Hybridization REF p difference q subclass Composite Element REF p difference q subclass EIF4EBP1|4E-BP1_PT37_T46 1.77564013089872e-10 1.77200316835312 1.70461452566277e-08 1 RB1|RB_PS807_S811 5.49613138200164e-14 1.60742170056979 1.05525722534431e-11 1 MAPK14|P38_PT180_Y182 1.13234235414129e-08 1.17366215231979 5.43524329987819e-07 1 PDCD4|PDCD4 7.41682080477593e-09 0.984462290532292 4.7467653150566e-07 1 BAK1|BAK 0.000254679261159188 0.960062395061458 0.00257360095487179 1 CDKN1A|P21 0.0327411858400982 0.854487378011458 0.0795735149531501 1 AKT1 AKT2 AKT3|AKT_PS473 2.2211994027927e-05 0.844463794494792 0.00032805406564323 1 PKC|PKC-PAN_BETAII_PS660 2.12827875133769e-06 0.829051607398958 6.81049200428061e-05 1 GSK3A GSK3B|GSK3-ALPHA-BETA_PS21_S9 1.04379569891582e-05 0.621005641903125 0.000200408774191837 1 RPS6KA1|P90RSK 9.28835997203919e-06 0.606822323711458 0.000198151679403503 1 GSK3A GSK3B|GSK3_PS9 0.000299480539709081 0.587092917136458 0.00287501318120718 1 AKT1 AKT2 AKT3|AKT_PT308 0.000224504164598959 0.545749752528125 0.00239471108905556 1 CHEK1|CHK1_PS345 0.00187536001148743 0.464175151532292 0.00923254159501504 1 ACACA ACACB|ACC_PS79 8.65046884479906e-05 0.456934481253125 0.00118635001300101 1 FRAP1|MTOR_PS2448 0.000191029818799461 0.449827279057292 0.00215751324761744 1 PRKCA |PKC-ALPHA_PS657 0.0185864389755362 0.427567829128125 0.0540696406561053 1 SRC|SRC 0.00695331530279346 0.359029427411458 0.0261771870222813 1 STAT5A|STAT5-ALPHA 0.0316938910150623 0.341397689732292 0.0780157317293841 1 AKT1S1|PRAS40_PT246 1.22638911450933e-06 0.335182444898958 4.70933419971583e-05 1 GATA3|GATA3 0.0218621262703429 0.326464615707292 0.0582990033875811 1 BAD|BAD_PS112 0.00155858522506747 0.312502482232292 0.00854995323465584 1 PRKAA1|AMPK_PT172 0.0150007289088646 0.308151395815625 0.0480023325083667 1 RAF1|C-RAF_PS338 0.0102150666088345 0.307576131982292 0.0363202368314116 1 EIF4EBP1|4E-BP1_PS65 0.000109118202597758 0.281254173544792 0.0013967129932513 1 PDK1|PDK1_PS241 0.0113263712625184 0.252947701336458 0.0387484757537192 1 JUN|C-JUN_PS73 0.00241929261696194 0.252839730711458 0.0113293703038218 1 CCND1|CYCLIN_D1 0.0230306600625014 0.246072167494792 0.0604715767972569 1 AKT1 AKT2 AKT3|AKT 0.00180436353918239 0.239031790336458 0.00915998237234405 1 PTEN|PTEN 0.0149168094533936 0.218118046878125 0.0480023325083667 1 YBX1|YB-1_PS102 0.0168567655250162 0.160919059398958 0.0513729996952875 1 ANXA7 |ANNEXIN_VII 0.0171380410065658 0.155661342590625 0.0514141230196974 1 PRKAA1|AMPK_ALPHA 0.025914810855073 0.150113530898958 0.0663419157889869 1 RPS6KA1|P90RSK_PT359_S363 0.00798041111323576 0.147226613353125 0.028910168561156 1 MAPK8|JNK_PT183_PY185 0.0498382049466514 0.144004320411458 0.113915897020917 1 PDK1|PDK1 0.00135014687486052 0.142059477594792 0.00806785669018106 1 EIF4EBP1|4E-BP1_PT70 0.0484187950429424 0.137110376682292 0.112004923472831 1 ESR1|ER-ALPHA_PS118 0.00138666286862487 0.136262688478125 0.00806785669018106 1 RPTOR|RAPTOR 0.0436293519770051 0.100718075740625 0.102156531458353 1 CDH2|N-CADHERIN 0.0233067535572761 -0.098632675696875 0.0604715767972569 1 ADAR|ADAR1 0.0423227775649853 -0.100648052238542 0.100320657931817 1 NRAS|N-RAS 0.0074741947794013 -0.109127316326042 0.0275970268777894 1 STK11|LKB1 0.0125614823172318 -0.112045145876042 