Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.017 0.144 -9999.0 0.0 -0.627 7.0 7.0 IHH 0.007 0.078 -9999.0 0.0 -0.47 4.0 4.0 SHH Np/Cholesterol/GAS1 -0.111 0.203 -9999.0 0.0 -0.484 33.0 33.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.11 0.202 0.48 33.0 -9999.0 0.0 33.0 SMO/beta Arrestin2 0.014 0.09 -9999.0 0.0 -0.488 2.0 2.0 SMO 0.008 0.094 -9999.0 0.0 -0.517 2.0 2.0 AKT1 0.022 0.053 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.0 0.07 -9999.0 0.0 -0.4 5.0 5.0 ADRBK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.008 0.093 -9999.0 0.0 -0.509 2.0 2.0 STIL -0.049 0.173 -9999.0 0.0 -0.514 2.0 2.0 DHH N/PTCH2 -0.003 0.094 -9999.0 0.0 -0.567 3.0 3.0 DHH N/PTCH1 0.017 0.087 -9999.0 0.0 -0.444 2.0 2.0 PIK3CA 0.01 0.032 -9999.0 0.0 -0.4 1.0 1.0 DHH -0.003 0.077 -9999.0 0.0 -0.4 6.0 6.0 PTHLH 0.015 0.158 -9999.0 0.0 -0.641 8.0 8.0 determination of left/right symmetry 0.008 0.093 -9999.0 0.0 -0.509 2.0 2.0 PIK3R1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.016 0.157 -9999.0 0.0 -0.635 8.0 8.0 IHH N/Hhip -0.027 0.123 -9999.0 0.0 -0.325 22.0 22.0 DHH N/Hhip -0.031 0.109 -9999.0 0.0 -0.273 28.0 28.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.008 0.093 -9999.0 0.0 -0.509 2.0 2.0 pancreas development -0.042 0.139 -9999.0 0.0 -0.399 22.0 22.0 HHAT 0.01 0.032 -9999.0 0.0 -0.4 1.0 1.0 PI3K 0.017 0.022 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.064 0.165 -9999.0 0.0 -0.411 30.0 30.0 somite specification 0.008 0.093 -9999.0 0.0 -0.509 2.0 2.0 SHH Np/Cholesterol/PTCH1 -0.056 0.182 -9999.0 0.0 -0.402 33.0 33.0 SHH Np/Cholesterol/PTCH2 -0.079 0.192 -9999.0 0.0 -0.449 35.0 35.0 SHH Np/Cholesterol/Megalin -0.116 0.231 -9999.0 0.0 -0.49 43.0 43.0 SHH -0.096 0.232 -9999.0 0.0 -0.568 32.0 32.0 catabolic process 0.021 0.088 -9999.0 0.0 -0.5 2.0 2.0 SMO/Vitamin D3 -0.045 0.174 -9999.0 0.0 -0.54 2.0 2.0 SHH Np/Cholesterol/Hhip -0.099 0.194 -9999.0 0.0 -0.467 32.0 32.0 LRP2 -0.062 0.216 -9999.0 0.0 -0.748 15.0 15.0 receptor-mediated endocytosis -0.061 0.186 -9999.0 0.0 -0.57 7.0 7.0 SHH Np/Cholesterol/BOC -0.077 0.186 -9999.0 0.0 -0.449 32.0 32.0 SHH Np/Cholesterol/CDO -0.072 0.188 -9999.0 0.0 -0.455 32.0 32.0 mesenchymal cell differentiation 0.099 0.193 0.463 32.0 -9999.0 0.0 32.0 mol:Vitamin D3 -0.054 0.183 -9999.0 0.0 -0.4 33.0 33.0 IHH N/PTCH2 0.004 0.096 -9999.0 0.0 -0.54 4.0 4.0 CDON 0.01 0.032 -9999.0 0.0 -0.4 1.0 1.0 IHH N/PTCH1 0.023 0.089 -9999.0 0.0 -0.505 2.0 2.0 Megalin/LRPAP1 -0.039 0.167 -9999.0 0.0 -0.567 15.0 15.0 PTCH2 -0.001 0.101 -9999.0 0.0 -0.748 3.0 3.0 SHH Np/Cholesterol -0.078 0.185 -9999.0 0.0 -0.455 32.0 32.0 PTCH1 0.021 0.088 -9999.0 0.0 -0.501 2.0 2.0 HHIP -0.042 0.14 -9999.0 0.0 -0.4 22.0 22.0