Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.014 0.011 -9999.0 0.0 -0.162 1.0 1.0 epithelial cell differentiation 0.045 0.022 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.02 0.086 0.366 15.0 -9999.0 0.0 15.0 EGFR 0.021 0.01 -9999.0 0.0 -9999.0 0.0 0.0 EPHA2 0.025 0.019 0.244 3.0 -9999.0 0.0 3.0 MYO6 0.003 0.064 0.169 39.0 -9999.0 0.0 39.0 CTNNB1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.049 0.014 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.138 0.178 -9999.0 0.0 -0.376 175.0 175.0 CTNND1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.01 0.053 0.188 29.0 -9999.0 0.0 29.0 regulation of calcium-dependent cell-cell adhesion -0.009 0.054 0.183 32.0 -9999.0 0.0 32.0 EGF 0.042 0.061 0.244 40.0 -9999.0 0.0 40.0 NCKAP1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.015 0.068 0.337 2.0 -0.348 15.0 17.0 cortical microtubule organization 0.045 0.022 -9999.0 0.0 -9999.0 0.0 0.0 GO:0000145 -0.011 0.05 0.175 29.0 -9999.0 0.0 29.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.05 0.025 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.042 0.029 -9999.0 0.0 -0.127 28.0 28.0 ARF6 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.043 0.057 0.195 3.0 -0.129 39.0 42.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.011 0.033 0.16 11.0 -0.165 2.0 13.0 PVRL2 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.013 0.044 0.191 18.0 -9999.0 0.0 18.0 ARF6/GTP 0.048 0.058 -9999.0 0.0 -0.125 39.0 39.0 CDH1 0.023 0.009 -9999.0 0.0 -9999.0 0.0 0.0 EGFR/EGFR/EGF/EGF 0.024 0.061 -9999.0 0.0 -0.122 54.0 54.0 RhoA/GDP 0.046 0.024 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.008 0.043 0.154 18.0 -9999.0 0.0 18.0 IGF-1R heterotetramer 0.026 0.01 0.244 1.0 -9999.0 0.0 1.0 GIT1 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.026 0.01 0.244 1.0 -9999.0 0.0 1.0 IGF1 0.031 0.041 0.244 17.0 -9999.0 0.0 17.0 DIAPH1 0.022 0.119 -9999.0 0.0 -0.487 20.0 20.0 Wnt receptor signaling pathway -0.045 0.022 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.042 0.028 -9999.0 0.0 -0.126 28.0 28.0 CTNNA1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.008 0.043 0.156 18.0 -9999.0 0.0 18.0 EFNA1 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.018 0.039 0.174 16.0 -9999.0 0.0 16.0 Ephrin A1/EPHA2 0.027 0.049 -9999.0 0.0 -0.116 40.0 40.0 SEC6/SEC8 -0.032 0.016 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.009 0.055 0.185 32.0 -9999.0 0.0 32.0 HGF/MET 0.022 0.059 -9999.0 0.0 -0.14 45.0 45.0 HGF 0.026 0.031 0.244 9.0 -9999.0 0.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.014 0.007 -9999.0 0.0 -9999.0 0.0 0.0 actin cable formation 0.003 0.11 0.349 29.0 -0.211 9.0 38.0 KIAA1543 -0.014 0.044 0.176 22.0 -9999.0 0.0 22.0 KIFC3 -0.014 0.045 0.184 21.0 -9999.0 0.0 21.0 NCK1 0.024 0.007 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.012 0.047 0.187 23.0 -9999.0 0.0 23.0 NCK1/GIT1 0.036 0.011 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.045 0.022 -9999.0 0.0 -9999.0 0.0 0.0 EXOC4 0.023 0.008 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.011 0.051 0.191 26.0 -9999.0 0.0 26.0 PIP5K1C -0.01 0.053 0.189 29.0 -9999.0 0.0 29.0 LIMA1 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.017 0.095 0.377 16.0 -9999.0 0.0 16.0 adherens junction assembly -0.02 0.097 0.278 15.0 -0.466 9.0 24.0 IGF-1R heterotetramer/IGF1 0.032 0.044 0.215 1.0 -0.118 24.0 25.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.037 0.009 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.021 0.01 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 -0.013 0.047 0.188 22.0 -9999.0 0.0 22.0 mol:GTP 0.042 0.056 0.189 3.0 -0.129 39.0 42.0 establishment of epithelial cell apical/basal polarity -0.01 0.092 0.335 22.0 -9999.0 0.0 22.0 cortical actin cytoskeleton stabilization 0.014 0.011 -9999.0 0.0 -0.162 1.0 1.0 regulation of cell-cell adhesion -0.008 0.043 0.154 18.0 -9999.0 0.0 18.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.014 0.007 -9999.0 0.0 -9999.0 0.0 0.0