0.0415828380156639 1 ARAF|A-RAF_PS299 0.0312580657121008 -0.117143911571875 0.077942189827576 1 C12ORF5|TIGAR 0.000162782346803427 -0.122656512676042 0.00195338816164112 1 TTF1|TTF1 0.0164708937399259 -0.125822866688542 0.0510066386784802 1 PGR|PR 0.00114269810774382 -0.142157385080208 0.00731326788956045 1 BID|BID 0.0115034537393854 -0.144692116351042 0.0387484757537192 1 TGM2|TRANSGLUTAMINASE 0.0200996175730745 -0.145758591305208 0.0544371762607255 1 ITGA2|CD49B 0.00330862572890442 -0.161831455917708 0.0135160880840351 1 YWHAB|14-3-3_BETA 0.0013657720362107 -0.170526621076042 0.00806785669018106 1 IRS1|IRS1 0.0010173773055036 -0.172643652009375 0.00707595236541195 1 FOXO3|FOXO3A 0.00148863999051802 -0.173317804755208 0.00840643759351353 1 ESR1|ER-ALPHA 0.000533517039644379 -0.178970289934375 0.00465614870962367 1 ACVRL1|ACVRL1 0.00179663283868581 -0.180107317501042 0.00915998237234405 1 ERRFI1|MIG-6 0.00271463365172316 -0.181638866384375 0.0124097538364487 1 TP53|P53 0.00602920779659419 -0.191109314584375 0.0231521579389217 1 EIF4EBP1|4E-BP1 0.0269494899607569 -0.192317205746875 0.0680829220061227 1 PECAM1|CD31 0.00469862188933261 -0.193146286226042 0.0184109265867727 1 ERBB2|HER2_PY1248 0.00352115201245708 -0.197673088667708 0.0140846080498283 1 BAX|BAX 0.000959486124288756 -0.204161850959375 0.00707595236541195 1 YAP1|YAP 0.00306128224049204 -0.213728975988542 0.013061470892766 1 PEA15|PEA15_PS116 0.0192508697846381 -0.227229869138542 0.0543553970389782 1 NOTCH1|NOTCH1 0.00240562180621549 -0.229220425251042 0.0113293703038218 1 BRCA2|BRCA2 0.00102098772164819 -0.229701075026042 0.00707595236541195 1 CASP7|CASPASE-7_CLEAVEDD198 1.91589823153517e-05 -0.240697359342708 0.00032805406564323 1 CCNB1|CYCLIN_B1 0.00107079562015948 -0.252254304780208 0.0070894054851938 1 CDH3|P-CADHERIN 0.000335245580870709 -0.256084334151042 0.00306510245367505 1 MYC|C-MYC 0.0192136668536394 -0.263114071063542 0.0543553970389782 1 RAD51|RAD51 0.0182727091356717 -0.272738784488542 0.0539747716007533 1 EEF2K|EEF2K 0.0153662175938544 -0.274325796909375 0.0483657996396729 1 EEF2|EEF2 0.000819005442008632 -0.275213370692708 0.00655204353606906 1 STAT3|STAT3_PY705 0.0198071762423707 -0.278855643571875 0.0544371762607255 1 KIT|C-KIT 0.000595712221430101 -0.280858167901042 0.00497290202237302 1 CHEK1|CHK1 0.00288567367313741 -0.287063718692708 0.0128848684940089 1 EGFR|EGFR 5.07077643491643e-06 -0.290481944226042 0.000121698634437994 1 ETS1|ETS-1 3.66798476372249e-06 -0.302336666296875 0.000100607582090674 1 BCL2L11|BIM 0.00181291317785976 -0.307049862005208 0.00915998237234405 1 FOXM1|FOXM1 0.00296000196318946 -0.314748821609375 0.0129163722030086 1 YAP1|YAP_PS127 0.0359781208165432 -0.338841139088542 0.0863474899597037 1 ERBB2|HER2 0.00316286668467271 -0.360808588867708 0.0132015305099383 1 TFRC|TFRC 0.0201304141380808 -0.364643826059375 0.0544371762607255 1 HSPA1A|HSP70 0.0106712492404969 -0.395359321746875 0.0372523609850074 1 XBP1|XBP1 0.00103190971995591 -0.501590561138542 0.00707595236541195 1 FN1|FIBRONECTIN 2.21394808907335e-05 -0.576445672638542 0.00032805406564323 1 MYH11|MYH11 7.50759630741839e-05 1.88613682922937 0.00180182311378041 2 YAP1|YAP_PS127 5.17330866530681e-07 1.08446917007147 4.96637631869454e-05 2 CAV1|CAVEOLIN-1 0.00120082972169297 