Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.013 0.071 0.271 20.0 -9999.0 0.0 20.0 KIRREL -0.001 0.096 -9999.0 0.0 -0.374 22.0 22.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.013 0.072 -9999.0 0.0 -0.272 20.0 20.0 PLCG1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.025 0.011 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.035 0.066 -9999.0 0.0 -0.207 17.0 17.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.007 0.06 -9999.0 0.0 -0.223 18.0 18.0 FYN 0.042 0.132 0.262 82.0 -0.196 19.0 101.0 mol:Ca2+ 0.037 0.068 -9999.0 0.0 -0.205 19.0 19.0 mol:DAG 0.038 0.069 -9999.0 0.0 -0.206 19.0 19.0 NPHS2 0.002 0.025 -9999.0 0.0 -9999.0 0.0 0.0 mol:IP3 0.038 0.069 -9999.0 0.0 -0.206 19.0 19.0 regulation of endocytosis 0.025 0.058 -9999.0 0.0 -0.182 19.0 19.0 Nephrin/NEPH1/podocin/Cholesterol 0.022 0.061 0.175 4.0 -0.2 19.0 23.0 establishment of cell polarity 0.013 0.071 -9999.0 0.0 -0.271 20.0 20.0 Nephrin/NEPH1/podocin/NCK1-2 0.05 0.075 -9999.0 0.0 -0.202 19.0 19.0 Nephrin/NEPH1/beta Arrestin2 0.027 0.06 -9999.0 0.0 -0.184 19.0 19.0 NPHS1 0.014 0.034 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin 0.023 0.058 -9999.0 0.0 -0.197 19.0 19.0 TJP1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.03 0.002 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.028 0.021 -9999.0 0.0 -0.37 1.0 1.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.039 0.07 -9999.0 0.0 -0.207 19.0 19.0 CD2AP 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.039 0.067 -9999.0 0.0 -0.207 17.0 17.0 GRB2 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 0.035 0.124 0.258 72.0 -0.187 17.0 89.0 cytoskeleton organization -0.01 0.065 0.196 8.0 -0.24 16.0 24.0 Nephrin/NEPH1 0.013 0.05 -9999.0 0.0 -0.183 20.0 20.0 Nephrin/NEPH1/ZO-1 0.027 0.066 -9999.0 0.0 -0.218 20.0 20.0