.03 0.045 -9999.0 0.0 -0.146 30.0 30.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.043 0.077 -9999.0 0.0 -0.206 27.0 27.0 RAPGEF1 -0.037 0.11 -9999.0 0.0 -0.318 39.0 39.0 CTNND1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.021 0.131 -9999.0 0.0 -0.333 52.0 52.0 CRK -0.023 0.112 -9999.0 0.0 -0.341 37.0 37.0 E-cadherin/gamma catenin/alpha catenin 0.036 0.069 -9999.0 0.0 -0.226 22.0 22.0 alphaE/beta7 Integrin 0.033 0.037 -9999.0 0.0 -0.247 5.0 5.0 IQGAP1 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.03 0.002 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.049 0.02 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.03 0.125 -9999.0 0.0 -0.331 51.0 51.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.034 0.031 -9999.0 0.0 -0.143 22.0 22.0 MLLT4 0.027 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.04 0.057 -9999.0 0.0 -0.202 18.0 18.0 PI3K -0.042 0.04 0.127 1.0 -0.18 22.0 23.0 ARF6 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.021 0.074 -9999.0 0.0 -0.264 22.0 22.0 TIAM1 0.008 0.089 -9999.0 0.0 -0.37 19.0 19.0 E-cadherin(dimer)/Ca2+ 0.047 0.066 -9999.0 0.0 -0.196 22.0 22.0 AKT1 -0.024 0.034 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.027 0.03 -9999.0 0.0 -0.37 2.0 2.0 CDH1 0.003 0.095 -9999.0 0.0 -0.37 22.0 22.0 RhoA/GDP -0.01 0.084 -9999.0 0.0 -0.248 22.0 22.0 actin cytoskeleton organization -0.006 0.054 0.501 1.0 -0.2 1.0 2.0 CDC42/GDP -0.009 0.083 -9999.0 0.0 -0.248 22.0 22.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.003 0.052 -9999.0 0.0 -0.201 22.0 22.0 ITGB7 0.024 0.047 -9999.0 0.0 -0.37 5.0 5.0 RAC1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.051 0.07 -9999.0 0.0 -0.21 22.0 22.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.033 0.059 -9999.0 0.0 -0.191 22.0 22.0 mol:GDP -0.027 0.088 -9999.0 0.0 -0.28 22.0 22.0 CDC42/GTP/IQGAP1 0.037 0.011 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP -0.001 0.09 -9999.0 0.0 -0.255 22.0 22.0 RAC1/GTP/IQGAP1 0.038 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.043 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.008 0.047 0.161 1.0 -0.175 15.0 16.0 NME1 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.03 0.125 -9999.0 0.0 -0.331 51.0 51.0 regulation of cell-cell adhesion -0.031 0.038 0.073 1.0 -0.163 22.0 23.0 WASF2 -0.013 0.03 0.092 3.0 -0.093 9.0 12.0 Rap1/GTP -0.028 0.057 0.159 7.0 -0.198 22.0 29.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.05 0.08 -9999.0 0.0 -0.198 27.0 27.0 CCND1 -0.011 0.058 0.183 1.0 -0.211 16.0 17.0 VAV2 -0.029 0.158 -9999.0 0.0 -0.594 11.0 11.0 RAP1/GDP 0.003 0.072 -9999.0 0.0 -0.209 21.0 21.0 adherens junction assembly -0.029 0.121 -9999.0 0.0 -0.321 51.0 51.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.034 0.072 -9999.0 0.0 -0.195 27.0 27.0 E-cadherin/beta catenin -0.007 0.074 -9999.0 0.0 -0.299 22.0 22.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.029 0.127 -9999.0 0.0 -0.33 52.0 52.0 PIK3CA 0.028 0.021 -9999.0 0.0 -0.37 1.0 1.0 Rac1/GTP -0.03 0.104 -9999.0 0.0 -0.349 20.0 20.0 E-cadherin/beta catenin/alpha catenin 0.037 0.069 -9999.0 0.0 -0.226 22.0 22.0 ITGAE 0.025 0.011 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.022 0.133 -9999.0 0.0 -0.34 52.0 52.0