1.07502298923295 0.00896801968941105 2 RICTOR|RICTOR 0.00934042376014279 0.748908573626495 0.0404500009085882 2 HSPA1A|HSP70 0.00249325287801888 0.672995144645634 0.0170867575036418 2 FN1|FIBRONECTIN 0.00112831927174364 0.631722761506878 0.00896801968941105 2 XBP1|XBP1 0.000563378161917041 0.629583137887261 0.00603601063137091 2 MYC|C-MYC 8.98950921865335e-05 0.617518467823864 0.00191776196664605 2 MYH9|MYOSIN-IIA_PS1943 2.22495848057911e-05 0.590745761998505 0.000711986713785315 2 YAP1|YAP 9.29731536269994e-07 0.48622800267195 5.95028183212796e-05 2 ERBB2|HER2 0.00121441933294108 0.480323931929127 0.00896801968941105 2 SYK|SYK 0.0131604930860031 0.472227823060706 0.0505362934502519 2 ERBB2|HER2_PY1248 6.67554364523251e-06 0.38790808354994 0.000320426094971161 2 RICTOR|RICTOR_PT1135 0.000364632390338527 0.37756702578439 0.00437558868406232 2 ETS1|ETS-1 1.3680793004102e-05 0.356238627510467 0.000525342451357517 2 RAD51|RAD51 0.030531798048673 0.34943740624372 0.0809003186457211 2 STAT3|STAT3_PY705 0.0196320045776361 0.346658035655203 0.0649887048087264 2 BID|BID 0.000841992535409978 0.337585414161184 0.00769821746660551 2 FOXM1|FOXM1 0.037912487066979 0.298420991695873 0.0933230450879483 2 PRDX1|PRDX1 0.0372144900447825 0.298181858675538 0.0927945725791979 2 ANXA1|ANNEXIN-1 0.0357002719138489 0.281132414854964 0.0901901606244604 2 AKT1 AKT2 AKT3|AKT_PT308 0.0222122740778927 0.280453872704246 0.0689055638208009 2 NOTCH1|NOTCH1 0.000663054406772005 0.277252188285586 0.00670033926843289 2 CASP7|CASPASE-7_CLEAVEDD198 0.00797591060582988 0.222163454848983 0.0377902539493297 2 EGFR|EGFR 0.000101718524318717 0.221528383096591 0.00195299566691937 2 STMN1|STATHMIN 0.0283729435445622 0.218741913388457 0.0778229308650849 2 PREX1|PREX1 0.0201515254589706 0.216727983438696 0.0653292354384224 2 YWHAB|14-3-3_BETA 0.00308512764794207 0.216306352857356 0.0176644588746244 2 MRE11A|MRE11 0.0251063529134548 0.195177532860945 0.0730366630209594 2 WWTR1|TAZ 0.00923733967168262 0.189415810923146 0.0404500009085882 2 TSC2|TUBERIN_PT1462 0.0112470668806338 0.182303310808313 0.0459454647038657 2 MAP2K1|MEK1_PS217_S221 0.00752763749562857 0.180364597979366 0.0370591384400176 2 FOXO3|FOXO3A_PS318_S321 0.0192899722894454 0.173273205073864 0.0649887048087264 2 ACVRL1|ACVRL1 0.0108114974682056 0.166787913152811 0.0451262503020756 2 ESR1|ER-ALPHA 0.0256426796846981 0.154504960002093 0.0734834999919707 2 PGR|PR 0.019144300165571 0.121417075521232 0.0649887048087264 2 ADAR|ADAR1 0.0269752602106376 -0.0887089179309211 0.0750615936296003 2 PRKCD|PKC-DELTA_PS664 0.0336969891725584 -0.114715462820873 0.0862642922817495 2 SCD1|SCD1 0.0222507549838003 -0.121299469192883 0.0689055638208009 2 EIF4EBP1|4E-BP1_PS65 0.0307589753184252 -0.126772684292165 0.0809003186457211 2 SMAD3|SMAD3 0.0234574754321945 -0.127159219838816 0.0703724262965835 2 RPTOR|RAPTOR 0.0226534060806966 -0.130827517208433 0.0690389518649801 2 DVL3|DVL3 0.0149146895853935 -0.131667372027811 0.0550696230845298 2 SHC1|SHC_PY317 0.0194020891769291 -0.137331870412978 0.0649887048087264 2 CTNNB1|ALPHA-CATENIN 0.0249499041175445 -0.142417580673744 0.0730366630209594 2 PDK1|PDK1 0.00430987545299003 -0.151800419085227 0.0223647591074077 2 JUN|C-JUN_PS73 0.0317763002980889 -0.160031110354366 0.0824466169896361 2 