Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.125 0.258 -9999.0 0.0 -0.523 44.0 44.0 IHH -0.017 0.071 -9999.0 0.0 -0.258 4.0 4.0 SHH Np/Cholesterol/GAS1 -0.041 0.116 -9999.0 0.0 -0.251 33.0 33.0 LRPAP1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.04 0.115 0.25 33.0 -9999.0 0.0 33.0 SMO/beta Arrestin2 -0.102 0.217 -9999.0 0.0 -0.553 19.0 19.0 SMO -0.115 0.226 -9999.0 0.0 -0.586 19.0 19.0 AKT1 -0.062 0.179 -9999.0 0.0 -0.67 8.0 8.0 ARRB2 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.009 0.024 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.113 0.223 -9999.0 0.0 -0.575 19.0 19.0 STIL -0.057 0.144 -9999.0 0.0 -0.405 11.0 11.0 DHH N/PTCH2 0.023 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 -0.05 0.139 -9999.0 0.0 -0.263 44.0 44.0 PIK3CA 0.007 0.053 -9999.0 0.0 -0.436 2.0 2.0 DHH 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.227 0.421 -9999.0 0.0 -0.882 44.0 44.0 determination of left/right symmetry -0.113 0.223 -9999.0 0.0 -0.575 19.0 19.0 PIK3R1 -0.006 0.083 -9999.0 0.0 -0.436 5.0 5.0 skeletal system development -0.223 0.416 -9999.0 0.0 -0.871 44.0 44.0 IHH N/Hhip -0.053 0.126 -9999.0 0.0 -0.352 21.0 21.0 DHH N/Hhip -0.031 0.108 -9999.0 0.0 -0.303 20.0 20.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.113 0.223 -9999.0 0.0 -0.575 19.0 19.0 pancreas development -0.06 0.149 -9999.0 0.0 -0.436 20.0 20.0 HHAT -0.02 0.121 -9999.0 0.0 -0.436 12.0 12.0 PI3K 0.001 0.069 -9999.0 0.0 -0.303 7.0 7.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.065 0.162 -9999.0 0.0 -0.436 24.0 24.0 somite specification -0.113 0.223 -9999.0 0.0 -0.575 19.0 19.0 SHH Np/Cholesterol/PTCH1 -0.058 0.147 -9999.0 0.0 -0.349 17.0 17.0 SHH Np/Cholesterol/PTCH2 0.002 0.069 -9999.0 0.0 -0.224 13.0 13.0 SHH Np/Cholesterol/Megalin -0.003 0.073 -9999.0 0.0 -0.232 14.0 14.0 SHH -0.009 0.089 -9999.0 0.0 -0.303 13.0 13.0 catabolic process -0.066 0.156 -9999.0 0.0 -0.304 44.0 44.0 SMO/Vitamin D3 -0.085 0.189 -9999.0 0.0 -0.476 19.0 19.0 SHH Np/Cholesterol/Hhip -0.038 0.106 -9999.0 0.0 -0.24 31.0 31.0 LRP2 0.005 0.044 -9999.0 0.0 -0.436 1.0 1.0 receptor-mediated endocytosis -0.078 0.183 -9999.0 0.0 -0.445 20.0 20.0 SHH Np/Cholesterol/BOC -0.001 0.069 -9999.0 0.0 -0.224 13.0 13.0 SHH Np/Cholesterol/CDO 0.001 0.07 -9999.0 0.0 -0.227 13.0 13.0 mesenchymal cell differentiation 0.038 0.105 0.239 31.0 -9999.0 0.0 31.0 mol:Vitamin D3 -0.056 0.148 -9999.0 0.0 -0.35 17.0 17.0 IHH N/PTCH2 0.005 0.039 -9999.0 0.0 -0.26 1.0 1.0 CDON 0.012 0.017 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.063 0.159 -9999.0 0.0 -0.305 45.0 45.0 Megalin/LRPAP1 0.015 0.031 -9999.0 0.0 -0.303 1.0 1.0 PTCH2 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.006 0.068 -9999.0 0.0 -0.229 13.0 13.0 PTCH1 -0.066 0.156 -9999.0 0.0 -0.305 44.0 44.0 HHIP -0.06 0.15 -9999.0 0.0 -0.436 20.0 20.0