rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 ABCB1(1), ATM(5), CDKN1A(2), HIC1(1), HIF1A(1), MDM2(1), TP53(89) 7512770 100 90 86 12 11 13 14 21 41 0 0.00246 <1.00e-15 <2.18e-13 2 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 ARF1(1), CCND1(1), CDK2(1), CDK4(1), CDKN1A(2), CDKN2A(2), MDM2(1), TP53(89) 2970476 98 90 84 4 12 12 11 20 43 0 8.00e-08 <1.00e-15 <2.18e-13 3 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(5), ATR(4), CHEK2(2), TP53(89) 5707218 100 87 86 6 10 14 12 21 43 0 0.000100 1.11e-15 2.18e-13 4 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(2), CDKN2A(2), MDM2(1), MYC(3), PIK3CA(6), PIK3R1(1), POLR1A(1), RAC1(1), RB1(25), TP53(89), TWIST1(1) 7224205 132 103 117 7 13 13 13 23 68 2 6.80e-08 1.89e-15 2.18e-13 5 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 IFNG(1), LIN7A(1), NFKB1(1), RB1(25), RELA(2), TNF(1), TNFRSF1A(1), TP53(89), USH1C(2) 6645294 123 99 109 7 14 14 13 19 61 2 1.93e-07 2.66e-15 2.18e-13 6 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 EGFR(3), IGF1R(2), MYC(3), PRKCA(1), RB1(25), TEP1(3), TERF1(3), TERT(1), TP53(89) 10130981 130 103 116 6 14 14 14 19 67 2 7.49e-09 2.78e-15 2.18e-13 7 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 ATM(5), CCND1(1), CDK2(1), CDK4(1), CDKN1A(2), MDM2(1), RB1(25), TP53(89) 6521754 125 101 111 7 12 13 15 21 62 2 1.24e-06 3.11e-15 2.18e-13 8 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 EIF2S2(1), NFKB1(1), RELA(2), TP53(89) 3632340 93 87 79 6 12 13 10 18 40 0 2.80e-05 3.11e-15 2.18e-13 9 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 MYC(3), SP1(2), SP3(2), TP53(89) 2470479 96 88 82 3 11 13 11 19 42 0 7.50e-08 3.33e-15 2.18e-13 10 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(5), CDC25B(1), CDK2(1), CDK4(1), MYT1(3), RB1(25), TP53(89), WEE1(1) 6298210 126 99 112 10 10 16 17 19 62 2 4.01e-05 3.89e-15 2.18e-13 11 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(4), DAXX(1), PML(1), RARA(1), RB1(25), SIRT1(1), TNF(1), TNFRSF1A(1), TP53(89) 6718971 124 98 110 5 14 12 13 19 64 2 1.12e-08 3.89e-15 2.18e-13 12 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 RB1(25), SP1(2), SP3(2) 2291449 29 27 29 0 0 1 3 1 22 2 0.00946 4.33e-15 2.22e-13 13 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(1), CDK2(1), CUL1(3), RB1(25), TFDP1(1) 3139600 31 28 31 1 2 1 3 1 22 2 0.00645 6.33e-15 2.74e-13 14 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 ATM(5), PRKCA(1), PTK2(3), STAT1(2), TLN1(2), TP53(89) 9931993 102 89 88 7 11 13 14 20 44 0 1.98e-05 6.44e-15 2.74e-13 15 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 42 CASP2(1), CASP8(1), FAS(1), JUN(1), MAP2K4(2), MAPK10(2), MDM2(1), MYC(3), NFKB1(1), RELA(2), RIPK1(2), TNF(1), TNFRSF1A(1), TNFSF10(1), TP53(89), TRADD(1), TRAF2(2) 13618986 112 91 98 12 14 18 13 21 46 0 9.20e-05 6.77e-15 2.74e-13 16 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(2), ATM(5), BRCA1(2), CDKN1A(2), CHEK2(2), JUN(1), MDM2(1), NFKB1(1), RAD50(2), RBBP8(2), RELA(2), TP53(89) 10620380 111 94 97 11 13 19 13 22 44 0 0.000347 7.11e-15 2.74e-13 17 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CDK2(1), CUL1(3), NEDD8(1), RB1(25), TFDP1(1) 3096754 31 28 31 1 2 1 2 1 23 2 0.00670 8.10e-15 2.81e-13 18 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(2), ATM(5), ATR(4), CCNA1(1), CCND1(1), CDK2(1), CDK4(1), CDKN1A(2), CDKN2A(2), RB1(25), TFDP1(1), TGFB1(1), TP53(89) 10860729 135 106 121 8 13 13 17 23 67 2 3.75e-07 8.22e-15 2.81e-13 19 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(5), ATR(4), BRCA1(2), BRCA2(5), CHEK2(2), FANCC(2), RAD17(1), RAD50(2), TP53(89) 15635682 112 96 98 10 11 17 13 23 47 1 0.000437 9.10e-15 2.95e-13 20 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 65 