PRKAA1|AMPK_ALPHA 0.020415386074507 -0.167427994917763 0.0653292354384224 2 ERCC1|ERCC1 0.000182680427968896 -0.199569108769438 0.00269804939769446 2 ANXA7 |ANNEXIN_VII 0.00331004753288024 -0.202500116859151 0.0176644588746244 2 YWHAE|14-3-3_EPSILON 0.000237447981755451 -0.206525496960825 0.00325642946407476 2 RPS6KB1|P70S6K 0.0411270959792635 -0.211755155682117 0.0999544611141594 2 CDH1|E-CADHERIN 0.011571598503358 -0.239327844074462 0.046286394013432 2 XRCC1|XRCC1 0.019607945286664 -0.239994118707237 0.0649887048087264 2 MSH6|MSH6 0.000171594582075279 -0.243576262747907 0.00269804939769446 2 MAPK9|JNK2 0.00083444551583475 -0.281469815149821 0.00769821746660551 2 GSK3A GSK3B|GSK3-ALPHA-BETA 0.0182143887015684 -0.306750941718002 0.0649887048087264 2 BAP1|BAP1-C-4 0.000358532408126903 -0.307156695203648 0.00437558868406232 2 RPS6|S6 0.00948046896295036 -0.323169911877093 0.0404500009085882 2 PRKCA |PKC-ALPHA 0.00806979381209645 -0.335033032691687 0.0377902539493297 2 VHL|VHL 0.000126197057376405 -0.336252726302931 0.00220271227420634 2 BRAF|B-RAF 0.0265997849257967 -0.348349908180921 0.0750615936296003 2 FASN|FASN 0.0141508925053839 -0.350609048423744 0.0532739482555629 2 PRKCA |PKC-ALPHA_PS657 0.0474944290383941 -0.357055306194079 0.112579387350267 2 FRAP1|MTOR 0.012617222568601 -0.361193076609151 0.0494389129218651 2 CHEK1|CHK1_PS345 0.0011252746401566 -0.365404376189294 0.00896801968941105 2 PDK1|PDK1_PS241 0.00308751655260794 -0.37799618563427 0.0176644588746244 2 GAB2|GAB2 0.029678286765518 -0.379601244656998 0.0802567754785839 2 SQSTM1|P62-LCK-LIGAND 0.000565875996691023 -0.389153031873505 0.00603601063137091 2 ATM|ATM 0.00863903499522855 -0.406230997283792 0.0394927314067591 2 RPS6KA1|P90RSK 0.0026239636417059 -0.411177971499103 0.0170867575036418 2 MSH2|MSH2 6.45898648811257e-05 -0.414985815273026 0.00177160772245373 2 TSC2|TUBERIN 0.00325246393488341 -0.426590857212022 0.0176644588746244 2 PKC|PKC-PAN_BETAII_PS660 0.00533989562729897 -0.449245297225179 0.0269805252747737 2 SRC|SRC 0.00310701556222491 -0.478100867653409 0.0176644588746244 2 CCNE1|CYCLIN_E1 1.63109661805731e-08 -0.482268167070873 3.13170550667004e-06 2 TP53BP1|53BP1 0.00266980585994403 -0.515817753052931 0.0170867575036418 2 ACACA|ACC1 0.00146120604527167 -0.521206152581639 0.0103907985441541 2 RB1|RB_PS807_S811 0.0430670084576749 -0.526632233311304 0.10336082029842 2 GATA3|GATA3 0.00106537602514085 -0.527476418698864 0.00896801968941105 2 BAK1|BAK 0.00331208603899207 -0.886124249219199 0.0176644588746244 2 IGFBP2|IGFBP2 0.0032503882439693 1.53316408962755 0.0152213303132221 3 BAK1|BAK 0.00279668112423049 0.783402815484694 0.0134240693963064 3 TUBA1B|ACETYL-A-TUBULIN-LYS40 0.029565343061728 0.623233056545918 0.0746913929980497 3 GAB2|GAB2 4.48680903390292e-06 0.548712583341837 0.00021536683362734 3 SRC|SRC 0.000118007115307631 0.470236089372449 0.00151049107593768 3 BRAF|B-RAF 0.000170233920634783 0.440384339392857 0.00187638609295749 3 TSC2|TUBERIN 0.000229821215969385 0.392406598454082 0.0022062836733061 3 PDK1|PDK1_PS241 0.00246595373417792 0.357666583719388 0.0121400799221067 3 RAF1|C-RAF_PS338 0.0262619330643943 0.317783459168367 0.0672305486448494 3 FASN|FASN 0.0477114213989986 0.313126169790816 0.107380227899839 3 PXN|PAXILLIN 0.0238002122459716 