rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 AKT1(3), ATM(13), HSPA1A(1), NFKBIB(1), TP53(23) 10237566 41 39 38 2 1 13 2 13 12 0 0.0117 2.78e-15 9.35e-13 2 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(1), ATM(13), RB1(2), TP53(23) 8943084 39 37 37 2 1 11 1 14 12 0 0.0164 5.88e-15 9.35e-13 3 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(1), PIK3CA(7), POLR1A(2), POLR1B(1), POLR1C(1), RAC1(1), RB1(2), TP53(23) 10023689 38 37 36 1 3 6 3 16 10 0 0.00348 8.22e-15 9.35e-13 4 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(2), DAXX(1), HRAS(4), PAX3(1), RB1(2), SIRT1(1), SP100(1), TP53(23) 9353517 35 35 31 1 2 6 2 15 10 0 0.00675 8.88e-15 9.35e-13 5 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 CDKN1B(4), CFL1(1), TP53(23) 4146431 28 28 26 1 0 5 1 7 15 0 0.0603 8.99e-15 9.35e-13 6 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 SP1(2), SP3(3), TP53(23) 3469530 28 28 26 0 0 7 2 7 12 0 0.00532 9.10e-15 9.35e-13 7 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 NFKB1(2), RELA(2), TP53(23) 4782176 27 27 25 1 2 6 1 8 10 0 0.0314 1.09e-14 9.57e-13 8 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 AKT1(3), EGFR(4), IGF1R(2), PRKCA(1), RB1(2), TEP1(4), TNKS(2), TP53(23), XRCC5(1) 13842900 42 41 39 1 6 9 4 13 10 0 0.000760 6.84e-14 5.27e-12 9 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(13), MYT1(1), RB1(2), TP53(23) 8673699 39 37 37 3 2 10 1 14 12 0 0.0441 3.99e-13 2.73e-11 10 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 AKT1(3), APAF1(1), ATM(13), BAD(1), PRKCA(1), STAT1(1), TLN1(2), TP53(23) 13528093 45 43 42 3 1 13 3 15 13 0 0.0166 7.20e-13 4.44e-11 11 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(13), TP53(23) 7914519 36 34 34 3 0 10 1 13 12 0 0.0867 2.02e-11 1.13e-09 12 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 HSPA1A(1), NFKB1(2), RB1(2), RELA(2), TP53(23) 8905685 30 28 28 0 4 6 1 9 10 0 0.00225 9.67e-11 4.96e-09 13 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(1), ATM(13), CDKN1B(4), DHFR(1), RB1(2), TFDP1(1), TP53(23) 14930913 45 42 43 4 1 10 1 16 17 0 0.0688 3.13e-10 1.48e-08 14 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(1), ATM(13), BRCA1(2), NFKB1(2), RELA(2), TP53(23) 14728966 43 40 41 3 3 11 1 16 12 0 0.0225 5.95e-10 2.62e-08 15 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 AKT1(3), GH1(1), GHR(2), HRAS(4), IGF1R(2), PIK3CA(7), SHC1(1), SOD3(1) 6571496 21 19 18 1 2 6 3 10 0 0 0.0328 3.99e-07 1.64e-05 16 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(13), BRCA1(2), BRCA2(4), FANCA(1), FANCC(1), FANCD2(1), FANCF(1), FANCG(1), TP53(23), TREX1(1) 21785706 48 43 46 3 4 12 2 15 15 0 0.0140 7.29e-07 2.81e-05 17 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(3), CDKN1B(4), PDK2(1), PIK3CA(7), PTEN(9), SHC1(1) 9485011 25 24 24 2 0 4 4 7 10 0 0.175 3.48e-06 0.000126 18 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(1), BIRC2(1), FAS(1), FASLG(1), MAP2K4(2), MAPK10(1), MCL1(1), NFKB1(2), PARP1(2), RELA(2), TP53(23), TRAF2(1) 18347983 38 38 36 4 4 12 1 10 11 0 0.0587 2.17e-05 0.000711 19 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(3), EIF4E(1), EIF4G1(3), GHR(2), IRS1(2), PDK2(1), PIK3CA(7), PRKCA(1), PTEN(9) 13871576 29 26 28 1 3 4 4 10 8 0 0.0212 2.19e-05 0.000711 20 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(3), EIF4E(1), IGF1R(2), INPPL1(1), PDK2(1), PIK3CA(7), PTEN(9) 9685680 24 23 23 2 1 3 4 10 6 0 0.127 2.83e-05 0.000873 21 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(3), CDKN1B(4), HRAS(4), NFKB1(2), PIK3CA(7), RAC1(1), RB1(2), RELA(2), TFDP1(1) 9948949 26 23 23 2 3 5 2 12 4 0 0.0555 0.000113 0.00330 22 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(3), EIF4E(1), EIF4G1(3), PDK2(1), PIK3CA(7), PTEN(9), TSC2(1) 13600692 25 24 24 1 1 5 4 8 7 0 0.0399 0.000171 0.00480 23 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(3), BAD(1), HRAS(4), NFKB1(2), PIK3CA(7), RAC1(1), RALGDS(1), RELA(2) 9321885 21 20 18 2 3 6 2 10 0 0 0.0784 0.00153 0.0410 24 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(3), BAD(1), HRAS(4), IGF1R(2), IRS1(2), PIK3CA(7), SHC1(1) 9372555 20 18 17 2 1 5 2 11 1 0 0.122 0.00177 0.0437 25 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(3), BPNT1(1), PDK1(1), PIK3CA(7), PIK3CD(2), PTEN(9), RBL2(2), SHC1(1) 10041577 26 25 25 4 1 5 5 8 7 0 0.305 0.00178 0.0437 26 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(1), PGLYRP2(3) 890560 4 4 4 0 1 1 1 0 1 0 0.327 0.00219 0.0519 27 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(13), BMPR1B(1), CDKN1B(4), EGR1(1), INHA(1), LHCGR(1), MSH5(1), NCOR1(6), NRIP1(2), PGR(2), PRLR(2) 17288944 34 30 34 4 2 8 0 10 14 0 0.126 0.00246 0.0560 28 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYC(1), RB1(2), SP1(2), SP3(3) 3297294 8 8 8 0 1 3 1 1 2 0 0.170 0.00267 0.0588 29 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(3), HRAS(4), KLK2(1), NTRK1(1), PIK3CA(7), PRKCA(1), SHC1(1) 7682929 18 16 15 2 0 5 2 9 2 0 0.218 0.00310 0.0658 30 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(3), BAD(1), GH1(1), GHR(2), NFKB1(2), PIK3CA(7), RELA(2) 6945623 18 16 17 2 5 4 3 6 0 0 0.154 0.00542 0.111 31 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(1), BAD(1), BCL2L11(1), BIRC2(1), BIRC5(1), CASP1(1), FAS(1), FASLG(1), IRF4(4), IRF6(1), LTA(1), MAP2K4(2), MAPK10(1), NFKB1(2), NFKBIB(1), RELA(2), TNFRSF10B(1), TNFRSF21(1), TP53(23), TRAF2(1) 28161966 48 46 46 6 8 12 2 12 14 0 0.0639 0.00632 0.126 32 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ3(2), COQ5(1), COQ7(1), NDUFA13(1) 1961734 5 5 5 0 0 2 0 2 1 0 0.269 0.00795 0.153 33 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(2), SDHA(1), SDHB(1), SDHC(2), UQCRC1(1) 3258606 7 7 7 0 1 2 0 1 3 0 0.189 0.0155 0.277 34 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(2), EGF(2), EGFR(4), TF(2) 6338332 10 10 10 1 4 2 1 3 0 0 0.266 0.0157 0.277 35 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(3), HRAS(4), MEF2C(1), NTRK1(1), PIK3CA(7), SHC1(1) 9310898 17 16 14 2 0 5 2 9 1 0 0.200 0.0158 0.277 36 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(2), EGFR(4), ERBB3(2), UBE2D1(1) 5068951 9 9 9 1 3 0 1 4 1 0 0.296 0.0166 0.284 37 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(3), ACAA2(1), ACAT1(1), EHHADH(5) 4121609 10 8 10 1 3 1 1 2 3 0 0.267 0.0198 0.325 38 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(4), MMP2(1), MMP9(2) 3686987 7 7 5 1 2 1 1 3 0 0 0.409 0.0201 0.325 39 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(1), EXT2(4), EXTL1(1), EXTL3(1), HS6ST1(1), HS6ST2(1), NDST2(2), NDST4(4) 10133977 15 15 15 1 1 7 0 5 2 0 0.0826 0.0220 0.348 40 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(3), HRAS(4), NTRK1(1), PIK3CA(7), PIK3CD(2), SHC1(1) 7904985 18 17 15 3 0 6 2 8 2 0 0.290 0.0248 0.382 41 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 NR1I3(2), PTGS1(2), PTGS2(2) 2640607 6 6 6 0 1 4 0 0 1 0 0.142 0.0257 0.386 42 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(3), APC(2), BRAF(8), CCL15(1), DAG1(2), EGFR(4), ITPKB(1), ITPR1(1), ITPR2(5), MAPK10(1), PIK3CA(7), PIK3CD(2) 26190926 37 34 36 4 6 8 5 11 7 0 0.0390 0.0298 0.437 43 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(2), ARHGEF1(2), GNA12(1), GNA13(1), MYLK(3), PLCB1(3), PRKCA(1), ROCK1(4) 10184546 17 17 16 2 3 4 2 6 2 0 0.223 0.0312 0.447 44 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CDKN1B(4), RB1(2), TFDP1(1) 4222280 7 7 7 0 1 0 0 2 4 0 0.380 0.0328 0.459 45 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(3), APC(2), CD14(1), CTNNB1(8), LEF1(1), LY96(1), NFKB1(2), PIK3CA(7), RELA(2) 15110668 27 26 25 4 3 8 4 10 2 0 0.137 0.0353 0.483 46 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(1), ARHGEF1(2), F2(1), F2R(1), GNA12(1), GNA13(1), MAP3K7(1), PIK3CA(7), PLCB1(3), PRKCA(1), ROCK1(4) 12702113 23 21 22 3 4 4 2 10 3 0 0.184 0.0385 0.516 47 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(3), NFKB1(2), PIK3CA(7), RB1(2), RELA(2), SP1(2) 9557021 18 16 17 2 3 5 2 7 1 0 0.147 0.0488 0.634 48 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKB1(2), PLCB1(3), PRKCA(1), RELA(2) 4046992 8 8 8 0 3 3 0 2 0 0 0.0984 0.0497 0.634 49 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 BTK(1), CAD(2), DAXX(1), EGFR(4), FAF1(1), MAP2K4(2), MAPK10(1), MAPK9(1), MET(3), NFKB1(2), NFKBIB(1), PFN1(1), PFN2(2), ROCK1(4), TNFRSF6B(1), TP53(23), TPX2(1), TRAF2(1) 35746209 52 47 49 6 10 8 3 17 14 0 0.0352 0.0511 0.634 50 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 F13B(3), HSD17B4(1), HSD3B1(1), HSD3B2(1) 3991688 6 6 6 0 0 0 1 2 3 0 0.284 0.0516 0.634 51 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOC(2), GPI(1), PFKL(2), PFKM(2), PFKP(2), PGM3(1), PRPS1L1(3), RBKS(1), RPE(1), TKT(1) 11958051 16 16 16 2 2 3 1 6 4 0 0.189 0.0525 0.634 52 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 DCN(1), KERA(2) 1770834 3 3 3 1 0 0 2 0 1 0 0.888 0.0561 0.656 53 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 AKT1(3), ATF2(2), DUSP4(1), DUSP8(1), GCK(1), MAP2K4(2), MAP3K12(3), MAP3K13(1), MAP3K3(1), MAP3K4(1), MAP3K7(1), MAP3K9(1), MAPK10(1), MAPK9(1), PAPPA(2), SHC1(1), TP53(23) 24782778 46 41 43 7 8 11 4 10 13 0 0.132 0.0565 0.656 54 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(3), BAD(1), MUSK(1), PIK3CA(7) 7995097 12 11 11 1 1 3 3 5 0 0 0.185 0.0577 0.659 55 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(1), AKT1(3), NFKB1(2), NOS3(2), PIK3CA(7), RELA(2), SYT1(1) 8760309 18 16 17 3 4 5 3 6 0 0 0.289 0.0630 0.697 56 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(1), AKT1(3), ITGAV(1), PIK3CA(7), PLCB1(3), PRKCA(1), RAC1(1), SMPD2(2) 13525334 19 18 18 2 2 7 2 8 0 0 0.115 0.0634 0.697 57 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 CHAT(2), DBH(2), DDC(1), GAD1(1), GAD2(3), HDC(1), MAOA(1), TPH1(1) 7059830 12 12 12 2 1 3 1 4 3 0 0.414 0.0668 0.722 58 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(1), EHHADH(5), SDHB(1) 3844398 7 6 7 1 2 2 1 0 2 0 0.483 0.0775 0.823 59 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOC(2), GPI(1), PFKM(2), PFKP(2), PGM3(1), PRPS1L1(3), RBKS(1), RPE(1), TKT(1) 10059450 14 14 14 2 2 3 1 6 2 0 0.269 0.0802 0.837 60 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(3), PIK3CA(7), PLCB1(3), PRKCA(1) 6333152 14 13 13 3 1 5 2 6 0 0 0.510 0.0834 0.856 61 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 ALDOC(2), GCK(1), GMPPB(1), HK2(1), HK3(1), PFKFB1(1), PFKFB4(1), PFKM(2), PFKP(2), PMM1(1), TPI1(1) 11701759 14 14 14 1 2 2 2 5 3 0 0.0996 0.0853 0.861 62 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 DHRS1(1), DHRS7(1), DHRSX(1), PON1(1), PON2(2), PON3(1) 4430596 7 7 7 0 1 1 1 4 0 0 0.176 0.0881 0.874 63 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 HRAS(4), NFKB1(2), PLCB1(3), PRKCA(1), RELA(2) 7648518 12 11 10 1 3 4 0 5 0 0 0.118 0.0894 0.874 64 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX15(2), ALOX5AP(1), LTC4S(1), PLA2G2A(1), PTGS1(2), PTGS2(2), TBXAS1(1) 7370397 10 10 10 0 2 5 2 0 1 0 0.0430 0.103 0.983 65 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(1), HMGCL(2) 1673620 3 3 3 1 0 1 1 0 1 0 0.807 0.105 0.983 66 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(1), ALDH1A2(2) 1923120 3 3 3 0 0 2 1 0 0 0 0.453 0.105 0.983 67 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(3), IL4R(3), IRS1(2), JAK1(2), JAK3(2), SHC1(1) 7238601 13 12 12 2 1 3 3 3 3 0 0.362 0.110 1.000 68 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 EHHADH(5) 2376418 5 4 5 0 2 1 0 0 2 0 0.325 0.118 1.000 69 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(2) 1000074 2 2 2 1 0 1 0 1 0 0 0.867 0.118 1.000 70 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 CRK(1), HRAS(4), NFKB1(2), PIK3CA(7), PRKCA(1), RELA(2) 13520355 17 15 15 1 2 3 1 11 0 0 0.0722 0.123 1.000 71 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(1), ATIC(3), DHFR(1), FTCD(1), GART(1), MTHFD1(1), MTHFD1L(1), MTHFR(2), MTR(1), SHMT2(1), TYMS(1) 9340808 14 14 14 2 2 7 0 1 4 0 0.240 0.125 1.000 72 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 ANPEP(1), GSTA2(2), GSTA3(1), GSTM2(1), GSTM3(1), GSTO2(1), IDH1(3) 8889670 10 10 9 1 1 5 1 3 0 0 0.195 0.132 1.000 73 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(3), BAD(1), BTK(1), EEA1(2), LYN(1), PFKL(2), PFKM(2), PFKP(2), RAC1(1), VAV2(2) 12314219 17 15 16 3 4 6 2 2 3 0 0.214 0.140 1.000 74 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDOC(2), TPI1(1) 1924683 3 3 3 1 1 0 1 1 0 0 0.784 0.140 1.000 75 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CSF1R(2), EGF(2), EGFR(4), MET(3), PRKCA(1), SH3GLB2(1) 9567310 13 12 13 2 4 0 1 8 0 0 0.295 0.141 1.000 76 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 GAD1(1), GAD2(3) 2829624 4 4 4 1 0 1 1 1 1 0 0.776 0.141 1.000 77 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR2(1), MTMR6(1), THTPA(2) 3152669 4 4 4 1 0 2 0 2 0 0 0.684 0.157 1.000 78 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 ALDOC(2), GMPPB(1), HK2(1), HK3(1), MTMR2(1), MTMR6(1), PFKFB1(1), PFKFB4(1), PFKL(2), PFKM(2), PFKP(2), PGM2(1), PMM1(1), TPI1(1), TSTA3(1) 18186292 19 18 19 2 3 3 2 7 4 0 0.0959 0.158 1.000 79 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 HRAS(4), SHC1(1) 4324154 5 5 3 1 0 2 0 3 0 0 0.562 0.161 1.000 80 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNE2(1), CDKN1B(4) 4410373 5 5 5 1 0 0 0 1 4 0 0.875 0.162 1.000 81 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CYP11B2(1), HSD11B1(1), HSD3B1(1), HSD3B2(1) 3402096 4 4 4 0 0 0 0 1 3 0 0.314 0.165 1.000 82 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(2), GAD1(1), HDC(1), TPH1(1) 2967303 5 5 5 0 1 1 0 3 0 0 0.274 0.165 1.000 83 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(1), ATIC(3), DHFR(1), GART(1), MTHFD1(1), MTHFD1L(1), MTHFR(2), MTR(1), SHMT2(1), TYMS(1) 8836757 13 13 13 2 2 7 0 1 3 0 0.263 0.173 1.000 84 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), EHHADH(5) 5971516 10 8 10 2 3 3 1 1 2 0 0.468 0.176 1.000 85 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(13), MYT1(1) 6787806 14 14 14 3 1 5 0 6 2 0 0.552 0.178 1.000 86 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 PARK2(1), SNCAIP(2), UBE2L3(1) 3171568 4 4 4 0 0 1 3 0 0 0 0.495 0.183 1.000 87 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 CTNNA1(1), CTNNA2(1), CTNNB1(8) 9396675 10 10 9 0 1 3 2 4 0 0 0.0806 0.190 1.000 88 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(2), ENPP1(2), ENPP3(1), NMNAT1(1), NNT(3), NT5E(1) 7164398 10 9 10 1 3 2 0 3 2 0 0.240 0.190 1.000 89 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 EPN1(1), EPS15(2), NME1(1), PICALM(1), PPP3CA(1), PPP3CC(1), SYNJ1(1), SYNJ2(2), SYT1(1) 10691275 11 11 11 1 1 1 1 6 2 0 0.238 0.192 1.000 90 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC2(2), CES1(3) 2955227 5 4 5 1 3 0 2 0 0 0 0.496 0.194 1.000 91 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(1), AASDH(1), AASDHPPT(1), AASS(1) 3429471 4 4 4 1 1 0 0 3 0 0 0.667 0.211 1.000 92 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CFL1(1), CFLAR(1) 1909680 2 2 2 0 0 1 0 0 1 0 0.730 0.213 1.000 93 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL4R(3), JAK1(2), TYK2(1) 5175873 7 6 7 0 0 0 1 3 3 0 0.231 0.215 1.000 94 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL4R(3), JAK1(2), TYK2(1) 5175873 7 6 7 0 0 0 1 3 3 0 0.231 0.215 1.000 95 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 DUSP1(1), MAP2K4(2), MAPK10(1), MAPK9(1), MAPKAPK5(1), NFKB1(2), NFKBIB(1), PIK3CA(7), PIK3CD(2), SYT1(1), TRAF2(1) 16519465 20 