Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Nephrin/Neph1 signaling in the kidney podocyte	19.0	648.0	34.0	-0.102	0.01	1000.0	-1000.0	-0.008	-1000.0
TCGA08_retinoblastoma	15.0	123.0	8.0	-0.039	0.045	1000.0	-1000.0	0.0	-1000.0
Ephrin A  reverse signaling	12.0	87.0	7.0	-0.044	0.0	1000.0	-1000.0	-0.003	-1000.0
Syndecan-1-mediated signaling events	10.0	364.0	34.0	-0.113	0.011	1000.0	-1000.0	-0.019	-1000.0
Glucocorticoid receptor regulatory network	10.0	1232.0	114.0	-0.41	0.184	1000.0	-1000.0	-0.032	-1000.0
Signaling events regulated by Ret tyrosine kinase	10.0	867.0	82.0	-0.063	0.01	1000.0	-1000.0	-0.042	-1000.0
Endothelins	10.0	978.0	96.0	-0.133	0.037	1000.0	-1000.0	-0.037	-1000.0
E-cadherin signaling events	10.0	53.0	5.0	-0.069	0.01	1000.0	-1000.0	0.003	-1000.0
TCGA08_p53	9.0	64.0	7.0	-0.039	0.027	1000.0	-1000.0	-0.001	-1000.0
Signaling mediated by p38-alpha and p38-beta	9.0	419.0	44.0	-0.064	0.01	1000.0	-1000.0	-0.019	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	9.0	707.0	74.0	-0.069	0.019	1000.0	-1000.0	-0.03	-1000.0
p75(NTR)-mediated signaling	8.0	1077.0	125.0	-0.095	0.029	1000.0	-1000.0	-0.035	-1000.0
IL4-mediated signaling events	8.0	760.0	91.0	-0.452	0.363	1000.0	-1000.0	-0.139	-1000.0
Reelin signaling pathway	8.0	496.0	56.0	-0.091	0.021	1000.0	-1000.0	-0.023	-1000.0
Ephrin B reverse signaling	8.0	397.0	48.0	-0.123	0.016	1000.0	-1000.0	-0.015	-1000.0
Integrins in angiogenesis	8.0	699.0	84.0	-0.121	0.021	1000.0	-1000.0	-0.029	-1000.0
ErbB2/ErbB3 signaling events	7.0	490.0	65.0	-0.11	0.014	1000.0	-1000.0	-0.025	-1000.0
Signaling events mediated by the Hedgehog family	7.0	396.0	52.0	-0.08	0.02	1000.0	-1000.0	-0.015	-1000.0
Thromboxane A2 receptor signaling	7.0	774.0	105.0	-0.09	0.018	1000.0	-1000.0	-0.031	-1000.0
HIF-1-alpha transcription factor network	7.0	564.0	76.0	-0.127	0.016	1000.0	-1000.0	-0.049	-1000.0
Fc-epsilon receptor I signaling in mast cells	7.0	703.0	97.0	-0.074	0.019	1000.0	-1000.0	-0.035	-1000.0
amb2 Integrin signaling	7.0	610.0	82.0	-0.138	0.013	1000.0	-1000.0	-0.015	-1000.0
EPHB forward signaling	7.0	636.0	85.0	-0.051	0.039	1000.0	-1000.0	-0.033	-1000.0
Calcium signaling in the CD4+ TCR pathway	7.0	238.0	31.0	-0.113	0.012	1000.0	-1000.0	-0.028	-1000.0
E-cadherin signaling in the nascent adherens junction	7.0	575.0	76.0	-0.069	0.018	1000.0	-1000.0	-0.035	-1000.0
IL23-mediated signaling events	7.0	475.0	60.0	-0.294	0.011	1000.0	-1000.0	-0.08	-1000.0
E-cadherin signaling in keratinocytes	7.0	312.0	43.0	-0.069	0.011	1000.0	-1000.0	-0.014	-1000.0
Caspase cascade in apoptosis	6.0	461.0	74.0	-0.081	0.04	1000.0	-1000.0	-0.027	-1000.0
Osteopontin-mediated events	6.0	243.0	38.0	-0.041	0.012	1000.0	-1000.0	-0.027	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	6.0	576.0	85.0	-0.112	0.01	1000.0	-1000.0	-0.028	-1000.0
TCR signaling in naïve CD8+ T cells	6.0	607.0	93.0	-0.103	0.033	1000.0	-1000.0	-0.037	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	6.0	446.0	68.0	-0.177	0.039	1000.0	-1000.0	-0.041	-1000.0