0.292618304954082 0.0625978185099527 3 YBX1|YB-1 0.00118075687396548 0.291469564107143 0.00666780352356977 3 GAPDH|GAPDH 0.0355864393316198 0.282095944280612 0.086488561413557 3 ATM|ATM 0.0317884545504005 0.277912072852041 0.0782485035086782 3 YWHAE|14-3-3_EPSILON 0.000367862675126635 0.272883654933674 0.00336331588687209 3 MAPK9|JNK2 0.00117879115147838 0.254812499076531 0.00666780352356977 3 PTEN|PTEN 0.00213498275406295 0.248200990454082 0.0107872812836865 3 ANXA7 |ANNEXIN_VII 0.000639449577401306 0.245602397035714 0.00468251350081565 3 AKT1 AKT2 AKT3|AKT 0.00640668852046399 0.244558819260204 0.0236554653063286 3 TSC1|TSC1 0.00487216570171706 0.241276145117347 0.0199033152070144 3 PEA15|PEA15 0.0224990659369153 0.237595789984694 0.0609342053529089 3 SMAD3|SMAD3 0.000743225167375726 0.237577714566327 0.00492066317710825 3 RPS6KB1|P70S6K 0.00385003352609549 0.235665197392857 0.0171908473723334 3 PDK1|PDK1 7.86688947697631e-05 0.234044321933674 0.00118935431335444 3 YWHAZ|14-3-3_ZETA 0.0149619817726415 0.229846232076531 0.0463338790378575 3 COL6A1|COLLAGEN_VI 0.0230584908651067 0.226319420688776 0.0614893089736179 3 RPTOR|RAPTOR 0.000640448141271215 0.197867640015306 0.00468251350081565 3 CDKN1B|P27_PT157 0.000924356046957402 0.180279714586735 0.00572504390373617 3 RPS6|S6 0.0396742314728764 0.162976369943878 0.0935450537835224 3 WWTR1|TAZ 0.0443342235393325 0.153554407647959 0.101335368089903 3 PRKAA1|AMPK_ALPHA 0.00616503121868152 0.148475048637755 0.0236554653063286 3 EGFR|EGFR_PY1173 0.0225329613544611 0.142726931484694 0.0609342053529089 3 RAB11A RAB11B|RAB11 0.0195390617349568 0.134259844392857 0.0568409068653289 3 CCNE2|CYCLIN_E2 0.010868005032945 0.133041791443878 0.0366080169530779 3 ESR1|ER-ALPHA_PS118 0.00963637224469925 0.127173579964286 0.0336396994724047 3 MET|C-MET_PY1235 0.0166056933715495 0.110486634362245 0.0506078274180556 3 PCNA|PCNA 0.00458948397252181 0.109699002433673 0.019330562150643 3 CDH2|N-CADHERIN 0.0374016415821685 0.0830321960969388 0.0897639397972044 3 ARAF|A-RAF_PS299 0.00874874687436752 -0.107504593943878 0.0311066555533067 3 RPS6KB1|P70S6K_PT389 0.0315609632299721 -0.112286671362245 0.0782485035086782 3 FOXO3|FOXO3A 0.048097393746803 -0.11279972780102 0.107380227899839 3 PIK3CA |PI3K-P110-ALPHA 0.0207588613268086 -0.130305466372449 0.058613255510989 3 ESR1|ER-ALPHA 0.00582049601805928 -0.140733058147959 0.0228068415401506 3 RAD50|RAD50 0.0175165717666786 -0.14162709880102 0.0525497153000358 3 CTNNB1|ALPHA-CATENIN 0.0121195612318644 -0.142934593137755 0.0394399280765757 3 CASP7|CASPASE-7_CLEAVEDD198 0.0105940019533187 -0.144529885260204 0.0363222924113784 3 MAPK8|JNK_PT183_PY185 0.00463128051525822 -0.147119280209184 0.019330562150643 3 BAD|BAD_PS112 0.0125945468709011 -0.152689703147959 0.0403025499868835 3 TP53|P53 0.0399515333867127 -0.154906789178571 0.0935450537835224 3 AKT1S1|PRAS40_PT246 0.00662678721156795 -0.165112306739796 0.0240064744268122 3 CHEK1|CHK1 0.0186457573402879 -0.184095902392857 0.0550766986051581 3 RPS6KA1|P90RSK_PT359_S363 0.00552342616616825 -0.188114985505102 0.022093704664673 3 PRKCD|PKC-DELTA_PS664 0.00631811065677841 -0.203024992464286 0.0236554653063286 3 BRCA2|BRCA2 0.000890625679755403 -0.207028551362245 0.00570000435043458 3 PECAM1|CD31 0.000503000354554417 -0.253838327229592 