Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.108 0.246 -9999.0 0.0 -0.561 16.0 16.0 IHH -0.026 0.086 -9999.0 0.0 -0.225 6.0 6.0 SHH Np/Cholesterol/GAS1 -0.0 0.076 -9999.0 0.0 -0.351 3.0 3.0 LRPAP1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.001 0.076 0.349 3.0 -9999.0 0.0 3.0 SMO/beta Arrestin2 -0.036 0.149 -9999.0 0.0 -0.506 3.0 3.0 SMO -0.052 0.146 -9999.0 0.0 -0.483 4.0 4.0 AKT1 -0.009 0.105 -9999.0 0.0 -0.377 4.0 4.0 ARRB2 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.006 0.085 -9999.0 0.0 -0.292 6.0 6.0 ADRBK1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.046 0.147 -9999.0 0.0 -0.475 4.0 4.0 STIL -0.039 0.15 -9999.0 0.0 -0.387 6.0 6.0 DHH N/PTCH2 -0.025 0.126 -9999.0 0.0 -0.235 20.0 20.0 DHH N/PTCH1 -0.065 0.17 -9999.0 0.0 -0.38 14.0 14.0 PIK3CA 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.003 0.117 -9999.0 0.0 -0.414 6.0 6.0 PTHLH -0.125 0.308 -9999.0 0.0 -0.931 9.0 9.0 determination of left/right symmetry -0.046 0.147 -9999.0 0.0 -0.475 4.0 4.0 PIK3R1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.123 0.303 -9999.0 0.0 -0.917 9.0 9.0 IHH N/Hhip -0.145 0.167 -9999.0 0.0 -0.306 38.0 38.0 DHH N/Hhip -0.121 0.182 -9999.0 0.0 -0.391 21.0 21.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.046 0.147 -9999.0 0.0 -0.475 4.0 4.0 pancreas development -0.164 0.205 -9999.0 0.0 -0.347 44.0 44.0 HHAT 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.04 0.011 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.006 0.12 -9999.0 0.0 -0.391 7.0 7.0 somite specification -0.046 0.147 -9999.0 0.0 -0.475 4.0 4.0 SHH Np/Cholesterol/PTCH1 -0.055 0.134 -9999.0 0.0 -0.407 5.0 5.0 SHH Np/Cholesterol/PTCH2 -0.013 0.071 -9999.0 0.0 -0.282 2.0 2.0 SHH Np/Cholesterol/Megalin -0.049 0.133 -9999.0 0.0 -0.289 19.0 19.0 SHH -0.006 0.028 -9999.0 0.0 -9999.0 0.0 0.0 catabolic process -0.068 0.168 -9999.0 0.0 -0.37 17.0 17.0 SMO/Vitamin D3 -0.035 0.149 -9999.0 0.0 -0.496 3.0 3.0 SHH Np/Cholesterol/Hhip -0.073 0.123 -9999.0 0.0 -0.272 18.0 18.0 LRP2 -0.101 0.219 -9999.0 0.0 -0.453 23.0 23.0 receptor-mediated endocytosis -0.087 0.171 -9999.0 0.0 -0.447 8.0 8.0 SHH Np/Cholesterol/BOC 0.006 0.053 -9999.0 0.0 -0.282 1.0 1.0 SHH Np/Cholesterol/CDO -0.013 0.103 -9999.0 0.0 -0.31 9.0 9.0 mesenchymal cell differentiation 0.072 0.123 0.27 18.0 -9999.0 0.0 18.0 mol:Vitamin D3 -0.034 0.156 -9999.0 0.0 -0.408 5.0 5.0 IHH N/PTCH2 -0.037 0.117 -9999.0 0.0 -0.264 13.0 13.0 CDON -0.028 0.16 -9999.0 0.0 -0.496 9.0 9.0 IHH N/PTCH1 -0.055 0.176 -9999.0 0.0 -0.372 17.0 17.0 Megalin/LRPAP1 -0.057 0.166 -9999.0 0.0 -0.358 19.0 19.0 PTCH2 -0.031 0.127 -9999.0 0.0 -0.286 16.0 16.0 SHH Np/Cholesterol 0.009 0.023 -9999.0 0.0 -9999.0 0.0 0.0 PTCH1 -0.069 0.169 -9999.0 0.0 -0.371 17.0 17.0 HHIP -0.164 0.206 -9999.0 0.0 -0.347 44.0 44.0