Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.014 0.099 -9999.0 0.0 -0.419 7.0 7.0 IHH 0.021 0.076 -9999.0 0.0 -0.433 4.0 4.0 SHH Np/Cholesterol/GAS1 -0.061 0.134 0.179 2.0 -0.244 53.0 55.0 LRPAP1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.061 0.133 0.242 53.0 -0.177 2.0 55.0 SMO/beta Arrestin2 0.022 0.082 -9999.0 0.0 -0.411 2.0 2.0 SMO 0.005 0.074 -9999.0 0.0 -0.365 4.0 4.0 AKT1 0.0 0.106 -9999.0 0.0 -0.408 4.0 4.0 ARRB2 0.024 0.01 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.015 0.069 -9999.0 0.0 -0.371 5.0 5.0 ADRBK1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.006 0.074 -9999.0 0.0 -0.361 4.0 4.0 STIL -0.02 0.113 0.339 1.0 -0.354 2.0 3.0 DHH N/PTCH2 0.022 0.074 -9999.0 0.0 -0.282 9.0 9.0 DHH N/PTCH1 0.025 0.079 -9999.0 0.0 -0.331 3.0 3.0 PIK3CA 0.025 0.031 -9999.0 0.0 -0.371 1.0 1.0 DHH 0.01 0.075 -9999.0 0.0 -0.371 6.0 6.0 PTHLH 0.007 0.119 -9999.0 0.0 -0.724 3.0 3.0 determination of left/right symmetry 0.006 0.074 -9999.0 0.0 -0.361 4.0 4.0 PIK3R1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.007 0.118 -9999.0 0.0 -0.716 3.0 3.0 IHH N/Hhip -0.006 0.121 -9999.0 0.0 -0.302 22.0 22.0 DHH N/Hhip -0.009 0.109 -9999.0 0.0 -0.26 26.0 26.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.006 0.074 -9999.0 0.0 -0.361 4.0 4.0 pancreas development -0.023 0.13 -9999.0 0.0 -0.371 20.0 20.0 HHAT 0.025 0.031 -9999.0 0.0 -0.371 1.0 1.0 PI3K 0.037 0.025 -9999.0 0.0 -0.261 1.0 1.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.046 0.155 -9999.0 0.0 -0.374 30.0 30.0 somite specification 0.006 0.074 -9999.0 0.0 -0.361 4.0 4.0 SHH Np/Cholesterol/PTCH1 -0.021 0.11 -9999.0 0.0 -0.332 3.0 3.0 SHH Np/Cholesterol/PTCH2 -0.028 0.112 0.179 2.0 -0.248 33.0 35.0 SHH Np/Cholesterol/Megalin -0.047 0.134 0.172 2.0 -0.273 40.0 42.0 SHH -0.043 0.141 0.347 3.0 -0.323 30.0 33.0 catabolic process 0.021 0.072 -9999.0 0.0 -0.368 3.0 3.0 SMO/Vitamin D3 -0.02 0.106 -9999.0 0.0 -0.36 3.0 3.0 SHH Np/Cholesterol/Hhip -0.048 0.125 0.179 2.0 -0.244 44.0 46.0 LRP2 -0.037 0.134 -9999.0 0.0 -0.452 15.0 15.0 receptor-mediated endocytosis -0.034 0.112 -9999.0 0.0 -0.383 5.0 5.0 SHH Np/Cholesterol/BOC -0.029 0.112 0.179 2.0 -0.242 34.0 36.0 SHH Np/Cholesterol/CDO -0.023 0.108 0.179 2.0 -0.248 30.0 32.0 mesenchymal cell differentiation 0.048 0.125 0.243 44.0 -0.177 2.0 46.0 mol:Vitamin D3 -0.015 0.119 0.354 1.0 -0.37 2.0 3.0 IHH N/PTCH2 0.028 0.072 -9999.0 0.0 -0.297 7.0 7.0 CDON 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.029 0.074 -9999.0 0.0 -0.371 3.0 3.0 Megalin/LRPAP1 0.003 0.104 -9999.0 0.0 -0.325 15.0 15.0 PTCH2 0.019 0.064 -9999.0 0.0 -0.452 3.0 3.0 SHH Np/Cholesterol -0.033 0.101 -9999.0 0.0 -0.246 30.0 30.0 PTCH1 0.021 0.072 -9999.0 0.0 -0.369 3.0 3.0 HHIP -0.023 0.13 -9999.0 0.0 -0.371 20.0 20.0