Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.002 0.085 0.17 90.0 -0.185 10.0 100.0 KIRREL 0.022 0.014 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.002 0.085 0.186 10.0 -0.17 90.0 100.0 PLCG1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.024 0.007 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.024 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.027 0.081 0.216 2.0 -0.13 88.0 90.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.014 0.07 -9999.0 0.0 -0.167 78.0 78.0 FYN -0.025 0.058 0.213 12.0 -0.13 70.0 82.0 mol:Ca2+ 0.025 0.079 0.209 2.0 -0.129 87.0 89.0 mol:DAG 0.026 0.08 0.212 2.0 -0.129 87.0 89.0 NPHS2 -0.011 0.032 0.232 3.0 -9999.0 0.0 3.0 mol:IP3 0.026 0.08 0.212 2.0 -0.129 87.0 89.0 regulation of endocytosis 0.011 0.068 0.164 9.0 -0.121 88.0 97.0 Nephrin/NEPH1/podocin/Cholesterol 0.017 0.073 0.168 12.0 -0.124 89.0 101.0 establishment of cell polarity 0.002 0.085 0.185 10.0 -0.17 90.0 100.0 Nephrin/NEPH1/podocin/NCK1-2 0.034 0.081 0.252 1.0 -0.123 84.0 85.0 Nephrin/NEPH1/beta Arrestin2 0.012 0.07 0.17 9.0 -0.122 88.0 97.0 NPHS1 0.002 0.047 0.238 11.0 -0.044 42.0 53.0 Nephrin/NEPH1/podocin 0.013 0.07 0.166 13.0 -0.124 92.0 105.0 TJP1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.024 0.007 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.027 0.08 0.216 2.0 -0.129 87.0 89.0 CD2AP 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.028 0.081 0.186 12.0 -0.13 86.0 98.0 GRB2 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.032 0.073 0.22 12.0 -0.156 84.0 96.0 cytoskeleton organization -0.032 0.063 0.198 3.0 -0.168 74.0 77.0 Nephrin/NEPH1 0.007 0.06 0.153 10.0 -0.11 91.0 101.0 Nephrin/NEPH1/ZO-1 0.017 0.076 0.181 10.0 -0.136 88.0 98.0