Clinical Features MRNA_CNMF MRNA_CHIERARCHICAL CN_CNMF METHLYATION_CNMF RPPA_CNMF RPPA_CHIERARCHICAL MRNASEQ_CNMF MRNASEQ_CHIERARCHICAL MIRSEQ_CNMF MIRSEQ_CHIERARCHICAL MIRSEQ_MATURE_CNMF MIRSEQ_MATURE_CHIERARCHICAL nMutated (%) nWild-Type Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q TP53 145 (81%) 33 0.062179 0.394 0.02245 0.233 5.9999e-05 0.00342 0.00367 0.0761 0.12337 0.586 0.71323 1 0.00095999 0.0274 0.00405 0.0769 0.17449 0.686 0.36694 0.878 0.03026 0.248 0.01143 0.163 CDKN2A 26 (15%) 152 0.00162 0.0369 0.0057199 0.0951 0.02428 0.241 0.54038 0.959 0.43831 0.938 0.34399 0.878 0.37775 0.878 0.088239 0.491 0.66619 1 0.81793 1 0.84416 1 0.03049 0.248 NFE2L2 27 (15%) 151 0.00024 0.00912 0.00018 0.00821 0.01407 0.178 0.04704 0.333 0.12187 0.586 0.3481 0.878 9.9999e-06 0.00114 9.9999e-06 0.00114 0.0058399 0.0951 5e-05 0.00342 0.62989 1 0.8631 1 MLL2 36 (20%) 142 0.17006 0.68 0.46546 0.948 0.54755 0.959 0.30671 0.878 0.9823 1 0.93773 1 0.5322 0.959 0.74051 1 0.94976 1 0.9212 1 0.74607 1 1 1 KEAP1 22 (12%) 156 0.00147 0.0369 0.00069999 0.0228 0.11748 0.582 0.060939 0.394 0.01608 0.193 0.35884 0.878 0.18683 0.691 0.02882 0.248 0.17988 0.691 0.44476 0.938 0.48282 0.948 0.66967 1 PTEN 14 (8%) 164 0.38138 0.878 0.32438 0.878 0.41406 0.918 0.15228 0.62 1 1 0.77115 1 0.59385 0.974 0.51424 0.953 0.5702 0.959 0.511 0.953 0.19661 0.712 1 1 PIK3CA 27 (15%) 151 0.68986 1 0.7551 1 0.29546 0.878 0.91796 1 0.85439 1 0.76325 1 0.34341 0.878 0.58956 0.974 0.36507 0.878 0.37309 0.878 0.72333 1 0.75687 1 RB1 12 (7%) 166 0.31404 0.878 0.64509 1 0.52204 0.959 0.12896 0.588 0.10089 0.523 0.57066 0.959 0.77564 1 0.24226 0.824 0.32161 0.878 0.75233 1 NA NA NA NA CYP11B1 15 (8%) 163 0.65248 1 0.67944 1 0.66274 1 0.34787 0.878 0.67037 1 0.44248 0.938 0.5721 0.959 0.36765 0.878 0.56015 0.959 0.97667 1 NA NA NA NA NOTCH1 14 (8%) 164 0.81706 1 0.60272 0.982 0.47103 0.948 0.04793 0.333 0.50943 0.953 0.58684 0.974 0.75626 1 0.39216 0.894 0.34763 0.878 0.31773 0.878 0.01001 0.152 0.02892 0.248 ASB5 9 (5%) 169 0.49065 0.948 0.54901 0.959 0.25905 0.849 NA NA 0.45384 0.938 1 1 0.48188 0.948 0.49512 0.949 0.25449 0.849 0.33498 0.878 NA NA NA NA IRF6 6 (3%) 172 0.26053 0.849 0.44727 0.938 0.1349 0.603 0.33047 0.878 0.7945 1 0.14622 0.612 0.75198 1 0.74725 1 0.53842 0.959 0.82234 1 NA NA NA NA EP300 8 (4%) 170 0.14738 0.612 0.11719 0.582 0.43786 0.938 NA NA 1 1 0.71377 1 0.082829 0.477 0.083679 0.477 0.56895 0.959 0.82316 1 NA NA NA NA CPS1 24 (13%) 154 0.75407 1 0.20807 0.73 0.40328 0.91 1 1 0.62064 1 0.85665 1 0.91257 1 0.84719 1 0.02127 0.231 0.12769 0.588 1 1 1 1 ARID1A 13 (7%) 165 0.30544 0.878 0.64793 1 0.48051 0.948 0.35536 0.878 0.14217 0.612 0.67385 1 0.10083 0.523 0.80781 1 0.34426 0.878 0.50323 0.953 NA NA NA NA SLC28A1 9 (5%) 169 0.01361 0.178 0.050259 0.337 0.080599 0.477 0.098039 0.523 0.4148 0.918 0.45684 0.938 0.03839 0.302 0.02723 0.248 0.18792 0.691 0.01742 0.199 0.81727 1 0.1818 0.691 POLR2B 6 (3%) 172 1 1 0.79438 1 1 1 0.2384 0.824 1 1 0.20079 0.715 0.37353 0.878 0.31139 0.878 0.04817 0.333 0.4549 0.938 1 1 0.28877 0.878 HRAS 5 (3%) 173 0.90765 1 0.68047 1 0.27265 0.876 NA NA NA NA NA NA 0.92965 1 1 1 0.53307 0.959 0.75235 1 NA NA NA NA PI16 7 (4%) 171 0.14754 0.612 0.72114 1 0.55871 0.959 0.074039 0.456 0.04412 0.333 0.28556 0.878 0.73195 1 0.88164 1 0.30676 0.878 0.48678 0.948 NA NA NA NA