0.00419895948149774 3 JUN|C-JUN_PS73 0.00150096718127553 -0.261162096607143 0.00778880267040275 3 BECN1|BECLIN 0.00115112576402042 -0.264640122015306 0.00666780352356977 3 PRDX1|PRDX1 0.0221349028412954 -0.264832406596939 0.0609342053529089 3 PKC|PKC-PAN_BETAII_PS660 0.0418256081221059 -0.267466225280612 0.0967532139692088 3 TSC2|TUBERIN_PT1462 0.000175911196214765 -0.291367378882653 0.00187638609295749 3 NOTCH1|NOTCH1 6.08891601308476e-05 -0.292833030331633 0.00106279261319298 3 NFKB1|NF-KB-P65_PS536 0.00149062877692531 -0.297804696239796 0.00778880267040275 3 MAPK1 MAPK3|MAPK_PT202_Y204 0.00433651641861519 -0.305634464096939 0.0189229807357754 3 FOXO3|FOXO3A_PS318_S321 8.052919830004e-05 -0.31606525597449 0.00118935431335444 3 PREX1|PREX1 5.84383375987437e-05 -0.318037017719388 0.00106279261319298 3 FN1|FIBRONECTIN 0.0131797361010806 -0.32178902552551 0.0414837595312701 3 MYH9|MYOSIN-IIA_PS1943 0.0206291673410535 -0.356232492760204 0.058613255510989 3 ANXA1|ANNEXIN-1 4.77850784198433e-05 -0.370919205913265 0.00101941500628999 3 RICTOR|RICTOR 0.0117213276506377 -0.372005918811224 0.0388016363607317 3 YAP1|YAP 4.34694688834721e-09 -0.375504350719388 8.34613802562664e-07 3 ACACA ACACB|ACC_PS79 0.0249504396363082 -0.40283068575 0.064736275813124 3 STAT3|STAT3_PY705 0.00356147871267621 -0.425275686382653 0.0162810455436627 3 XBP1|XBP1 0.000426148976741287 -0.493615961994898 0.00371911834246941 3 NDRG1|NDRG1_PT346 4.07290868668824e-05 -0.547199693311224 0.000977498084805178 3 SRC|SRC_PY527 0.000142911879961027 -0.573585240229592 0.00171494255953232 3 CHEK2|CHK2 5.07822097609693e-07 -0.574758648045918 3.25006142470204e-05 3 GSK3A GSK3B|GSK3-ALPHA-BETA_PS21_S9 9.37695095831016e-06 -0.632999938852041 0.000300062430665925 3 MAPK14|P38_PT180_Y182 0.00130935709433122 -0.653114771729592 0.00718275891747412 3 AKT1 AKT2 AKT3|AKT_PT308 2.09653535598982e-05 -0.694980980158163 0.000575049697642922 3 AKT1 AKT2 AKT3|AKT_PS473 9.62141334741879e-05 -0.776104104923469 0.00131950811621743 3 YAP1|YAP_PS127 3.39126916686682e-08 -0.860101439841837 3.25561840019215e-06 3 GSK3A GSK3B|GSK3_PS9 7.65417631141624e-06 -0.897551594811224 0.000293920370358384 3 CAV1|CAVEOLIN-1 0.000666874156353283 -0.932325813576531 0.00468251350081565 3 CDKN1A|P21 0.000600921023650539 -1.14083766415816 0.00468251350081565 3 MYH11|MYH11 0.000229792124479882 -1.30633146513776 0.0022062836733061 3 SFRS1|SF2 0.000682866552202283 -1.37490158334184 0.00468251350081565 3 SFRS1|SF2 1.36379469773032e-09 1.88784865681875 8.72828606547405e-08 4 CHEK2|CHK2 1.03538158765848e-06 0.84671132155625 1.48617744274536e-05 4 MSH2|MSH2 6.28894274336996e-08 0.571928498285417 1.72496715246719e-06 4 VHL|VHL 4.68470297031583e-05 0.561493290427083 0.000299820990100213 4 CCNE1|CYCLIN_E1 4.49841364945273e-06 0.560578685085417 4.79830789274958e-05 4 CHEK1|CHK1 2.40098489315225e-09 0.530598544097917 1.15247274871308e-07 4 CDH1|E-CADHERIN 0.00416018990932701 0.51532042876875 0.0126786740093776 4 BCL2L11|BIM 0.000664515875531137 0.515180829422917 0.00265806350212455 4 RAB25|RAB25 0.000121355897925697 0.51137653625625 0.000685303894168642 4 GSK3A GSK3B|GSK3-ALPHA-BETA 0.000448196186576065 0.428642475727083 0.00191230372939121 4 EGFR|EGFR_PY1068 7.87703672214635e-08 0.407846946922917 1.89048881331512e-06 4 