Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.007 0.092 -9999.0 0.0 -0.239 19.0 19.0 epithelial cell differentiation 0.011 0.066 -9999.0 0.0 -0.204 13.0 13.0 CYFIP2 0.01 0.039 -9999.0 0.0 -0.436 1.0 1.0 ENAH 0.007 0.076 -9999.0 0.0 -0.251 7.0 7.0 EGFR -0.044 0.145 -9999.0 0.0 -0.436 18.0 18.0 EPHA2 -0.024 0.121 -9999.0 0.0 -0.436 12.0 12.0 MYO6 0.003 0.076 -9999.0 0.0 -0.219 15.0 15.0 CTNNB1 0.011 0.038 -9999.0 0.0 -0.436 1.0 1.0 ABI1/Sra1/Nap1 0.024 0.034 -9999.0 0.0 -0.249 2.0 2.0 AQP5 -0.049 0.17 -9999.0 0.0 -0.431 23.0 23.0 CTNND1 0.0 0.08 -9999.0 0.0 -0.436 5.0 5.0 mol:PI-4-5-P2 0.006 0.062 -9999.0 0.0 -0.189 14.0 14.0 regulation of calcium-dependent cell-cell adhesion -0.008 0.082 -9999.0 0.0 -0.21 20.0 20.0 EGF -0.045 0.133 -9999.0 0.0 -0.436 15.0 15.0 NCKAP1 0.009 0.04 -9999.0 0.0 -0.436 1.0 1.0 AQP3 -0.087 0.192 -9999.0 0.0 -0.43 34.0 34.0 cortical microtubule organization 0.011 0.066 -9999.0 0.0 -0.204 13.0 13.0 GO:0000145 0.003 0.058 -9999.0 0.0 -0.18 14.0 14.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.014 0.067 -9999.0 0.0 -0.206 13.0 13.0 MLLT4 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.037 0.089 -9999.0 0.0 -0.362 7.0 7.0 ARF6 0.005 0.063 -9999.0 0.0 -0.436 3.0 3.0 Ephrin A1/EPHA2/NCK1/GIT1 0.004 0.096 -9999.0 0.0 -0.262 16.0 16.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.006 0.068 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.011 0.038 -9999.0 0.0 -0.436 1.0 1.0 ZYX 0.004 0.065 -9999.0 0.0 -0.191 15.0 15.0 ARF6/GTP 0.004 0.1 -9999.0 0.0 -0.246 18.0 18.0 CDH1 -0.007 0.094 -9999.0 0.0 -0.436 7.0 7.0 EGFR/EGFR/EGF/EGF -0.043 0.116 -9999.0 0.0 -0.231 38.0 38.0 RhoA/GDP 0.013 0.062 -9999.0 0.0 -0.189 13.0 13.0 actin cytoskeleton organization 0.002 0.09 -9999.0 0.0 -0.248 15.0 15.0 IGF-1R heterotetramer -0.024 0.125 -9999.0 0.0 -0.436 13.0 13.0 GIT1 0.009 0.052 -9999.0 0.0 -0.436 2.0 2.0 IGF1R -0.024 0.126 -9999.0 0.0 -0.436 13.0 13.0 IGF1 -0.054 0.151 -9999.0 0.0 -0.436 20.0 20.0 DIAPH1 0.025 0.077 -9999.0 0.0 -0.625 2.0 2.0 Wnt receptor signaling pathway -0.011 0.066 0.204 13.0 -9999.0 0.0 13.0 RHOA 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.034 0.083 -9999.0 0.0 -0.336 7.0 7.0 CTNNA1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.001 0.092 -9999.0 0.0 -0.253 15.0 15.0 EFNA1 0.004 0.064 -9999.0 0.0 -0.436 3.0 3.0 LPP 0.008 0.063 -9999.0 0.0 -0.192 3.0 3.0 Ephrin A1/EPHA2 -0.012 0.096 -9999.0 0.0 -0.227 23.0 23.0 SEC6/SEC8 -0.016 0.053 -9999.0 0.0 -0.355 1.0 1.0 MGAT3 -0.008 0.083 -9999.0 0.0 -0.213 20.0 20.0 HGF/MET 0.005 0.065 -9999.0 0.0 -0.183 16.0 16.0 HGF 0.012 0.017 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.007 0.092 -9999.0 0.0 -0.241 19.0 19.0 actin cable formation 0.02 0.072 -9999.0 0.0 -0.23 5.0 5.0 KIAA1543 0.006 0.064 -9999.0 0.0 -0.181 16.0 16.0 KIFC3 0.008 0.061 -9999.0 0.0 -0.191 13.0 13.0 NCK1 0.009 0.052 -9999.0 0.0 -0.436 2.0 2.0 EXOC3 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.008 0.062 -9999.0 0.0 -0.194 13.0 13.0 NCK1/GIT1 0.013 0.052 -9999.0 0.0 -0.303 4.0 4.0 mol:GDP 0.011 0.066 -9999.0 0.0 -0.204 13.0 13.0 EXOC4 0.012 0.036 -9999.0 0.0 -0.436 1.0 1.0 STX4 0.008 0.062 -9999.0 0.0 -0.194 13.0 13.0 PIP5K1C 0.007 0.063 -9999.0 0.0 -0.191 14.0 14.0 LIMA1 -0.012 0.106 -9999.0 0.0 -0.436 9.0 9.0 ABI1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.003 0.087 -9999.0 0.0 -0.296 7.0 7.0 adherens junction assembly 0.014 0.069 -9999.0 0.0 -0.259 2.0 2.0 IGF-1R heterotetramer/IGF1 -0.039 0.107 -9999.0 0.0 -0.206 41.0 41.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.02 0.027 -9999.0 0.0 -0.303 1.0 1.0 MET 0.004 0.064 -9999.0 0.0 -0.436 3.0 3.0 PLEKHA7 0.008 0.061 -9999.0 0.0 -0.191 13.0 13.0 mol:GTP 0.003 0.095 -9999.0 0.0 -0.26 16.0 16.0 establishment of epithelial cell apical/basal polarity 0.021 0.063 -9999.0 0.0 -0.338 1.0 1.0 cortical actin cytoskeleton stabilization -0.007 0.092 -9999.0 0.0 -0.239 19.0 19.0 regulation of cell-cell adhesion 0.002 0.09 -9999.0 0.0 -0.248 15.0 15.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.007 0.092 -9999.0 0.0 -0.241 19.0 19.0