Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.029 0.11 -9999.0 0.0 -0.251 16.0 16.0 epithelial cell differentiation 0.001 0.112 -9999.0 0.0 -0.256 13.0 13.0 CYFIP2 0.02 0.057 -9999.0 0.0 -0.496 1.0 1.0 ENAH -0.024 0.116 0.349 2.0 -0.342 5.0 7.0 EGFR -0.01 0.133 -9999.0 0.0 -0.496 6.0 6.0 EPHA2 0.021 0.056 -9999.0 0.0 -0.496 1.0 1.0 MYO6 -0.012 0.121 0.339 2.0 -0.246 14.0 16.0 CTNNB1 0.025 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.042 0.057 -9999.0 0.0 -0.305 2.0 2.0 AQP5 -0.076 0.172 -9999.0 0.0 -0.49 10.0 10.0 CTNND1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.011 0.111 0.349 1.0 -0.242 13.0 14.0 regulation of calcium-dependent cell-cell adhesion -0.03 0.129 0.337 2.0 -0.257 15.0 17.0 EGF -0.019 0.135 -9999.0 0.0 -0.373 10.0 10.0 NCKAP1 0.022 0.056 -9999.0 0.0 -0.496 1.0 1.0 AQP3 -0.041 0.128 -9999.0 0.0 -0.478 4.0 4.0 cortical microtubule organization 0.001 0.112 -9999.0 0.0 -0.256 13.0 13.0 GO:0000145 -0.025 0.102 0.337 1.0 -0.231 13.0 14.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.005 0.115 -9999.0 0.0 -0.258 13.0 13.0 MLLT4 0.015 0.079 -9999.0 0.0 -0.496 2.0 2.0 ARF6/GDP -0.05 0.118 -9999.0 0.0 -0.465 5.0 5.0 ARF6 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.041 0.097 -9999.0 0.0 -0.325 5.0 5.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.022 0.089 -9999.0 0.0 -0.245 1.0 1.0 PVRL2 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.012 0.11 0.339 2.0 -0.246 12.0 14.0 ARF6/GTP 0.047 0.095 -9999.0 0.0 -0.303 5.0 5.0 CDH1 -0.058 0.193 -9999.0 0.0 -0.496 14.0 14.0 EGFR/EGFR/EGF/EGF -0.038 0.143 -9999.0 0.0 -0.287 17.0 17.0 RhoA/GDP 0.003 0.108 -9999.0 0.0 -0.243 13.0 13.0 actin cytoskeleton organization -0.016 0.116 0.324 2.0 -0.24 14.0 16.0 IGF-1R heterotetramer -0.001 0.113 -9999.0 0.0 -0.446 5.0 5.0 GIT1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R -0.001 0.114 -9999.0 0.0 -0.447 5.0 5.0 IGF1 -0.028 0.151 -9999.0 0.0 -0.407 11.0 11.0 DIAPH1 -0.004 0.181 -9999.0 0.0 -0.727 3.0 3.0 Wnt receptor signaling pathway -0.001 0.112 0.256 13.0 -9999.0 0.0 13.0 RHOA 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.05 0.119 -9999.0 0.0 -0.465 5.0 5.0 CTNNA1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.017 0.118 0.326 2.0 -0.245 14.0 16.0 EFNA1 -0.004 0.122 -9999.0 0.0 -0.496 5.0 5.0 LPP -0.024 0.102 -9999.0 0.0 -0.24 11.0 11.0 Ephrin A1/EPHA2 -0.014 0.148 -9999.0 0.0 -0.366 11.0 11.0 SEC6/SEC8 -0.023 0.096 -9999.0 0.0 -0.395 3.0 3.0 MGAT3 -0.03 0.131 0.339 2.0 -0.261 15.0 17.0 HGF/MET -0.072 0.161 -9999.0 0.0 -0.307 22.0 22.0 HGF -0.062 0.164 -9999.0 0.0 -0.332 21.0 21.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.029 0.11 -9999.0 0.0 -0.252 16.0 16.0 actin cable formation 0.023 0.151 0.348 8.0 -0.362 3.0 11.0 KIAA1543 -0.03 0.121 0.33 2.0 -0.251 14.0 16.0 KIFC3 -0.016 0.105 -9999.0 0.0 -0.249 11.0 11.0 NCK1 0.029 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.025 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.008 0.118 0.339 2.0 -0.245 13.0 15.0 NCK1/GIT1 0.04 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.001 0.112 -9999.0 0.0 -0.256 13.0 13.0 EXOC4 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.018 0.103 -9999.0 0.0 -0.247 13.0 13.0 PIP5K1C -0.011 0.112 0.351 1.0 -0.245 13.0 14.0 LIMA1 0.01 0.096 -9999.0 0.0 -0.496 3.0 3.0 ABI1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.01 0.153 0.413 4.0 -0.406 5.0 9.0 adherens junction assembly -0.012 0.142 0.465 2.0 -0.505 2.0 4.0 IGF-1R heterotetramer/IGF1 -0.039 0.135 -9999.0 0.0 -0.271 19.0 19.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.029 0.063 -9999.0 0.0 -0.359 2.0 2.0 MET -0.029 0.16 -9999.0 0.0 -0.496 9.0 9.0 PLEKHA7 -0.016 0.13 0.339 2.0 -0.263 14.0 16.0 mol:GTP 0.039 0.096 -9999.0 0.0 -0.322 5.0 5.0 establishment of epithelial cell apical/basal polarity 0.003 0.132 0.429 3.0 -0.431 2.0 5.0 cortical actin cytoskeleton stabilization -0.029 0.11 -9999.0 0.0 -0.251 16.0 16.0 regulation of cell-cell adhesion -0.016 0.116 0.324 2.0 -0.24 14.0 16.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.029 0.11 -9999.0 0.0 -0.252 16.0 16.0