ATM(5), ATR(4), BAI1(4), CASP8(1), CCNB3(1), CCND1(1), CCNG1(1), CDK2(1), CDK4(1), CDKN1A(2), CDKN2A(2), CHEK2(2), DDB2(1), EI24(1), FAS(1), GTSE1(1), IGF1(1), MDM2(1), PTEN(8), RRM2(1), THBS1(3), TNFRSF10B(1), TP53(89), TSC2(4), ZMAT3(1) 23963893 138 106 124 11 17 18 19 33 51 0 9.92e-07 4.76e-14 1.43e-12 21 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CDK2(1), CUL1(3), RB1(25), TFDP1(1) 3054264 30 27 30 2 2 1 2 1 22 2 0.0314 4.88e-14 1.43e-12 22 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(1), CCND1(1), CCNH(1), CDK2(1), CDK4(1), CDKN1A(2), CDKN2A(2), CDKN2D(1), RB1(25), TFDP1(1) 5848032 36 33 36 1 2 2 5 2 23 2 0.00248 5.92e-12 1.66e-10 23 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 GAB1(1), GCK(2), JUN(1), MAP2K4(2), MAP2K5(1), MAP2K7(3), MAP3K11(1), MAP3K12(1), MAP3K13(1), MAP3K4(1), MAP3K5(4), MAP3K7(1), MAP3K9(2), MAPK10(2), MAPK7(1), NFATC3(1), PAPPA(6), TP53(89), TRAF6(2), ZAK(4) 18205437 126 98 112 13 14 22 18 27 45 0 3.15e-05 2.75e-11 7.36e-10 24 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 MAP2K2(1), MAP2K3(2), MAP2K6(2), MAPK1(1), NFKB1(1), PIK3CA(6), PIK3R1(1), RB1(25), RELA(2), SP1(2) 7127215 43 39 42 3 3 3 5 6 24 2 0.0128 3.50e-11 8.98e-10 25 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 58 ALG2(1), BFAR(2), BTK(1), CAD(4), CASP8(1), DAXX(1), DEDD(1), EGFR(3), EPHB2(1), FAF1(2), FAIM2(1), IL1A(1), MAP2K4(2), MAP2K7(3), MAP3K5(4), MAPK1(1), MAPK10(2), MAPK8IP3(3), MET(4), NFAT5(4), NFKB1(1), NFKBIL1(1), PFN2(1), RIPK1(2), ROCK1(1), TP53(89), TPX2(2), TRAF2(2) 26761346 141 111 127 13 16 29 20 25 51 0 1.74e-06 1.48e-09 3.65e-08 26 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 CCND1(1), CDK2(1), CDK4(1), CDKN1A(2), MAPK1(1), NFKB1(1), PAK1(1), PIK3CA(6), PIK3R1(1), RAC1(1), RB1(25), RELA(2), TFDP1(1) 7360569 44 40 43 4 4 4 5 5 24 2 0.0153 3.17e-09 7.50e-08 27 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 65 ATM(5), CCNA1(1), CCND1(1), CCNH(1), CDK2(1), CDK4(1), CDKN1A(2), CDKN2A(2), CDKN2D(1), CREB3L1(1), CREB3L3(1), E2F3(1), E2F4(2), E2F5(1), E2F6(1), GBA2(3), MCM3(3), MCM4(1), MCM5(1), MCM7(2), MDM2(1), MYC(3), MYT1(3), NACA(2), POLE(5), POLE2(1), RB1(25), RPA1(1), TFDP1(1), TFDP2(1), TNXB(6), TP53(89), WEE1(1) 28030618 171 117 157 21 19 26 26 29 69 2 1.09e-05 4.40e-09 1.00e-07 28 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(5), ATR(4), BRCA1(2), CDC25B(1), CDKN1A(2), CDKN2D(1), CHEK2(2), EP300(2), MDM2(1), MYT1(3), PRKDC(6), RPS6KA1(1), TP53(89), WEE1(1), YWHAQ(1) 15630732 121 95 107 16 11 21 16 25 48 0 0.00205 1.33e-08 2.93e-07 29 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 67 BNIP3L(1), CASP2(1), CASP4(2), CASP8(1), FAS(1), HELLS(1), IRF2(1), IRF3(1), IRF5(1), IRF6(1), JUN(1), MAP2K4(2), MAPK10(2), MDM2(1), MYC(3), NFKB1(1), PLEKHG5(3), RELA(2), RIPK1(2), TNF(1), TNFRSF10B(1), TNFRSF1A(1), TNFRSF21(3), TNFSF10(1), TP53(89), TRADD(1), TRAF2(2) 20955477 127 97 113 17 16 22 15 23 51 0 0.000324 1.24e-07 2.64e-06 30 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 82 AIFM1(1), ATM(5), CAPN1(1), CAPN2(1), CASP8(1), CSF2RB(2), FAS(1), IL1A(1), IRAK2(2), IRAK3(2), NFKB1(1), NTRK1(3), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PPP3CB(1), PPP3CC(2), PRKACA(2), PRKACG(1), PRKAR1B(1), PRKAR2B(1), RELA(2), RIPK1(2), TNF(1), TNFRSF10B(1), TNFRSF10D(1), TNFRSF1A(1), TNFSF10(1), TP53(89), TRADD(1), TRAF2(2) 30799782 142 109 127 16 21 19 25 28 49 0 4.04e-05 8.50e-07 1.75e-05 31 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 BAG4(1), CASP2(1), CASP8(1), JUN(1), LMNB1(1), MADD(2), MAP2K4(2), MAP3K7(1), PAK1(1), PRKDC(6), RB1(25), RIPK1(2), SPTAN1(4), TNF(1), TNFRSF1A(1), TRADD(1), TRAF2(2) 14509550 53 46 53 6 4 6 8 1 32 2 0.0317 0.00204 0.0405 32 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 BCAR1(2), MAPK1(1), PIK3CA(6), PIK3R1(1), PTEN(8), PTK2(3), SOS1(2) 