IL12-mediated signaling events	5.0	514.0	87.0	-0.19	0.013	1000.0	-1000.0	-0.088	-1000.0
FAS signaling pathway (CD95)	5.0	267.0	47.0	-0.189	0.027	1000.0	-1000.0	-0.017	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	5.0	713.0	125.0	-0.044	0.016	1000.0	-1000.0	-0.036	-1000.0
EGFR-dependent Endothelin signaling events	5.0	114.0	21.0	-0.02	0.015	1000.0	-1000.0	-0.018	-1000.0
Syndecan-4-mediated signaling events	5.0	377.0	67.0	-0.073	0.015	1000.0	-1000.0	-0.023	-1000.0
IGF1 pathway	5.0	297.0	57.0	-0.028	0.02	1000.0	-1000.0	-0.033	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	5.0	611.0	120.0	-0.084	0.077	1000.0	-1000.0	-0.029	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	4.0	243.0	54.0	-0.043	0.021	1000.0	-1000.0	-0.035	-1000.0
BMP receptor signaling	4.0	381.0	81.0	-0.071	0.034	1000.0	-1000.0	-0.037	-1000.0
HIF-2-alpha transcription factor network	4.0	177.0	43.0	-0.11	0.018	1000.0	-1000.0	-0.044	-1000.0
Nongenotropic Androgen signaling	4.0	250.0	52.0	-0.086	0.037	1000.0	-1000.0	-0.02	-1000.0
Wnt signaling	4.0	30.0	7.0	-0.018	0.01	1000.0	-1000.0	-0.011	-1000.0
IL6-mediated signaling events	4.0	374.0	75.0	-0.088	0.029	1000.0	-1000.0	-0.027	-1000.0
BCR signaling pathway	4.0	481.0	99.0	-0.061	0.019	1000.0	-1000.0	-0.037	-1000.0
Angiopoietin receptor Tie2-mediated signaling	4.0	402.0	88.0	-0.079	0.015	1000.0	-1000.0	-0.045	-1000.0
Visual signal transduction: Rods	4.0	230.0	52.0	-0.048	0.015	1000.0	-1000.0	-0.024	-1000.0
ErbB4 signaling events	3.0	208.0	69.0	-0.078	0.082	1000.0	-1000.0	-0.036	-1000.0
BARD1 signaling events	3.0	220.0	57.0	-0.029	0.025	1000.0	-1000.0	-0.019	-1000.0
Noncanonical Wnt signaling pathway	3.0	89.0	26.0	-0.045	0.01	1000.0	-1000.0	-0.017	-1000.0
Signaling events mediated by PTP1B	3.0	257.0	76.0	-0.041	0.02	1000.0	-1000.0	-0.021	-1000.0
FOXA2 and FOXA3 transcription factor networks	3.0	158.0	46.0	-0.125	0.012	1000.0	-1000.0	-0.075	-1000.0
Glypican 1 network	3.0	149.0	48.0	-0.068	0.02	1000.0	-1000.0	-0.012	-1000.0
IFN-gamma pathway	3.0	270.0	68.0	-0.07	0.017	1000.0	-1000.0	-0.047	-1000.0
Nectin adhesion pathway	3.0	241.0	63.0	-0.069	0.012	1000.0	-1000.0	-0.034	-1000.0
S1P1 pathway	3.0	134.0	36.0	-0.055	0.01	1000.0	-1000.0	-0.024	-1000.0
Signaling mediated by p38-gamma and p38-delta	3.0	46.0	15.0	-0.02	0.011	1000.0	-1000.0	-0.006	-1000.0
Retinoic acid receptors-mediated signaling	3.0	186.0	58.0	-0.039	0.02	1000.0	-1000.0	-0.028	-1000.0
Effects of Botulinum toxin	3.0	80.0	26.0	-0.032	0.015	1000.0	-1000.0	-0.005	-1000.0
Glypican 2 network	3.0	13.0	4.0	-0.003	-0.0	1000.0	-1000.0	0.001	-1000.0
IL27-mediated signaling events	3.0	160.0	51.0	-0.072	0.04	1000.0	-1000.0	-0.033	-1000.0
S1P3 pathway	3.0	138.0	42.0	-0.088	0.015	1000.0	-1000.0	-0.028	-1000.0
Class IB PI3K non-lipid kinase events	3.0	9.0	3.0	-0.003	-1000.0	1000.0	-1000.0	-0.002	-1000.0
FOXM1 transcription factor network	3.0	189.0	51.0	-0.133	0.023	1000.0	-1000.0	-0.139	-1000.0