18 20 1 6 6 1 6 1 0 0.0160 0.221 1.000 96 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ACADSB(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), AOC2(2), CNDP1(1), DPYD(4), EHHADH(5), GAD1(1), GAD2(3) 14310081 22 19 22 3 6 6 2 4 4 0 0.151 0.222 1.000 97 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 SEC61A2(1), SRP19(1), SRP54(2), SRPR(2) 3727610 6 5 5 0 3 1 0 1 1 0 0.243 0.224 1.000 98 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(1), AASDHPPT(1), AASS(1) 2320434 3 3 3 1 1 0 0 2 0 0 0.765 0.230 1.000 99 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 EPX(1), MPO(1), MTHFR(2), SHMT2(1), TPO(1) 5715637 6 6 6 1 0 4 1 0 1 0 0.365 0.237 1.000 100 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(2), CYR61(1), EIF4E(1), NR4A3(1) 5296783 5 5 5 0 0 2 0 3 0 0 0.282 0.240 1.000 101 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(1) 356311 1 1 1 0 1 0 0 0 0 0 0.739 0.244 1.000 102 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ENO1(2), GPI(1), PFKL(2), PGK1(1), TPI1(1) 4547116 7 6 7 2 3 0 0 0 4 0 0.522 0.245 1.000 103 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(4), HRAS(4), IGF1R(2), KLK2(1), PTPRR(1), RPS6KA5(2), SHC1(1), STAT3(3) 16223146 18 18 16 2 4 2 1 10 1 0 0.181 0.245 1.000 104 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(1), CS(2), PC(1), SLC25A11(1) 4544204 5 5 5 0 1 0 1 2 1 0 0.253 0.246 1.000 105 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 CS(2), PC(1), PDHX(1), PDK1(1), PDK2(1), PDK3(1), PDK4(1), PDP2(1), SDHA(1), SDHB(1), SDHC(2), SUCLG1(1) 13936051 14 13 14 1 1 4 2 3 4 0 0.140 0.249 1.000 106 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(1), ACOT11(1), DHRS1(1), DHRS7(1), DHRSX(1), EHHADH(5), ESCO1(4), ESCO2(1) 12795882 15 13 15 1 6 3 1 1 4 0 0.108 0.250 1.000 107 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(1), ACPT(1), ENPP1(2), ENPP3(1), RFK(1) 4786437 6 6 6 0 2 0 0 2 2 0 0.198 0.258 1.000 108 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 CYP11B2(1), CYP21A2(1), HSD11B1(1), HSD3B1(1), HSD3B2(1) 4535581 5 5 5 0 1 0 0 1 3 0 0.229 0.260 1.000 109 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 CYP11B2(1), CYP21A2(1), HSD11B1(1), HSD3B1(1), HSD3B2(1) 4535581 5 5 5 0 1 0 0 1 3 0 0.229 0.260 1.000 110 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(1), PAPSS2(1), SULT1E1(1), SUOX(1) 3013654 4 4 4 0 1 1 0 1 1 0 0.342 0.265 1.000 111 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 EHHADH(5), HSD17B4(1), SIRT1(1) 5819258 7 6 7 1 2 1 0 1 3 0 0.495 0.276 1.000 112 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(1), ACO1(1), ACSS1(2), ACSS2(1), IDH1(3) 6540024 8 7 7 0 3 4 0 0 1 0 0.0682 0.276 1.000 113 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(13), BRCA1(2), CDC34(1), MYT1(1), PRKDC(3), TP53(23) 20609313 43 40 41 8 4 11 2 14 12 0 0.396 0.284 1.000 114 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(1), ACPT(1), ENPP1(2), ENPP3(1), MTMR2(1), MTMR6(1), RFK(1) 7416865 8 8 8 1 2 1 0 3 2 0 0.349 0.292 1.000 115 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(1), GSTA2(2), GSTA3(1), GSTM2(1), GSTM3(1), GSTO2(1), IDH1(3) 10831091 10 10 9 1 1 5 1 3 0 0 0.191 0.294 1.000 116 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 INPP5B(2), INPP5E(2), INPPL1(1), IPMK(1), ITPKB(1), OCRL(1), PI4KA(1), PI4KB(1), PIK3CA(7), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIP4K2B(1), PIP5K1A(1), PLCB1(3), PLCB4(7), PLCE1(1), PLCG2(1), PLCZ1(1), PTEN(9), SYNJ1(1), SYNJ2(2) 36556866 49 43 49 7 5 11 7 16 10 0 0.0672 0.296 1.000 117 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 EGR1(1), HRAS(4), KLK2(1) 4039899 6 6 4 2 0 2 0 3 1 0 0.760 0.296 1.000 118 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(1), IDH1(3), SDHB(1) 4391055 5 5 4 0 1 4 0 0 0 0 0.216 0.302 1.000 119 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(1), IL12A(1) 1477864 2 2 2 1 0 1 0 0 1 0 0.866 0.304 1.000 120 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(1), ACO1(1), CS(2), IDH1(3), PC(1), PCK2(1), SDHA(1), SDHB(1), SDHC(2), SUCLG1(1) 14686187 14 13 13 1 2 4 1 3 4 0 0.0956 0.312 1.000 121 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMPR1A(1), BMPR1B(1), BMPR2(1) 3078847 3 3 3 0 0 1 0 1 1 0 0.591 0.313 1.000 122 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(3), EGF(2), EGFR(4), HRAS(4), NFKB1(2), PRKCA(1), RELA(2) 10110963 18 16 16 4 6 3 1 8 0 0 0.356 0.316 1.000 123 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 NFATC2(1), NFATC4(1), PPP3CA(1), PPP3CC(1), PRKCA(1), SP1(2), SP3(3), SYT1(1) 10328225 11 10 11 1 3 2 2 2 2 0 0.199 0.316 1.000 124 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 DPYD(4), ENPP1(2), ENPP3(1), PANK1(1) 6866362 8 8 8 1 4 1 0 2 1 0 0.321 0.325 1.000 125 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 DAG1(2), ITPKB(1) 2975533 3 3 3 0 0 2 1 0 0 0 0.415 0.326 1.000 126 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNB1(1), IL12A(1), IL16(2), IL9(1), LTA(1) 4910173 6 6 6 1 1 1 0 2 2 0 0.557 0.329 1.000 127 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 ARSB(2), ARSD(1), ARSE(1), CYP11B2(1), HSD11B1(1), HSD3B1(1), HSD3B2(1), STS(1), SULT1E1(1), UGT1A1(2), UGT1A3(1), UGT1A7(1), UGT2B15(3) 13416124 17 14 17 3 4 2 0 6 5 0 0.244 0.332 1.000 128 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 BRAF(8) 5466508 8 8 8 2 1 1 1 3 2 0 0.673 0.334 1.000 129 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(1), F2R(1), HRAS(4), ITGA1(1), PLA2G4A(1), PLCB1(3), PRKCA(1), PTGS1(2), SYK(2), TBXAS1(1) 12006759 17 16 15 3 2 8 1 5 1 0 0.255 0.352 1.000 130 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(1), BAD(1), BCL2L11(1), CES1(3) 5284666 6 6 6 0 2 1 2 1 0 0 0.245 0.358 1.000 131 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(1), ACOX3(1), FADS2(1), PLA2G2A(1), PLA2G4A(1) 4976179 5 5 5 1 1 1 1 1 1 0 0.587 0.360 1.000 132 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(1), DHRS7(1), DHRSX(1), ESCO1(4), ESCO2(1) 8169443 8 8 8 0 3 2 0 1 2 0 0.137 0.363 1.000 133 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(1), HRAS(4), IGF1R(2), IRS1(2), PIK3CA(7), SHC1(1) 12166297 17 15 15 3 1 3 1 11 1 0 0.335 0.365 1.000 134 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIPT1(1) 756907 1 1 1 0 0 1 0 0 0 0 0.809 0.370 1.000 135 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 FLT1(1), HRAS(4), KDR(4), NOS3(2), PIK3CA(7), PRKCA(1), SHC1(1), VHL(2) 16717262 22 20 20 3 4 6 2 9 1 0 0.160 0.374 1.000 136 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(1), CHST12(1), PAPSS2(1), SULT1E1(1), SUOX(1) 4539998 5 5 5 0 1 1 0 2 1 0 0.279 0.376 1.000 137 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(2), HRAS(4), ITGA1(1), MYLK(3), PFN1(1), PIK3CA(7), ROCK1(4), SHC1(1), TLN1(2) 18437889 25 23 22 4 1 5 3 13 3 0 0.276 0.379 1.000 138 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 NFKB1(2), RELA(2), TNFRSF13B(2), TRAF2(1) 7128577 7 7 7 1 4 2 0 1 0 0 0.363 0.388 1.000 139 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(1), CD74(1), CD8A(1), CD8B(1), CIITA(1), HLA-DMB(1), HLA-DQA2(1), HLA-G(1), HSP90AA1(2), HSP90AB1(1), HSPA5(2), IFI30(1), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(1), IFNA21(1), IFNA6(1), KIR3DL1(2), LTA(1), NFYC(1), PSME2(1), RFXAP(1) 22782062 27 22 27 4 7 5 2 4 9 0 0.159 0.401 1.000 140 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), XYLT1(2) 3179774 3 3 3 1 0 1 1 0 1 0 0.881 0.405 1.000 141 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), XYLT1(2) 3179774 3 3 3 1 0 1 1 0 1 0 0.881 0.405 1.000 142 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOC(2), GOT2(1), GPT(1), ME3(1), PGK1(1), PGK2(1), RPE(1), TKT(1), TPI1(1) 9913368 10 10 10 0 3 1 1 4 1 0 0.0519 0.405 1.000 143 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 EGF(2), EGFR(4), HRAS(4), PTPRB(1), SHC1(1), SPRY3(1) 12289230 13 12 11 2 2 2 2 7 0 0 0.314 0.407 1.000 144 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAD(1), MAP2K4(2), NFKB1(2), NSMAF(2), RELA(2), TRAF2(1) 10064369 10 10 10 0 4 4 0 2 0 0 0.0505 0.413 1.000 145 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR3(1), ARHGAP5(2), ARHGAP6(1), ARHGEF1(2), ARHGEF11(2), ARHGEF5(2), ARPC4(1), CFL1(1), LIMK1(1), MYLK(3), PFN1(1), PIP5K1A(1), ROCK1(4), TLN1(2) 22138347 24 22 23 3 3 5 3 5 8 0 0.191 0.419 1.000 146 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOC(2), GOT2(1), GPT(1), ME3(1), PGK1(1), RPE(1), TKT(1), TPI1(1) 8860419 9 9 9 0 3 1 1 3 1 0 0.0678 0.425 1.000 147 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(2), ENPP1(2), ENPP3(1), NADK(2), NMNAT1(1), NNT(3), NT5E(1), NUDT12(2) 10609429 14 10 14 2 4 3 0 3 4 0 0.277 0.426 1.000 148 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT2(1) 1286413 1 1 1 0 0 1 0 0 0 0 0.726 0.427 1.000 149 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(1), CS(2), IDH1(3), PC(1), SDHA(1), SDHB(1), SUCLG1(1) 10127732 10 9 9 0 2 4 1 2 1 0 0.0641 0.432 1.000 150 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(3), BRAF(8), DAG1(2), DRD2(1), EGFR(4), ITPKB(1), ITPR1(1), ITPR2(5), PIK3CB(2), PLCB1(3), PLCB4(7), SHC1(1), STAT3(3) 28785181 41 38 40 7 6 14 6 10 5 0 0.123 0.433 1.000 151 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(2), FUCA2(1), HEXB(2), LCT(1), MAN2B1(2), MAN2B2(1), MAN2C1(1), NEU4(1) 10030126 11 10 11 2 2 5 0 2 2 0 0.338 0.438 1.000 152 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 CA12(1), CA14(1), CA2(2), CA3(1), CA5A(1), CA6(1), CA8(1), CA9(1), CPS1(2), GLUL(1), HAL(1) 9362483 13 13 13 3 1 5 1 3 3 0 0.456 0.438 1.000 153 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNB1(1), JAK1(2), STAT1(1), STAT2(1), TYK2(1) 5342351 6 5 6 1 1 0 0 2 3 0 0.641 0.440 1.000 154 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ERBB4(2), NRG2(1), PRKCA(1) 4442513 4 4 4 1 1 1 0 2 0 0 0.707 0.441 1.000 155 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1) 3924876 5 4 5 2 1 2 1 1 0 0 0.776 0.454 1.000 156 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1) 3924876 5 4 5 2 1 2 1 1 0 0 0.776 0.454 1.000 157 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 TPI1(1) 810274 1 1 1 1 1 0 0 0 0 0 0.925 0.459 1.000 158 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(2), GNA12(1), PRKAG1(2) 4968569 5 5 5 0 2 0 1 2 0 0 0.286 0.466 1.000 159 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(1), GOT2(1) 2308555 2 2 2 1 0 1 0 0 1 0 0.792 0.466 1.000 160 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(1), PLCB1(3) 3532231 4 4 4 1 2 2 0 0 0 0 0.593 0.470 1.000 161 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(1), CS(2), HAO1(1), MTHFD1(1), MTHFD1L(1) 6313639 6 6 6 0 1 3 0 2 0 0 0.176 0.472 1.000 162 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(1), HSD17B4(1), MECR(1) 4159674 3 3 3 1 0 1 0 1 1 0 0.760 0.473 1.000 163 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 ALOX15(2), CYP4F2(1), CYP4F3(1), EPX(1), MPO(1), PLA2G2A(1), PLA2G4A(1), PTGS1(2), PTGS2(2), TBXAS1(1), TPO(1) 13686542 14 14 14 2 2 7 4 0 1 0 0.171 0.479 1.000 164 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 ALOX12B(1), ALOX15(2), CYP2B6(2), CYP2C19(2), CYP2C8(2), CYP2J2(1), CYP4F2(1), CYP4F3(1), LTC4S(1), PLA2G2A(1), PLA2G4A(1), PTGS1(2), PTGS2(2), TBXAS1(1) 19112755 20 20 20 3 2 7 4 4 3 0 0.179 0.480 1.000 165 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 KEAP1(2), PRKCA(1) 4348277 3 3 3 1 1 1 0 1 0 0 0.706 0.484 1.000 166 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 IFNB1(1), NFKB1(2), RELA(2) 5442661 5 5 5 0 2 1 0 1 1 0 0.302 0.485 1.000 167 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BIRC2(1), CFLAR(1), MAP2K4(2), MAP3K3(1), MAP3K7(1), NFKB1(2), NFKBIB(1), TNFAIP3(1), TRAF2(1) 13364486 11 11 11 1 3 4 1 1 2 0 0.183 0.485 1.000 168 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(1), ACTG1(2), ARHGEF2(2), ARPC5L(1), CD14(1), CDH1(2), CTNNB1(8), EZR(1), KRT18(1), LY96(1), PRKCA(1), ROCK1(4), ROCK2(1), TLR5(1), TUBA1C(1), TUBA3C(3), TUBB1(1), TUBB2B(1), TUBB8(1), WAS(1) 25833959 35 35 33 6 5 10 5 12 3 0 0.174 0.487 1.000 169 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(1), ACTG1(2), ARHGEF2(2), ARPC5L(1), CD14(1), CDH1(2), CTNNB1(8), EZR(1), KRT18(1), LY96(1), PRKCA(1), ROCK1(4), ROCK2(1), TLR5(1), TUBA1C(1), TUBA3C(3), TUBB1(1), TUBB2B(1), TUBB8(1), WAS(1) 25833959 35 35 33 6 5 10 5 12 3 0 0.174 0.487 1.000 170 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ALDH1A3(1), ALDH1B1(1), AOC2(2), CNDP1(1), DPYD(4), EHHADH(5), GAD1(1), GAD2(3) 13288318 18 16 18 3 6 4 1 4 3 0 0.267 0.488 1.000 171 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 64 APAF1(1), ATM(13), BAI1(2), CCNE2(1), CCNG1(1), CCNG2(1), FAS(1), GTSE1(1), MDM4(1), PTEN(9), RCHY1(1), RRM2B(1), SERPINB5(1), SESN1(1), SESN2(1), SESN3(1), THBS1(1), TNFRSF10B(1), TP53(23), TSC2(1) 32103586 63 60 61 11 0 15 5 21 22 0 0.327 0.498 1.000 172 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 64 ATM(13), CCNE2(1), CCNG2(1), CCNH(1), CDKN1B(4), CREB3L3(1), E2F3(1), GBA2(1), MCM2(1), MCM3(1), MCM4(1), MCM5(1), MCM6(1), MCM7(1), MYT1(1), NACA(1), POLE(3), RB1(2), RBL1(1), RPA1(1), RPA2(1), TFDP1(1), TFDP2(1), TNXB(5), TP53(23) 38017679 69 55 67 12 9 19 2 23 16 0 0.113 0.499 1.000 173 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(1), HRAS(4), KLK2(1), PIK3CA(7), SHC1(1) 9362527 14 13 12 3 1 3 1 8 1 0 0.480 0.500 1.000 174 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(2), EGFR(4) 8453084 6 6 6 0 2 0 1 3 0 0 0.225 0.500 1.000 175 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR1(1), CCR2(3), CCR4(1), IL12A(1), IL12RB2(1), IL4R(3) 9785701 10 9 10 1 3 2 2 1 2 0 0.184 0.501 1.000 176 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 63 AGPAT2(1), AGPAT3(1), AGPAT4(1), CDS1(1), CHAT(2), DGKD(3), DGKI(4), DGKQ(1), DGKZ(1), ESCO1(4), ESCO2(1), GNPAT(1), GPD1(1), PLA2G2A(1), PLA2G4A(1), PLD1(2), PPAP2A(1), PTDSS1(1) 32036902 28 26 28 2 2 7 5 4 10 0 0.0307 0.509 1.000 177 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(1), CS(2), HAO1(1), MTHFD1(1), MTHFD1L(1) 6610809 6 6 6 0 1 3 0 2 0 0 0.175 0.516 1.000 178 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(1), HDAC9(1), MEF2C(1) 3749643 3 3 3 1 0 0 1 2 0 0 0.814 0.518 1.000 179 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 INPPL1(1), ITPKB(1), OCRL(1), PIK3C2A(1), PIK3CA(7), PIK3CB(2), PIK3CG(1), PLCB1(3), PLCB4(7), PLCG2(1) 21987545 25 22 25 4 3 8 3 9 2 0 0.171 0.525 1.000 180 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGTR1(1), ATF2(2), EGFR(4), HRAS(4), MAP2K4(2), MEF2C(1), PRKCA(1), RAC1(1), SHC1(1), SYT1(1) 16399877 18 17 16 3 3 3 2 10 0 0 0.261 0.527 1.000 181 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(1), PSMA2(1), PSMA6(1) 4314925 3 3 3 0 1 2 0 0 0 0 0.397 0.532 1.000 182 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(1), AKT1(3), CAMK2D(1), HRAS(4), PIK3CA(7), PRKCA(1), RAC1(1), RPS6KA5(2) 14336529 20 18 17 4 1 4 3 12 0 0 0.443 0.535 1.000 183 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(1), MPO(1), TPO(1) 4100566 3 3 3 0 0 2 1 0 0 0 0.410 0.536 1.000 184 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(1), PRKCA(1) 2416383 2 2 2 0 0 0 0 1 1 0 0.864 0.536 1.000 185 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(2), AGTR1(1), NOS3(2) 4801110 5 5 5 0 2 2 0 1 0 0 0.179 0.544 1.000 186 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F2(1), F2R(1), F3(1), F5(4), FGA(4), FGB(1), PROC(1), PROS1(2) 8083283 15 15 15 4 4 3 3 4 1 0 0.641 0.547 1.000 187 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH4(1), ADHFE1(1) 2789302 2 2 2 0 0 1 0 1 0 0 0.581 0.547 1.000 188 