Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.092 0.184 0.317 7.0 -0.502 46.0 53.0 IHH -0.015 0.127 0.274 7.0 -0.386 45.0 52.0 SHH Np/Cholesterol/GAS1 -0.036 0.058 0.115 1.0 -0.183 65.0 66.0 LRPAP1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.036 0.058 0.183 65.0 -0.113 1.0 66.0 SMO/beta Arrestin2 -0.148 0.183 0.301 2.0 -0.325 212.0 214.0 SMO -0.15 0.187 0.343 1.0 -0.338 211.0 212.0 AKT1 -0.081 0.142 0.266 1.0 -0.474 36.0 37.0 ARRB2 0.02 0.006 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.02 0.016 -9999.0 0.0 -0.325 1.0 1.0 ADRBK1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.149 0.185 0.342 1.0 -0.334 211.0 212.0 STIL -0.088 0.142 0.264 11.0 -0.321 68.0 79.0 DHH N/PTCH2 0.013 0.066 -9999.0 0.0 -0.228 36.0 36.0 DHH N/PTCH1 -0.109 0.154 -9999.0 0.0 -0.359 65.0 65.0 PIK3CA 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.003 0.088 -9999.0 0.0 -0.325 36.0 36.0 PTHLH -0.125 0.224 0.383 7.0 -0.562 44.0 51.0 determination of left/right symmetry -0.149 0.185 0.342 1.0 -0.334 211.0 212.0 PIK3R1 0.02 0.016 -9999.0 0.0 -0.325 1.0 1.0 skeletal system development -0.124 0.223 0.382 7.0 -0.558 44.0 51.0 IHH N/Hhip -0.22 0.18 0.208 3.0 -0.318 371.0 374.0 DHH N/Hhip -0.12 0.141 -9999.0 0.0 -0.244 280.0 280.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.149 0.185 0.342 1.0 -0.334 211.0 212.0 pancreas development -0.163 0.172 -9999.0 0.0 -0.324 273.0 273.0 HHAT 0.018 0.022 -9999.0 0.0 -0.325 2.0 2.0 PI3K 0.029 0.014 -9999.0 0.0 -0.229 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.012 0.054 -9999.0 0.0 -0.325 13.0 13.0 somite specification -0.149 0.185 0.342 1.0 -0.334 211.0 212.0 SHH Np/Cholesterol/PTCH1 -0.099 0.14 -9999.0 0.0 -0.337 72.0 72.0 SHH Np/Cholesterol/PTCH2 -0.034 0.052 0.115 1.0 -0.175 60.0 61.0 SHH Np/Cholesterol/Megalin -0.069 0.087 0.115 1.0 -0.191 159.0 160.0 SHH -0.039 0.07 0.155 1.0 -0.229 60.0 61.0 catabolic process -0.11 0.162 0.233 3.0 -0.253 248.0 251.0 SMO/Vitamin D3 -0.125 0.172 0.37 2.0 -0.293 213.0 215.0 SHH Np/Cholesterol/Hhip -0.104 0.101 0.115 1.0 -0.198 251.0 252.0 LRP2 -0.072 0.155 0.324 1.0 -0.325 139.0 140.0 receptor-mediated endocytosis -0.17 0.185 0.303 2.0 -0.41 136.0 138.0 SHH Np/Cholesterol/BOC -0.033 0.052 0.115 1.0 -0.175 59.0 60.0 SHH Np/Cholesterol/CDO -0.035 0.056 0.115 1.0 -0.178 64.0 65.0 mesenchymal cell differentiation 0.103 0.1 0.197 251.0 -0.113 1.0 252.0 mol:Vitamin D3 -0.093 0.153 0.357 6.0 -0.344 69.0 75.0 IHH N/PTCH2 -0.097 0.128 0.208 4.0 -0.21 279.0 283.0 CDON 0.013 0.048 -9999.0 0.0 -0.325 10.0 10.0 IHH N/PTCH1 -0.102 0.174 0.271 3.0 -0.255 251.0 254.0 Megalin/LRPAP1 -0.038 0.115 0.234 1.0 -0.228 136.0 137.0 PTCH2 0.02 0.015 -9999.0 0.0 -0.325 1.0 1.0 SHH Np/Cholesterol -0.029 0.052 -9999.0 0.0 -0.17 60.0 60.0 PTCH1 -0.11 0.163 0.233 3.0 -0.254 248.0 251.0 HHIP -0.164 0.172 -9999.0 0.0 -0.325 273.0 273.0