CTNNB1|ALPHA-CATENIN 4.00647763840929e-07 0.404970006672917 6.41036422145486e-06 4 FOXO3|FOXO3A 1.65332425053227e-05 0.389314090047917 0.000132265940042582 4 PECAM1|CD31 2.67116882119007e-05 0.388635179402083 0.000191242824986859 4 SRC|SRC_PY416 0.00754792609648012 0.36539296744375 0.0210029247902055 4 TP53BP1|53BP1 0.0400149818020123 0.36255788915625 0.0826115753331867 4 EEF2|EEF2 0.000203028900211346 0.345542619510417 0.0010258302326468 4 CCNB1|CYCLIN_B1 0.000185758920096768 0.333759135972917 0.00097477174126369 4 EIF4EBP1|4E-BP1 0.000228465551528198 0.32374012833125 0.00112475348444651 4 EEF2K|EEF2K 0.000336022978201731 0.32126737423125 0.00146628208669846 4 XRCC1|XRCC1 1.11474702189591e-06 0.32029498243125 1.48617744274536e-05 4 RBM15|RBM15 0.000281339120362395 0.309105393939583 0.0013174905148678 4 BAP1|BAP1-C-4 5.45899455112047e-06 0.30463505710625 5.51645765165858e-05 4 PIK3CA |PI3K-P110-ALPHA 1.46485868410874e-07 0.296992796114583 2.81252867348878e-06 4 STAT3|STAT3_PY705 0.0321485865629726 0.28154037003125 0.0726179837657734 4 TP53|P53 6.50089471606925e-05 0.27905525903125 0.000402636059833966 4 BRCA2|BRCA2 1.16107612714481e-06 0.256896833864583 1.48617744274536e-05 4 PRKCD|PKC-DELTA_PS664 0.00030759698707342 0.251074064639584 0.00138778747996531 4 DVL3|DVL3 0.00158972945364079 0.24041062754375 0.00586977029036599 4 ERCC1|ERCC1 0.000877326483184301 0.235207967127083 0.003437687444314 4 BECN1|BECLIN 0.00125567898583483 0.23505969200625 0.00482180730560575 4 INPP4B|INPP4B 0.000187846637639357 0.22850281176875 0.00097477174126369 4 CDH3|P-CADHERIN 4.17949380181789e-05 0.227764368227083 0.000276711313775529 4 SQSTM1|P62-LCK-LIGAND 0.0418274596178097 0.226119144139583 0.0851264904158788 4 SCD1|SCD1 4.40846163538188e-08 0.208345771914583 1.4107077233222e-06 4 XRCC5|KU80 0.00400431729259497 0.207124526885417 0.0124004664544876 4 SMAD4|SMAD4 4.01954733393418e-05 0.202134277110417 0.000275626102898344 4 ANXA1|ANNEXIN-1 0.0472368187174816 0.199329104527083 0.0925456040179231 4 ADAR|ADAR1 2.6893522263777e-05 0.189332143577083 0.000191242824986859 4 NOTCH1|NOTCH1 0.00833167265817367 0.186304632752083 0.0225307204277372 4 JUN|C-JUN_PS73 0.012788777293798 0.181803611689583 0.0327392698721229 4 PREX1|PREX1 0.00820079903210484 0.17926567405625 0.0224936202023447 4 EIF4E|EIF4E 0.0376080288218188 0.154641719589583 0.0802304614865468 4 MSH6|MSH6 0.00865008709269787 0.146470761947917 0.023066898913861 4 ARAF|A-RAF_PS299 1.04819465799422e-05 0.13511452691875 9.58349401594715e-05 4 ESR1|ER-ALPHA 0.0277734691873044 0.13366019455625 0.0634822152852672 4 ITGA2|CD49B 0.00450484705659599 0.127443889160417 0.0133066251517912 4 CASP7|CASPASE-7_CLEAVEDD198 0.0176590777691408 0.120445766335417 0.0423817866459379 4 RAD50|RAD50 0.0142711331426131 0.11436079255625 0.0351289431202784 4 EGFR|EGFR 0.0163559816024703 0.111020328339583 0.0397512464262569 4 BCL2L1|BCL-XL 0.00703138677504247 0.104835747077083 0.019863790259631 4 YWHAB|14-3-3_BETA 0.033600052793606 -0.0945088408854167 0.0741518406479581 4 CDKN1B|P27_PT198 0.00243050389274087 -0.103167944460417 0.00804580598976288 4 STK11|LKB1 0.0211044472044888 -0.103765608110417 0.050025356336566 4 BIRC2 |CIAP 0.0135274947242499 -0.104035509789583 0.033730895935792 4 MS4A1|CD20 0.00206504836390197 -0.128270512127083 0.00720889610671233 