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CDC34(1), RB1(2), TFDP1(1) 4071151 4 4 4 0 2 0 0 2 0 0 0.348 0.556 1.000 189 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 CRY1(1), NPAS2(1), PER1(2), PER2(1), PER3(3) 8400979 8 7 8 1 3 4 0 0 1 0 0.270 0.560 1.000 190 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(2), JAK3(2), STAT3(3), TYK2(1) 5764681 8 7 8 2 2 0 1 3 2 0 0.696 0.560 1.000 191 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(2), MAP2(4), PPP1CA(1), PRKAG1(2) 8969268 9 9 9 2 1 1 1 5 1 0 0.562 0.561 1.000 192 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA3(2) 2942673 2 2 2 0 0 1 1 0 0 0 0.518 0.563 1.000 193 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 APC(2), CTNNB1(8) 10544228 10 10 9 2 1 2 2 3 2 0 0.526 0.567 1.000 194 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA2(1), ANXA4(1), ANXA6(2), HSD11B1(1), PLA2G4A(1), PTGS1(2), PTGS2(2), SCGB1A1(1), TBXAS1(1) 10203130 12 12 12 3 1 3 3 2 3 0 0.541 0.570 1.000 195 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNB1(1), JAK1(2), STAT1(1), STAT2(1), TYK2(1) 6160881 6 5 6 1 1 0 0 2 3 0 0.639 0.573 1.000 196 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(1), DNMT1(3), MTNR1B(1), PTAFR(1) 5497433 6 5 6 0 3 3 0 0 0 0 0.0818 0.578 1.000 197 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CDC34(1), RB1(2), TFDP1(1) 4203209 4 4 4 1 2 0 0 2 0 0 0.674 0.583 1.000 198 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 AKT1(3), BRD4(1), INPPL1(1), IRS1(2), PDK1(1), PIK3CA(7), PIK3CD(2), PTEN(9), RPS6KA3(1), SHC1(1), SORBS1(2) 29310594 30 28 29 4 1 6 6 8 9 0 0.185 0.585 1.000 199 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 EPX(1), MPO(1), SHMT2(1), TPO(1) 5804252 4 4 4 1 0 2 1 0 1 0 0.574 0.587 1.000 200 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(1), PPARG(1) 2860956 2 2 2 0 0 0 0 1 1 0 0.582 0.589 1.000 201 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(1), GPR171(1), GPR75(1) 4836125 3 3 3 0 0 1 1 1 0 0 0.462 0.590 1.000 202 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(2), GALNS(1), HEXB(2), LCT(1), NAGLU(1) 7021415 7 6 7 1 2 3 0 1 1 0 0.402 0.591 1.000 203 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(2), FUCA2(1), HEXB(2), LCT(1), MAN2C1(1), NEU4(1) 8137119 8 7 8 2 2 2 0 2 2 0 0.583 0.592 1.000 204 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 HEMK1(1), METTL6(1), PRMT3(2), PRMT5(2) 6884541 6 6 6 4 0 1 0 1 4 0 0.942 0.594 1.000 205 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 ACAT1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), EHHADH(5), GAD1(1), GAD2(3), HMGCL(2), SDHB(1) 12697651 18 15 18 4 3 6 3 2 4 0 0.463 0.601 1.000 206 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 DUSP1(1), IKBKAP(1), LTA(1), NFKB1(2), RELA(2), TANK(1), TNFAIP3(1), TRAF2(1) 11017878 10 9 10 1 4 3 0 2 1 0 0.198 0.611 1.000 207 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(1), HK2(1), HK3(1), PGM3(1) 5032384 4 4 4 0 1 0 1 1 1 0 0.383 0.611 1.000 208 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOC(2), ENO1(2), GCK(1), GOT2(1), GPI(1), HK2(1), HK3(1), PC(1), PDHX(1), PFKL(2), PFKM(2), PFKP(2), PGK1(1), PGK2(1), TPI1(1) 20892986 20 19 20 3 4 4 3 3 6 0 0.130 0.618 1.000 209 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 ITGAL(2), ITGAM(1), ITGB2(1), SELE(2) 5080535 6 6 6 2 2 3 0 1 0 0 0.648 0.618 1.000 210 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(2), GOT2(1) 4087765 3 3 3 0 1 1 0 0 1 0 0.400 0.621 1.000 211 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGEF2(1), COPA(3), GBF1(2), KDELR3(1) 8006623 7 6 7 1 2 2 1 1 1 0 0.398 0.623 1.000 212 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(1), MPO(1), TPO(1) 4737717 3 3 3 0 0 2 1 0 0 0 0.418 0.632 1.000 213 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 GCK(1), HEXB(2), HK2(1), HK3(1), PGM3(1) 8323629 6 6 6 1 1 1 1 1 2 0 0.572 0.637 1.000 214 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 RPE(1), UGT1A1(2), UGT1A3(1), UGT1A7(1), UGT2A3(1), UGT2B11(2), UGT2B15(3), UGT2B28(1), UGT2B7(1) 13456900 13 10 13 2 5 1 2 4 1 0 0.279 0.638 1.000 215 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 DRD2(1), GRM1(4), PLCB1(3), PPP1CA(1), PPP3CA(1) 7901111 10 10 10 3 3 5 0 2 0 0 0.533 0.642 1.000 216 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 ALOX15(2), CYP2C19(2), CYP2C8(2), CYP2J2(1), CYP3A43(2), PLA2G2A(1), PLA2G4A(1) 11774026 11 11 11 2 2 2 2 2 3 0 0.417 0.642 1.000 217 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(1), AOC2(2), CES1(3), DDHD1(2), ESCO1(4), ESCO2(1) 12446979 13 11 13 2 5 1 3 2 2 0 0.348 0.643 1.000 218 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 CRY1(1), PER1(2) 4169325 3 3 3 1 2 1 0 0 0 0 0.730 0.644 1.000 219 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(3), ACOX1(1), ACOX3(1), FADS2(1), FASN(1), PECR(1) 6974104 8 7 8 2 3 0 2 2 1 0 0.549 0.644 1.000 220 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 GRIN1(1), NFKB1(2), RELA(2) 6231374 5 5 5 1 2 1 0 2 0 0 0.549 0.648 1.000 221 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CFL1(1), HRAS(4), LIMK1(1), PLCB1(3), PRKCA(1), ROCK2(1) 12302876 11 9 9 0 2 4 0 4 1 0 0.0721 0.653 1.000 222 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 NFKB1(2), RELA(2) 4850208 4 4 4 1 2 1 0 1 0 0 0.580 0.657 1.000 223 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 DHRS1(1), DHRS7(1), DHRSX(1), HEMK1(1), METTL6(1), PRMT3(2), PRMT5(2) 7390907 9 9 9 4 1 2 0 2 4 0 0.811 0.657 1.000 224 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(1), PSMA2(1), PSMA6(1), PSMD2(1), PSMD6(1) 7904895 5 5 5 0 1 3 0 1 0 0 0.243 0.659 1.000 225 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(2), DYRK1B(1), GLI2(2), GLI3(2), SHH(1) 8191454 8 8 8 2 0 5 0 3 0 0 0.533 0.662 1.000 226 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CSNK2A1(1), HRAS(4), IL6ST(3), JAK1(2), JAK3(2), SHC1(1), STAT3(3) 11681734 16 14 14 4 3 2 1 6 4 0 0.609 0.665 1.000 227 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 PDE1B(1), PLCB1(3) 5473864 4 4 4 0 1 2 0 1 0 0 0.297 0.665 1.000 228 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 SHMT2(1) 2044131 1 1 1 1 0 0 0 0 1 0 0.893 0.670 1.000 229 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ADH4(1), ADHFE1(1), DHRS1(1), DHRS7(1), DHRSX(1), ESCO1(4), ESCO2(1) 12303315 10 9 10 0 3 3 0 2 2 0 0.0786 0.670 1.000 230 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 BAD(1), BRAF(8), DUSP4(1), DUSP9(1), EIF4E(1), NFKB1(2), RPS6KA3(1), SHC1(1) 14520649 16 12 16 2 6 2 1 4 3 0 0.172 0.677 1.000 231 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 DUSP1(1), IKBKAP(1), NFKB1(2), RELA(2), TNFAIP3(1) 8896606 7 7 7 1 2 3 0 1 1 0 0.389 0.678 1.000 232 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAS1(1), ALAS2(1), HMBS(1) 3667461 3 3 3 1 2 0 1 0 0 0 0.745 0.681 1.000 233 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(1), ACPT(1), ALPP(2), CYP3A43(2), DHRS1(1), DHRS7(1), DHRSX(1), PON1(1), PON2(2), PON3(1) 8883597 13 13 13 4 2 3 2 5 1 0 0.586 0.683 1.000 234 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(1), EIF4E(1), FBL(1), GPT(1) 4405972 4 3 4 1 2 1 0 1 0 0 0.644 0.683 1.000 235 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 B4GALT2(1), GAA(1), GANAB(1), GCK(1), HK2(1), HK3(1), LCT(1), MGAM(2), PFKM(2), PFKP(2), PGM3(1) 15953445 14 11 14 2 3 3 2 3 3 0 0.245 0.685 1.000 236 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 LDLR(1), NR1H3(1) 2687096 2 2 2 1 1 1 0 0 0 0 0.837 0.691 1.000 237 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 BCHE(2), CES1(3), UGT1A1(2), UGT1A3(1), UGT1A7(1) 11270070 9 8 9 1 3 1 2 1 2 0 0.278 0.691 1.000 238 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAS1(1), ALAS2(1), HBB(1), HMBS(1) 3750172 4 3 4 1 3 0 1 0 0 0 0.620 0.699 1.000 239 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(1), AGTR1(1), CMA1(1), COL4A1(1), COL4A2(2), COL4A4(2) 12275962 8 8 8 1 1 3 0 2 2 0 0.420 0.700 1.000 240 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLUD2(1) 2244243 1 1 1 0 0 1 0 0 0 0 0.751 0.709 1.000 241 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(1), GOT2(1) 3380751 2 2 2 0 0 2 0 0 0 0 0.558 0.711 1.000 242 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(1), HK2(1), HK3(1), PGM3(1) 5730797 4 4 4 0 1 0 1 1 1 0 0.379 0.712 1.000 243 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(1), IL22(1), JAK1(2), JAK3(2), STAT1(1), STAT3(3), STAT5A(1), STAT5B(1), TYK2(1) 9028839 13 11 13 3 3 2 1 5 2 0 0.540 0.713 1.000 244 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(1) 1603764 1 1 1 0 1 0 0 0 0 0 0.657 0.722 1.000 245 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 EHHADH(5), PECR(1), SLC25A20(1) 8296025 7 6 7 1 3 1 0 1 2 0 0.473 0.727 1.000 246 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNH(1), CDKN1B(4), RB1(2), RBL1(1), TFDP1(1) 7935527 9 9 9 4 2 0 0 3 4 0 0.933 0.729 1.000 247 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(1), EGF(2), EGFR(4), HRAS(4), JAK1(2), MAP2K4(2), PIK3CA(7), PRKCA(1), SHC1(1), STAT1(1), STAT3(3), STAT5A(1) 18412237 29 23 27 5 5 4 2 17 1 0 0.198 0.730 1.000 248 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(2) 2395489 2 2 2 2 0 0 0 1 1 0 0.978 0.734 1.000 249 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(1), MARS(1), MARS2(1), PAPSS2(1), SEPHS1(1) 6086327 5 4 5 1 2 2 0 1 0 0 0.466 0.737 1.000 250 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 CHAT(2) 3413045 2 2 2 0 0 1 0 1 0 0 0.575 0.738 1.000 251 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 IL5RA(1) 2634034 1 1 1 1 0 0 1 0 0 0 0.970 0.740 1.000 252 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(1), GOT2(1), SULT4A1(2) 6182458 4 4 4 1 1 2 0 1 0 0 0.621 0.748 1.000 253 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNH(1), SHH(1) 4282988 2 2 2 1 0 0 0 2 0 0 0.883 0.749 1.000 254 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(2), ARSB(2), FUCA2(1), GALNS(1), HEXB(2), LCT(1), MAN2B1(2), MAN2B2(1), MAN2C1(1), NAGLU(1), NEU4(1), SPAM1(1) 16877655 16 15 16 3 3 7 1 3 2 0 0.290 0.750 1.000 255 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 CS(2), SDHA(1) 4633120 3 3 3 0 1 0 0 2 0 0 0.449 0.750 1.000 256 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 DHFR(1), POLG(1), RRM1(3) 6142170 5 4 5 0 2 1 0 0 2 0 0.309 0.752 1.000 257 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(1), LEPR(1), PRKAA2(2), PRKAG1(2), PRKAG2(1) 7150176 7 7 7 2 1 0 1 5 0 0 0.697 0.755 1.000 258 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(1), HMGCL(2), HMGCS1(2) 3544528 5 5 5 2 0 1 1 1 2 0 0.768 0.757 1.000 259 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(1), CAPNS1(1), EGF(2), EGFR(4), HRAS(4), ITGA1(1), MYLK(3), TLN1(2) 16026238 18 18 16 4 3 2 3 9 1 0 0.455 0.757 1.000 260 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 GRIA2(1) 1841514 1 1 1 1 1 0 0 0 0 0 0.914 0.757 1.000 261 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(1), ACTR3(1), ARPC4(1), RAC1(1), WASF1(1) 4006826 5 5 5 2 0 2 1 1 1 0 0.813 0.761 1.000 262 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 B4GALT2(1), G6PC2(1), GAA(1), GCK(1), HK2(1), HK3(1), LCT(1), MGAM(2), PFKL(2), PFKM(2), PFKP(2), PGM3(1) 18936220 16 14 16 3 3 3 2 4 4 0 0.279 0.761 1.000 263 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 DPYD(4), ENPP1(2), ENPP3(1), PANK1(1) 8528499 8 8 8 2 4 1 0 2 1 0 0.536 0.764 1.000 264 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD34(1), CD8A(1) 3052993 2 2 2 2 0 1 0 0 1 0 0.947 0.771 1.000 265 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD8A(1), IL7(1), IL9(1) 2993126 3 3 3 3 0 1 0 1 1 0 0.968 0.773 1.000 266 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 JAK1(2), STAT1(1) 4062228 3 2 3 1 0 0 0 2 1 0 0.807 0.776 1.000 267 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 JAK1(2), PLA2G2A(1), STAT1(1) 5668112 4 3 4 1 0 1 0 2 1 0 0.702 0.780 1.000 268 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(1), PSMA2(1), PSMA6(1) 6357250 3 3 3 1 1 2 0 0 0 0 0.721 0.782 1.000 269 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2D(1), DAG1(2), ITPKB(1), ITPR1(1), ITPR2(5), PDE6C(1), TF(2) 17586625 13 13 13 2 2 5 2 2 2 0 0.351 0.783 1.000 270 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 CA12(1), CA14(1), CA2(2), CA3(1), CA5A(1), CA6(1), CA8(1), CA9(1), CPS1(2), GLUD2(1), GLUL(1), HAL(1) 10460630 14 14 14 4 1 6 1 3 3 0 0.563 0.784 1.000 271 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 RPE(1), UGT1A1(2), UGT1A3(1), UGT1A7(1), UGT2B15(3) 8666500 8 6 8 2 4 1 0 2 1 0 0.479 0.785 1.000 272 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 SHMT2(1) 2691562 1 1 1 1 0 0 0 0 1 0 0.903 0.785 1.000 273 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 JAK1(2), JAK3(2), PIAS3(1), STAT3(3) 7493719 8 7 8 2 2 0 1 4 1 0 0.680 0.786 1.000 274 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH4(1), ADHFE1(1), AKR1C1(1), ALDH1A3(1), CYP1A1(1), CYP2B6(2), CYP2C19(2), CYP2C8(2), CYP2S1(1), CYP3A43(2), EPHX1(1), GSTA2(2), GSTA3(1), GSTM2(1), GSTM3(1), GSTO2(1), UGT1A1(2), UGT1A3(1), UGT1A7(1), UGT2A3(1), UGT2B11(2), UGT2B15(3), UGT2B28(1), UGT2B7(1) 28278667 33 30 33 5 7 6 5 13 2 0 0.0974 0.803 1.000 275 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(1), CAMK2D(1), CLCA1(1), CLCA2(2), CLCA4(1), CNGA3(1), CNGA4(1), CNGB1(1), GUCA1A(1), PDE1C(1), PRKACA(1) 15008401 12 12 12 2 1 6 1 3 1 0 0.335 0.804 1.000 276 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(1), ALDH1A3(1), ALDH1B1(1), CYP2C19(2), DHRS1(1), DHRS7(1), DHRSX(1), EHHADH(5), ESCO1(4), ESCO2(1) 15216224 18 16 18 3 7 4 0 3 4 0 0.262 0.805 1.000 277 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 TOP2A(1), TOP2B(1) 4402578 2 2 2 1 0 1 0 0 1 0 0.953 0.810 1.000 278 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 GABRA4(1), GPHN(1), UBQLN1(1) 5873875 3 3 3 0 1 0 1 1 0 0 0.480 0.815 1.000 279 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 JAK1(2), JAK3(2), PIAS3(1) 6763430 5 4 5 1 1 0 1 2 1 0 0.652 0.815 1.000 280 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPP(2), DHFR(1), SPR(1) 3204947 4 4 4 4 0 3 0 0 1 0 0.964 0.818 1.000 281 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA4(1) 3892632 1 1 1 0 0 0 1 0 0 0 0.849 0.822 1.000 282 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 LARS(1), LARS2(1) 4936247 2 2 2 0 1 0 0 1 0 0 0.591 0.827 1.000 283 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CAMK1(1), CAMK2D(1), SYT1(1) 5678528 3 3 3 0 1 0 1 1 0 0 0.486 0.833 1.000 284 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(1), DNMT1(3), DNMT3A(1), MARS(1), MARS2(1), MTR(1) 8548666 8 6 8 1 5 1 0 1 1 0 0.236 0.833 1.000 285 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(1), APAF1(1), DAXX(1), FAS(1), FASLG(1), MAPKAPK3(1) 5584717 6 6 6 5 0 1 1 2 2 0 0.993 0.833 1.000 286 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(2), GALNS(1), HEXB(2), LCT(1), NAGLU(1), SPAM1(1) 10019237 8 7 8 2 2 3 1 1 1 0 0.622 0.837 1.000 287 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 PRKCA(1) 3289206 1 1 1 0 0 0 0 1 0 0 0.857 0.838 1.000 288 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 NEK1(1) 3412059 1 1 1 0 0 1 0 0 0 0 0.786 0.839 1.000 289 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BET1(1), GOSR1(1), STX10(1), STX16(1) 8196598 4 4 4 1 1 0 0 2 1 0 0.729 0.841 1.000 290 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(1), AMD1(1), DNMT1(3), DNMT3A(1), MARS(1), MARS2(1), MTR(1) 10177294 9 7 9 1 5 1 0 2 1 0 0.207 0.848 1.000 291 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDK(1) 2416459 1 1 1 1 1 0 0 0 0 0 