7064175 23 20 22 1 2 2 5 9 5 0 0.0325 0.00417 0.0802 33 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(2), ATM(5), BUB1(1), BUB1B(2), CCNA1(1), CCNB3(1), CCNH(1), CDC20(1), CDC25B(1), CDH1(1), CDK2(1), CDK4(1), CDKN1A(2), CDKN2A(2), CHEK2(2), DTX4(2), E2F3(1), E2F4(2), E2F5(1), E2F6(1), EP300(2), ESPL1(3), HDAC3(1), HDAC4(1), HDAC5(3), HDAC6(2), MCM3(3), MCM4(1), MCM5(1), MCM7(2), MDM2(1), MPEG1(1), PRKDC(6), PTPRA(2), PTTG1(1), RB1(25), TFDP1(1), TGFB1(1), TP53(89), WEE1(1) 40568452 178 122 164 23 17 24 31 29 75 2 6.45e-05 0.00449 0.0838 34 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 PIK3CA(6), PIK3R1(1), PLCB1(5), PLCG1(1), PRKCA(1), VAV1(3) 4699509 17 15 16 1 2 3 1 8 3 0 0.0506 0.00995 0.180 35 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 110 ABL1(2), ANAPC1(2), ANAPC2(3), ANAPC4(2), ANAPC5(1), ATM(5), ATR(4), BUB1(1), BUB1B(2), CCNA1(1), CCNB3(1), CCND1(1), CCNH(1), CDC20(1), CDC25B(1), CDK2(1), CDK4(1), CDKN1A(2), CDKN2A(2), CDKN2D(1), CHEK2(2), CREBBP(4), CUL1(3), DBF4(2), E2F3(1), EP300(2), ESPL1(3), FZR1(2), MCM3(3), MCM4(1), MCM5(1), MCM7(2), MDM2(1), PKMYT1(1), PRKDC(6), PTTG1(1), RB1(25), SMAD3(2), TFDP1(1), TGFB1(1), TP53(89), WEE1(1), YWHAE(2), YWHAQ(1) 49979179 192 128 177 23 19 28 29 34 80 2 1.79e-05 0.0117 0.200 36 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 F13A1(3), F2(3), F2R(1), FGA(2), FGB(2), FGG(2), PLG(1) 4869769 14 14 14 1 1 3 6 3 1 0 0.113 0.0117 0.200 37 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(2), JAK1(1), JAK3(2), PIAS1(3), PTPRU(8), SOAT1(1) 5161931 17 16 17 2 4 2 5 4 2 0 0.130 0.0146 0.243 38 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 EIF2S2(1), IGF1(1), IGF1R(2), INPPL1(1), PIK3CA(6), PIK3R1(1), PTEN(8), RPS6(1) 7276708 21 18 20 1 5 2 1 9 4 0 0.0294 0.0172 0.278 39 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(1), COASY(1), DPYD(6), ENPP1(3), ENPP3(2), PANK1(2), PANK3(1), PANK4(1), PPCS(1) 5105361 18 16 18 1 0 6 4 2 6 0 0.0264 0.0178 0.280 40 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(2), TAT(2), TYR(2) 1661167 6 6 6 0 2 2 1 0 1 0 0.161 0.0182 0.280 41 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 CASP8(1), DAXX(1), FAF1(2), JUN(1), LMNB1(1), MAP2K4(2), MAP3K7(1), PAK1(1), PRKDC(6), RB1(25), RIPK2(1), SPTAN1(4) 15557868 46 42 46 8 1 4 7 2 30 2 0.335 0.0307 0.462 42 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(2), IFNG(1), JAK1(1), PTPRU(8), STAT1(2) 4202463 14 13 14 2 3 3 3 4 1 0 0.144 0.0366 0.536 43 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 DPM2(1), NTRK1(3), PIK3CA(6), PIK3R1(1), PLCG1(1), PRKCA(1), SOS1(2) 5667907 15 15 14 1 4 1 3 4 3 0 0.102 0.0398 0.571 44 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRB(2), HMOX1(1), IL10RA(2), IL1A(1), JAK1(1), STAT1(2), STAT3(1), STAT5A(1), TNF(1) 4447478 12 12 12 0 3 1 3 2 3 0 0.0252 0.0423 0.592 45 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(2), IL6R(2), JAK1(1), JAK3(2), PTPRU(8), STAT3(1) 5659860 16 15 16 2 4 2 4 6 0 0 0.123 0.0486 0.657 46 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(2), CYP2E1(3), NR1I3(1), PTGS1(1), PTGS2(1) 1930001 8 7 8 1 1 0 4 2 1 0 0.332 0.0491 0.657 47 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(1), GABRA2(2), GABRA4(1), GABRA5(2), GABRA6(2), PRKCE(2) 2932096 10 9 10 1 2 4 1 1 2 0 0.131 0.0568 0.744 48 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 MAPK1(1), PIK3CA(6), PIK3CD(1), PTEN(8), PTK2B(2), SOS1(2) 7272117 20 17 19 2 2 2 3 7 6 0 0.178 0.0646 0.829 49 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(2), AASDHPPT(1), AASS(1), KARS(1) 1721168 5 5 5 0 0 2 1 0 2 0 0.354 0.0696 0.876 50 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(1), ALPL(3), ALPP(1), FPGS(2), GGH(1) 2456794 8 8 8 1 1 2 4 0 1 0 0.235 0.0739 0.910 51 