Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.001 0.06 -9999.0 0.0 -0.193 26.0 26.0 epithelial cell differentiation 0.041 0.063 -9999.0 0.0 -0.195 22.0 22.0 CYFIP2 0.007 0.091 -9999.0 0.0 -0.37 20.0 20.0 ENAH -0.027 0.064 0.282 3.0 -0.261 3.0 6.0 EGFR 0.019 0.062 -9999.0 0.0 -0.37 9.0 9.0 EPHA2 0.009 0.084 -9999.0 0.0 -0.37 17.0 17.0 MYO6 -0.031 0.054 -9999.0 0.0 -0.352 2.0 2.0 CTNNB1 0.03 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.044 0.061 -9999.0 0.0 -0.226 17.0 17.0 AQP5 -0.014 0.062 -9999.0 0.0 -0.275 1.0 1.0 CTNND1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.03 0.051 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.03 0.05 -9999.0 0.0 -0.191 2.0 2.0 EGF 0.017 0.012 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.03 0.002 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.054 0.13 -9999.0 0.0 -0.432 31.0 31.0 cortical microtubule organization 0.041 0.063 -9999.0 0.0 -0.195 22.0 22.0 GO:0000145 -0.029 0.048 0.168 2.0 -9999.0 0.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.047 0.066 -9999.0 0.0 -0.196 22.0 22.0 MLLT4 0.027 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.044 0.05 -9999.0 0.0 -0.203 26.0 26.0 ARF6 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.044 0.059 -9999.0 0.0 -0.21 12.0 12.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.02 0.047 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.03 0.052 -9999.0 0.0 -0.192 22.0 22.0 ARF6/GTP 0.048 0.061 -9999.0 0.0 -0.2 12.0 12.0 CDH1 0.003 0.095 -9999.0 0.0 -0.37 22.0 22.0 EGFR/EGFR/EGF/EGF 0.04 0.072 -9999.0 0.0 -0.208 21.0 21.0 RhoA/GDP 0.042 0.063 -9999.0 0.0 -0.19 22.0 22.0 actin cytoskeleton organization -0.032 0.052 -9999.0 0.0 -0.344 2.0 2.0 IGF-1R heterotetramer 0.02 0.059 -9999.0 0.0 -0.369 8.0 8.0 GIT1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.02 0.059 -9999.0 0.0 -0.37 8.0 8.0 IGF1 -0.127 0.195 -9999.0 0.0 -0.37 142.0 142.0 DIAPH1 0.019 0.156 -9999.0 0.0 -0.538 26.0 26.0 Wnt receptor signaling pathway -0.041 0.063 0.195 22.0 -9999.0 0.0 22.0 RHOA 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.043 0.049 -9999.0 0.0 -0.205 25.0 25.0 CTNNA1 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.033 0.053 -9999.0 0.0 -0.352 2.0 2.0 EFNA1 0.019 0.038 -9999.0 0.0 -0.37 3.0 3.0 LPP -0.035 0.047 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 0.02 0.071 -9999.0 0.0 -0.207 26.0 26.0 SEC6/SEC8 -0.042 0.04 -9999.0 0.0 -0.189 22.0 22.0 MGAT3 -0.03 0.051 -9999.0 0.0 -0.194 2.0 2.0 HGF/MET -0.083 0.131 -9999.0 0.0 -0.204 189.0 189.0 HGF -0.184 0.199 -9999.0 0.0 -0.37 194.0 194.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.001 0.06 -9999.0 0.0 -0.195 26.0 26.0 actin cable formation 0.02 0.097 0.31 8.0 -9999.0 0.0 8.0 KIAA1543 -0.031 0.049 0.169 1.0 -0.183 25.0 26.0 KIFC3 -0.031 0.051 -9999.0 0.0 -0.192 22.0 22.0 NCK1 0.03 0.002 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.031 0.048 -9999.0 0.0 -0.192 22.0 22.0 NCK1/GIT1 0.044 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.041 0.063 -9999.0 0.0 -0.195 22.0 22.0 EXOC4 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.031 0.052 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C -0.03 0.052 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 0.03 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.009 0.095 0.309 5.0 -0.298 3.0 8.0 adherens junction assembly -0.03 0.076 -9999.0 0.0 -0.627 2.0 2.0 IGF-1R heterotetramer/IGF1 -0.058 0.125 -9999.0 0.0 -0.197 155.0 155.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.039 0.015 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.027 0.022 -9999.0 0.0 -0.37 1.0 1.0 PLEKHA7 -0.033 0.052 -9999.0 0.0 -0.192 25.0 25.0 mol:GTP 0.043 0.058 -9999.0 0.0 -0.209 12.0 12.0 establishment of epithelial cell apical/basal polarity -0.025 0.081 0.312 6.0 -9999.0 0.0 6.0 cortical actin cytoskeleton stabilization -0.001 0.06 -9999.0 0.0 -0.193 26.0 26.0 regulation of cell-cell adhesion -0.032 0.052 -9999.0 0.0 -0.344 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.001 0.06 -9999.0 0.0 -0.195 26.0 26.0