Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.031 0.21 -9999.0 0.0 -0.624 9.0 9.0 IHH 0.006 0.05 -9999.0 0.0 -0.191 1.0 1.0 SHH Np/Cholesterol/GAS1 -0.005 0.065 -9999.0 0.0 -0.219 7.0 7.0 LRPAP1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.005 0.064 0.218 7.0 -9999.0 0.0 7.0 SMO/beta Arrestin2 -0.008 0.124 -9999.0 0.0 -0.354 7.0 7.0 SMO -0.014 0.13 -9999.0 0.0 -0.336 10.0 10.0 AKT1 0.008 0.061 -9999.0 0.0 -0.28 1.0 1.0 ARRB2 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.009 0.049 -9999.0 0.0 -0.413 1.0 1.0 ADRBK1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.013 0.128 -9999.0 0.0 -0.331 10.0 10.0 STIL -0.012 0.099 -9999.0 0.0 -0.258 10.0 10.0 DHH N/PTCH2 0.002 0.083 -9999.0 0.0 -0.291 6.0 6.0 DHH N/PTCH1 -0.013 0.13 -9999.0 0.0 -0.312 12.0 12.0 PIK3CA 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.009 0.09 -9999.0 0.0 -0.413 4.0 4.0 PTHLH -0.054 0.275 -9999.0 0.0 -0.835 9.0 9.0 determination of left/right symmetry -0.013 0.128 -9999.0 0.0 -0.331 10.0 10.0 PIK3R1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.053 0.271 -9999.0 0.0 -0.824 9.0 9.0 IHH N/Hhip -0.035 0.149 0.136 2.0 -0.324 17.0 19.0 DHH N/Hhip -0.041 0.152 0.125 1.0 -0.315 19.0 20.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.013 0.128 -9999.0 0.0 -0.331 10.0 10.0 pancreas development -0.05 0.183 -9999.0 0.0 -0.412 17.0 17.0 HHAT 0.005 0.045 -9999.0 0.0 -0.413 1.0 1.0 PI3K 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.017 0.109 -9999.0 0.0 -0.413 6.0 6.0 somite specification -0.013 0.128 -9999.0 0.0 -0.331 10.0 10.0 SHH Np/Cholesterol/PTCH1 -0.003 0.105 -9999.0 0.0 -0.281 9.0 9.0 SHH Np/Cholesterol/PTCH2 0.013 0.047 -9999.0 0.0 -0.214 3.0 3.0 SHH Np/Cholesterol/Megalin -0.038 0.103 -9999.0 0.0 -0.226 19.0 19.0 SHH 0.004 0.032 -9999.0 0.0 -0.286 1.0 1.0 catabolic process -0.008 0.129 -9999.0 0.0 -0.361 9.0 9.0 SMO/Vitamin D3 -0.002 0.118 -9999.0 0.0 -0.306 9.0 9.0 SHH Np/Cholesterol/Hhip -0.02 0.103 -9999.0 0.0 -0.216 18.0 18.0 LRP2 -0.08 0.178 -9999.0 0.0 -0.413 19.0 19.0 receptor-mediated endocytosis -0.045 0.136 -9999.0 0.0 -0.39 7.0 7.0 SHH Np/Cholesterol/BOC 0.01 0.036 -9999.0 0.0 -0.213 2.0 2.0 SHH Np/Cholesterol/CDO -0.014 0.08 -9999.0 0.0 -0.24 9.0 9.0 mesenchymal cell differentiation 0.02 0.102 0.215 18.0 -9999.0 0.0 18.0 mol:Vitamin D3 0.001 0.108 -9999.0 0.0 -0.282 9.0 9.0 IHH N/PTCH2 0.016 0.065 -9999.0 0.0 -0.34 2.0 2.0 CDON -0.035 0.129 -9999.0 0.0 -0.413 9.0 9.0 IHH N/PTCH1 -0.0 0.134 -9999.0 0.0 -0.364 9.0 9.0 Megalin/LRPAP1 -0.049 0.126 -9999.0 0.0 -0.286 19.0 19.0 PTCH2 0.012 0.071 -9999.0 0.0 -0.413 2.0 2.0 SHH Np/Cholesterol 0.004 0.024 -9999.0 0.0 -0.215 1.0 1.0 PTCH1 -0.008 0.13 -9999.0 0.0 -0.363 9.0 9.0 HHIP -0.05 0.183 -9999.0 0.0 -0.413 17.0 17.0