E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.068 0.189 -9999.0 0.0 -0.451 15.0 15.0 KLHL20 -0.01 0.098 0.176 2.0 -0.242 4.0 6.0 CYFIP2 0.02 0.057 -9999.0 0.0 -0.496 1.0 1.0 Rac1/GDP -0.028 0.121 -9999.0 0.0 -0.301 10.0 10.0 ENAH -0.068 0.19 -9999.0 0.0 -0.46 15.0 15.0 AP1M1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.025 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.007 0.094 -9999.0 0.0 -0.358 2.0 2.0 ABI1/Sra1/Nap1 -0.031 0.055 -9999.0 0.0 -0.198 3.0 3.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.003 0.132 -9999.0 0.0 -0.274 15.0 15.0 RAPGEF1 -0.051 0.165 -9999.0 0.0 -0.411 13.0 13.0 CTNND1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.069 0.197 -9999.0 0.0 -0.463 15.0 15.0 CRK -0.059 0.18 -9999.0 0.0 -0.426 15.0 15.0 E-cadherin/gamma catenin/alpha catenin -0.019 0.145 -9999.0 0.0 -0.321 15.0 15.0 alphaE/beta7 Integrin 0.028 0.058 -9999.0 0.0 -0.216 4.0 4.0 IQGAP1 0.021 0.056 -9999.0 0.0 -0.496 1.0 1.0 NCKAP1 0.022 0.056 -9999.0 0.0 -0.496 1.0 1.0 Rap1/GTP/I-afadin 0.039 0.053 -9999.0 0.0 -0.277 2.0 2.0 DLG1 -0.068 0.189 -9999.0 0.0 -0.45 15.0 15.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.02 0.062 -9999.0 0.0 -0.258 2.0 2.0 MLLT4 0.015 0.079 -9999.0 0.0 -0.496 2.0 2.0 ARF6/GTP/NME1/Tiam1 0.039 0.05 -9999.0 0.0 -0.277 1.0 1.0 PI3K -0.022 0.082 -9999.0 0.0 -0.34 2.0 2.0 ARF6 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.04 0.164 -9999.0 0.0 -0.375 16.0 16.0 TIAM1 0.01 0.08 -9999.0 0.0 -0.3 5.0 5.0 E-cadherin(dimer)/Ca2+ 0.005 0.115 -9999.0 0.0 -0.258 13.0 13.0 AKT1 -0.01 0.051 -9999.0 0.0 -0.19 2.0 2.0 PIK3R1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.058 0.193 -9999.0 0.0 -0.496 14.0 14.0 RhoA/GDP -0.018 0.128 0.341 1.0 -0.345 4.0 5.0 actin cytoskeleton organization -0.006 0.074 0.145 2.0 -0.184 3.0 5.0 CDC42/GDP -0.021 0.13 0.341 1.0 -0.345 4.0 5.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.033 0.11 -9999.0 0.0 -0.259 15.0 15.0 ITGB7 0.013 0.075 -9999.0 0.0 -0.312 4.0 4.0 RAC1 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.006 0.123 -9999.0 0.0 -0.275 13.0 13.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.005 0.109 -9999.0 0.0 -0.257 13.0 13.0 mol:GDP -0.039 0.143 0.351 1.0 -0.348 10.0 11.0 CDC42/GTP/IQGAP1 0.031 0.038 -9999.0 0.0 -0.304 1.0 1.0 JUP 0.008 0.096 -9999.0 0.0 -0.496 3.0 3.0 p120 catenin/RhoA/GDP -0.022 0.13 0.339 1.0 -0.354 4.0 5.0 RAC1/GTP/IQGAP1 0.03 0.038 -9999.0 0.0 -0.304 1.0 1.0 PIP5K1C/AP1M1 0.041 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.004 0.074 0.162 3.0 -0.21 5.0 8.0 NME1 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.064 0.194 -9999.0 0.0 -0.473 14.0 14.0 regulation of cell-cell adhesion -0.014 0.078 -9999.0 0.0 -0.311 2.0 2.0 WASF2 -0.002 0.04 -9999.0 0.0 -0.139 1.0 1.0 Rap1/GTP -0.007 0.106 -9999.0 0.0 -0.407 2.0 2.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.005 0.141 -9999.0 0.0 -0.276 16.0 16.0 CCND1 -0.006 0.089 0.184 3.0 -0.263 5.0 8.0 VAV2 -0.068 0.211 -9999.0 0.0 -0.551 8.0 8.0 RAP1/GDP -0.004 0.119 0.372 1.0 -0.393 2.0 3.0 adherens junction assembly -0.062 0.187 -9999.0 0.0 -0.456 14.0 14.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.004 0.137 -9999.0 0.0 -0.264 16.0 16.0 E-cadherin/beta catenin -0.05 0.138 -9999.0 0.0 -0.348 15.0 15.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.071 0.19 -9999.0 0.0 -0.451 15.0 15.0 PIK3CA 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.069 0.124 -9999.0 0.0 -0.391 5.0 5.0 E-cadherin/beta catenin/alpha catenin -0.007 0.128 -9999.0 0.0 -0.302 13.0 13.0 ITGAE 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.071 0.201 -9999.0 0.0 -0.474 15.0 15.0