0.936 0.848 1.000 292 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CAMK1(1), HRAS(4), NCF2(1), NFATC2(1), NFATC4(1), NFKB1(2), PLCB1(3), PPP3CA(1), PPP3CC(1), RAC1(1), RELA(2), SYT1(1) 18733094 19 16 17 3 7 4 1 7 0 0 0.162 0.854 1.000 293 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR3(1), ARPC4(1), PIK3CA(7), RAC1(1) 6620221 10 8 10 3 0 2 1 6 1 0 0.689 0.858 1.000 294 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 CPS1(2) 3839921 2 2 2 2 0 1 0 0 1 0 0.956 0.860 1.000 295 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(1), AKT1(3), DAG1(2), ITPKB(1), ITPR1(1), ITPR2(5), NFKB1(2), NFKBIB(1), PDK1(1), PIK3CB(2), PLD1(2) 22059945 21 18 20 4 4 7 4 3 3 0 0.270 0.865 1.000 296 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 IL12A(1), IL12RB2(1), STAT4(3), TYK2(1) 7177382 6 6 6 2 1 0 1 2 2 0 0.772 0.866 1.000 297 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP2(2) 4154217 2 1 2 1 0 1 0 0 1 0 0.962 0.869 1.000 298 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(1), CDC7(2), MCM2(1), MCM3(1), MCM4(1), MCM5(1), MCM6(1), MCM7(1), NACA(1), POLD3(1), POLE(3), RFC2(1), RFC3(1), RPA1(1), RPA2(1), UBB(1), UBC(1) 24931291 20 15 20 2 6 6 1 5 2 0 0.0575 0.869 1.000 299 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 AKT1(3), BAD(1), CFLAR(1), HRAS(4), IRS1(2), JAK1(2), JAK3(2), PIK3CA(7), SHC1(1), STAT5A(1), STAT5B(1), SYK(2) 17743340 27 23 24 6 3 9 3 10 2 0 0.350 0.874 1.000 300 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(1), HRAS(4), INSR(1), IRS1(2), PIK3CA(7), SHC1(1) 12491819 16 15 14 4 2 3 1 9 1 0 0.539 0.874 1.000 301 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(3), BRAF(8), DDIT4(1), FIGF(1), PIK3CA(7), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIK3R2(1), PIK3R3(1), PRKAA2(2), RPS6KA3(1), RPS6KA6(1), RPS6KB2(1), TSC2(1) 26087517 33 31 32 6 1 9 3 14 6 0 0.230 0.875 1.000 302 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 TRAF2(1) 4089381 1 1 1 0 1 0 0 0 0 0 0.705 0.882 1.000 303 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 IL10RA(1), JAK1(2), STAT1(1), STAT3(3), STAT5A(1) 6003104 8 6 8 2 2 0 0 5 1 0 0.666 0.883 1.000 304 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CAMK1(1), CAMK2D(1), MEF2C(1), PPP3CA(1), PPP3CC(1), SYT1(1) 9908223 6 5 6 0 1 0 2 3 0 0 0.264 0.883 1.000 305 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH4(1), ADHFE1(1), AGPAT2(1), AGPAT3(1), AGPAT4(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), DGKD(3), DGKQ(1), DGKZ(1), GK(1), LCT(1), PNLIPRP1(2), PPAP2A(1) 23611503 20 18 20 3 2 5 4 5 4 0 0.223 0.885 1.000 306 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 FLT3(1), IL9(1) 4065467 2 2 2 3 0 0 0 1 1 0 0.991 0.889 1.000 307 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GH1(1), GHR(2), HRAS(4), INSR(1), IRS1(2), PIK3CA(7), PRKCA(1), SHC1(1), STAT5A(1), STAT5B(1) 16299306 21 17 19 4 4 4 2 10 1 0 0.332 0.891 1.000 308 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(1), IFNB1(1), IL12A(1), ITGAX(3) 9175859 6 6 6 2 1 1 1 0 3 0 0.718 0.893 1.000 309 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(1), BIRC2(1), SCAP(1), SREBF2(1) 8987006 4 4 4 1 0 2 0 2 0 0 0.651 0.893 1.000 310 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 ITGA4(1), ITGAL(2), ITGAM(1), ITGB2(1), SELE(2), SELP(2) 7823955 9 9 9 3 2 3 1 3 0 0 0.727 0.901 1.000 311 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLE(3), POLG(1), POLQ(1) 8236216 5 5 5 1 2 2 0 1 0 0 0.521 0.901 1.000 312 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(2), ACE2(1), AGTR1(1), ANPEP(1), CMA1(1), CTSA(1), ENPEP(1), MAS1(1), MME(2) 10400699 11 11 11 3 3 5 1 2 0 0 0.558 0.903 1.000 313 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(1) 4700525 1 1 1 1 1 0 0 0 0 0 0.964 0.904 1.000 314 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(1), BAD(1), CASP1(1), CD40(1), DAXX(1), FAS(1), FASLG(1), LTA(1), MCL1(1), NFKB1(2), NTRK1(1), TFG(1), TRAF2(1) 21378285 14 13 14 1 5 4 0 2 3 0 0.114 0.906 1.000 315 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 THBS1(1) 3646982 1 1 1 1 0 0 0 1 0 0 0.943 0.906 1.000 316 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 CTSD(1), GREB1(1), MTA1(1), MTA3(1) 5309050 4 4 4 2 2 2 0 0 0 0 0.759 0.907 1.000 317 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(1), BIRC2(1), CFLAR(1), LMNA(1), NFKB1(2), RELA(2), SPTAN1(1), TNFRSF10A(1), TNFRSF10B(1), TRAF2(1) 16397083 12 12 12 2 5 5 0 1 1 0 0.289 0.907 1.000 318 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 GOT2(1) 4281056 1 1 1 0 0 1 0 0 0 0 0.725 0.911 1.000 319 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH4(1), ADHFE1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), ALDOC(2), ENO1(2), GCK(1), GPI(1), HK2(1), HK3(1), PFKM(2), PFKP(2), PGK1(1), PGM3(1), TPI1(1) 24039266 22 19 22 4 5 5 3 5 4 0 0.201 0.912 1.000 320 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH4(1), ADHFE1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), ALDOC(2), ENO1(2), GCK(1), GPI(1), HK2(1), HK3(1), PFKM(2), PFKP(2), PGK1(1), PGM3(1), TPI1(1) 24039266 22 19 22 4 5 5 3 5 4 0 0.201 0.912 1.000 321 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(2), POLR1B(1), POLR1C(1), POLR2B(1), POLR3A(2) 11540660 7 7 7 2 3 1 2 1 0 0 0.646 0.925 1.000 322 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1B(1), ACVRL1(1), AKT1(3), AURKB(1), BMPR1A(1), BMPR2(1), BUB1(1), CDKL2(1), CDS1(1), CLK1(1), CLK2(1), COL4A3BP(1), CSNK2A1(1), CSNK2A2(1), DGKD(3), DGKQ(1), DGKZ(1), INPPL1(1), ITPKB(1), NEK1(1), OCRL(1), PIK3C2A(1), PIK3CA(7), PIK3CB(2), PIK3CG(1), PLCB1(3), PLCB4(7), PLCG2(1), PLK3(3), PRKACA(1), PRKCA(1), PRKCG(1), PRKD1(1), RPS6KA3(1), TGFBR1(1) 55388983 56 49 55 8 6 17 8 20 5 0 0.0372 0.926 1.000 323 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 GBGT1(1), HEXB(2), NAGA(2), ST3GAL1(1) 4969106 6 6 6 4 2 3 0 0 1 0 0.916 0.928 1.000 324 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP2A13(2), CYP2A6(1) 3940625 3 3 3 2 0 2 0 1 0 0 0.861 0.928 1.000 325 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 PRKCA(1) 4709002 1 1 1 1 0 0 0 1 0 0 0.971 0.937 1.000 326 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 MAP3K7(1), NFKB1(2), RELA(2), TNFAIP3(1) 11866380 6 6 6 1 2 1 0 1 2 0 0.552 0.937 1.000 327 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(1), BIRC2(1) 6640164 2 2 2 0 0 2 0 0 0 0 0.569 0.938 1.000 328 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 GBGT1(1), HEXB(2), NAGA(2), ST3GAL1(1) 5275825 6 6 6 4 2 3 0 0 1 0 0.921 0.940 1.000 329 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(1), BIRC2(1), CASP1(1), LMNA(1) 9527513 4 4 4 1 0 3 0 0 1 0 0.729 0.940 1.000 330 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 CAPNS1(1) 4545485 1 1 1 1 0 0 0 1 0 0 0.948 0.942 1.000 331 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(1), HNF4A(1), NR1D2(2), NR1H3(1), NR1I3(2), NR2F1(1), NR5A2(1), PGR(2), PPARG(1) 20515668 12 12 12 1 2 2 1 4 3 0 0.179 0.942 1.000 332 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 CAD(2), CANT1(1), CTPS2(1), DPYD(4), ENTPD3(1), ENTPD6(1), ENTPD8(1), NME1(1), NT5E(1), POLA1(1), POLD3(1), POLE(3), POLR1A(2), POLR1B(1), POLR1C(1), POLR2B(1), POLR3A(2), PRIM2(1), RRM1(3), RRM2B(1), TXNRD1(1), TYMS(1), UCK2(1), UMPS(1), UPP1(1) 39779483 35 27 35 5 12 4 3 11 5 0 0.0693 0.944 1.000 333 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH4(1), ADHFE1(1), AGK(1), AGPAT2(1), AGPAT3(1), AGPAT4(1), ALDH1A3(1), ALDH1B1(1), DAK(1), DGAT2(1), DGKD(3), DGKI(4), DGKQ(1), DGKZ(1), GK(1), LCT(1), MGLL(1), PNLIPRP1(2), PPAP2A(1) 28783072 25 23 25 4 4 4 5 6 6 0 0.208 0.948 1.000 334 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 IFNB1(1), IL12A(1), IL7(1), LTA(1) 6542511 4 4 4 3 1 1 0 0 2 0 0.959 0.948 1.000 335 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD8A(1), ITGAL(2), ITGB2(1), PTPRC(3) 5293080 7 7 7 6 1 3 0 2 1 0 0.975 0.950 1.000 336 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(1), ITGAL(2), ITGB2(1) 4295718 4 4 4 4 1 2 0 0 1 0 0.961 0.950 1.000 337 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(1), HEMK1(1), MARS(1), MARS2(1), METTL6(1), PAPSS2(1), PRMT3(2), PRMT5(2), SEPHS1(1), SEPHS2(2) 12265090 13 12 13 5 2 3 0 4 4 0 0.730 0.951 1.000 338 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(4), PPP1CA(1) 5701401 5 5 5 3 0 0 0 4 1 0 0.923 0.951 1.000 339 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 AKT1(3), BRAF(8), CREBBP(2), DAG1(2), EGR1(1), FRS2(1), MAP2K4(2), MAPK10(1), MAPK9(1), NTRK1(1), PIK3CA(7), PIK3CD(2), RPS6KA3(1), SHC1(1) 25132294 33 29 32 7 4 10 4 10 5 0 0.260 0.956 1.000 340 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 ACOX1(1), CITED2(1), CPT1B(1), CREBBP(2), DUSP1(1), EHHADH(5), FABP1(1), HSD17B4(1), HSPA1A(1), NCOA1(2), NCOR1(6), NR1H3(1), NR2F1(1), NRIP1(2), PIK3CA(7), PRKCA(1), PTGS2(2), RB1(2), RELA(2), SP1(2), STAT5A(1), STAT5B(1) 31113329 44 35 44 9 11 11 1 13 8 0 0.211 0.959 1.000 341 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(1), ACTR3(1), ARPC4(1), NTRK1(1), RAC1(1), WASF1(1), WASF2(1), WASF3(1) 7529058 8 8 8 4 0 4 1 1 2 0 0.920 0.962 1.000 342 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(1), UBE2D1(1), UBE2I(1), UBE2L3(1) 5183827 4 3 4 2 2 2 0 0 0 0 0.858 0.963 1.000 343 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 AKT1(3), BAD(1), BTK(1), INPP5D(1), PDK1(1), PIK3CA(7), PTEN(9), RPS6KA3(1), SHC1(1) 17769333 25 22 24 7 2 5 5 6 7 0 0.729 0.963 1.000 344 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(1), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(1), IFNA21(1), IFNA6(1), PRKAA2(2) 10395665 10 10 10 3 2 2 0 5 1 0 0.719 0.968 1.000 345 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ALDH1A3(1), AOC2(2), DDC(1), EPX(1), ESCO1(4), ESCO2(1), GOT2(1), MAOA(1), MPO(1), TPO(1) 16769574 14 13 14 4 4 4 1 1 4 0 0.595 0.972 1.000 346 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(2), ACSS2(1), ADH4(1), ADHFE1(1), ALDH1A3(1), ALDH1B1(1), ALDOC(2), ENO1(2), G6PC2(1), GCK(1), GPI(1), HK2(1), HK3(1), PFKL(2), PFKM(2), PFKP(2), PGK1(1), PGK2(1), PGM3(1), TPI1(1) 28619988 26 24 26 5 7 4 2 7 6 0 0.179 0.974 1.000 347 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 ARSD(1), ARSE(1), CYP11B2(1), CYP19A1(1), HEMK1(1), HSD11B1(1), HSD3B1(1), HSD3B2(1), METTL6(1), PRMT3(2), PRMT5(2), STS(1), SULT1E1(1), UGT1A1(2), UGT1A3(1), UGT1A7(1), UGT2A3(1), UGT2B11(2), UGT2B15(3), UGT2B28(1), UGT2B7(1) 24694487 27 22 27 7 5 2 2 9 9 0 0.451 0.975 1.000 348 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 PRKCA(1), SYT1(1) 6771094 2 2 2 1 1 0 0 1 0 0 0.840 0.976 1.000 349 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B2(1), ATP6V1C2(3) 7408602 8 7 8 3 4 0 2 1 1 0 0.725 0.977 1.000 350 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B2(1), ATP6V1C2(3) 7408602 8 7 8 3 4 0 2 1 1 0 0.725 0.977 1.000 351 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B2(1), ATP6V1C2(3) 7408602 8 7 8 3 4 0 2 1 1 0 0.725 0.977 1.000 352 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPL13(1), RPL10A(2), RPL11(2), RPL28(1), RPL7(1), RPS10(1) 11230363 8 8 8 3 1 2 0 4 1 0 0.759 0.981 1.000 353 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(1), CAPNS1(1), ITGA1(1), RAC1(1), SPTAN1(1), TLN1(2) 14039613 7 7 7 2 1 0 2 3 1 0 0.665 0.983 1.000 354 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AGXT(1), ASPA(1), CAD(2), DDO(1), GAD1(1), GAD2(3), GOT2(1), GPT(1), PC(1) 12826108 12 12 12 4 2 3 2 2 3 0 0.779 0.983 1.000 355 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 GFPT2(1), GNPNAT1(1), HEXB(2), HK2(1), HK3(1), MTMR2(1), MTMR6(1), NAGK(1), PGM3(1) 14095011 10 10 10 3 1 3 1 3 2 0 0.758 0.984 1.000 356 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 DAB1(2), LRP8(1), RELN(2), VLDLR(1) 6915912 6 6 6 3 1 1 0 3 1 0 0.903 0.984 1.000 357 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB11(2) 7052447 2 2 2 3 1 0 0 0 1 0 0.990 0.985 1.000 358 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(1), HRAS(4), JAK1(2), MAP2K4(2), PIK3CA(7), PRKCA(1), SHC1(1), STAT1(1), STAT3(3), STAT5A(1) 17149505 23 17 21 5 3 4 1 14 1 0 0.371 0.986 1.000 359 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(2), LDLR(1), MBTPS1(1), SCAP(1), SREBF2(1) 5854042 6 6 6 3 0 1 0 4 1 0 0.888 0.987 1.000 360 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH4(1), ADHFE1(1), ALDH1A3(1), ALDH1B1(1) 6525777 4 4 4 2 1 1 0 2 0 0 0.842 0.987 1.000 361 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(1), C6(4), C9(2) 6203052 7 7 7 4 2 4 0 0 1 0 0.910 0.987 1.000 362 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 CFLAR(1), DAXX(1), FAF1(1), LMNA(1), MAP2K4(2), MAP3K7(1), PAK2(1), PRKDC(3), RB1(2), RIPK2(2), SPTAN1(1) 20009069 16 14 16 3 3 3 1 6 3 0 0.439 0.988 1.000 363 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(2), CANT1(1), CTPS2(1), DPYD(4), NME1(1), NT5E(1), POLE(3), POLG(1), POLQ(1), POLR1B(1), POLR2B(1), RRM1(3), TXNRD1(1), TYMS(1), UCK2(1), UMPS(1), UPP1(1) 28166208 25 21 25 5 7 4 1 10 3 0 0.279 0.988 1.000 364 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 PGAP1(1), PIGA(1), PIGO(1), PIGT(1) 11710680 4 4 4 0 1 2 0 1 0 0 0.290 0.988 1.000 365 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT2(1), B3GNT3(1), B3GNT4(1), B4GALT2(1), B4GALT4(1), ST3GAL6(1) 7954625 6 6 6 3 2 1 1 1 0 1 0.901 0.989 1.000 366 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(3), ACAA2(1), ACADSB(1), ACAT1(1), ACOX1(1), ACOX3(1), ADH4(1), ADHFE1(1), ALDH1A3(1), ALDH1B1(1), CPT1B(1), CPT1C(1), EHHADH(5), HSD17B4(1) 24128097 20 16 20 4 5 3 1 6 5 0 0.321 0.989 1.000 367 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(1), CRK(1), DOCK1(1), HGF(3), HRAS(4), ITGA1(1), MET(3), PIK3CA(7), PTEN(9), STAT3(3) 21654970 33 32 31 8 2 3 5 16 7 0 0.578 0.989 1.000 368 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(3), BCR(1), HRAS(4), MAP2K4(2), PIK3CA(7), STAT1(1), STAT5A(1), STAT5B(1) 13856630 20 18 17 5 1 6 2 11 0 0 0.480 0.989 1.000 369 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT2(1), AGPAT3(1), AGPAT4(1), ENPP2(2), PLA2G2A(1), PLA2G4A(1), PLD1(2), PPAP2A(1) 11406026 10 9 10 4 1 3 2 1 3 0 0.807 0.989 1.000 370 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(3), ACAA2(1), ACADSB(1), ACAT1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), AOX1(2), BCKDHA(1), EHHADH(5), HMGCL(2), IVD(1) 17740250 22 17 22 8 4 4 3 4 7 0 0.804 0.990 1.000 371 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), AOC2(2), ASPA(1), CNDP1(1), DDC(1), HAL(1), HARS(1), HDC(1), MAOA(1) 11968004 14 11 14 6 5 4 1 1 3 0 0.820 0.990 1.000 372 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 15 B3GAT3(1), CHPF(1), CHST12(1), CHSY1(1), XYLT1(2) 6711824 6 6 6 3 2 1 1 1 1 0 0.833 0.990 1.000 373 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 IL12A(1), IL12RB2(1), STAT4(3), TYK2(1) 9132156 6 6 6 4 1 0 1 2 2 0 0.954 0.990 1.000 374 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 HMGCS1(2), LSS(1) 6438484 3 3 3 4 1 0 0 1 1 0 0.992 0.990 1.000 375 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACAA1(3), ACOX1(1), ACOX3(1), CPT1B(1), CPT1C(1), CYP7A1(1), CYP8B1(1), EHHADH(5), FABP1(1), FABP2(1), FABP3(1), FABP4(1), FADS2(1), GK(1), MMP1(2), NR1H3(1), PCK2(1), PPARG(1), SLC27A4(1), SLC27A5(1), SLC27A6(1), SORBS1(2), UBC(1) 32178790 31 25 30 6 9 4 1 11 6 0 0.237 0.990 1.000 376 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(3), EBP(1), GGCX(1), LSS(1), TM7SF2(1) 9409730 7 7 7 3 1 3 0 1 2 0 0.857 0.990 1.000 377 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 