4 RPTOR|RAPTOR 0.0498153808498481 -0.13733668221875 0.0966116477087963 4 RAB11A RAB11B|RAB11 0.0329051389736831 -0.13796374248125 0.0734626358482227 4 CHEK2|CHK2_PT68 0.00428667247756437 -0.138599040902083 0.0128600174326931 4 CDKN1B|P27 0.0381435237664492 -0.145815671297917 0.0804786435511895 4 BAD|BAD_PS112 0.0366533214694394 -0.147975278364583 0.0790723339565434 4 ANXA7 |ANNEXIN_VII 0.00380409687879792 -0.15454071296875 0.0119735508316262 4 ESR1|ER-ALPHA_PS118 0.00187718856855663 -0.16094134008125 0.00680038122948817 4 AKT1S1|PRAS40_PT246 0.0134809691843323 -0.161848052547917 0.033730895935792 4 EIF4EBP1|4E-BP1_PS65 0.0216857439749411 -0.168050803664583 0.0507763761364474 4 SMAD3|SMAD3 0.0354514880065121 -0.171406721822917 0.0773487011051173 4 ARHI|ARHI 0.000139621586326273 -0.178119904677083 0.000765924130704126 4 MET|C-MET_PY1235 3.17852451879546e-06 -0.178438322314583 3.5898629859337e-05 4 MAPK1 MAPK3|MAPK_PT202_Y204 0.0392666533240647 -0.18123096644375 0.0819477982415263 4 CDKN1B|P27_PT157 0.000644020164674932 -0.185374115235417 0.00263089088548057 4 PDK1|PDK1 0.00192610545479503 -0.188794553277083 0.00684837495038233 4 MRE11A|MRE11 1.80152156252795e-05 -0.190545243210417 0.000138356856002147 4 ERBB2|HER2_PY1248 0.00010567315125296 -0.191226022889583 0.000614825607289949 4 YWHAZ|14-3-3_ZETA 0.0062660116715292 -0.201816013552083 0.0182283975899031 4 NRG1|HEREGULIN 0.00376616834649313 -0.204109484472917 0.0119735508316262 4 MAP2K1|MEK1_PS217_S221 3.48928509068245e-07 -0.224693476635417 6.09038852191846e-06 4 FRAP1|MTOR_PS2448 0.0102900614918992 -0.240387315789583 0.0266985379249277 4 PTEN|PTEN 0.00939348251729994 -0.24212382203125 0.0247061457989259 4 SRC|SRC 0.0421198780703567 -0.251931694010417 0.0851264904158788 4 TSC1|TSC1 0.00703509238361933 -0.262256243447917 0.019863790259631 4 BID|BID 1.40121178869525e-06 -0.305984654860417 1.6814541464343e-05 4 STMN1|STATHMIN 1.57854457345258e-05 -0.31269706248125 0.000132265940042582 4 YBX1|YB-1_PS102 9.6815273778506e-08 -0.317697578510417 2.06539250727479e-06 4 RICTOR|RICTOR_PT1135 7.22438258048285e-05 -0.320221056247917 0.000433462954828971 4 WWTR1|TAZ 1.66564753309202e-08 -0.330429855502083 6.39608652707336e-07 4 CHEK1|CHK1_PS345 0.00142082816177899 -0.331227599727083 0.00534900013846208 4 CCND1|CYCLIN_D1 0.00213001013431493 -0.337950642264583 0.00730289188907976 4 EGFR|EGFR_PY1173 1.63574079952865e-05 -0.338149147847917 0.000132265940042582 4 RICTOR|RICTOR 0.0448622222279558 -0.380351237172917 0.0897244444559116 4 PDCD4|PDCD4 0.047202337505887 -0.404619992452083 0.0925456040179231 4 PXN|PAXILLIN 0.000240020487523571 -0.40464569113125 0.00115209834011314 4 MYC|C-MYC 6.03342557759837e-06 -0.430727616485417 5.79208855449443e-05 4 MAPK14|P38_PT180_Y182 0.0223699020179049 -0.438593863527083 0.0517472432221415 4 RAF1|C-RAF_PS338 5.81674045195293e-10 -0.487570214702083 6.66225728233752e-08 4 SERPINE1|PAI-1 0.00368418090496005 -0.636293521760417 0.0119735508316262 4 COL6A1|COLLAGEN_VI 6.93985133576825e-10 -0.640512026964583 6.66225728233752e-08 4 EIF4EBP1|4E-BP1_PT37_T46 0.00222908448081383 -0.99193453896875 0.00750849509326764 4 RB1|RB_PS807_S811 0.000310806571033897 -1.03782082831458 0.00138778747996531 4 IGFBP2|IGFBP2 0.000559284357627247 -1.80567620167292 0.00233440427531373 4