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAS1(1), ALAS2(3), CPOX(1), PPOX(1), UROD(1), UROS(1) 2756873 8 8 8 0 0 1 4 1 2 0 0.108 0.0850 1.000 52 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARSA(1), FARSB(2), PAH(1), TAT(2), YARS(1), YARS2(2) 3169326 9 9 9 0 0 3 3 2 1 0 0.0786 0.0894 1.000 53 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(1), ADH4(2), ADH6(1), ADH7(3) 2053931 7 6 7 1 1 1 0 1 4 0 0.568 0.0977 1.000 54 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(2), AASDH(1), AASDHPPT(1), AASS(1), KARS(1) 2522076 6 6 6 0 0 2 1 1 2 0 0.282 0.103 1.000 55 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CCL3(1), EPO(1), FLT3(2), IGF1(1), IL1A(1), KITLG(1), TGFB1(1) 3069948 8 8 8 1 1 1 5 0 1 0 0.297 0.105 1.000 56 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(2), MAPK1(1), NFKB1(1), PIK3C2G(7), PIK3CA(6), PIK3R1(1), PLCG1(1), PRKCA(1), PTK2(3), PTK2B(2), RELA(2) 10306290 27 26 26 3 2 5 5 8 7 0 0.0662 0.107 1.000 57 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(1), ENO2(2), ENO3(1), PAH(1), TAT(2), YARS(1) 2962340 8 8 8 0 1 2 2 1 2 0 0.133 0.109 1.000 58 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 AGT(1), AGTR1(2), AGTR2(1), COL4A1(6), COL4A2(3), COL4A3(7), COL4A4(4), COL4A5(3), COL4A6(4), REN(1) 9310142 32 24 31 3 0 12 5 6 9 0 0.0191 0.121 1.000 59 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 CBS(1), CTH(1), MUT(3) 1785709 5 5 5 1 0 2 1 2 0 0 0.471 0.123 1.000 60 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 FUT1(3), FUT2(1), FUT9(3) 2229696 7 6 7 1 3 3 0 1 0 0 0.187 0.127 1.000 61 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 23 APC(5), AXIN1(1), BTRC(2), CCND1(1), CREBBP(4), CTBP1(3), DVL1(2), MAP3K7(1), MYC(3), TLE1(2), WIF1(4) 10816158 28 22 28 1 10 7 2 1 8 0 0.000977 0.143 1.000 62 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 17 CDKN1A(2), NFATC2(2), NFATC3(1), PLCG1(1), PPP3CB(1), PPP3CC(2), PRKCA(1), SP1(2), SP3(2), SYT1(2) 7256637 16 16 16 1 2 2 6 3 3 0 0.111 0.143 1.000 63 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(2), BDH2(2), HMGCS2(2), OXCT2(1) 2638910 7 7 7 1 3 0 2 1 1 0 0.415 0.154 1.000 64 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR2(2), ITPKA(1), PDE1A(2), PDE1B(3), PLCB1(5), PLCB2(2), VIP(1) 4001845 16 13 16 3 4 5 1 4 2 0 0.139 0.164 1.000 65 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA2A(1), ADORA3(3), P2RY2(1), P2RY6(1) 2024181 6 6 6 0 0 1 3 2 0 0 0.162 0.166 1.000 66 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT1(3), FUT2(1), FUT5(1) 1864311 5 5 5 0 2 2 1 0 0 0 0.104 0.168 1.000 67 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 DOCK1(3), GAB1(1), HGF(2), ITGA1(1), JUN(1), MAP2K2(1), MAP4K1(3), MAPK1(1), MET(4), PAK1(1), PIK3CA(6), PIK3R1(1), PTEN(8), PTK2(3), PTK2B(2), PTPN11(3), RAP1A(1), RASA1(3), SOS1(2), STAT3(1) 16638868 48 39 47 5 8 9 9 12 10 0 0.00536 0.178 1.000 68 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 CDKN1A(2), MAP2K2(1), NGFR(1), NTRK1(3), PIK3CA(6), PIK3CD(1), SOS1(2) 6145534 16 15 15 2 7 0 3 4 2 0 0.171 0.179 1.000 69 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(1), PLCB1(5), TUB(4) 2563556 10 9 10 2 2 4 1 3 0 0 0.267 0.186 1.000 70 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLD1(3), POLE(5), POLG(1), POLL(1), POLQ(7) 6066222 17 14 16 0 1 5 9 1 1 0 0.00738 0.196 1.000 71 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(3), CHAT(2), PDHA2(2) 2513069 7 7 7 1 3 2 1 0 1 0 0.159 0.202 1.000 72 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 KLRC3(2), LAT(1), PAK1(1), PIK3CA(6), PIK3R1(1), PTK2B(2), RAC1(1), SYK(2), VAV1(3) 6927674 19 18 18 3 3 4 3 5 4 0 0.109 0.203 1.000 73 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(1), LPL(2), RXRA(1), TNF(1) 2089629 5 5 5 1 2 0 2 0 1 0 0.468 0.204 1.000 74 