E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.045 0.101 -9999.0 0.0 -0.324 61.0 61.0 KLHL20 -0.057 0.078 0.468 1.0 -0.268 20.0 21.0 CYFIP2 0.029 0.006 -9999.0 0.0 0.0 24.0 24.0 Rac1/GDP -0.044 0.079 0.237 5.0 -0.251 18.0 23.0 ENAH -0.046 0.102 -9999.0 0.0 -0.322 63.0 63.0 AP1M1 0.026 0.01 -9999.0 0.0 0.0 65.0 65.0 RAP1B 0.029 0.006 -9999.0 0.0 0.0 23.0 23.0 RAP1A 0.029 0.004 -9999.0 0.0 0.0 8.0 8.0 CTNNB1 0.029 0.004 -9999.0 0.0 0.0 8.0 8.0 CDC42/GTP -0.057 0.051 0.116 25.0 -0.234 2.0 27.0 ABI1/Sra1/Nap1 -0.052 0.045 -9999.0 0.0 -0.169 34.0 34.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.057 0.047 -9999.0 0.0 -0.142 8.0 8.0 RAPGEF1 -0.045 0.098 0.25 3.0 -0.307 53.0 56.0 CTNND1 0.029 0.003 -9999.0 0.0 0.0 5.0 5.0 regulation of calcium-dependent cell-cell adhesion -0.022 0.113 -9999.0 0.0 -0.324 65.0 65.0 CRK -0.045 0.101 -9999.0 0.0 -0.318 58.0 58.0 E-cadherin/gamma catenin/alpha catenin 0.044 0.043 -9999.0 0.0 -0.157 18.0 18.0 alphaE/beta7 Integrin 0.041 0.014 -9999.0 0.0 -0.164 1.0 1.0 IQGAP1 0.029 0.006 -9999.0 0.0 0.0 24.0 24.0 NCKAP1 0.029 0.005 -9999.0 0.0 0.0 17.0 17.0 Rap1/GTP/I-afadin 0.04 0.043 -9999.0 0.0 -0.131 21.0 21.0 DLG1 -0.031 0.102 0.192 1.0 -0.325 51.0 52.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.043 0.042 -9999.0 0.0 -0.152 12.0 12.0 MLLT4 0.026 0.01 -9999.0 0.0 0.0 72.0 72.0 ARF6/GTP/NME1/Tiam1 0.048 0.024 -9999.0 0.0 -0.131 1.0 1.0 PI3K -0.053 0.054 -9999.0 0.0 -0.207 7.0 7.0 ARF6 0.029 0.004 -9999.0 0.0 0.0 11.0 11.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.031 0.041 -9999.0 0.0 -0.177 18.0 18.0 TIAM1 0.028 0.006 -9999.0 0.0 -0.001 24.0 24.0 E-cadherin(dimer)/Ca2+ 0.053 0.042 -9999.0 0.0 -0.132 7.0 7.0 AKT1 -0.012 0.069 0.141 42.0 -9999.0 0.0 42.0 PIK3R1 0.021 0.013 -9999.0 0.0 0.0 159.0 159.0 CDH1 0.026 0.01 -9999.0 0.0 -0.0 70.0 70.0 RhoA/GDP -0.043 0.08 0.232 6.0 -0.252 17.0 23.0 actin cytoskeleton organization -0.043 0.059 0.405 1.0 -0.202 14.0 15.0 CDC42/GDP -0.042 0.08 0.232 6.0 -0.252 17.0 23.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.013 0.057 -9999.0 0.0 -0.189 33.0 33.0 ITGB7 0.029 0.004 -9999.0 0.0 0.0 8.0 8.0 RAC1 0.028 0.007 -9999.0 0.0 -0.001 27.0 27.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.058 0.045 -9999.0 0.0 -0.142 7.0 7.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.04 0.032 -9999.0 0.0 -0.122 7.0 7.0 mol:GDP -0.042 0.085 0.24 5.0 -0.276 20.0 25.0 CDC42/GTP/IQGAP1 0.037 0.014 -9999.0 0.0 -0.134 2.0 2.0 JUP 0.028 0.008 -9999.0 0.0 0.0 40.0 40.0 p120 catenin/RhoA/GDP -0.045 0.083 0.239 6.0 -0.26 15.0 21.0 RAC1/GTP/IQGAP1 0.036 0.015 -9999.0 0.0 -0.134 2.0 2.0 PIP5K1C/AP1M1 0.037 0.017 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.029 0.003 -9999.0 0.0 0.0 7.0 7.0 CDC42 0.029 0.005 -9999.0 0.0 0.0 13.0 13.0 CTNNA1 0.029 0.004 -9999.0 0.0 0.0 13.0 13.0 positive regulation of S phase of mitotic cell cycle -0.044 0.057 0.098 2.0 -0.131 141.0 143.0 NME1 0.028 0.008 -9999.0 0.0 0.0 42.0 42.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.047 0.104 -9999.0 0.0 -0.323 65.0 65.0 regulation of cell-cell adhesion -0.053 0.041 0.083 22.0 -0.207 2.0 24.0 WASF2 -0.03 0.035 0.096 5.0 -0.107 31.0 36.0 Rap1/GTP -0.053 0.058 0.252 2.0 -0.252 2.0 4.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.058 0.063 -9999.0 0.0 -0.152 18.0 18.0 CCND1 -0.054 0.07 0.132 1.0 -0.159 142.0 143.0 VAV2 -0.038 0.165 -9999.0 0.0 -0.66 24.0 24.0 RAP1/GDP -0.044 0.067 0.243 4.0 -0.254 3.0 7.0 adherens junction assembly -0.045 0.101 -9999.0 0.0 -0.315 65.0 65.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.029 0.005 -9999.0 0.0 0.0 14.0 14.0 PIP5K1C 0.027 0.008 -9999.0 0.0 0.0 44.0 44.0 regulation of heterotypic cell-cell adhesion -0.06 0.03 0.172 4.0 -0.229 2.0 6.0 E-cadherin/beta catenin -0.009 0.048 -9999.0 0.0 -0.179 37.0 37.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.044 0.1 -9999.0 0.0 -0.327 59.0 59.0 PIK3CA 0.021 0.014 -9999.0 0.0 0.0 174.0 174.0 Rac1/GTP -0.088 0.112 0.553 1.0 -0.386 37.0 38.0 E-cadherin/beta catenin/alpha catenin 0.049 0.03 -9999.0 0.0 -0.146 7.0 7.0 ITGAE 0.028 0.007 -9999.0 0.0 0.0 30.0 30.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.022 0.115 -9999.0 0.0 -0.33 65.0 65.0