LMNA(1), MADD(3), MAP2K4(2), MAP3K7(1), PAK2(1), PRKDC(3), RB1(2), SPTAN1(1), TRAF2(1) 19002383 15 12 15 3 6 2 1 3 3 0 0.414 0.991 1.000 378 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 IL12A(1), IL12RB2(1), IL4R(3) 6252386 5 4 5 2 1 0 1 1 2 0 0.816 0.991 1.000 379 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 LTA(1), MAP2K4(2), NFKB1(2), RELA(2), TANK(1), TRAF2(1) 11782062 9 8 9 3 4 2 0 3 0 0 0.646 0.991 1.000 380 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(1), B4GALNT1(1), HEXB(2), LCT(1), ST3GAL1(1), ST6GALNAC4(1), ST6GALNAC5(1), ST8SIA5(1) 8127989 9 7 9 6 3 4 0 1 1 0 0.926 0.991 1.000 381 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT1(3), BAD(1), IL4R(3), IRS1(2), JAK1(2), JAK3(2), PDK1(1), PIK3CA(7), PIK3CD(2), SHC1(1) 17987102 24 21 23 6 2 5 5 8 4 0 0.514 0.991 1.000 382 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 CARS(1), EPRS(1), GARS(1), HARS(1), LARS(1), LARS2(1), MARS(1), MARS2(1), QARS(2) 15815368 10 9 10 2 5 2 0 2 1 0 0.450 0.991 1.000 383 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6V0A1(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B2(1), ATP6V1C2(3) 7874541 8 7 8 4 4 0 2 1 1 0 0.857 0.992 1.000 384 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(1), EPHA4(1), EPHB1(2), ITGA1(1), L1CAM(2), LYN(1), SELP(2) 7758058 10 9 10 6 3 1 2 3 1 0 0.943 0.992 1.000 385 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 BTG1(1), CRY1(1), DAZAP2(1), ETV6(1), GSTM3(1), HERPUD1(1), HSPA8(5), NCOA4(2), NR1D2(2), PER1(2), PER2(1), SF3A3(1), VAPA(2), ZFR(1) 17988363 22 20 22 6 5 3 2 7 5 0 0.654 0.992 1.000 386 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 NFATC2(1) 5959965 1 1 1 1 1 0 0 0 0 0 0.944 0.992 1.000 387 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(2), GRM1(4), GRM2(1), GRM5(1), GRM8(1) 10345592 9 9 9 4 4 2 1 0 2 0 0.760 0.993 1.000 388 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(2), CDH1(2), CREBBP(2), MAP3K7(1), TGFBR1(1) 12666520 8 7 8 4 1 0 1 3 3 0 0.941 0.993 1.000 389 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(2), ANAPC2(1), ANAPC4(1), ANAPC5(1), ANAPC7(1), CDC16(1), CDC20(2), CDC27(1), CUL2(3), CUL3(1), FBXW11(2), FZR1(1), SMURF2(1), TCEB2(1), UBE2D1(1), VHL(2), WWP1(1) 19750993 23 23 23 5 2 5 2 8 6 0 0.547 0.993 1.000 390 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(1), ADCY8(2), ATF4(1), BRAF(8), CACNA1C(2), CAMK2D(1), CREBBP(2), GRIA1(3), GRIA2(1), GRIN1(1), GRIN2A(6), GRIN2B(5), GRM1(4), GRM5(1), HRAS(4), ITPR1(1), ITPR2(5), PLCB1(3), PLCB4(7), PPP1CA(1), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKCA(1), PRKCG(1), RPS6KA3(1), RPS6KA6(1) 48744024 66 59 64 12 9 16 11 20 10 0 0.118 0.993 1.000 391 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(1), ACPT(1), ALPP(2), CYP19A1(1), CYP1A1(1), CYP2A13(2), CYP2A6(1), CYP2B6(2), CYP2C19(2), CYP2C8(2), CYP2J2(1), PON1(1) 14432115 17 16 17 7 0 6 1 7 3 0 0.795 0.994 1.000 392 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 DLG4(1), GRIN1(1), GRIN2A(6), GRIN2B(5), NOS1(1), PPP3CA(1), PPP3CC(1), PRKCA(1), SYT1(1) 12547055 18 18 18 5 3 6 4 4 1 0 0.506 0.995 1.000 393 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(1), ATM(13), BUB1(1), BUB1B(1), CCNE2(1), CCNH(1), CDC14B(1), CDC20(2), CDC6(1), CDC7(2), CDH1(2), E2F3(1), ESPL1(1), HDAC3(2), HDAC6(2), HDAC8(1), MCM2(1), MCM3(1), MCM4(1), MCM5(1), MCM6(1), MCM7(1), MPEG1(1), PLK1(1), PRKDC(3), PTPRA(1), RB1(2), RBL1(1), SMAD4(4), TFDP1(1), TP53(23) 53815202 76 64 74 14 9 19 5 30 13 0 0.143 0.995 1.000 394 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ALDH18A1(1), ARG2(1), CKB(1), CKMT1B(1), CKMT2(1), CPS1(2), PYCR1(1) 8586618 8 7 8 4 3 2 1 1 1 0 0.834 0.995 1.000 395 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR3(1), AKT1(3), ARHGEF11(2), BTK(1), CFL1(1), CFL2(1), INPPL1(1), ITPR1(1), ITPR2(5), LIMK1(1), MYLK(3), MYLK2(3), PAK2(1), PAK6(2), PDK1(1), PIK3CA(7), PIK3CD(2), PIK3CG(1), PTEN(9), ROCK1(4), ROCK2(1), SAG(2), WASF1(1) 34472326 54 47 52 11 7 12 7 15 13 0 0.307 0.995 1.000 396 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ALDH1A3(1), AOC2(2), DDC(1), EPX(1), GOT2(1), MAOA(1), MPO(1), TPO(1) 10728999 9 8 9 4 2 3 1 1 2 0 0.806 0.996 1.000 397 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 DAXX(1), EGF(2), EGFR(4), HRAS(4), MAP2K4(2), NFKB1(2), PRKCA(1), PRKCG(1), RELA(2), SP1(2), TRAF2(1) 24122824 22 21 20 5 5 5 1 10 1 0 0.369 0.996 1.000 398 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1R(2), ETV3(3), HRAS(4), RBL1(1), RBL2(2), SIN3B(2) 12710853 14 12 12 6 2 2 0 7 3 0 0.839 0.996 1.000 399 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR3(1), AKT1(3), DAG1(2), ETFA(1), ITGA9(2), ITPKB(1), ITPR1(1), ITPR2(5), NR1I3(2), PDE3B(1), PIK3CA(7), PIK3CD(2) 23928271 28 27 27 7 1 12 3 8 4 0 0.493 0.996 1.000 400 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(1), CASP1(1), INSR(1), MAGI1(1), MAGI2(1), WWP1(1) 11817584 6 5 6 2 2 2 0 2 0 0 0.728 0.996 1.000 401 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 HRAS(4), MAP2K4(2), PRKCA(1), RAC1(1), SHC1(1), SYT1(1) 13979119 10 9 8 3 1 3 0 6 0 0 0.624 0.997 1.000 402 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(2), CREBBP(2), CTNNB1(8), LEF1(1), TRRAP(3) 16361979 16 16 15 7 2 3 2 5 4 0 0.868 0.997 1.000 403 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ADH4(1), ADHFE1(1), ALDH1A3(1), AOC2(2), AOX1(2), DBH(2), DDC(1), ESCO1(4), ESCO2(1), GOT2(1), HEMK1(1), MAOA(1), METTL6(1), PRMT3(2), PRMT5(2), TPO(1), TYRP1(2) 29207291 26 24 26 9 5 6 0 6 9 0 0.745 0.997 1.000 404 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(2), NFKB1(2), RELA(2), TRAF2(1) 9519873 7 7 7 3 3 1 1 2 0 0 0.803 0.997 1.000 405 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AADAC(1), ACAT1(1), ACSM1(1), ALDH1A3(1), ALDH1B1(1), DDHD1(2), EHHADH(5), GAD1(1), GAD2(3), HMGCL(2), HMGCS1(2), HSD17B4(1) 19937207 21 19 21 6 4 3 3 5 6 0 0.619 0.997 1.000 406 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ACACA(1), ACADSB(1), ACAT1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), EHHADH(5), SUCLG1(1) 16317449 14 12 14 6 3 3 2 2 4 0 0.899 0.997 1.000 407 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(2), CREBBP(2), CSNK2A1(1), CTNNB1(8), MAP3K7(1), WIF1(2) 14473911 16 16 15 5 4 2 2 5 3 0 0.724 0.998 1.000 408 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(1), HRAS(4), PIK3CA(7), PRKCA(1), SHC1(1), STAT1(1), STAT3(3), STAT5A(1), STAT5B(1) 14782116 20 15 18 5 3 4 1 12 0 0 0.501 0.998 1.000 409 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1S(2), C3(1), C6(4), C9(2) 8608283 9 9 9 5 2 4 0 2 1 0 0.911 0.998 1.000 410 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(3), CAMK1(1), IGF1R(2), INSR(1), MEF2C(1), NFATC2(1), PIK3CA(7), PPP3CA(1), PPP3CC(1), SYT1(1) 17070412 19 16 18 5 3 3 3 10 0 0 0.545 0.998 1.000 411 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(1), PIK3CA(7), RAC1(1), SYK(2) 9163580 11 10 11 5 0 3 1 6 1 0 0.898 0.998 1.000 412 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG5(1), B4GALT2(1), DPAGT1(1), FUT8(1), MGAT5(1), ST6GAL1(2) 9768514 7 7 7 3 4 1 1 1 0 0 0.729 0.999 1.000 413 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 80 AKT1(3), APAF1(1), ATM(13), BAD(1), BIRC2(1), CFLAR(1), FAS(1), FASLG(1), IL3RA(1), IRAK2(1), NFKB1(2), NTRK1(1), PIK3CA(7), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIK3R2(1), PIK3R3(1), PPP3CA(1), PPP3CC(1), PRKACA(1), RELA(2), TNFRSF10A(1), TNFRSF10B(1), TP53(23), TRAF2(1) 40969220 72 68 69 15 5 21 4 26 16 0 0.317 0.999 1.000 414 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(1), AASDH(1), AASDHPPT(1), AASS(1), ACAT1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), BBOX1(1), DOT1L(2), EHHADH(5), EHMT2(1), PLOD1(1), PLOD3(1), SHMT2(1) 18191172 22 19 22 7 6 4 3 5 4 0 0.612 0.999 1.000 415 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 CP(3), EPRS(1), HMBS(1), UGT1A1(2), UGT1A3(1), UGT1A7(1), UGT2B15(3) 13511500 12 11 12 7 4 2 1 3 2 0 0.925 0.999 1.000 416 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 CAD(2), CPS1(2), EPRS(1), GAD1(1), GAD2(3), GLUL(1), GOT2(1), GPT(1), QARS(2) 16356644 14 13 14 5 3 4 1 3 3 0 0.743 0.999 1.000 417 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 CAD(2), CPS1(2), EPRS(1), GAD1(1), GAD2(3), GFPT2(1), GLUD2(1), GLUL(1), GNPNAT1(1), GOT2(1), GPT(1), NAGK(1), QARS(2) 19452125 18 17 18 7 3 6 1 4 4 0 0.817 0.999 1.000 418 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ADH4(1), ADHFE1(1), ALDH1A3(1), AOC2(2), AOX1(2), DBH(2), DDC(1), GOT2(1), MAOA(1), TPO(1) 15539269 13 12 13 5 2 4 0 4 3 0 0.790 0.999 1.000 419 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(8), CPEB1(1), EGFR(4), ERBB4(2), ETV6(1), ETV7(1), FMN2(2), NOTCH2(2), NOTCH4(2), PIWIL1(4), PIWIL2(1), PIWIL3(2) 25651351 30 27 30 7 7 5 5 8 5 0 0.450 0.999 1.000 420 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 CD97(1), ELTD1(1), EMR2(3), GHRHR(1), GIPR(1), GLP1R(1), GLP2R(3), GPR64(1), LPHN1(1), LPHN2(1), LPHN3(4), VIPR1(1) 13069231 19 19 19 7 3 1 1 12 2 0 0.795 0.999 1.000 421 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(1), COL4A2(2), COL4A4(2), SLC23A2(1) 12186134 6 6 6 2 1 3 0 0 2 0 0.853 0.999 1.000 422 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 CFL1(1), CHN1(1), LIMK1(1), MYLK(3), NCF2(1), PIK3CA(7), PLD1(2), RAC1(1), TRIO(4), WASF1(1) 17185535 22 19 22 6 4 4 2 9 3 0 0.610 0.999 1.000 423 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ALDH18A1(1), ALDH1A3(1), ALDH1B1(1), AMD1(1), AOC2(2), ARG2(1), CPS1(2), MAOA(1), SAT2(1) 14419327 11 10 11 7 5 2 0 2 2 0 0.951 0.999 1.000 424 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(2), DAG1(2), ITPKB(1), MAP2K4(2), MAPK10(1), MAPK9(1) 14056046 9 8 9 4 2 3 1 1 2 0 0.834 0.999 1.000 425 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AGXT(1), ASPA(1), CAD(2), DDO(1), GAD1(1), GAD2(3), GOT2(1), GPT(1), PC(1) 18608959 12 12 12 4 2 3 2 2 3 0 0.781 0.999 1.000 426 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1S(2), C3(1), C6(4), C9(2), MASP1(1) 10232615 10 10 10 5 2 4 0 3 1 0 0.884 0.999 1.000 427 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 IFNB1(1), IRAK2(1), MAP3K7(1), NFKB1(2), RELA(2) 14517576 7 7 7 5 2 2 0 1 2 0 0.981 0.999 1.000 428 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(1), ATP8A1(1), AVPR1A(3), AVPR1B(1), BRS3(1), CCKAR(1), CCKBR(1), CCR1(1), CCR2(3), CCR4(1), LHCGR(1), MC4R(1), NPY1R(1), NPY2R(2), OPRL1(1), OXTR(1), SSTR1(2), TACR1(1), TACR3(3), TSHR(1) 25728469 28 24 28 8 7 9 3 5 4 0 0.351 1.000 1.000 429 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(2), APAF1(1), BIRC2(1), CFLAR(1), DAXX(1), LMNA(1), NFKB1(2), NUMA1(1), PAK2(1), PRKDC(3), RB1(2), RELA(2), SPTAN1(1), TRAF2(1) 33955858 20 17 20 4 6 6 1 5 2 0 0.350 1.000 1.000 430 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1S(2), C3(1), C6(4), C9(2), MASP1(1), MASP2(1) 10479506 11 11 11 5 2 4 0 4 1 0 0.853 1.000 1.000 431 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(1), COL4A2(2), COL4A4(2), F11(3), F2(1), F2R(1), F5(4), F8(3), FGA(4), FGB(1), PROC(1), PROS1(2) 21744198 25 25 25 7 7 6 3 4 5 0 0.774 1.000 1.000 432 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 AGXT(1), ALAS1(1), ALAS2(1), AOC2(2), CPT1B(1), DAO(1), GARS(1), GLDC(2), MAOA(1), PLCG2(1), SARDH(1), SHMT2(1) 20530391 14 13 14 5 4 0 3 3 4 0 0.801 1.000 1.000 433 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(1), HRAS(4), JAK1(2), JAK3(2), SHC1(1), STAT5A(1), STAT5B(1), SYK(2) 11365117 14 13 12 5 3 5 1 4 1 0 0.685 1.000 1.000 434 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 BRAF(8), CACNA1A(2), GNA12(1), GNA13(1), GNAI2(1), GNAO1(1), GNAZ(1), GRIA1(3), GRIA2(1), GRIA3(1), GRID2(2), GRM1(4), GRM5(1), GUCY1A2(1), GUCY1A3(1), GUCY2C(1), GUCY2F(1), HRAS(4), IGF1R(2), ITPR1(1), ITPR2(5), LYN(1), NOS1(1), NOS3(2), PLA2G2A(1), PLA2G4A(1), PLCB1(3), PLCB4(7), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), PRKCA(1), PRKCG(1), RYR1(2) 54026345 68 54 66 13 10 19 8 21 10 0 0.0863 1.000 1.000 435 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 APC(2), ATF2(2), BMP4(1), BMPR1A(1), BMPR2(1), CTNNB1(8), MAP3K7(1), MEF2C(1), NPPB(1), TGFBR1(1), TGFBR3(1) 17920534 20 18 19 7 2 5 3 7 3 0 0.785 1.000 1.000 436 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(1), HRAS(4), NFATC2(1), NFATC4(1), PPP3CA(1), PPP3CC(1), PRKCA(1), RPS6KA3(1), SYT1(1) 17112407 12 9 10 4 4 1 1 5 1 0 0.680 1.000 1.000 437 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 AGXT(1), ALAS1(1), ALAS2(1), AOC2(2), DAO(1), GARS(1), GLDC(2), MAOA(1), SARDH(1), SHMT2(1), TARS2(1) 20889781 13 12 13 6 5 0 3 1 4 0 0.908 1.000 1.000 438 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSB(2), ARSD(1), ARSE(1), GAL3ST1(1), LCT(1), NEU4(1), PPAP2A(1), SMPD2(2), SPTLC2(1) 11856491 11 11 11 5 2 2 1 5 1 0 0.836 1.000 1.000 439 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 56 BMP4(1), BMP6(1), CSNK1G1(1), CSNK1G3(1), DHH(1), FBXW11(2), GLI1(3), GLI2(2), GLI3(2), HHIP(3), LRP2(2), PRKACA(1), PTCH2(3), SHH(1), STK36(1), WNT2(1), WNT6(1), WNT9A(1) 29940508 28 27 28 7 2 13 1 9 3 0 0.334 1.000 1.000 440 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(3), ACAA2(1), ADH4(1), ADHFE1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), CYP7A1(1) 11430989 12 10 12 5 2 3 1 5 1 0 0.789 1.000 1.000 441 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 AKT1(3), APC(2), CAV3(1), DAG1(2), DLG4(1), ITPR1(1), ITPR2(5), RAC1(1), RYR1(2) 22526372 18 18 17 7 2 5 3 4 4 0 0.827 1.000 1.000 442 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 GALNT10(1), GALNT11(1), GALNT13(1), GALNT14(1), GALNT3(1), GALNT4(1), GALNT8(1), GALNTL5(1), OGT(1), ST3GAL1(1), ST6GALNAC1(1), WBSCR17(1) 15889504 12 11 12 5 1 6 0 3 2 0 0.820 1.000 1.000 443 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG12(1), ALG14(1), ALG5(1), B4GALT2(1), DPAGT1(1), FUT8(1), GANAB(1), MAN1A2(1), MAN2A1(3), MGAT5(1), MGAT5B(1), ST6GAL1(2) 20713763 15 14 15 7 5 1 1 4 4 0 0.913 1.000 1.000 444 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(3), IL13RA1(1), IL4R(3), INPP5D(1), JAK1(2), JAK3(2), PIK3CA(7), SHC1(1), TYK2(1) 18151255 21 19 20 7 1 5 4 8 3 0 0.746 1.000 1.000 445 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(3), APC(2), CTNNB1(8), DACT1(2), DKK1(2), LRP1(1), PTPRA(1), WIF1(2) 19799578 21 20 19 6 2 7 3 7 2 0 0.618 1.000 1.000 446 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(1), AASDHPPT(1), AASS(1), ACAT1(1), ALDH1A3(1), ALDH1B1(1), BBOX1(1), DOT1L(2), EHHADH(5), EHMT2(1), HSD17B4(1), NSD1(1), PLOD1(1), PLOD3(1), SETD1A(1), SETDB1(1), SHMT2(1) 28467156 22 19 22 9 6 4 2 4 6 0 0.832 1.000 1.000 447 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ACACA(1), ACACB(1), ACAT1(1), ACSS1(2), ACSS2(1), ALDH1A3(1), ALDH1B1(1), EHHADH(5), SUCLG1(1) 19532573 14 12 14 7 5 2 1 3 3 0 0.933 1.000 1.000 448 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CDC40(1), CLK2(1), CLK3(2), CPSF2(1), CPSF4(1), CSTF2T(1), CSTF3(1), DDX1(1), DHX16(1), DHX9(1), DNAJC8(1), METTL3(3), NXF1(1), PABPN1(1), PPM1G(2), PRPF3(1), PRPF8(1), RBM17(1), RBM5(1), RNMT(1), SF3A1(1), SF3A3(1), SF3B1(1), SNRPA(1), SNRPA1(1), SNRPN(1), SPOP(38), SUPT5H(1) 51885911 69 62 45 13 7 12 4 40 6 0 0.111 1.000 1.000 449 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1B(1), ADRA1D(2), ADRA2C(1), ADRB2(1), CHRM1(1), CHRM2(2), CHRM3(1), DRD2(1), DRD3(1), HTR1D(1), HTR5A(1), HTR6(1), HTR7(1) 12597329 15 14 15 7 4 7 1 2 1 0 0.769 1.000 1.000 450 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(1), AKT1(3), CPT1B(1), CPT1C(1), G6PC2(1), IRS1(2), JAK1(2), JAK3(2), LEPR(1), MAPK10(1), MAPK9(1), NFKB1(2), NFKBIB(1), PCK2(1), PRKAA2(2), PRKAG1(2), PRKAG2(1), RELA(2), STAT3(3), TRAF2(1), TYK2(1) 