Regulation of nuclear SMAD2/3 signaling	2.0	338.0	136.0	-0.155	0.152	1000.0	-1000.0	-0.023	-1000.0
Coregulation of Androgen receptor activity	2.0	189.0	76.0	-0.055	0.019	1000.0	-1000.0	-0.021	-1000.0
PLK2 and PLK4 events	2.0	6.0	3.0	0.001	0.002	1000.0	-1000.0	-0.002	-1000.0
JNK signaling in the CD4+ TCR pathway	2.0	39.0	17.0	-0.028	0.019	1000.0	-1000.0	-0.02	-1000.0
Arf6 signaling events	2.0	184.0	62.0	-0.035	0.017	1000.0	-1000.0	-0.016	-1000.0
Hedgehog signaling events mediated by Gli proteins	2.0	183.0	65.0	-0.155	0.037	1000.0	-1000.0	-0.036	-1000.0
Presenilin action in Notch and Wnt signaling	2.0	181.0	61.0	-0.078	0.029	1000.0	-1000.0	-0.026	-1000.0
PDGFR-alpha signaling pathway	2.0	125.0	44.0	-0.104	0.017	1000.0	-1000.0	-0.012	-1000.0
IL1-mediated signaling events	2.0	155.0	62.0	-0.025	0.033	1000.0	-1000.0	-0.031	-1000.0
IL2 signaling events mediated by PI3K	2.0	137.0	58.0	-0.048	0.024	1000.0	-1000.0	-0.032	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	2.0	90.0	45.0	-0.02	0.025	1000.0	-1000.0	-0.033	-1000.0
Canonical Wnt signaling pathway	2.0	124.0	51.0	-0.078	0.039	1000.0	-1000.0	-0.027	-1000.0
TCGA08_rtk_signaling	2.0	65.0	26.0	-0.035	0.026	1000.0	-1000.0	-0.004	-1000.0
LPA receptor mediated events	2.0	256.0	102.0	-0.054	0.026	1000.0	-1000.0	-0.043	-1000.0
IL2 signaling events mediated by STAT5	2.0	60.0	22.0	-0.038	0.01	1000.0	-1000.0	-0.03	-1000.0
PDGFR-beta signaling pathway	2.0	206.0	97.0	-0.049	0.027	1000.0	-1000.0	-0.028	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	2.0	171.0	78.0	-0.018	0.025	1000.0	-1000.0	-0.051	-1000.0
Regulation of Androgen receptor activity	2.0	204.0	70.0	-0.135	0.023	1000.0	-1000.0	-0.032	-1000.0
Ras signaling in the CD4+ TCR pathway	2.0	46.0	17.0	-0.017	0.016	1000.0	-1000.0	-0.021	-1000.0
Aurora B signaling	2.0	172.0	67.0	-0.082	0.014	1000.0	-1000.0	-0.027	-1000.0
LPA4-mediated signaling events	1.0	21.0	12.0	-0.025	0.009	1000.0	-1000.0	-0.009	-1000.0
Sphingosine 1-phosphate (S1P) pathway	1.0	51.0	28.0	-0.014	0.018	1000.0	-1000.0	-0.011	-1000.0
Visual signal transduction: Cones	1.0	65.0	38.0	-0.037	0.019	1000.0	-1000.0	-0.004	-1000.0
Syndecan-2-mediated signaling events	1.0	125.0	69.0	-0.041	0.021	1000.0	-1000.0	-0.022	-1000.0
Cellular roles of Anthrax toxin	1.0	76.0	39.0	-0.024	0.01	1000.0	-1000.0	-0.009	-1000.0
Aurora A signaling	1.0	87.0	60.0	-0.043	0.027	1000.0	-1000.0	-0.01	-1000.0
PLK1 signaling events	1.0	130.0	85.0	-0.016	0.02	1000.0	-1000.0	-0.022	-1000.0
Ceramide signaling pathway	1.0	101.0	76.0	-0.049	0.023	1000.0	-1000.0	-0.015	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	47.0	37.0	-0.017	0.025	1000.0	-1000.0	-0.017	-1000.0
Signaling events mediated by HDAC Class III	1.0	57.0	40.0	-0.036	0.019	1000.0	-1000.0	-0.005	-1000.0
TRAIL signaling pathway	1.0	90.0	48.0	-0.015	0.025	1000.0	-1000.0	-0.018	-1000.0
S1P5 pathway	1.0	33.0	17.0	-0.008	0.01	1000.0	-1000.0	-0.01	-1000.0