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG3(1), ATG5(1), BECN1(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA17(1), IFNA6(1), IFNA8(1), IFNG(1), PIK3R4(2), PRKAA2(5), ULK1(3), ULK2(2), ULK3(1) 7772672 23 19 23 2 2 11 6 3 1 0 0.0132 0.217 1.000 75 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(3), ENO1(1), PFKL(3), PKLR(2) 3423391 9 8 9 1 4 0 1 1 3 0 0.162 0.218 1.000 76 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 12 IGF1(1), IGF1R(2), PIK3CA(6), PIK3R1(1) 4769192 10 10 9 0 2 1 1 4 2 0 0.0646 0.220 1.000 77 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDPS(2), IDI1(1) 1210986 3 3 3 0 0 0 1 0 2 0 0.835 0.225 1.000 78 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 CLOCK(1), CRY1(3), CRY2(1), PER1(3) 3053904 8 8 8 0 0 3 1 2 2 0 0.133 0.235 1.000 79 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(2), MTMR2(1), NFS1(1), THTPA(1), TPK1(1) 2291177 6 5 6 1 1 0 3 0 2 0 0.613 0.238 1.000 80 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 MMP2(2), MMP9(1), RECK(1), TIMP1(2), TIMP2(1) 2838598 7 7 7 0 0 1 3 2 1 0 0.175 0.241 1.000 81 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(1), CCND1(1), CDK2(1), CDK4(1), CDKN2A(2), E2F4(2) 3270479 8 7 8 0 1 1 2 2 2 0 0.111 0.254 1.000 82 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 TAT(2) 933936 2 2 2 0 0 1 0 0 1 0 0.617 0.259 1.000 83 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(2), ACO1(3), ACO2(1), ACSS2(2), IDH1(2) 4807792 10 9 10 1 1 3 1 2 3 0 0.132 0.261 1.000 84 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(1), CASP8(1), RIPK1(2), TNF(1), TNFRSF1A(1), TRADD(1), TRAF2(2) 3033151 9 9 9 2 2 3 3 0 1 0 0.394 0.264 1.000 85 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AMD1(1), CBS(1), CTH(1), DNMT1(2), DNMT3A(3), DNMT3B(2), MARS(1), MARS2(2), MTFMT(1), MTR(2), TAT(2) 7629131 18 17 18 2 1 1 6 3 6 1 0.308 0.267 1.000 86 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(1), PLCG1(1), PRKCA(1), PTK2B(2) 2380601 5 5 5 0 0 2 0 1 2 0 0.183 0.267 1.000 87 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ARPC1B(1), PAK1(1), PDGFRA(1), PIK3CA(6), PIK3R1(1), RAC1(1) 4916517 11 10 10 0 2 1 2 4 2 0 0.0619 0.273 1.000 88 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 EIF4A2(2), EIF4G1(1), EIF4G3(4), MKNK1(1), PIK3CA(6), PIK3R1(1), PTEN(8), RPS6(1), TSC1(1), TSC2(4) 10168116 29 25 28 4 4 4 3 11 7 0 0.124 0.275 1.000 89 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(1), GNAS(2), PRKACA(2) 2414448 5 5 5 1 2 0 0 3 0 0 0.584 0.279 1.000 90 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 FMOD(3) 1295790 3 3 3 0 1 1 1 0 0 0 0.310 0.289 1.000 91 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(1), CD34(1), CD3G(1), CD58(1), KITLG(1) 2286355 5 5 5 1 0 2 1 0 2 0 0.612 0.310 1.000 92 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 EGF(4), EGFR(3), JAK1(1), JUN(1), MAP2K4(2), PIK3CA(6), PIK3R1(1), PLCG1(1), PRKCA(1), RASA1(3), SOS1(2), SRF(1), STAT1(2), STAT3(1), STAT5A(1) 13682107 30 23 29 3 2 8 5 6 8 1 0.0172 0.312 1.000 93 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 FUT1(3), FUT2(1), FUT9(3), GLA(1) 3591708 8 7 8 0 3 3 0 1 1 0 0.0506 0.317 1.000 94 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(3), ANXA3(2), ANXA4(1), ANXA6(2), EDNRA(1), HSD11B1(1), PLA2G4A(1), PTGER2(2), PTGIR(1), PTGIS(1), PTGS1(1), PTGS2(1), SCGB1A1(1), TBXAS1(1) 7468312 19 15 19 2 2 6 4 3 3 1 0.0504 0.318 1.000 95 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(1), ACAT1(2), HADHA(1) 1998983 4 4 4 0 0 0 2 2 0 0 0.418 0.335 1.000 96 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAS1(1), ALAS2(3), UROD(1), UROS(1) 3016547 6 6 6 1 0 0 3 1 2 0 0.508 0.341 1.000 97 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3G(1) 410001 1 1 1 1 0 0 1 0 0 0 0.974 0.350 1.000 98 