Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.093 0.256 0.568 67.0 -0.468 15.0 82.0 IHH 0.059 0.122 0.244 72.0 -0.245 23.0 95.0 SHH Np/Cholesterol/GAS1 -0.018 0.087 -9999.0 0.0 -0.219 54.0 54.0 LRPAP1 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.018 0.087 0.218 54.0 -9999.0 0.0 54.0 SMO/beta Arrestin2 0.068 0.203 0.362 66.0 -0.448 28.0 94.0 SMO 0.066 0.215 0.378 76.0 -0.48 26.0 102.0 AKT1 0.045 0.165 0.31 25.0 -0.437 17.0 42.0 ARRB2 0.025 0.011 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.067 0.213 0.377 76.0 -0.473 26.0 102.0 STIL 0.049 0.165 0.324 61.0 -0.37 14.0 75.0 DHH N/PTCH2 0.039 0.025 -9999.0 0.0 -0.264 2.0 2.0 DHH N/PTCH1 0.076 0.184 0.376 70.0 -0.356 27.0 97.0 PIK3CA 0.028 0.021 -9999.0 0.0 -0.37 1.0 1.0 DHH 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.116 0.31 0.66 75.0 -0.525 15.0 90.0 determination of left/right symmetry 0.067 0.213 0.377 76.0 -0.473 26.0 102.0 PIK3R1 0.027 0.03 -9999.0 0.0 -0.37 2.0 2.0 skeletal system development 0.116 0.309 0.659 75.0 -0.521 15.0 90.0 IHH N/Hhip -0.096 0.17 0.205 9.0 -0.271 164.0 173.0 DHH N/Hhip -0.098 0.148 -9999.0 0.0 -0.264 161.0 161.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.067 0.213 0.377 76.0 -0.473 26.0 102.0 pancreas development -0.152 0.194 -9999.0 0.0 -0.369 161.0 161.0 HHAT 0.022 0.024 -9999.0 0.0 -0.37 1.0 1.0 PI3K 0.041 0.032 -9999.0 0.0 -0.368 2.0 2.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.045 0.155 -9999.0 0.0 -0.37 67.0 67.0 somite specification 0.067 0.213 0.377 76.0 -0.473 26.0 102.0 SHH Np/Cholesterol/PTCH1 0.04 0.155 0.322 57.0 -0.334 22.0 79.0 SHH Np/Cholesterol/PTCH2 0.011 0.043 -9999.0 0.0 -0.217 11.0 11.0 SHH Np/Cholesterol/Megalin -0.02 0.076 -9999.0 0.0 -0.205 50.0 50.0 SHH -0.021 0.046 -9999.0 0.0 -0.285 10.0 10.0 catabolic process 0.089 0.232 0.472 76.0 -0.392 27.0 103.0 SMO/Vitamin D3 0.082 0.205 0.375 74.0 -0.412 25.0 99.0 SHH Np/Cholesterol/Hhip -0.072 0.104 -9999.0 0.0 -0.208 130.0 130.0 LRP2 -0.029 0.135 -9999.0 0.0 -0.37 49.0 49.0 receptor-mediated endocytosis 0.035 0.204 0.35 59.0 -0.467 23.0 82.0 SHH Np/Cholesterol/BOC 0.012 0.042 -9999.0 0.0 -0.219 10.0 10.0 SHH Np/Cholesterol/CDO 0.012 0.043 -9999.0 0.0 -0.215 11.0 11.0 mesenchymal cell differentiation 0.072 0.103 0.207 130.0 -9999.0 0.0 130.0 mol:Vitamin D3 0.09 0.189 0.374 74.0 -0.365 18.0 92.0 IHH N/PTCH2 0.051 0.082 0.172 65.0 -0.223 12.0 77.0 CDON 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.087 0.223 0.48 68.0 -0.394 27.0 95.0 Megalin/LRPAP1 -0.003 0.103 -9999.0 0.0 -0.262 49.0 49.0 PTCH2 0.026 0.03 -9999.0 0.0 -0.37 2.0 2.0 SHH Np/Cholesterol 0.005 0.04 -9999.0 0.0 -0.212 11.0 11.0 PTCH1 0.089 0.232 0.473 76.0 -0.393 27.0 103.0 HHIP -0.152 0.194 -9999.0 0.0 -0.37 161.0 161.0