E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.014 0.095 -9999.0 0.0 -0.292 26.0 26.0 KLHL20 -0.009 0.082 0.21 2.0 -0.249 16.0 18.0 CYFIP2 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.005 0.072 0.258 3.0 -0.24 3.0 6.0 ENAH -0.015 0.096 -9999.0 0.0 -0.292 26.0 26.0 AP1M1 0.024 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.012 0.043 0.133 1.0 -0.182 1.0 2.0 ABI1/Sra1/Nap1 -0.023 0.046 -9999.0 0.0 -0.168 17.0 17.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.053 0.05 -9999.0 0.0 -0.19 9.0 9.0 RAPGEF1 -0.012 0.089 0.267 3.0 -0.313 8.0 11.0 CTNND1 0.027 0.002 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.005 0.102 -9999.0 0.0 -0.288 33.0 33.0 CRK -0.01 0.085 -9999.0 0.0 -0.286 20.0 20.0 E-cadherin/gamma catenin/alpha catenin 0.045 0.035 -9999.0 0.0 -0.208 4.0 4.0 alphaE/beta7 Integrin 0.033 0.04 -9999.0 0.0 -0.239 6.0 6.0 IQGAP1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.045 0.023 -9999.0 0.0 -0.187 1.0 1.0 DLG1 -0.012 0.088 -9999.0 0.0 -0.291 22.0 22.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.019 0.019 -9999.0 0.0 -0.133 2.0 2.0 MLLT4 0.024 0.023 -9999.0 0.0 -0.345 1.0 1.0 ARF6/GTP/NME1/Tiam1 0.047 0.027 -9999.0 0.0 -0.187 3.0 3.0 PI3K -0.022 0.024 -9999.0 0.0 -0.168 2.0 2.0 ARF6 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.033 0.035 -9999.0 0.0 -0.244 4.0 4.0 TIAM1 0.023 0.037 -9999.0 0.0 -0.345 3.0 3.0 E-cadherin(dimer)/Ca2+ 0.054 0.035 -9999.0 0.0 -0.18 4.0 4.0 AKT1 -0.003 0.038 0.136 3.0 -9999.0 0.0 3.0 PIK3R1 0.025 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.02 0.043 -9999.0 0.0 -0.345 4.0 4.0 RhoA/GDP 0.006 0.075 0.258 3.0 -0.238 3.0 6.0 actin cytoskeleton organization -0.005 0.061 0.175 2.0 -0.179 16.0 18.0 CDC42/GDP 0.006 0.074 0.258 3.0 -0.238 3.0 6.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.012 0.025 -9999.0 0.0 -0.193 4.0 4.0 ITGB7 0.02 0.052 -9999.0 0.0 -0.345 6.0 6.0 RAC1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.058 0.038 -9999.0 0.0 -0.193 4.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.04 0.03 -9999.0 0.0 -0.175 4.0 4.0 mol:GDP -0.008 0.077 0.263 3.0 -0.263 4.0 7.0 CDC42/GTP/IQGAP1 0.036 0.008 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.015 0.078 0.256 3.0 -0.24 4.0 7.0 RAC1/GTP/IQGAP1 0.034 0.01 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.033 0.016 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.027 0.002 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.009 0.06 0.119 2.0 -0.157 35.0 37.0 NME1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.01 0.089 -9999.0 0.0 -0.29 22.0 22.0 regulation of cell-cell adhesion -0.023 0.023 -9999.0 0.0 -0.155 4.0 4.0 WASF2 -0.008 0.031 0.101 1.0 -0.119 4.0 5.0 Rap1/GTP 0.013 0.051 0.233 3.0 -0.198 1.0 4.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.061 0.054 -9999.0 0.0 -0.18 10.0 10.0 CCND1 -0.012 0.073 0.136 2.0 -0.194 35.0 37.0 VAV2 -0.017 0.162 -9999.0 0.0 -0.644 13.0 13.0 RAP1/GDP 0.014 0.06 0.28 2.0 -9999.0 0.0 2.0 adherens junction assembly -0.01 0.086 -9999.0 0.0 -0.283 22.0 22.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.042 0.046 -9999.0 0.0 -0.179 9.0 9.0 E-cadherin/beta catenin 0.006 0.028 -9999.0 0.0 -0.249 3.0 3.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.013 0.094 -9999.0 0.0 -0.295 24.0 24.0 PIK3CA 0.022 0.011 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.035 0.116 -9999.0 0.0 -0.4 18.0 18.0 E-cadherin/beta catenin/alpha catenin 0.045 0.035 -9999.0 0.0 -0.208 4.0 4.0 ITGAE 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.006 0.103 -9999.0 0.0 -0.293 33.0 33.0