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 FUT1(3), FUT2(1), FUT9(3), GLA(1) 3800907 8 7 8 1 3 3 0 1 1 0 0.160 0.356 1.000 99 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(2), LPL(2) 1932232 4 4 4 1 1 0 2 1 0 0 0.694 0.357 1.000 100 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDPS(2), IDI1(1) 1596756 3 3 3 0 0 0 1 0 2 0 0.839 0.365 1.000 101 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(6), COL4A2(3), COL4A3(7), COL4A4(4), COL4A5(3), COL4A6(4) 9375404 27 21 26 3 0 12 4 4 7 0 0.0395 0.365 1.000 102 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(1), ARHGEF1(1), F2(3), F2R(1), MAP3K7(1), PIK3CA(6), PIK3R1(1), PLCB1(5), PPP1R12B(1), PRKCA(1), PTK2B(2), ROCK1(1) 9449923 24 21 23 4 2 6 5 6 5 0 0.132 0.383 1.000 103 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(4), FTCD(2), GART(2), MTFMT(1), MTHFD1(1), MTHFD1L(1), MTHFR(1), MTHFS(1), MTR(2) 6960957 15 13 15 2 2 1 7 2 3 0 0.301 0.384 1.000 104 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(1) 598636 1 1 1 0 0 1 0 0 0 0 0.623 0.388 1.000 105 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(4), GART(2), MTHFD1(1), MTHFD1L(1), MTHFR(1), MTHFS(1), MTR(2) 6531366 12 11 12 1 2 0 6 2 2 0 0.276 0.392 1.000 106 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 CBS(1), CTH(1), DNMT1(2), DNMT3A(3), DNMT3B(2), MARS(1), MARS2(2), MTR(2) 6442203 14 14 14 2 1 0 5 3 4 1 0.442 0.396 1.000 107 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(1), ITGAV(3), MAPK1(1), PDGFRA(1), PIK3CA(6), PIK3R1(1), PLCB1(5), PRKCA(1), PTK2(3), RAC1(1), SMPD2(2) 9881048 25 19 24 3 3 4 5 8 5 0 0.0586 0.398 1.000 108 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(1), CTH(1), LDHB(1), MPST(1) 2471833 4 4 4 0 0 0 1 1 2 0 0.663 0.419 1.000 109 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(3), GABRA1(1), GABRA2(2), GABRA4(1), GABRA5(2), GABRA6(2) 4462982 11 10 11 2 2 4 2 2 1 0 0.226 0.442 1.000 110 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 RAB27A(1), RAB4A(1), RAB6A(1) 1539364 3 3 3 0 1 1 0 0 1 0 0.332 0.444 1.000 111 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 FUT1(3), FUT2(1) 2584592 4 4 4 0 2 2 0 0 0 0 0.162 0.458 1.000 112 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD86(1), HLA-DRB1(1), IFNG(1), IL12RB1(1), IL12RB2(3), IL18R1(1), IL2RA(1) 4608748 9 9 9 2 1 2 3 1 2 0 0.408 0.458 1.000 113 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 BCR(2), JUN(1), MAP2K4(2), MYC(3), PIK3CA(6), PIK3R1(1), SOS1(2), STAT1(2), STAT5A(1) 10277181 20 19 19 2 3 2 5 4 6 0 0.0728 0.464 1.000 114 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDOB(3) 1377982 3 3 3 1 1 0 1 0 1 0 0.721 0.466 1.000 115 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 HLA-DRB1(1) 847222 1 1 1 1 1 0 0 0 0 0 0.868 0.476 1.000 116 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 NFKB1(1), PIK3CA(6), PIK3R1(1), RELA(2) 5148906 10 10 9 2 2 2 1 3 2 0 0.421 0.487 1.000 117 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 BRAF(1), CAMP(1), CREBBP(4), EGR1(1), EGR2(2), FRS2(2), JUN(1), MAP1B(5), MAP2K4(2), MAP2K7(3), MAPK1(1), MAPK10(2), MAPK8IP3(3), NTRK1(3), OPN1LW(1), PIK3C2G(7), PIK3CA(6), PIK3CD(1), PIK3R1(1), PTPN11(3), TH(1) 18973204 51 43 50 6 8 12 8 11 12 0 0.00531 0.500 1.000 118 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(1), CSF2RB(2), IGF1(1), IGF1R(2), KIT(5), KITLG(1), PIK3CA(6), PIK3R1(1), PRKACG(1), PRKAR1B(1), PRKAR2B(1) 8029323 22 19 21 4 4 3 5 5 4 1 0.209 0.509 1.000 119 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(1), IFNG(1), IL16(1), IL1A(1), TNF(1) 3573687 5 5 5 0 1 0 1 2 1 0 0.210 0.512 1.000 120 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 CLOCK(1), CRY1(3), CRY2(1), NPAS2(1), NR1D1(1), PER1(3), PER2(1), PER3(3) 6075426 14 11 14 1 2 5 2 2 3 0 0.0977 0.515 1.000 121 