40758096 32 27 31 7 8 5 3 13 3 0 0.335 1.000 1.000 451 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 CREBBP(2), IL7(1), IL7R(1), JAK1(2), JAK3(2), PIK3CA(7), STAT5A(1), STAT5B(1) 13716098 17 14 17 5 4 3 2 7 1 0 0.633 1.000 1.000 452 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(1), DLG4(1), F2(1), PLD1(2) 13478352 5 5 5 8 3 0 1 0 1 0 0.999 1.000 1.000 453 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 AGPAT2(1), AGPAT3(1), AGPAT4(1), CDS1(1), CHAT(2), CPT1B(1), DGKD(3), DGKQ(1), DGKZ(1), GNPAT(1), GPD1(1), PLA2G2A(1), PLA2G4A(1), PLCG2(1), PPAP2A(1) 24422789 18 17 18 5 0 5 2 6 5 0 0.605 1.000 1.000 454 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(2), DAXX(1), HRAS(4), MAP2K4(2), MAP3K7(1), MAP3K9(1), MAPKAPK5(1), MEF2C(1), PLA2G4A(1), RAC1(1), RPS6KA5(2), SHC1(1), STAT1(1), TGFBR1(1), TRAF2(1) 17939748 21 21 19 8 1 5 1 12 2 0 0.821 1.000 1.000 455 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CREBBP(2), DUSP1(1), MAP3K7(1), NFKB1(2), RELA(2), TGFBR1(1) 14585889 9 8 9 6 3 2 0 3 1 0 0.968 1.000 1.000 456 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(2), ADCY3(1), ARF4(1), ARF5(1), ATP6V0A1(1), ATP6V0A2(3), ATP6V0D1(1), ATP6V1A(2), ATP6V1C2(3), PLCG2(1), PRKCA(1), SEC61A1(1), SEC61A2(1) 18175362 19 17 19 8 5 3 2 7 2 0 0.802 1.000 1.000 457 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(2), AMY2B(1), ENPP1(2), ENPP3(1), GAA(1), GANAB(1), GBE1(1), GCK(1), GPI(1), GYS1(1), HK2(1), HK3(1), MGAM(2), PGM3(1), PYGL(1), SI(2), UGT1A1(2), UGT1A3(1), UGT1A7(1), UGT2B15(3) 28039418 27 20 27 7 9 4 2 7 5 0 0.469 1.000 1.000 458 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CDS1(1), DGKD(3), DGKI(4), DGKQ(1), DGKZ(1), INPP5B(2), INPP5D(1), INPP5E(2), INPPL1(1), ITPKB(1), ITPR1(1), ITPR2(5), OCRL(1), PI4KA(1), PI4KB(1), PIK3C2A(1), PIK3CA(7), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIK3R2(1), PIK3R3(1), PIP4K2B(1), PIP5K1A(1), PLCB1(3), PLCB4(7), PLCE1(1), PLCG2(1), PLCZ1(1), PRKCA(1), PRKCG(1), PTEN(9), SYNJ1(1), SYNJ2(2) 61186583 70 58 70 13 7 17 10 20 16 0 0.128 1.000 1.000 459 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 250 ACVR1B(1), ACVR2A(1), BMPR1A(1), BMPR1B(1), BMPR2(1), CCL15(1), CCL28(1), CCL7(1), CCR1(1), CCR2(3), CCR4(1), CD40(1), CSF1R(2), CSF2RA(1), EGF(2), EGFR(4), FAS(1), FASLG(1), FLT1(1), FLT3(1), GH1(1), GH2(1), GHR(2), HGF(3), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(1), IFNA21(1), IFNA6(1), IFNB1(1), IL10RA(1), IL12A(1), IL12RB2(1), IL13RA1(1), IL17RA(1), IL17RB(1), IL20(1), IL21(1), IL22(1), IL23A(1), IL3RA(1), IL4R(3), IL5RA(1), IL6ST(3), IL7(1), IL7R(1), IL9(1), INHBA(2), INHBE(1), KDR(4), LEPR(1), LIF(1), LIFR(3), LTA(1), LTBR(2), MET(3), PRLR(2), TGFBR1(1), TNFRSF10A(1), TNFRSF10B(1), TNFRSF11B(1), TNFRSF13B(2), TNFRSF18(1), TNFRSF19(1), TNFRSF21(1), TNFRSF4(1), TNFRSF6B(1), TNFRSF8(1), TNFSF14(1), TNFSF15(1), TPO(1), XCL1(1), XCR1(1) 86988637 100 75 100 19 29 21 7 28 15 0 0.0403 1.000 1.000 460 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 ANKHD1(1), EEF2(1), EIF2AK3(4), EIF4E(1), EIF4G1(3), EIF5B(1) 21547485 11 11 11 8 1 2 1 5 2 0 0.988 1.000 1.000 461 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAS1(1), ALAS2(1), COX10(1), CP(3), EPRS(1), HMBS(1), UGT1A1(2), UGT1A3(1), UGT1A7(1), UGT2A3(1), UGT2B11(2), UGT2B15(3), UGT2B28(1), UGT2B7(1) 20745874 20 17 20 9 6 2 5 5 2 0 0.889 1.000 1.000 462 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(1), POLD3(1), POLE(3), POLG(1), POLG2(1), POLQ(1), PRIM2(1) 19947864 9 8 9 4 2 2 1 2 2 0 0.864 1.000 1.000 463 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(1), GTF2B(1), GTF2E2(1), GTF2H3(1), GTF2I(1), TAF1(1), TAF13(1), TAF1L(5), TAF2(1), TAF4(1), TAF5(1), TAF5L(1), TAF6(2) 17734997 18 14 18 7 8 3 0 6 1 0 0.784 1.000 1.000 464 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(2), CTNNB1(8), DVL3(1), FZD2(3), FZD5(1), FZD6(3), FZD7(1), FZD9(1), LDLR(1), MAPK10(1), MAPK9(1), PPP2R5E(2), PRKCA(1), PRKCG(1), PRKD1(1), RAC1(1), WNT2(1), WNT6(1) 29555223 31 27 30 9 5 11 3 9 3 0 0.490 1.000 1.000 465 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 109 ABL1(1), ANAPC1(2), ANAPC2(1), ANAPC4(1), ANAPC5(1), ANAPC7(1), ATM(13), BUB1(1), BUB1B(1), CCNE2(1), CCNH(1), CDC14B(1), CDC16(1), CDC20(2), CDC27(1), CDC6(1), CDC7(2), CDKN1B(4), CREBBP(2), E2F3(1), ESPL1(1), FZR1(1), MCM2(1), MCM3(1), MCM4(1), MCM5(1), MCM6(1), MCM7(1), PLK1(1), PRKDC(3), RB1(2), RBL1(1), RBL2(2), SMAD2(1), SMAD3(1), SMAD4(4), TFDP1(1), TP53(23) 66804616 86 71 84 17 10 16 6 34 20 0 0.279 1.000 1.000 466 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(3), DUSP1(1), EIF4E(1), MAP2K4(2), MAP3K4(1), MAP3K7(1), MAPKAPK5(1), NFKB1(2) 16328832 12 12 11 5 2 5 1 3 1 0 0.832 1.000 1.000 467 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(3), ACAA2(1), ADH4(1), ADHFE1(1), ALDH1A3(1), ALDH1B1(1), CYP7A1(1), SLC27A5(1) 15531660 10 9 10 5 2 1 0 6 1 0 0.868 1.000 1.000 468 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ARG2(1), CKB(1), CKMT1B(1), CKMT2(1), CPS1(2), DAO(1), EPRS(1), GLUD2(1), GOT2(1), NOS1(1), NOS3(2), P4HA1(1), P4HA2(2), P4HA3(2), PARS2(1), PYCR1(1) 17621763 20 17 20 8 7 7 2 3 1 0 0.706 1.000 1.000 469 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 CAMK2D(1), F2(1), HRAS(4), MYLK(3), PRKCA(1), SHC1(1), STAT1(1), STAT3(3), STAT5A(1), SYT1(1) 20492584 17 14 15 5 5 3 1 8 0 0 0.604 1.000 1.000 470 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(1), AKT1(3), CHRM1(1), FLT1(1), KDR(4), NOS3(2), PDE3B(1), RYR2(7), SYT1(1), TNNI1(1) 19798558 22 19 21 7 8 6 5 1 2 0 0.637 1.000 1.000 471 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSD(1), ARSE(1), GAL3ST1(1), LCT(1), NEU4(1), PPAP2A(1), SGMS1(1), SMPD2(2), SPTLC2(1) 17471896 10 9 10 6 2 2 1 4 1 0 0.921 1.000 1.000 472 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(1), ATP6V0A1(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B2(1), ATP6V1C2(3), ATP7A(1), ATP7B(2), COX10(1), COX7A1(1), NDUFA10(1), NDUFS2(1), SDHA(1), SDHB(1), UQCRC1(1), UQCRFS1(1) 18807063 20 16 20 7 8 4 4 3 1 0 0.659 1.000 1.000 473 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(3), ARHGEF11(2), DLG4(1), GNA13(1), MAP2K4(2), NFKB1(2), NFKBIB(1), PDK1(1), PIK3CB(2), PLD1(2), ROCK1(4), ROCK2(1) 24176880 22 21 20 6 5 5 3 6 3 0 0.527 1.000 1.000 474 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(1), LY96(1), MAP2K4(2), MAP3K7(1), NFKB1(2), RELA(2) 17833754 9 9 9 4 2 3 0 3 1 0 0.834 1.000 1.000 475 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY8(2), CACNA1A(2), CACNA1B(1), GNB3(1), PRKACA(1), SCNN1B(2), TAS2R4(1), TAS2R5(1), TAS2R60(2) 27920857 13 12 13 9 2 1 0 7 3 0 0.987 1.000 1.000 476 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(1), BCR(1), CAPNS1(1), HRAS(4), ITGA1(1), ROCK1(4), SHC1(1), TLN1(2) 23175323 15 14 12 5 0 2 2 9 2 0 0.743 1.000 1.000 477 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 HRAS(4), MAP2K4(2), NFATC2(1), NFATC4(1), NFKB1(2), PIK3CA(7), PPP3CA(1), PPP3CC(1), PRKCA(1), RAC1(1), RELA(2), SHC1(1), SYT1(1), ZAP70(2) 23510077 27 23 25 8 5 7 2 13 0 0 0.562 1.000 1.000 478 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1B(1), ACVR1C(1), ACVR2A(1), ACVRL1(1), BMP4(1), BMP6(1), BMPR1A(1), BMPR1B(1), BMPR2(1), COMP(1), CREBBP(2), DCN(1), FST(1), GDF6(1), INHBA(2), INHBE(1), LTBP1(3), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), RBL1(1), RBL2(2), ROCK1(4), ROCK2(1), RPS6KB2(1), SMAD2(1), SMAD3(1), SMAD4(4), SMAD6(1), SMAD9(1), SMURF2(1), SP1(2), TFDP1(1), TGFBR1(1), THBS1(1), THBS3(1), ZFYVE16(1), ZFYVE9(1) 48704950 52 45 51 11 8 14 5 20 5 0 0.218 1.000 1.000 479 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(1), FCER1A(1), HRAS(4), LYN(1), MAP2K4(2), NFATC2(1), NFATC4(1), PAK2(1), PIK3CA(7), PLA2G4A(1), PPP3CA(1), PPP3CC(1), SHC1(1), SYK(2), SYT1(1) 21165016 26 22 24 8 6 6 2 11 1 0 0.622 1.000 1.000 480 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(1), AKT1(3), CAMK1(1), CREBBP(2), F2(1), HRAS(4), LIF(1), MEF2C(1), NFATC2(1), NFATC4(1), PIK3CA(7), PPP3CA(1), PPP3CC(1), SYT1(1) 25037279 26 23 23 8 6 4 4 12 0 0 0.620 1.000 1.000 481 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 B3GALT2(1), B3GALT4(1), B3GNT2(1), B3GNT3(1), B3GNT4(1), B4GALNT1(1), B4GALT2(1), B4GALT4(1), GBGT1(1), PIGA(1), PIGO(1), PIGT(1), ST3GAL1(1), ST3GAL6(1), ST6GALNAC4(1), ST6GALNAC5(1), ST8SIA5(1) 23853211 17 15 17 9 6 6 1 3 0 1 0.889 1.000 1.000 482 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(2), CREBBP(2), ERCC3(1), GRIP1(1), GTF2A1(1), HDAC3(2), HDAC6(2), MEF2C(1), NRIP1(2) 22398681 14 12 14 5 3 3 1 6 1 0 0.713 1.000 1.000 483 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT1(3), BAD(1), HRAS(4), KDR(4), MAPKAPK3(1), NFATC2(1), NFATC4(1), NOS3(2), PIK3CA(7), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIK3R2(1), PIK3R3(1), PLA2G2A(1), PLA2G4A(1), PLCG2(1), PPP3CA(1), PPP3CC(1), PRKCA(1), PRKCG(1), PTGS2(2), RAC1(1), RAC2(1), RAC3(1), SH2D2A(1), SHC2(1) 35359432 45 37 42 11 9 14 3 15 4 0 0.263 1.000 1.000 484 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 CARS(1), EPRS(1), GARS(1), HARS(1), LARS(1), LARS2(1), MARS(1), MARS2(1), PARS2(1), QARS(2), TARS2(1), VARS(1), VARS2(1) 26718219 14 13 14 6 6 3 0 4 1 0 0.824 1.000 1.000 485 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 CREBBP(2), DLL4(2), DTX1(1), DTX3L(1), DVL3(1), JAG1(1), JAG2(2), MAML1(1), MAML2(1), MAML3(3), MFNG(1), NOTCH2(2), NOTCH4(2), NUMB(1), NUMBL(1), RBPJ(1), SNW1(1) 33968062 24 18 24 9 8 6 0 7 3 0 0.715 1.000 1.000 486 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(3), CAPN3(1), CAPN5(1), CAPN6(1), CAPN7(1), CAPN9(1), CAPNS1(1), CAV3(1), CRK(1), DOCK1(1), GIT2(1), ITGA10(2), ITGA2(2), ITGA2B(1), ITGA3(1), ITGA4(1), ITGA6(1), ITGA8(2), ITGA9(2), ITGAD(2), ITGAL(2), ITGAM(1), ITGAV(1), ITGAX(3), ITGB2(1), ITGB4(1), ITGB5(1), ITGB6(2), MAPK10(1), MYLK2(3), PAK2(1), PAK6(2), PIK3R2(1), RAC1(1), RAC2(1), RAC3(1), ROCK1(4), ROCK2(1), SHC1(1), SORBS1(2), TLN1(2), TNS1(4), VAV2(2), VAV3(3) 65756261 69 58 67 15 9 24 10 18 8 0 0.132 1.000 1.000 487 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(1), ACTR3(1), AKT1(3), BRAF(8), CRK(1), DOCK1(1), GRB7(2), ITGA1(1), ITGA10(2), ITGA2(2), ITGA3(1), ITGA4(1), ITGA6(1), ITGA8(2), ITGA9(2), MAP2K4(2), MAPK10(1), MAPK9(1), MYLK(3), MYLK2(3), PAK2(1), PAK6(2), PIK3CA(7), PIK3CB(2), PLCG2(1), PTEN(9), ROCK1(4), ROCK2(1), SHC1(1), TLN1(2), TLN2(1), WAS(1) 60121518 71 62 69 17 6 17 10 25 13 0 0.391 1.000 1.000 488 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 131 ACTG1(2), AKT1(3), ASH1L(7), CLDN20(1), CLDN9(1), CSNK2A1(1), CSNK2A2(1), CTNNA1(1), CTNNA2(1), CTNNB1(8), EPB41L1(1), EPB41L2(1), EPB41L3(3), EXOC4(2), GNAI2(1), HRAS(4), INADL(2), MAGI1(1), MAGI2(1), MLLT4(2), MPDZ(3), MYH1(3), MYH10(3), MYH11(1), MYH13(1), MYH15(1), MYH4(5), MYH6(5), MYH7(1), MYH7B(1), MYH8(4), MYH9(3), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), PPP2R3A(1), PPP2R3B(1), PPP2R4(1), PRKCA(1), PRKCG(1), PTEN(9), RAB13(1), RRAS2(1), SPTAN1(1), TJP1(2), TJP2(2), TJP3(1), VAPA(2), YES1(1) 95495064 105 77 101 23 17 29 13 27 19 0 0.121 1.000 1.000 489 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADORA3(2), ADRA1B(1), ADRA1D(2), ADRA2C(1), ADRB2(1), AGTR1(1), AVPR1A(3), AVPR1B(1), BRS3(1), CCKAR(1), CCKBR(1), CCR1(1), CCR2(3), CCR4(1), CCRL2(1), CHRM1(1), CHRM2(2), CHRM3(1), CMKLR1(1), CNR1(1), DRD2(1), DRD3(1), F2R(1), GPR17(1), GPR174(1), GPR37L1(3), GPR50(2), GPR83(2), GPR87(3), HCRTR2(2), HTR1D(1), HTR5A(1), HTR6(1), HTR7(1), LHCGR(1), MAS1(1), MC4R(1), MTNR1B(1), NMUR2(1), NPY1R(1), NPY2R(2), OPRL1(1), OR12D3(1), OR1F1(1), OR7A5(2), OXTR(1), P2RY10(1), PTAFR(1), SSTR1(2) 59718654 66 51 66 19 16 26 8 10 6 0 0.178 1.000 1.000 490 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACP1(1), ACTG1(2), ACVR1B(1), ACVR1C(1), CDH1(2), CREBBP(2), CSNK2A1(1), CSNK2A2(1), CTNNA1(1), CTNNA2(1), CTNNB1(8), EGFR(4), FARP2(2), FER(3), IGF1R(2), INSR(1), IQGAP1(3), LEF1(1), LMO7(2), MAP3K7(1), MET(3), MLLT4(2), PTPRB(1), PTPRM(1), PVRL1(1), PVRL2(1), RAC1(1), RAC2(1), RAC3(1), SMAD2(1), SMAD3(1), SMAD4(4), SNAI1(1), SORBS1(2), SSX2IP(1), TCF7L1(1), TCF7L2(1), TGFBR1(1), TJP1(2), WAS(1), WASF1(1), WASF2(1), WASF3(1), YES1(1) 58918941 72 58 71 18 12 16 10 28 6 0 0.325 1.000 1.000 491 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 84 ATF2(2), BRAF(8), DAXX(1), HRAS(4), MAP2K4(2), MAP3K12(3), MAP3K13(1), MAP3K3(1), MAP3K4(1), MAP3K6(1), MAP3K7(1), MAP3K9(1), MAPK10(1), MAPK9(1), MAPKAPK3(1), MAPKAPK5(1), MEF2C(1), NFKB1(2), PAK2(1), RAC1(1), RELA(2), RPS6KA3(1), RPS6KA5(2), RPS6KB2(1), SHC1(1), SP1(2), STAT1(1), TGFBR1(1), TRAF2(1) 46584908 47 38 45 12 9 10 3 18 7 0 0.382 1.000 1.000 492 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(1), AKT1(3), BAD(1), BRAF(8), CAMK2D(1), CDKN1B(4), CRK(1), EGF(2), EGFR(4), ERBB3(2), ERBB4(2), HRAS(4), MAP2K4(2), MAPK10(1), MAPK9(1), NRG2(1), PAK2(1), PAK6(2), PIK3CA(7), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIK3R2(1), PIK3R3(1), PLCG2(1), PRKCA(1), PRKCG(1), RPS6KB2(1), SHC1(1), SHC2(1), STAT5A(1), STAT5B(1) 50477100 63 55 60 16 9 15 5 25 9 0 0.395 1.000 1.000 493 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTG1(2), AKT1(3), ARHGAP5(2), BAD(1), BIRC2(1), BRAF(8), CAV3(1), COL11A1(7), COL11A2(3), COL1A1(1), COL1A2(1), COL3A1(2), COL4A1(1), COL4A2(2), COL4A4(2), COL5A2(1), COL5A3(2), COL6A1(1), COL6A3(5), COL6A6(2), COMP(1), CRK(1), CTNNB1(8), DOCK1(1), EGF(2), EGFR(4), FARP2(2), FIGF(1), FLNB(1), FLNC(2), FLT1(1), FN1(3), HGF(3), HRAS(4), IGF1R(2), ITGA1(1), ITGA10(2), ITGA2(2), ITGA2B(1), ITGA3(1), ITGA4(1), ITGA6(1), ITGA8(2), ITGA9(2), ITGAV(1), ITGB4(1), ITGB5(1), ITGB6(2), KDR(4), LAMA1(2), LAMA2(4), LAMA4(1), LAMA5(2), LAMB1(4), LAMB3(1), LAMC1(3), LAMC2(3), MAPK10(1), MAPK9(1), MET(3), MYLK(3), MYLK2(3), PAK2(1), PAK6(2), PARVB(1), PARVG(1), PDGFD(1), PIK3CA(7), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIK3R2(1), PIK3R3(1), PPP1CA(1), PRKCA(1), PRKCG(1), PTEN(9), RAC1(1), RAC2(1), RAC3(1), RELN(2), ROCK1(4), ROCK2(1), SHC1(1), SHC2(1), THBS1(1), THBS3(1), TLN1(2), TLN2(1), TNC(3), TNN(1), TNXB(5), VAV2(2), VAV3(3), VWF(5) 182130959 205 135 199 51 38 61 23 56 27 0 0.155 1.000 1.000 494 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 247 ACVR1B(1), ACVR1C(1), AKT1(3), ATF2(2), ATF4(1), BRAF(8), CACNA1A(2), CACNA1B(1), CACNA1C(2), CACNA1D(1), CACNA1E(6), CACNA1S(2), CACNA2D1(2), CACNA2D3(1), CACNB1(2), CACNB2(1), CACNB4(1), CACNG7(2), CD14(1), CRK(1), DAXX(1), DUSP1(1), DUSP16(1), DUSP4(1), DUSP7(1), DUSP8(1), DUSP9(1), EGF(2), EGFR(4), FAS(1), FASLG(1), FGF10(1), FGF3(1), FGF4(1), FGF5(1), FGF7(1), FLNB(1), FLNC(2), GNA12(1), HRAS(4), MAP2K4(2), MAP3K12(3), MAP3K13(1), MAP3K3(1), MAP3K4(1), MAP3K6(1), MAP3K7(1), MAPK10(1), MAPK9(1), MAPKAPK3(1), MAPKAPK5(1), MEF2C(1), NF1(1), NFATC2(1), NFATC4(1), NFKB1(2), NTRK1(1), PAK2(1), PLA2G2A(1), PLA2G4A(1), PPM1A(1), PPP3CA(1), PPP3CC(1), PPP5C(1), PRKACA(1), PRKCA(1), PRKCG(1), PTPRR(1), RAC1(1), RAC2(1), RAC3(1), RAPGEF2(2), RASA2(1), RASGRF1(1), RASGRF2(2), RPS6KA3(1), RPS6KA5(2), RPS6KA6(1), RRAS2(1), STK4(1), TAOK1(1), TAOK2(1), TAOK3(1), TGFBR1(1), TP53(23), TRAF2(1) 139844470 144 109 139 39 30 31 11 44 28 0 0.380 1.000 1.000 495 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 203 