ceramide signaling pathway	1.0	55.0	49.0	-0.009	0.019	1000.0	-1000.0	-0.019	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	1.0	90.0	52.0	-0.016	0.038	1000.0	-1000.0	-0.021	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	84.0	83.0	-0.041	0.028	1000.0	-1000.0	-0.023	-1000.0
FoxO family signaling	1.0	102.0	64.0	-0.041	0.045	1000.0	-1000.0	-0.028	-1000.0
Atypical NF-kappaB pathway	1.0	47.0	31.0	-0.018	0.016	1000.0	-1000.0	-0.011	-1000.0
Syndecan-3-mediated signaling events	1.0	62.0	35.0	-0.021	0.029	1000.0	-1000.0	-0.014	-1000.0
Regulation of p38-alpha and p38-beta	1.0	74.0	54.0	-0.026	0.026	1000.0	-1000.0	-0.031	-1000.0
Regulation of Telomerase	1.0	202.0	102.0	-0.125	0.028	1000.0	-1000.0	-0.05	-1000.0
Insulin Pathway	1.0	95.0	74.0	-0.047	0.029	1000.0	-1000.0	-0.029	-1000.0
Plasma membrane estrogen receptor signaling	1.0	131.0	86.0	-0.027	0.022	1000.0	-1000.0	-0.042	-1000.0
VEGFR1 specific signals	1.0	84.0	56.0	-0.02	0.025	1000.0	-1000.0	-0.027	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	1.0	56.0	33.0	-0.041	0.027	1000.0	-1000.0	-0.015	-1000.0
Signaling events mediated by PRL	1.0	38.0	34.0	-0.018	0.015	1000.0	-1000.0	-0.018	-1000.0
S1P4 pathway	1.0	39.0	25.0	-0.002	0.018	1000.0	-1000.0	-0.012	-1000.0
p38 MAPK signaling pathway	1.0	64.0	44.0	-0.028	0.019	1000.0	-1000.0	-0.028	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	9.0	23.0	-0.005	0.025	1000.0	-1000.0	-0.016	-1000.0
Canonical NF-kappaB pathway	0.0	18.0	39.0	-0.009	0.042	1000.0	-1000.0	-0.026	-1000.0
Signaling events mediated by HDAC Class II	0.0	31.0	75.0	-0.019	0.029	1000.0	-1000.0	-0.017	-1000.0
Circadian rhythm pathway	0.0	12.0	22.0	-0.006	0.022	1000.0	-1000.0	-0.026	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	2.0	5.0	0.007	0.015	1000.0	-1000.0	-0.002	-1000.0
Arf6 downstream pathway	0.0	36.0	43.0	-0.019	0.019	1000.0	-1000.0	-0.019	-1000.0
Aurora C signaling	0.0	6.0	7.0	-0.0	0.014	1000.0	-1000.0	-0.006	-1000.0
EPO signaling pathway	0.0	35.0	55.0	-0.005	0.041	1000.0	-1000.0	-0.031	-1000.0
Insulin-mediated glucose transport	0.0	29.0	32.0	-0.041	0.02	1000.0	-1000.0	-0.017	-1000.0
mTOR signaling pathway	0.0	42.0	53.0	-0.009	0.019	1000.0	-1000.0	-0.025	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	24.0	68.0	-0.041	0.03	1000.0	-1000.0	-0.019	-1000.0
Signaling events mediated by HDAC Class I	0.0	1.0	15.0	-0.005	0.01	1000.0	-1000.0	-0.002	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	15.0	36.0	-0.026	0.027	1000.0	-1000.0	-0.021	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	3.0	27.0	0.0	0.023	1000.0	-1000.0	-0.022	-1000.0
Class I PI3K signaling events	0.0	9.0	73.0	-0.096	0.043	1000.0	-1000.0	-0.026	-1000.0
Arf6 trafficking events	0.0	7.0	71.0	-0.017	0.025	1000.0	-1000.0	-0.023	-1000.0
Rapid glucocorticoid signaling	0.0	19.0	20.0	-0.006	0.013	1000.0	-1000.0	-0.003	-1000.0
Arf1 pathway	0.0	8.0	54.0	-0.0	0.02	1000.0	-1000.0	-0.011	-1000.0
Alternative NF-kappaB pathway	0.0	2.0	13.0	0.0	0.029	1000.0	-1000.0	-0.002	-1000.0
Total	459	30430	7114	-8.27310002033	-996.50094512	131000	-131000	-3.34690189458	-131000