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 FYN(1), JUN(1), THBS1(3) 2637190 5 5 5 1 1 1 1 1 1 0 0.548 0.521 1.000 122 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(2) 1254305 2 2 2 0 0 0 1 1 0 0 0.629 0.523 1.000 123 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(1), CD2(1), CD33(1), IFNA1(1), IFNG(1), ITGAX(1), TLR2(3), TLR4(1), TLR9(3) 6638696 13 13 13 2 1 2 3 5 2 0 0.343 0.529 1.000 124 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(3), ACO2(1), GRHPR(1), HAO1(1), MTHFD1(1), MTHFD1L(1) 4627844 8 7 8 1 0 2 2 1 3 0 0.324 0.530 1.000 125 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 GPD2(2), SDHA(1), UQCRC1(1) 2373935 4 4 4 0 1 0 2 1 0 0 0.387 0.537 1.000 126 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(1), ADH4(2), ADH6(1), ADH7(3), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1) 4866205 12 11 12 3 1 1 3 2 5 0 0.670 0.537 1.000 127 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(3), ACO2(1), IDH1(2) 3238529 6 5 6 0 1 2 1 0 2 0 0.125 0.538 1.000 128 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(2), JUN(1), MAP2K2(1), MAP2K3(2), MAP2K4(2), MAPK1(1), PAK1(1), PLCG1(1), PRKCA(1), PTK2B(2), RAC1(1), SOS1(2), SYT1(2) 10472422 19 18 19 2 1 4 5 4 5 0 0.0856 0.540 1.000 129 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(2), MPO(4), TPO(1), TYR(2) 3558806 9 8 9 2 0 6 1 0 2 0 0.158 0.541 1.000 130 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 IFNG(1) 1089207 1 1 1 0 0 0 0 1 0 0 0.799 0.546 1.000 131 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 16 ALOX12(2), ALOX15(1), ALOX5(2), DPEP1(2), GGT1(1), PTGIS(1), PTGS1(1), PTGS2(1), TBXAS1(1) 5802809 12 12 12 2 2 2 4 2 2 0 0.263 0.551 1.000 132 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 DPM2(1), JUN(1), NGFR(1), PIK3CA(6), PIK3R1(1), PLCG1(1), SOS1(2) 6964678 13 13 12 2 2 1 3 4 3 0 0.293 0.554 1.000 133 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ELOVL2(1), FADS1(2), FADS2(1), FASN(5), HADHA(1), HSD17B12(2), SCD(1) 5536673 13 13 13 3 2 3 3 3 2 0 0.328 0.563 1.000 134 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 JUN(1), PIK3CA(6), PIK3R1(1), PLCG1(1), PRKCA(1), RASA1(3), SOS1(2), STAT1(2), STAT3(1), STAT5A(1) 10907142 19 18 18 2 2 4 3 5 5 0 0.0892 0.572 1.000 135 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(1), C1QB(1), C1S(1), C2(1), C3(4), C5(2), C6(6), C7(1), C8A(1), C9(4), MASP1(3), MASP2(1), MBL2(1) 7889687 27 23 27 6 3 7 5 7 5 0 0.226 0.574 1.000 136 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 CBS(1), CTH(1), GGT1(1), MARS(1), MARS2(2), SEPHS1(1) 4555259 7 7 7 0 1 0 5 1 0 0 0.180 0.575 1.000 137 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ3(1), NDUFA13(1) 1582302 2 2 2 1 0 1 1 0 0 0 0.813 0.578 1.000 138 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 JAK1(1), JUN(1), MAP2K4(2), PDGFRA(1), PIK3CA(6), PIK3R1(1), PLCG1(1), PRKCA(1), RASA1(3), SOS1(2), SRF(1), STAT1(2), STAT3(1), STAT5A(1) 12787027 24 21 23 3 2 4 4 7 6 1 0.0854 0.581 1.000 139 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(1), AGT(1), AGTR1(2), AGTR2(1), ANPEP(1), CPA3(1), CTSG(1), ENPEP(2), LNPEP(3), MME(3), REN(1) 7614043 17 15 17 3 3 2 3 5 4 0 0.367 0.584 1.000 140 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(1), ACACB(4), FASN(5), OXSM(1) 6002411 11 11 11 2 3 0 4 3 1 0 0.307 0.597 1.000 141 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(1), CARS2(1), CTH(1), LDHB(1), MPST(1), SULT1B1(3), SULT1C2(1), SULT4A1(1) 4641251 10 9 10 2 2 1 3 2 2 0 0.486 0.604 1.000 142 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 GNS(2), GUSB(2), IDS(1), IDUA(4), LCT(5), NAGLU(1) 5364996 15 14 15 4 4 2 6 1 2 0 0.337 0.608 1.000 143 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(1), NR1H4(1), RXRA(1) 1979850 3 3 3 1 0 0 2 0 1 0 0.783 0.614 1.000 