APC(2), ARHGEF1(2), ARPC4(1), ARPC5L(1), BRAF(8), CD14(1), CFL1(1), CFL2(1), CHRM1(1), CHRM2(2), CHRM3(1), CRK(1), CYFIP1(1), CYFIP2(1), DIAPH3(1), DOCK1(1), EGF(2), EGFR(4), EZR(1), F2(1), F2R(1), FGD1(1), FGF10(1), FGF3(1), FGF4(1), FGF5(1), FGF7(1), FN1(3), GNA12(1), GNA13(1), HRAS(4), IQGAP1(3), IQGAP2(1), ITGA1(1), ITGA10(2), ITGA2(2), ITGA2B(1), ITGA3(1), ITGA4(1), ITGA6(1), ITGA8(2), ITGA9(2), ITGAD(2), ITGAL(2), ITGAM(1), ITGAV(1), ITGAX(3), ITGB2(1), ITGB4(1), ITGB5(1), ITGB6(2), LIMK1(1), LIMK2(1), MSN(1), MYH10(3), MYH9(3), MYLK(3), MYLK2(3), NCKAP1L(1), PAK2(1), PAK6(2), PFN1(1), PFN2(2), PIK3CA(7), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIK3R2(1), PIK3R3(1), PIP4K2B(1), PIP5K1A(1), PPP1CA(1), RAC1(1), RAC2(1), RAC3(1), ROCK1(4), ROCK2(1), RRAS2(1), SLC9A1(1), SSH1(1), SSH2(6), SSH3(2), TIAM1(1), TIAM2(1), VAV2(2), VAV3(3), WAS(1), WASF1(1), WASF2(1) 135485656 149 107 146 35 27 39 19 44 20 0 0.101 1.000 1.000 496 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(1), ADCY2(1), ADCY3(1), ADCY7(1), ADCY8(2), ADRA1B(1), ADRA1D(2), ADRB2(1), AGTR1(1), ATP2A2(2), ATP2B1(1), ATP2B2(3), ATP2B4(3), AVPR1A(3), AVPR1B(1), CACNA1A(2), CACNA1B(1), CACNA1C(2), CACNA1D(1), CACNA1E(6), CACNA1S(2), CAMK2D(1), CCKAR(1), CCKBR(1), CHRM1(1), CHRM2(2), CHRM3(1), CYSLTR1(1), EGFR(4), ERBB3(2), ERBB4(2), F2R(1), GRIN1(1), GRIN2A(6), GRM1(4), GRM5(1), HTR5A(1), HTR6(1), HTR7(1), ITPKB(1), ITPR1(1), ITPR2(5), LHCGR(1), MYLK(3), MYLK2(3), NOS1(1), NOS3(2), OXTR(1), P2RX2(1), P2RX5(1), PDE1B(1), PDE1C(1), PHKA1(1), PHKB(1), PLCB1(3), PLCB4(7), PLCE1(1), PLCG2(1), PLCZ1(1), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKCA(1), PRKCG(1), PTAFR(1), RYR1(2), RYR2(7), RYR3(4), SLC8A1(2), TACR1(1), TACR3(3) 131678937 132 100 132 49 26 38 20 32 16 0 0.869 1.000 1.000 497 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 236 ADORA3(2), ADRA1B(1), ADRA2C(1), ADRB2(1), AGTR1(1), AVPR1A(3), AVPR1B(1), BRS3(1), CCKAR(1), CCKBR(1), CHRM1(1), CHRM2(2), CHRM3(1), CNR1(1), CYSLTR1(1), DRD2(1), DRD3(1), F2(1), F2R(1), GABBR2(1), GABRA4(1), GABRB1(2), GABRB2(1), GABRD(1), GABRE(2), GABRG1(2), GABRR2(1), GH1(1), GH2(1), GHR(2), GHRHR(1), GIPR(1), GLP1R(1), GLP2R(3), GLRA2(1), GLRB(1), GPR50(2), GPR83(2), GRIA1(3), GRIA2(1), GRIA3(1), GRIA4(2), GRID1(2), GRID2(2), GRIK1(1), GRIK3(3), GRIK4(2), GRIN1(1), GRIN2A(6), GRIN2B(5), GRIN3A(2), GRM1(4), GRM2(1), GRM5(1), GRM8(1), HCRTR2(2), HTR1D(1), HTR5A(1), HTR6(1), HTR7(1), LEPR(1), LHCGR(1), MAS1(1), MC4R(1), MTNR1B(1), NMUR2(1), NPY1R(1), NPY2R(2), OPRL1(1), OXTR(1), P2RX2(1), P2RX5(1), P2RY10(1), PRLR(2), PRSS3(1), PTAFR(1), PTH2R(2), RXFP1(1), SSTR1(2), TAAR1(1), TAAR2(1), TAAR6(1), TAAR8(1), TACR1(1), TACR3(3), TSHR(1), VIPR1(1) 109101381 127 90 127 36 31 38 20 25 13 0 0.194 1.000 1.000 498 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 144 APC(2), CACYBP(1), CAMK2D(1), CREBBP(2), CSNK2A1(1), CSNK2A2(1), CTNNB1(8), DAAM1(2), DAAM2(1), DKK1(2), DVL3(1), FBXW11(2), FZD2(3), FZD4(2), FZD5(1), FZD6(3), FZD7(1), FZD9(1), LEF1(1), MAP3K7(1), MAPK10(1), MAPK9(1), NFATC2(1), NFATC4(1), PLCB1(3), PLCB4(7), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), PPP3CA(1), PPP3CC(1), PRICKLE2(1), PRKACA(1), PRKCA(1), PRKCG(1), RAC1(1), RAC2(1), RAC3(1), ROCK1(4), ROCK2(1), SFRP2(1), SMAD2(1), SMAD3(1), SMAD4(4), SOX17(1), TBL1XR1(2), TCF7L1(1), TCF7L2(1), TP53(23), WIF1(2), WNT2(1), WNT6(1), WNT9A(1) 79658980 110 85 106 32 13 32 11 31 23 0 0.648 1.000 1.000 499 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTG1(2), COL11A1(7), COL11A2(3), COL17A1(2), COL1A1(1), COL1A2(1), COL3A1(2), COL4A1(1), COL4A2(2), COL4A4(2), COL5A2(1), COL5A3(2), COL6A1(1), COL6A3(5), COL6A6(2), COMP(1), DSC3(1), DSG1(1), DSG2(2), DSG4(1), FN1(3), GJB5(1), ITGA6(1), ITGB4(1), KRT12(1), KRT13(1), KRT14(1), KRT16(1), KRT18(1), KRT19(1), KRT23(1), KRT25(3), KRT27(3), KRT28(1), KRT5(1), KRT6C(3), KRT72(1), KRT73(1), KRT75(1), KRT78(2), KRT79(1), KRT83(1), KRT84(1), KRT85(1), KRT9(1), LAMA1(2), LAMA2(4), LAMA4(1), LAMA5(2), LAMB1(4), LAMB3(1), LAMC1(3), LAMC2(3), LMNA(1), NES(3), RELN(2), THBS1(1), THBS3(1), TNC(3), TNN(1), TNXB(5), VWF(5) 122045260 116 78 115 34 30 41 8 19 18 0 0.369 1.000 1.000 500 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 COL11A1(7), COL11A2(3), COL1A1(1), COL1A2(1), COL3A1(2), COL4A1(1), COL4A2(2), COL4A4(2), COL5A2(1), COL5A3(2), COL6A1(1), COL6A3(5), COL6A6(2), DAG1(2), FN1(3), FNDC1(2), FNDC3A(1), GP5(2), HSPG2(3), ITGA1(1), ITGA10(2), ITGA2(2), ITGA2B(1), ITGA3(1), ITGA4(1), ITGA6(1), ITGA8(2), ITGA9(2), ITGAV(1), ITGB4(1), ITGB5(1), ITGB6(2), LAMA1(2), LAMA2(4), LAMA4(1), LAMA5(2), LAMB1(4), LAMB3(1), LAMC1(3), LAMC2(3), RELN(2), SDC1(1), SV2A(1), SV2B(1), THBS1(1), THBS3(1), TNC(3), TNN(1), TNXB(5), VWF(5) 109787461 102 71 101 30 24 34 11 21 12 0 0.483 1.000 1.000 501 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(1), CFL1(1), CFL2(1), DPYSL2(1), EFNA3(1), EFNA5(1), EPHA3(5), EPHA4(1), EPHA5(1), EPHA6(2), EPHA7(1), EPHB1(2), EPHB3(1), FES(3), GNAI2(1), HRAS(4), L1CAM(2), LIMK1(1), LIMK2(1), LRRC4C(1), MET(3), NFATC2(1), NFATC4(1), NRP1(1), NTNG1(2), PAK2(1), PAK6(2), PLXNA1(1), PLXNA2(2), PLXNB1(1), PLXNB2(1), PLXNC1(3), PPP3CA(1), PPP3CC(1), RAC1(1), RAC2(1), RAC3(1), ROBO1(4), ROBO2(3), ROBO3(1), ROCK1(4), ROCK2(1), SEMA3A(1), SEMA3D(1), SEMA3E(2), SEMA3F(1), SEMA4C(3), SEMA6A(1), SEMA6C(1), SEMA6D(2), SLIT1(2), SLIT3(2), SRGAP1(2), SRGAP3(2), UNC5A(1), UNC5B(1), UNC5D(1) 96591950 92 68 89 30 18 25 11 27 11 0 0.656 1.000 1.000 502 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 131 ACACA(1), ACACB(1), AKT1(3), BAD(1), BRAF(8), CRK(1), FASN(1), G6PC2(1), GCK(1), GYS1(1), HRAS(4), INPP5D(1), INSR(1), IRS1(2), MAPK10(1), MAPK9(1), PCK2(1), PDE3B(1), PFKL(2), PFKM(2), PFKP(2), PHKA1(1), PHKB(1), PIK3CA(7), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIK3R2(1), PIK3R3(1), PPP1CA(1), PPP1R3A(4), PPP1R3B(2), PRKAA2(2), PRKACA(1), PRKAG1(2), PRKAG2(1), PYGL(1), RPS6KB2(1), SHC1(1), SHC2(1), SOCS4(2), SORBS1(2), TRIP10(1), TSC2(1) 78504540 76 67 73 23 7 20 6 31 12 0 0.647 1.000 1.000 503 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(1), ADCY2(1), ADCY3(1), ADCY7(1), ADCY8(2), ADRA1B(1), ADRA1D(2), ADRB2(1), ANXA6(2), ATP2A2(2), ATP2B1(1), ATP2B2(3), CACNA1A(2), CACNA1B(1), CACNA1C(2), CACNA1D(1), CACNA1E(6), CACNA1S(2), CACNB1(2), CAMK1(1), CAMK2D(1), CHRM1(1), CHRM2(2), CHRM3(1), GJB5(1), GNAI2(1), GNAO1(1), GNAZ(1), GNB3(1), GNB5(2), ITPR1(1), ITPR2(5), MIB1(1), PRKACA(1), PRKCA(1), PRKCG(1), PRKD1(1), RGS10(1), RGS9(1), RYR1(2), RYR2(7), RYR3(4), SLC8A1(2) 91863727 75 60 75 39 10 21 12 19 13 0 0.999 1.000 1.000 504 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 BRAF(8), CD244(1), CD48(4), FAS(1), FASLG(1), HLA-G(1), HRAS(4), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(1), IFNA21(1), IFNA6(1), IFNB1(1), ITGAL(2), ITGB2(1), KIR3DL1(2), LCP2(2), MICB(1), NCR1(2), NCR2(1), NFATC2(1), NFATC4(1), PIK3CA(7), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIK3R2(1), PIK3R3(1), PLCG2(1), PPP3CA(1), PPP3CC(1), PRKCA(1), PRKCG(1), RAC1(1), RAC2(1), RAC3(1), SH3BP2(1), SHC1(1), SHC2(1), SYK(2), TNFRSF10A(1), TNFRSF10B(1), ULBP3(1), VAV2(2), VAV3(3), ZAP70(2) 55694249 78 60 76 23 13 25 6 24 10 0 0.541 1.000 1.000 505 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 151 AKT1(3), CREBBP(2), CSF2RA(1), GH1(1), GH2(1), GHR(2), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(1), IFNA21(1), IFNA6(1), IFNB1(1), IL10RA(1), IL12A(1), IL12RB2(1), IL13RA1(1), IL20(1), IL21(1), IL22(1), IL23A(1), IL3RA(1), IL4R(3), IL5RA(1), IL6ST(3), IL7(1), IL7R(1), IL9(1), JAK1(2), JAK3(2), LEPR(1), LIF(1), LIFR(3), PIAS3(1), PIAS4(1), PIK3CA(7), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIK3R2(1), PIK3R3(1), PRLR(2), SOCS4(2), SPRY3(1), STAT1(1), STAT2(1), STAT3(3), STAT4(3), STAT5A(1), STAT5B(1), TPO(1), TYK2(1) 71558635 79 59 78 21 17 12 10 27 13 0 0.514 1.000 1.000 506 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 110 ARHGAP5(2), CDH5(4), CLDN20(1), CLDN9(1), CTNNA1(1), CTNNA2(1), CTNNB1(8), CYBB(1), EZR(1), GNAI2(1), ITGA4(1), ITGAL(2), ITGAM(1), ITGB2(1), MLLT4(2), MMP2(1), MMP9(2), MSN(1), NCF2(1), PIK3CA(7), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIK3R2(1), PIK3R3(1), PLCG2(1), PRKCA(1), PRKCG(1), RAC1(1), RAC2(1), RAPGEF4(2), ROCK1(4), ROCK2(1), SIPA1(2), VAV2(2), VAV3(3), VCAM1(1) 60946262 67 59 65 21 7 21 8 23 8 0 0.642 1.000 1.000 507 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(1), CADM1(1), CD34(1), CD40(1), CD6(1), CD8A(1), CD8B(1), CDH1(2), CDH2(2), CDH3(2), CDH4(1), CDH5(4), CLDN20(1), CLDN9(1), CNTN2(1), CNTNAP1(4), CNTNAP2(1), HLA-DMB(1), HLA-DQA2(1), HLA-G(1), ICAM3(1), ITGA4(1), ITGA6(1), ITGA8(2), ITGA9(2), ITGAL(2), ITGAM(1), ITGAV(1), ITGB2(1), L1CAM(2), MAG(1), NCAM1(1), NCAM2(2), NEGR1(1), NEO1(1), NRCAM(2), NRXN1(1), NRXN2(1), NRXN3(2), PTPRC(3), PTPRM(1), PVRL1(1), PVRL2(1), SDC1(1), SELE(2), SELP(2), SIGLEC1(1), SPN(1), VCAM1(1), VCAN(4) 72339475 73 57 73 22 14 28 6 15 10 0 0.434 1.000 1.000 508 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(1), ADCY1(1), ADCY2(1), ADCY3(1), ADCY7(1), ADCY8(2), ATF2(2), ATF4(1), ATP2A2(2), CAMK2D(1), DGKZ(1), GBA2(1), GNB3(1), GNB5(2), GSTO1(1), GUCY1A3(1), IGFBP6(1), ITPR1(1), ITPR2(5), MIB1(1), MYLK2(3), NFKB1(2), NOS1(1), NOS3(2), OXTR(1), PLCG2(1), PRKACA(1), PRKCA(1), PRKD1(1), RGS10(1), RGS9(1), RYR1(2), RYR2(7), RYR3(4), SLC8A1(2), SP1(2), TNXB(5) 84868972 65 54 65 37 11 17 11 15 11 0 0.999 1.000 1.000 509 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(1), DMD(2), MYBPC2(2), MYBPC3(1), MYH6(5), MYH7(1), MYH8(4), MYL1(1), MYOM1(1), NEB(5), TNNI1(1), TPM4(1), TTN(43) 66721237 68 52 68 17 16 20 4 19 9 0 0.373 1.000 1.000 510 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(1), ADCY2(1), ADCY3(1), ADCY7(1), ADCY8(2), DRD2(1), EGF(2), EGFR(4), GNAI2(1), GRM1(4), GRM5(1), GUCY1A2(1), GUCY1A3(1), GUCY2C(1), GUCY2F(1), HRAS(4), ITPR1(1), ITPR2(5), PDGFD(1), PLCB1(3), PLCB4(7), PRKACA(1), PRKCA(1), PRKCG(1), TJP1(2), TUBA1C(1), TUBA3C(3), TUBB1(1), TUBB2B(1), TUBB8(1) 65046002 56 49 54 17 9 17 8 15 7 0 0.541 1.000 1.000 511 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(1), ADCY2(1), ADCY3(1), ADCY7(1), ADCY8(2), CAMK2D(1), CREB3L2(1), CREB3L3(1), CREBBP(2), CTNNB1(8), DVL3(1), FZD2(3), FZD4(2), FZD5(1), FZD6(3), FZD7(1), FZD9(1), GNAI2(1), GNAO1(1), HRAS(4), LEF1(1), PLCB1(3), PLCB4(7), PRKACA(1), PRKCA(1), PRKCG(1), TCF7L1(1), TCF7L2(1), TYRP1(2), WNT2(1), WNT6(1), WNT9A(1) 53568543 58 48 55 21 8 24 6 15 5 0 0.740 1.000 1.000 512 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(1), ADCY1(1), ADCY2(1), ADCY3(1), ADCY7(1), ADCY8(2), AK7(1), AMPD1(3), AMPD2(2), APRT(1), ATIC(3), CANT1(1), DGUOK(1), ENPP1(2), ENPP3(1), ENTPD3(1), ENTPD6(1), ENTPD8(1), FHIT(1), GART(1), GUCY1A2(1), GUCY1A3(1), GUCY2C(1), GUCY2F(1), NME1(1), NT5E(1), PAPSS2(1), PDE10A(4), PDE1C(1), PDE3B(1), PDE8A(3), PDE9A(1), POLA1(1), POLD3(1), POLE(3), POLR1A(2), POLR1B(1), POLR1C(1), POLR2B(1), POLR3A(2), PRIM2(1), PRPS1L1(3), RRM1(3), RRM2B(1) 80285268 64 46 64 16 16 15 6 15 12 0 0.265 1.000 1.000 513 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(1), ADCY2(1), ADCY3(1), ADCY7(1), ADCY8(2), ATF4(1), CACNA1C(2), CACNA1D(1), CACNA1S(2), CAMK2D(1), EGFR(4), HRAS(4), ITPR1(1), ITPR2(5), MAP2K4(2), MAP3K3(1), MAP3K4(1), MAPK10(1), MAPK9(1), MMP2(1), PLA2G2A(1), PLA2G4A(1), PLCB1(3), PLCB4(7), PLD1(2), PRKACA(1), PRKCA(1) 62100857 50 46 48 21 10 13 6 14 7 0 0.913 1.000 1.000 514 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(2), AMY2B(1), DDX23(1), DDX41(1), DDX47(3), DDX50(3), ENPP1(2), ENPP3(1), ERCC2(2), ERCC3(1), G6PC2(1), GAA(1), GBE1(1), GCK(1), GPI(1), GYS1(1), HK2(1), HK3(1), MGAM(2), MOV10L1(1), PGM3(1), PYGL(1), RAD54B(2), SETX(3), SI(2), SKIV2L2(3), SMARCA2(1), SMARCA5(3), UGT1A1(2), UGT1A3(1), UGT1A7(1), UGT2A3(1), UGT2B11(2), UGT2B15(3), UGT2B28(1), UGT2B7(1) 60923446 56 42 56 15 12 9 7 22 6 0 0.462 1.000 1.000 515 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 C1S(2), C3(1), C4BPA(1), C6(4), C9(2), CD46(3), CFB(1), CFH(3), CR1(1), F11(3), F13A1(1), F13B(3), F2(1), F2R(1), F3(1), F5(4), F8(3), FGA(4), FGB(1), MASP1(1), MASP2(1), PLAT(1), PLG(2), PROC(1), PROS1(2), SERPIND1(1), VWF(5) 44457614 54 42 54 19 15 13 4 16 6 0 0.799 1.000 1.000 516 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(1), ADCY1(1), ADCY2(1), ADCY3(1), ADCY7(1), ADCY8(2), AMPD1(3), AMPD2(2), APRT(1), ATIC(3), ATP5A1(2), ATP5J(1), CANT1(1), DGUOK(1), ENPP1(2), ENPP3(1), FHIT(1), GART(1), GUCY1A2(1), GUCY1A3(1), GUCY2C(1), GUCY2F(1), NME1(1), NT5E(1), PAPSS2(1), PDE6C(1), PDE8A(3), PDE9A(1), POLE(3), POLG(1), POLQ(1), POLR1B(1), POLR2B(1), PRPS1L1(3), RRM1(3) 63057677 51 42 51 16 11 13 4 14 9 0 0.633 1.000 1.000 517 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 107 ALG12(1), ALG14(1), B3GNT2(1), B4GALT2(1), B4GALT4(1), CHPF(1), CHST12(1), CHSY1(1), DPAGT1(1), EXT1(1), EXT2(4), EXTL1(1), EXTL3(1), FUT8(1), GALNT10(1), GALNT11(1), GALNT13(1), GALNT14(1), GALNT3(1), GALNT4(1), GALNT8(1), GALNTL5(1), GANAB(1), HS6ST1(1), HS6ST2(1), MAN1A2(1), MAN2A1(3), MGAT5(1), MGAT5B(1), NDST2(2), NDST4(4), OGT(1), ST3GAL1(1), ST6GAL1(2), ST6GALNAC1(1), WBSCR17(1), XYLT1(2) 53893162 48 41 48 17 11 14 1 13 9 0 0.751 1.000 1.000 518 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 62 AKT1(3), BTK(1), CARD11(2), CD72(1), CD81(1), FCGR2B(1), HRAS(4), INPP5D(1), LYN(1), NFATC2(1), NFATC4(1), NFKB1(2), NFKBIB(1), PIK3CA(7), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIK3R2(1), PIK3R3(1), PLCG2(1), PPP3CA(1), PPP3CC(1), RAC1(1), RAC2(1), RAC3(1), SYK(2), VAV2(2), VAV3(3) 36607045 47 41 44 19 9 14 4 16 4 0 0.864 1.000 1.000 519 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT1(3), BTK(1), FCER1A(1), GAB2(3), HRAS(4), INPP5D(1), LCP2(2), LYN(1), MAP2K4(2), MAPK10(1), MAPK9(1), PDK1(1), PIK3CA(7), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIK3R2(1), PIK3R3(1), PLA2G2A(1), PLA2G4A(1), PLCG2(1), PRKCA(1), RAC1(1), RAC2(1), RAC3(1), SYK(2), VAV2(2), VAV3(3) 35498629 49 41 46 15 7 16 5 17 4 0 0.591 1.000 1.000 520 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(1), ADCY2(1), ADCY3(1), ADCY7(1), ADCY8(2), AKAP1(1), AKAP11(1), AKAP12(1), AKAP2(3), AKAP3(1), AKAP6(2), AKAP8(1), AKAP9(2), ARHGEF1(2), GNA12(1), GNA13(1), GNAI2(1), GNAO1(1), GNAZ(1), GNB3(1), GNB5(2), HRAS(4), ITPR1(1), PDE1B(1), PDE1C(1), PDE8A(3), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKCA(1), PRKCG(1), PRKD1(1), PRKD3(2), SLC9A1(1) 57545604 47 40 45 13 8 11 5 17 6 0 0.535 1.000 1.000 521 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT1(3), CD14(1), CD40(1), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(1), IFNA21(1), IFNA6(1), IFNB1(1), IL12A(1), LY96(1), MAP2K4(2), MAP3K7(1), MAPK10(1), MAPK9(1), NFKB1(2), PIK3CA(7), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIK3R2(1), PIK3R3(1), RAC1(1), RELA(2), STAT1(1), TBK1(1), TLR5(1), TLR8(1) 44159536 43 39 42 17 7 9 2 17 8 0 0.915 1.000 1.000 522 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 AKT1(3), CARD11(2), CD8A(1), CD8B(1), HRAS(4), LCP2(2), NFATC2(1), NFATC4(1), NFKB1(2), NFKBIB(1), PAK2(1), PAK6(2), PDK1(1), PIK3CA(7), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIK3R2(1), PIK3R3(1), PPP3CA(1), PPP3CC(1), PTPRC(3), VAV2(2), VAV3(3), ZAP70(2) 49971984 48 38 45 21 8 13 5 18 4 0 0.938 1.000 1.000 523 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 63 AKT1(3), BAD(1), CDKN1B(4), EBP(1), ERBB4(2), INPPL1(1), IRS1(2), MET(3), PAK2(1), PAK6(2), PDK1(1), PIK3CA(7), PIK3CD(2), PTEN(9), RPS6KA3(1), SHC1(1), TSC2(1) 38054979 42 36 41 12 5 7 5 11 14 0 0.734 1.000 1.000 524 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 