Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity 0.093 0.167 0.313 30.0 -9999.0 0.0 30.0 KIRREL -0.046 0.133 0.094 1.0 -0.431 9.0 10.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs -0.093 0.167 -9999.0 0.0 -0.314 30.0 30.0 PLCG1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP -0.059 0.126 -9999.0 0.0 -0.223 30.0 30.0 ChemicalAbstracts:57-88-5 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.071 0.137 -9999.0 0.0 -0.242 30.0 30.0 FYN -0.075 0.114 -9999.0 0.0 -0.216 32.0 32.0 mol:Ca2+ -0.059 0.125 -9999.0 0.0 -0.221 30.0 30.0 mol:DAG -0.059 0.126 -9999.0 0.0 -0.222 30.0 30.0 NPHS2 -0.012 0.027 -9999.0 0.0 -9999.0 0.0 0.0 mol:IP3 -0.059 0.126 -9999.0 0.0 -0.222 30.0 30.0 regulation of endocytosis -0.055 0.117 -9999.0 0.0 -0.199 32.0 32.0 Nephrin/NEPH1/podocin/Cholesterol -0.064 0.125 0.12 2.0 -0.227 30.0 32.0 establishment of cell polarity -0.093 0.167 -9999.0 0.0 -0.313 30.0 30.0 Nephrin/NEPH1/podocin/NCK1-2 -0.05 0.125 -9999.0 0.0 -0.206 30.0 30.0 Nephrin/NEPH1/beta Arrestin2 -0.055 0.119 -9999.0 0.0 -0.201 32.0 32.0 NPHS1 -0.102 0.196 -9999.0 0.0 -0.42 23.0 23.0 Nephrin/NEPH1/podocin -0.063 0.125 0.122 2.0 -0.217 32.0 34.0 TJP1 0.005 0.045 -9999.0 0.0 -0.413 1.0 1.0 NCK1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.005 0.045 -9999.0 0.0 -0.413 1.0 1.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 -0.059 0.126 -9999.0 0.0 -0.223 30.0 30.0 CD2AP 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 -0.059 0.126 -9999.0 0.0 -0.223 30.0 30.0 GRB2 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.071 0.117 -9999.0 0.0 -0.216 31.0 31.0 cytoskeleton organization -0.08 0.148 -9999.0 0.0 -0.271 30.0 30.0 Nephrin/NEPH1 -0.061 0.118 -9999.0 0.0 -0.215 30.0 30.0 Nephrin/NEPH1/ZO-1 -0.068 0.143 -9999.0 0.0 -0.249 30.0 30.0