E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.018 0.087 -9999.0 0.0 -0.267 52.0 52.0 KLHL20 0.005 0.044 0.17 4.0 -0.198 1.0 5.0 CYFIP2 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP -0.009 0.062 0.328 6.0 -9999.0 0.0 6.0 ENAH -0.018 0.086 -9999.0 0.0 -0.267 50.0 50.0 AP1M1 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.026 0.025 0.118 6.0 -9999.0 0.0 6.0 ABI1/Sra1/Nap1 -0.015 0.021 -9999.0 0.0 -0.118 2.0 2.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.048 0.043 0.195 3.0 -0.124 15.0 18.0 RAPGEF1 -0.021 0.079 0.283 4.0 -0.241 45.0 49.0 CTNND1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.008 0.093 -9999.0 0.0 -0.269 55.0 55.0 CRK -0.017 0.077 -9999.0 0.0 -0.259 41.0 41.0 E-cadherin/gamma catenin/alpha catenin 0.044 0.02 -9999.0 0.0 -9999.0 0.0 0.0 alphaE/beta7 Integrin 0.029 0.04 0.189 3.0 -0.155 18.0 21.0 IQGAP1 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.045 0.015 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.017 0.086 -9999.0 0.0 -0.267 49.0 49.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.026 0.016 -9999.0 0.0 -0.116 2.0 2.0 MLLT4 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.048 0.027 0.178 11.0 -0.123 3.0 14.0 PI3K -0.032 0.02 -9999.0 0.0 -0.145 2.0 2.0 ARF6 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.033 0.014 -9999.0 0.0 -9999.0 0.0 0.0 TIAM1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.05 0.025 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 -0.019 0.027 0.114 2.0 -9999.0 0.0 2.0 PIK3R1 0.023 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.023 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GDP -0.008 0.07 0.302 11.0 -9999.0 0.0 11.0 actin cytoskeleton organization 0.008 0.044 0.191 12.0 -0.146 1.0 13.0 CDC42/GDP -0.006 0.073 0.276 16.0 -9999.0 0.0 16.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.012 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ITGB7 0.025 0.018 0.244 3.0 -9999.0 0.0 3.0 RAC1 0.024 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.054 0.027 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.038 0.018 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.005 0.077 0.288 16.0 -9999.0 0.0 16.0 CDC42/GTP/IQGAP1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.01 0.063 0.368 3.0 -9999.0 0.0 3.0 RAC1/GTP/IQGAP1 0.032 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.037 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.008 0.037 0.202 9.0 -0.095 1.0 10.0 NME1 0.03 0.033 0.244 11.0 -9999.0 0.0 11.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.017 0.085 -9999.0 0.0 -0.267 48.0 48.0 regulation of cell-cell adhesion -0.025 0.017 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 -0.005 0.021 0.073 6.0 -0.079 1.0 7.0 Rap1/GTP -0.021 0.037 0.178 11.0 -9999.0 0.0 11.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.055 0.046 0.198 3.0 -0.121 14.0 17.0 CCND1 0.009 0.042 0.228 9.0 -0.115 1.0 10.0 VAV2 -0.004 0.089 0.318 1.0 -0.56 1.0 2.0 RAP1/GDP 0.015 0.053 0.261 8.0 -9999.0 0.0 8.0 adherens junction assembly -0.016 0.083 -9999.0 0.0 -0.26 48.0 48.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.038 0.041 0.177 9.0 -0.126 11.0 20.0 E-cadherin/beta catenin 0.008 0.008 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.019 0.088 -9999.0 0.0 -0.267 52.0 52.0 PIK3CA 0.024 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.003 0.049 0.216 1.0 -0.307 1.0 2.0 E-cadherin/beta catenin/alpha catenin 0.043 0.021 -9999.0 0.0 -9999.0 0.0 0.0 ITGAE 0.024 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.009 0.095 -9999.0 0.0 -0.274 55.0 55.0