Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.136 0.276 -9999.0 0.0 -0.562 43.0 43.0 IHH -0.015 0.089 -9999.0 0.0 -0.259 5.0 5.0 SHH Np/Cholesterol/GAS1 -0.045 0.144 -9999.0 0.0 -0.322 30.0 30.0 LRPAP1 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.045 0.143 0.32 30.0 -9999.0 0.0 30.0 SMO/beta Arrestin2 -0.117 0.234 -9999.0 0.0 -0.571 21.0 21.0 SMO -0.13 0.239 -9999.0 0.0 -0.565 24.0 24.0 AKT1 -0.093 0.212 -9999.0 0.0 -0.701 13.0 13.0 ARRB2 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.022 0.027 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.128 0.235 -9999.0 0.0 -0.555 24.0 24.0 STIL -0.077 0.157 -9999.0 0.0 -0.441 12.0 12.0 DHH N/PTCH2 0.047 0.009 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 -0.05 0.163 -9999.0 0.0 -0.301 42.0 42.0 PIK3CA 0.009 0.062 -9999.0 0.0 -0.51 2.0 2.0 DHH 0.032 0.003 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.249 0.451 -9999.0 0.0 -0.96 43.0 43.0 determination of left/right symmetry -0.128 0.235 -9999.0 0.0 -0.555 24.0 24.0 PIK3R1 0.004 0.099 -9999.0 0.0 -0.51 5.0 5.0 skeletal system development -0.246 0.444 -9999.0 0.0 -0.946 43.0 43.0 IHH N/Hhip -0.055 0.157 -9999.0 0.0 -0.423 21.0 21.0 DHH N/Hhip -0.024 0.136 -9999.0 0.0 -0.371 19.0 19.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.128 0.235 -9999.0 0.0 -0.555 24.0 24.0 pancreas development -0.058 0.179 -9999.0 0.0 -0.51 20.0 20.0 HHAT -0.007 0.14 -9999.0 0.0 -0.51 11.0 11.0 PI3K 0.004 0.075 -9999.0 0.0 -0.371 5.0 5.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.056 0.188 -9999.0 0.0 -0.51 22.0 22.0 somite specification -0.128 0.235 -9999.0 0.0 -0.555 24.0 24.0 SHH Np/Cholesterol/PTCH1 -0.069 0.164 -9999.0 0.0 -0.295 47.0 47.0 SHH Np/Cholesterol/PTCH2 0.007 0.086 -9999.0 0.0 -0.287 12.0 12.0 SHH Np/Cholesterol/Megalin 0.001 0.091 -9999.0 0.0 -0.294 13.0 13.0 SHH -0.013 0.104 -9999.0 0.0 -0.371 12.0 12.0 catabolic process -0.07 0.174 -9999.0 0.0 -0.337 43.0 43.0 SMO/Vitamin D3 -0.103 0.204 -9999.0 0.0 -0.496 21.0 21.0 SHH Np/Cholesterol/Hhip -0.044 0.127 -9999.0 0.0 -0.297 29.0 29.0 LRP2 0.02 0.052 -9999.0 0.0 -0.51 1.0 1.0 receptor-mediated endocytosis -0.102 0.195 -9999.0 0.0 -0.487 20.0 20.0 SHH Np/Cholesterol/BOC -0.001 0.086 -9999.0 0.0 -0.287 12.0 12.0 SHH Np/Cholesterol/CDO 0.006 0.087 -9999.0 0.0 -0.29 12.0 12.0 mesenchymal cell differentiation 0.043 0.126 0.295 29.0 -9999.0 0.0 29.0 mol:Vitamin D3 -0.07 0.163 -9999.0 0.0 -0.374 19.0 19.0 IHH N/PTCH2 0.015 0.06 -9999.0 0.0 -0.325 1.0 1.0 CDON 0.028 0.02 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.063 0.18 -9999.0 0.0 -0.34 43.0 43.0 Megalin/LRPAP1 0.034 0.044 -9999.0 0.0 -0.371 1.0 1.0 PTCH2 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.004 0.082 -9999.0 0.0 -0.286 12.0 12.0 PTCH1 -0.07 0.174 -9999.0 0.0 -0.338 43.0 43.0 HHIP -0.058 0.179 -9999.0 0.0 -0.51 20.0 20.0