Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.035 0.061 0.239 8.0 -0.232 30.0 38.0 KIRREL 0.016 0.045 -9999.0 0.0 -0.333 8.0 8.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.036 0.061 0.233 30.0 -0.239 8.0 38.0 PLCG1 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.02 0.006 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.051 0.057 0.219 30.0 -0.181 8.0 38.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.014 0.041 0.162 2.0 -0.209 8.0 10.0 FYN 0.016 0.084 0.207 67.0 -0.173 8.0 75.0 mol:Ca2+ 0.048 0.055 0.211 29.0 -0.177 8.0 37.0 mol:DAG 0.049 0.056 0.215 29.0 -0.177 8.0 37.0 NPHS2 -0.004 0.023 -9999.0 0.0 -9999.0 0.0 0.0 mol:IP3 0.049 0.056 0.215 29.0 -0.177 8.0 37.0 regulation of endocytosis 0.036 0.05 0.198 26.0 -0.168 8.0 34.0 Nephrin/NEPH1/podocin/Cholesterol 0.041 0.054 0.204 30.0 -0.175 8.0 38.0 establishment of cell polarity 0.035 0.061 0.232 30.0 -0.239 8.0 38.0 Nephrin/NEPH1/podocin/NCK1-2 0.06 0.058 0.28 1.0 -0.166 8.0 9.0 Nephrin/NEPH1/beta Arrestin2 0.038 0.051 0.205 26.0 -0.169 8.0 34.0 NPHS1 0.041 0.083 0.332 36.0 -9999.0 0.0 36.0 Nephrin/NEPH1/podocin 0.04 0.052 0.204 30.0 -0.174 8.0 38.0 TJP1 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.021 0.002 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.05 0.057 0.219 29.0 -0.178 8.0 37.0 CD2AP 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.05 0.057 0.219 29.0 -0.181 8.0 37.0 GRB2 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 0.006 0.093 0.217 61.0 -0.179 30.0 91.0 cytoskeleton organization -0.003 0.054 0.219 12.0 -0.217 8.0 20.0 Nephrin/NEPH1 0.03 0.048 0.19 30.0 -0.159 8.0 38.0 Nephrin/NEPH1/ZO-1 0.04 0.053 0.216 26.0 -0.19 8.0 34.0