Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.009 0.027 -9999.0 0.0 -0.184 9.0 9.0 epithelial cell differentiation 0.041 0.018 -9999.0 0.0 -0.158 2.0 2.0 CYFIP2 0.016 0.04 -9999.0 0.0 -0.325 7.0 7.0 ENAH -0.02 0.055 0.289 5.0 -0.228 1.0 6.0 EGFR 0.014 0.045 0.324 1.0 -0.325 8.0 9.0 EPHA2 0.014 0.048 -9999.0 0.0 -0.325 10.0 10.0 MYO6 -0.018 0.038 0.433 2.0 -9999.0 0.0 2.0 CTNNB1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.039 0.022 -9999.0 0.0 -0.195 3.0 3.0 AQP5 -0.061 0.167 0.398 4.0 -0.376 98.0 102.0 CTNND1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.019 0.038 0.222 9.0 -9999.0 0.0 9.0 regulation of calcium-dependent cell-cell adhesion -0.086 0.074 -9999.0 0.0 -0.298 1.0 1.0 EGF 0.071 0.122 0.324 91.0 -0.325 5.0 96.0 NCKAP1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.022 0.072 0.239 1.0 -0.318 25.0 26.0 cortical microtubule organization 0.041 0.018 -9999.0 0.0 -0.158 2.0 2.0 GO:0000145 -0.018 0.036 0.211 9.0 -9999.0 0.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.045 0.02 -9999.0 0.0 -0.16 2.0 2.0 MLLT4 0.019 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.033 0.023 -9999.0 0.0 -0.165 5.0 5.0 ARF6 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.041 0.034 -9999.0 0.0 -0.181 7.0 7.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.01 0.037 0.424 2.0 -0.214 1.0 3.0 PVRL2 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.019 0.039 0.433 2.0 -9999.0 0.0 2.0 ARF6/GTP 0.044 0.035 -9999.0 0.0 -0.172 6.0 6.0 CDH1 0.019 0.022 -9999.0 0.0 -0.325 2.0 2.0 EGFR/EGFR/EGF/EGF 0.041 0.055 0.239 1.0 -0.176 11.0 12.0 RhoA/GDP 0.042 0.019 -9999.0 0.0 -0.155 2.0 2.0 actin cytoskeleton organization -0.02 0.036 0.414 2.0 -9999.0 0.0 2.0 IGF-1R heterotetramer 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.014 0.052 0.324 1.0 -0.325 11.0 12.0 DIAPH1 0.015 0.118 -9999.0 0.0 -0.542 13.0 13.0 Wnt receptor signaling pathway -0.041 0.018 0.158 2.0 -9999.0 0.0 2.0 RHOA 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.034 0.025 -9999.0 0.0 -0.185 6.0 6.0 CTNNA1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.021 0.036 0.416 2.0 -9999.0 0.0 2.0 EFNA1 0.017 0.017 -9999.0 0.0 -0.325 1.0 1.0 LPP -0.022 0.037 0.424 2.0 -9999.0 0.0 2.0 Ephrin A1/EPHA2 0.028 0.034 -9999.0 0.0 -0.177 9.0 9.0 SEC6/SEC8 -0.025 0.018 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.087 0.075 -9999.0 0.0 -0.302 1.0 1.0 HGF/MET 0.021 0.056 -9999.0 0.0 -0.165 37.0 37.0 HGF 0.007 0.078 0.324 4.0 -0.325 24.0 28.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.009 0.027 -9999.0 0.0 -0.185 9.0 9.0 actin cable formation 0.009 0.085 0.291 19.0 -0.249 3.0 22.0 KIAA1543 -0.02 0.028 0.175 8.0 -9999.0 0.0 8.0 KIFC3 -0.023 0.02 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.016 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.019 0.038 0.433 2.0 -9999.0 0.0 2.0 NCK1/GIT1 0.03 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.041 0.018 -9999.0 0.0 -0.158 2.0 2.0 EXOC4 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.021 0.029 0.189 7.0 -9999.0 0.0 7.0 PIP5K1C -0.019 0.038 0.224 9.0 -9999.0 0.0 9.0 LIMA1 0.021 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.021 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.008 0.078 0.309 11.0 -0.259 1.0 12.0 adherens junction assembly -0.026 0.09 0.353 6.0 -0.458 10.0 16.0 IGF-1R heterotetramer/IGF1 0.031 0.034 -9999.0 0.0 -0.16 12.0 12.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.028 0.011 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.011 0.072 0.324 6.0 -0.325 18.0 24.0 PLEKHA7 -0.021 0.029 0.186 8.0 -9999.0 0.0 8.0 mol:GTP 0.039 0.034 -9999.0 0.0 -0.18 7.0 7.0 establishment of epithelial cell apical/basal polarity 0.018 0.096 0.319 17.0 -9999.0 0.0 17.0 cortical actin cytoskeleton stabilization 0.009 0.027 -9999.0 0.0 -0.184 9.0 9.0 regulation of cell-cell adhesion -0.02 0.036 0.414 2.0 -9999.0 0.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.009 0.027 -9999.0 0.0 -0.185 9.0 9.0