E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.0 0.102 -9999.0 0.0 -0.404 8.0 8.0 KLHL20 -0.007 0.095 -9999.0 0.0 -0.279 11.0 11.0 CYFIP2 0.01 0.039 -9999.0 0.0 -0.436 1.0 1.0 Rac1/GDP 0.014 0.073 -9999.0 0.0 -0.23 8.0 8.0 ENAH 0.002 0.101 -9999.0 0.0 -0.4 8.0 8.0 AP1M1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.014 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.009 0.051 -9999.0 0.0 -0.437 2.0 2.0 CTNNB1 0.011 0.038 -9999.0 0.0 -0.436 1.0 1.0 CDC42/GTP -0.013 0.041 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.025 0.055 -9999.0 0.0 -0.183 12.0 12.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.024 0.058 -9999.0 0.0 -0.22 8.0 8.0 RAPGEF1 0.01 0.089 -9999.0 0.0 -0.344 8.0 8.0 CTNND1 0.0 0.08 -9999.0 0.0 -0.437 5.0 5.0 regulation of calcium-dependent cell-cell adhesion -0.001 0.104 -9999.0 0.0 -0.415 8.0 8.0 CRK 0.006 0.096 -9999.0 0.0 -0.373 8.0 8.0 E-cadherin/gamma catenin/alpha catenin -0.003 0.094 -9999.0 0.0 -0.263 17.0 17.0 alphaE/beta7 Integrin 0.023 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.009 0.04 -9999.0 0.0 -0.436 1.0 1.0 Rap1/GTP/I-afadin 0.026 0.029 -9999.0 0.0 -0.225 2.0 2.0 DLG1 0.001 0.102 -9999.0 0.0 -0.4 8.0 8.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.015 0.042 -9999.0 0.0 -0.196 4.0 4.0 MLLT4 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.024 0.036 -9999.0 0.0 -0.225 3.0 3.0 PI3K -0.019 0.054 -9999.0 0.0 -0.252 4.0 4.0 ARF6 0.005 0.063 -9999.0 0.0 -0.437 3.0 3.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.016 0.109 -9999.0 0.0 -0.318 17.0 17.0 TIAM1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.014 0.067 -9999.0 0.0 -0.206 13.0 13.0 AKT1 0.013 0.047 -9999.0 0.0 -0.166 5.0 5.0 PIK3R1 -0.006 0.083 -9999.0 0.0 -0.437 5.0 5.0 CDH1 -0.007 0.094 -9999.0 0.0 -0.436 7.0 7.0 RhoA/GDP 0.015 0.073 -9999.0 0.0 -0.23 8.0 8.0 actin cytoskeleton organization -0.003 0.069 -9999.0 0.0 -0.198 11.0 11.0 CDC42/GDP 0.015 0.073 -9999.0 0.0 -0.23 8.0 8.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.014 0.09 -9999.0 0.0 -0.233 21.0 21.0 ITGB7 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.016 0.072 -9999.0 0.0 -0.22 13.0 13.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.013 0.053 -9999.0 0.0 -0.21 8.0 8.0 mol:GDP 0.007 0.08 -9999.0 0.0 -0.268 8.0 8.0 CDC42/GTP/IQGAP1 0.021 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JUP -0.018 0.116 -9999.0 0.0 -0.436 11.0 11.0 p120 catenin/RhoA/GDP 0.013 0.08 -9999.0 0.0 -0.226 13.0 13.0 RAC1/GTP/IQGAP1 0.021 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.02 0.027 -9999.0 0.0 -0.303 1.0 1.0 RHOA 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.009 0.069 -9999.0 0.0 -0.192 15.0 15.0 NME1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.0 0.103 -9999.0 0.0 -0.4 8.0 8.0 regulation of cell-cell adhesion -0.012 0.037 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.001 0.04 -9999.0 0.0 -0.135 5.0 5.0 Rap1/GTP 0.021 0.059 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.015 0.083 -9999.0 0.0 -0.214 17.0 17.0 CCND1 -0.012 0.086 -9999.0 0.0 -0.247 14.0 14.0 VAV2 -0.041 0.203 -9999.0 0.0 -0.566 18.0 18.0 RAP1/GDP 0.018 0.065 -9999.0 0.0 -0.22 1.0 1.0 adherens junction assembly 0.0 0.1 -9999.0 0.0 -0.388 8.0 8.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.011 0.038 -9999.0 0.0 -0.436 1.0 1.0 regulation of heterotypic cell-cell adhesion 0.015 0.08 -9999.0 0.0 -0.199 18.0 18.0 E-cadherin/beta catenin -0.004 0.07 -9999.0 0.0 -0.296 8.0 8.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.002 0.101 -9999.0 0.0 -0.4 8.0 8.0 PIK3CA 0.007 0.053 -9999.0 0.0 -0.436 2.0 2.0 Rac1/GTP -0.06 0.141 -9999.0 0.0 -0.471 12.0 12.0 E-cadherin/beta catenin/alpha catenin 0.015 0.062 -9999.0 0.0 -0.249 8.0 8.0 ITGAE 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.002 0.106 -9999.0 0.0 -0.424 8.0 8.0