ANPEP(1), CD14(1), CD1B(1), CD1C(2), CD34(1), CD37(1), CD8A(1), CD8B(1), CR1(1), CSF1R(2), CSF2RA(1), DNTT(1), FCER2(1), FCGR1A(1), FLT3(1), GP5(2), IL3RA(1), IL4R(3), IL5RA(1), IL7(1), IL7R(1), ITGA1(1), ITGA2(2), ITGA2B(1), ITGA3(1), ITGA4(1), ITGA6(1), ITGAM(1), MME(2), TPO(1) 40052947 37 35 37 18 5 10 8 8 6 0 0.979 1.000 1.000 525 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 BAD(1), CNR1(1), CREBBP(2), CSNK2A1(1), FCER1A(1), HRAS(4), IFNB1(1), KPNA5(1), MAPK9(1), NFATC2(1), NFATC4(1), NFKBIB(1), NPPB(1), NUP214(1), PPP3CC(1), PTPRC(3), RELA(2), SP1(2), SP3(3), TRAF2(1), TRPV6(1), VAV2(2), VAV3(3), XPO5(3) 44788827 39 34 36 21 11 9 3 12 4 0 0.982 1.000 1.000 526 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(2), ABCA10(1), ABCA12(1), ABCA13(4), ABCA3(1), ABCA4(4), ABCA5(5), ABCA7(3), ABCA8(1), ABCA9(2), ABCB11(2), ABCB5(1), ABCB6(1), ABCB7(1), ABCC10(2), ABCC11(1), ABCC12(1), ABCC4(1), ABCC5(2), ABCC8(1), ABCC9(2), ABCD3(1), ABCG1(1), ABCG8(1) 57980435 42 34 42 21 7 15 4 8 8 0 0.963 1.000 1.000 527 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(3), BAD(1), BCR(1), BTK(1), CD81(1), DAG1(2), INPP5D(1), ITPR1(1), ITPR2(5), LYN(1), NFATC2(1), PDK1(1), PIK3CA(7), PIK3CD(2), PLCG2(1), PPP3CA(1), PPP3CC(1), PTPRC(3), SHC1(1), SYK(2) 36413734 37 34 36 16 5 11 5 12 4 0 0.933 1.000 1.000 528 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT1(3), BCR(1), BTK(1), ITPR1(1), ITPR2(5), LYN(1), PDK1(1), PIK3CA(7), PLCG2(1), PTEN(9), PTPRC(3), RPS6KA3(1), SAG(2), SYK(2) 27162502 38 34 37 15 3 8 5 12 10 0 0.944 1.000 1.000 529 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(7), DOT1L(2), EED(1), EHMT2(1), EZH1(2), HCFC1(1), JMJD4(1), KDM6A(6), MEN1(2), NSD1(1), OGT(1), PAXIP1(1), PPP1CA(1), PRDM2(2), PRDM9(1), PRMT1(1), PRMT5(2), RBBP5(1), SETD1A(1), SETD2(3), SETDB1(1), STK38(1), WHSC1L1(1) 58271677 41 33 41 10 7 8 3 10 13 0 0.577 1.000 1.000 530 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ADORA3(2), CCKBR(1), CCR2(3), CELSR2(2), CHRM2(2), CHRM3(1), EMR2(3), EMR3(1), F2R(1), GHRHR(1), GPR116(1), GPR132(1), GPR133(1), GPR17(1), GPR55(1), GPR84(3), GRM1(4), LPHN2(1), LPHN3(4), TSHR(1) 32697889 35 30 34 14 9 11 3 12 0 0 0.662 1.000 1.000 531 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(2), ATP6V0A1(1), ATP6V0A2(3), ATP6V0D1(1), ATP6V1A(2), ATP6V1B2(1), ATP6V1C2(3), EGFR(4), LYN(1), MAP2K4(2), MAPK10(1), MAPK9(1), MET(3), NFKB1(2), NOD1(1), PLCG2(1), RAC1(1), RELA(2), TCIRG1(1), TJP1(2) 34534831 35 28 35 14 12 5 4 11 3 0 0.804 1.000 1.000 532 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(2), ACTR3(1), AKT1(3), CFL1(1), CFL2(1), FLNC(2), FSCN2(1), FSCN3(1), LIMK1(1), MYLK(3), MYLK2(3), PAK2(1), PAK6(2), PFN1(1), PFN2(2), ROCK1(4), ROCK2(1), WASF1(1) 23497005 31 28 29 10 4 12 5 7 3 0 0.712 1.000 1.000 533 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 ACAT1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), AOC2(2), AOX1(2), CYP19A1(1), CYP1A1(1), CYP2A13(2), CYP2A6(1), CYP2B6(2), CYP2C19(2), CYP2C8(2), CYP2J2(1), DDC(1), EHHADH(5), KYNU(2), MAOA(1), TPH1(1) 27083187 32 28 32 10 5 7 4 8 8 0 0.679 1.000 1.000 534 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(1), ATP5A1(2), ATP5J(1), ATP6V0A1(1), ATP6V0A2(3), ATP6V0D1(1), ATP6V1A(2), ATP6V1B2(1), ATP6V1C2(3), COX10(1), COX7A1(1), CYC1(1), NDUFA10(1), NDUFA13(1), NDUFB9(1), NDUFS2(1), SDHA(1), SDHB(1), SDHC(2), TCIRG1(1), UQCRC1(1), UQCRFS1(1) 27417503 29 26 29 12 6 5 4 8 6 0 0.881 1.000 1.000 535 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(1), ACAT1(1), ALDH1A3(1), ALDH1B1(1), AOC2(2), AOX1(2), CYP1A1(1), DDC(1), EHHADH(5), HEMK1(1), HSD17B4(1), KYNU(2), LNX1(1), MAOA(1), METTL6(1), NFX1(1), PRMT3(2), PRMT5(2), TPH1(1) 29749010 28 26 28 12 6 3 2 5 12 0 0.909 1.000 1.000 536 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPP(2), DDX23(1), DDX41(1), DDX47(3), DDX50(3), DHFR(1), ERCC2(2), ERCC3(1), MOV10L1(1), RAD54B(2), SETX(3), SKIV2L2(3), SMARCA2(1), SMARCA5(3), SPR(1) 30924163 28 26 28 11 2 8 3 12 3 0 0.861 1.000 1.000 537 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F11(3), F13B(3), F2(1), F5(4), F8(3), FGA(4), FGB(1), PLAT(1), PLG(2), SERPINB2(1), VWF(5) 17327633 28 24 28 10 9 6 4 6 3 0 0.802 1.000 1.000 538 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(3), BAD(1), BCR(1), BTK(1), DAG1(2), ITPKB(1), LYN(1), NFKB1(2), NFKBIB(1), PIK3CA(7), PIK3CD(2), PLCG2(1), SHC1(1), SYK(2) 25948337 26 23 25 12 5 10 3 7 1 0 0.891 1.000 1.000 539 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(3), B3GALT4(1), CDR1(1), DGKI(4), IL6ST(3), RPL11(2), RPL28(1), RPL5(1), RPL7(1), RPS10(1), RPS6KA3(1), RPS6KA6(1), RPS6KB2(1), UBB(1), UBC(1) 25784014 23 21 23 11 5 5 2 3 8 0 0.959 1.000 1.000 540 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), AMD1(1), AOC2(2), ARG2(1), CKB(1), CKMT1B(1), CKMT2(1), CPS1(2), DAO(1), GOT2(1), MAOA(1), NOS1(1), NOS3(2), P4HA1(1), P4HA2(2), P4HA3(2), PYCR1(1) 21659262 26 20 26 10 10 7 3 4 2 0 0.721 1.000 1.000 541 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ALDH1A3(1), ALDH1B1(1), AMDHD1(1), AOC2(2), ASPA(1), CNDP1(1), DDC(1), FTCD(1), HAL(1), HARS(1), HDC(1), HEMK1(1), MAOA(1), METTL6(1), PRMT3(2), PRMT5(2), UROC1(2) 19427958 21 18 21 10 5 5 1 2 8 0 0.907 1.000 1.000 542 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ACAA1(3), ACAA2(1), ACAT1(1), ALDH1A3(1), ALDH1B1(1), AOX1(2), BCKDHA(1), EHHADH(5), HMGCL(2), HMGCS1(2), HSD17B4(1), IVD(1) 21173407 21 17 21 10 4 2 2 5 8 0 0.932 1.000 1.000 543 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(2), BCR(1), HRAS(4), LYN(1), PAPPA(2), RAC1(1), RPS6KA3(1), SHC1(1), SYK(2), VAV2(2), VAV3(3) 15717960 20 17 18 10 3 5 2 8 2 0 0.934 1.000 1.000 544 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(1), AKT1(3), BAD(1), IGF1R(2), IL3RA(1), PIK3CA(7) 10815374 15 14 14 5 2 3 2 8 0 0 0.733 1.000 1.000 545 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 DAG1(2), ITPKB(1), LCP2(2), NFKB1(2), NFKBIB(1), PAK2(1), PAK6(2), PTPRC(3), ZAP70(2) 27454769 16 14 16 10 5 7 1 3 0 0 0.967 1.000 1.000 546 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BTK(1), HRAS(4), LYN(1), NFATC2(1), NFATC4(1), PPP3CA(1), PPP3CC(1), PRKCA(1), RAC1(1), SHC1(1), SYK(2), SYT1(1) 18781397 16 12 14 6 5 4 1 6 0 0 0.757 1.000 1.000 547 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(1), C6(4), ITGA4(1), ITGAL(2), ITGB2(1), SELP(2), VCAM1(1) 12217529 12 12 12 7 3 6 1 2 0 0 0.949 1.000 1.000 548 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 F13A1(1), F2(1), F2R(1), FGA(4), FGB(1), PLAT(1), PLG(2), SERPINB2(1) 6598800 12 11 12 5 3 3 2 4 0 0 0.843 1.000 1.000 549 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(1), ACACB(1), ACAT1(1), ACSS1(2), ACSS2(1), ALDH1A3(1), ALDH1B1(1), ME3(1), PC(1), PCK2(1) 23001149 11 11 11 5 3 1 2 5 0 0 0.860 1.000 1.000 550 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(1), ERCC3(1), GTF2B(1), GTF2E2(1), POLR1A(2), POLR1B(1), POLR2B(1), TAF13(1), TAF5(1), TAF6(2) 17230596 12 11 12 7 4 1 2 5 0 0 0.957 1.000 1.000 551 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(1), GTF2A1(1), GTF2B(1), HDAC3(2), NCOA1(2), NCOA2(1), NCOA3(1) 12225140 9 9 9 4 4 3 0 2 0 0 0.754 1.000 1.000 552 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(1), CREBBP(2), PTPRC(3), ZAP70(2) 11306092 8 8 8 7 2 3 0 3 0 0 0.991 1.000 1.000 553 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CR1(1), FCGR2B(1), ITGAL(2), ITGB2(1), PTPRC(3) 7458063 8 8 8 5 3 3 0 2 0 0 0.933 1.000 1.000 554 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(1), CREBBP(2), PTPRC(3), ZAP70(2) 11306092 8 8 8 7 2 3 0 3 0 0 0.991 1.000 1.000 555 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(1), HRAS(4), SHC1(1), STAT5A(1), STAT5B(1) 10516832 8 8 6 4 2 3 0 3 0 0 0.841 1.000 1.000 556 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 HRAS(4), IL3RA(1), SHC1(1), STAT5A(1), STAT5B(1) 8711895 8 8 6 4 1 3 0 4 0 0 0.846 1.000 1.000 557 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(1), ACAT1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), ME3(1), PC(1) 18189660 9 8 9 4 1 2 3 3 0 0 0.861 1.000 1.000 558 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CREBBP(2), HDAC3(2), NFKB1(2), RELA(2) 10981192 8 8 8 5 3 2 0 3 0 0 0.930 1.000 1.000 559 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 NFATC2(1), NFKB1(2), PPP3CA(1), PPP3CC(1), RELA(2), SYT1(1) 13763110 8 8 8 4 4 1 1 2 0 0 0.853 1.000 1.000 560 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(1), ADCY1(1), HRAS(4), MYT1(1) 10076308 7 7 5 5 2 1 1 3 0 0 0.973 1.000 1.000 561 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(1), PRKAA2(2), PRKAG1(2), PRKAG2(1) 7530757 6 6 6 3 2 0 1 3 0 0 0.908 1.000 1.000 562 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 PIK3CA(7) 6325451 7 6 7 5 0 1 1 5 0 0 0.978 1.000 1.000 563 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 ITGA4(1), ITGAL(2), ITGB2(1), SELE(2) 5948612 6 6 6 3 2 2 1 1 0 0 0.883 1.000 1.000 564 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CAPNS1(1), NFATC2(1), PPP3CA(1), PPP3CC(1), PRKCA(1), SYT1(1) 11999370 6 6 6 4 2 0 1 3 0 0 0.935 1.000 1.000 565 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT10(1), GALNT3(1), GALNT4(1), GALNT8(1), ST3GAL1(1), WBSCR17(1) 7095988 6 6 6 3 0 5 0 1 0 0 0.809 1.000 1.000 566 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(2), CETP(1), CYP7A1(1), LDLR(1), LRP1(1), SCARB1(1) 13487550 7 6 7 4 0 4 0 3 0 0 0.913 1.000 1.000 567 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 ITGAL(2), ITGB2(1), PTPRC(3) 5552516 6 6 6 6 1 3 0 2 0 0 0.986 1.000 1.000 568 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(2), NCOA1(2), NCOA2(1), PPARG(1) 9116349 6 5 6 4 3 1 0 2 0 0 0.928 1.000 1.000 569 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 PTPRC(3), ZAP70(2) 4460931 5 5 5 4 0 3 0 2 0 0 0.957 1.000 1.000 570 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(1), ARHGAP5(2), CASP1(1) 6372276 4 4 4 3 0 3 1 0 0 0 0.952 1.000 1.000 571 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(1), ST3GAL1(1), ST6GALNAC2(1), ST6GALNAC4(1) 2770460 4 4 4 3 0 4 0 0 0 0 0.851 1.000 1.000 572 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 NOS3(2), VHL(2) 8344230 4 4 4 4 1 2 1 0 0 0 0.979 1.000 1.000 573 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(1), ACACB(1), FASN(1), OXSM(1) 7690864 4 4 4 4 1 0 1 2 0 0 0.987 1.000 1.000 574 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 LARS(1), LARS2(1), VARS(1), VARS2(1) 9135144 4 4 4 3 1 1 0 2 0 0 0.935 1.000 1.000 575 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT2(1), B4GALT2(1), B4GALT4(1), FUT8(1), ST3GAL1(1) 6130188 5 4 5 6 3 1 0 1 0 0 0.976 1.000 1.000 576 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(2), SPN(1), TNFRSF8(1) 6407805 4 4 4 3 3 1 0 0 0 0 0.887 1.000 1.000 577 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CREBBP(2), NCOA3(1) 10193447 3 3 3 4 1 0 0 2 0 0 0.990 1.000 1.000 578 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 LCT(1), PYGL(1), TPI1(1) 6578672 3 3 3 3 2 1 0 0 0 0 0.927 1.000 1.000 579 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B4GALT2(1), FUT8(1), ST3GAL1(1) 3862639 3 3 3 5 1 1 0 1 0 0 0.992 1.000 1.000 580 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(1), ADRB2(1), PLCE1(1) 7254107 3 3 3 4 2 0 1 0 0 0 0.995 1.000 1.000 581 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 CREBBP(2), NME1(1) 5223874 3 3 3 2 1 1 0 1 0 0 0.905 1.000 1.000 582 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(1), ADRB2(1) 6407639 2 2 2 4 1 0 1 0 0 0 0.999 1.000 1.000 583 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(1), PRKACA(1) 3229945 2 2 2 3 1 0 0 1 0 0 0.996 1.000 1.000 584 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(1), ALDH1B1(1) 4188083 2 2 2 2 1 0 0 1 0 0 0.955 1.000 1.000 585 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 APOBEC3B(1), APOBEC4(1) 3622104 2 2 2 2 1 1 0 0 0 0 0.964 1.000 1.000 586 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(1), LDLR(1) 2626695 2 2 2 3 0 1 1 0 0 0 0.987 1.000 1.000 587 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(2) 7231079 2 2 2 3 1 0 0 1 0 0 0.985 1.000 1.000 588 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(1), POLR2B(1) 6601566 2 2 2 2 0 0 1 1 0 0 0.971 1.000 1.000 589 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 PRKCA(1), PTPRA(1) 4530046 2 2 2 2 0 1 0 1 0 0 0.962 1.000 1.000 590 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 TGFBR1(1), TGFBR3(1) 5217566 2 2 2 3 0 1 0 1 0 0 0.987 1.000 1.000 591 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA10(1), NDUFS2(1) 3420566 2 2 2 2 0 1 0 1 0 0 0.958 1.000 1.000 592 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACAT1(1) 2668750 1 1 1 2 0 0 1 0 0 0 0.993 1.000 1.000 593 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 LSS(1) 5393125 1 1 1 2 1 0 0 0 0 0 0.987 1.000 1.000 594 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT2(1) 3558492 1 1 1 2 0 1 0 0 0 0 0.984 1.000 1.000 595 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(1) 2092805 1 1 1 4 0 0 1 0 0 0 1.000 1.000 1.000 596 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 2723436 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 597 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 1955043 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 598 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 1166609 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 599 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 2505900 0 0 0 2 0 0 0 0 0 0 1.000 1.000 1.000 600 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 3016626 0 0 0 3 0 0 0 0 0 0 1.000 1.000 1.000 601 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 6323233 0 0 0 3 0 0 0 0 0 0 1.000 1.000 1.000 602 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 1495957 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 603 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 2421039 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 604 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 2349470 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 605 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 251649 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 606 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 1106799 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 607 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 1038804 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 608 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 1521609 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 609 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 2088048 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 610 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 3224718 0 0 0 2 0 0 0 0 0 0 1.000 1.000 1.000 611 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 4546828 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 612 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 1901020 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 613 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 845788 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 614 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 1586566 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 615 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 562845 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 616 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 1553474 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000