144 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 HADHA(1), HSD17B4(1), SIRT1(1), SIRT7(1), VNN2(2) 4338533 6 6 5 1 0 2 0 2 2 0 0.374 0.618 1.000 145 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(1), JAK1(1), STAT1(2) 2992316 4 4 4 0 0 1 1 1 1 0 0.300 0.625 1.000 146 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT10(1), GALNT3(1), GALNT7(1), GALNT8(3), GALNT9(1), WBSCR17(3) 5376663 10 9 10 1 2 5 3 0 0 0 0.0815 0.637 1.000 147 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKB1(1), PLCB1(5), PRKCA(1), RELA(2) 2987636 9 8 9 3 1 5 0 2 1 0 0.540 0.648 1.000 148 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(1), BCAR1(2), CTNNA1(2), CTNNA2(5), PTK2(3) 7139877 13 11 13 1 3 4 2 4 0 0 0.0661 0.652 1.000 149 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(1), COASY(1), DPYD(6), ENPP1(3), ENPP3(2), ILVBL(1), PANK1(2), PANK3(1), PANK4(1), PPCS(1) 6404936 19 17 19 4 0 6 5 2 6 0 0.216 0.655 1.000 150 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCR3(2), HLA-DRB1(1) 1111319 3 3 3 3 1 0 1 0 1 0 0.958 0.661 1.000 151 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(2), CYP2C9(2) 738505 4 4 4 2 1 1 2 0 0 0 0.835 0.668 1.000 152 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP2(3), RANGAP1(2) 3116450 5 4 5 1 1 1 0 2 1 0 0.588 0.678 1.000 153 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 CREBBP(4), EP300(2), FYN(1), IL2RG(1), IL7R(1), JAK1(1), JAK3(2), LCK(1), NMI(1), PIK3CA(6), PIK3R1(1), PTK2B(2), STAT5A(1) 10181306 24 19 23 3 4 4 3 7 6 0 0.0933 0.686 1.000 154 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(4), C5(2), C6(6), C7(1), C8A(1), C9(4) 4650902 18 16 18 5 1 3 4 7 3 0 0.472 0.690 1.000 155 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 TGDS(1), UGDH(2) 1464152 3 2 3 1 0 1 0 0 2 0 0.717 0.692 1.000 156 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 DAXX(1), FAS(1), HSPB2(1), IL1A(1), TNF(1) 4033403 5 5 5 0 1 0 2 1 1 0 0.366 0.692 1.000 157 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(1), C1QB(1), C1S(1), C2(1), C3(4), C5(2), C6(6), C7(1), C8A(1), C9(4) 6488569 22 20 22 5 2 5 4 7 4 0 0.275 0.693 1.000 158 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CAMK2B(1), CAMK2G(1), CAMKK1(2), SYT1(2) 4266225 6 6 6 1 0 1 4 0 1 0 0.394 0.694 1.000 159 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 SULT1E1(1), SULT2A1(1), SUOX(1) 2144661 3 3 3 0 0 1 0 1 1 0 0.427 0.696 1.000 160 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(1), ACP6(1), ACPP(1), ENPP1(3), ENPP3(2), FLAD1(2), LHPP(2), MTMR2(1), TYR(2) 5486129 15 15 15 4 1 2 9 0 3 0 0.631 0.699 1.000 161 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(2), EIF2AK4(2), EIF2S2(1) 4162422 5 5 5 1 2 0 2 0 1 0 0.717 0.701 1.000 162 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(1), ABCB11(2), ABCB4(3), ABCC1(1), ABCC3(6) 5297672 13 12 13 3 2 3 4 2 2 0 0.289 0.709 1.000 163 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(2), DIAPH1(2), FYN(1), ITGA1(1), MAPK1(1), MYLK(3), PIK3CA(6), PIK3R1(1), PTK2(3), ROCK1(1), TLN1(2) 13685710 23 19 22 2 3 2 6 7 5 0 0.0837 0.712 1.000 164 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 PTK2B(2), SOS1(2) 3155763 4 4 4 0 0 1 2 0 1 0 0.302 0.721 1.000 165 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 APC(5), AR(5), BRAF(1), CAMP(1), CCL15(1), CCL16(1), EGFR(3), GNA11(1), ITPKA(1), ITPR1(4), ITPR2(6), ITPR3(2), KCNJ3(1), KCNJ5(2), KCNJ9(1), MAPK1(1), MAPK10(2), PHKA2(2), PIK3CA(6), PIK3CD(1), PIK3R1(1) 19537094 48 38 46 7 9 11 4 11 13 0 0.0132 0.729 1.000 166 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CSF1R(2), EGF(4), EGFR(3), MET(4), PDGFRA(1), PRKCA(1), SH3GLB1(1), SH3GLB2(1) 7095258 17 11 17 2 2 8 2 2 3 0 0.0433 0.732 1.000 167 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CD3G(1) 1143747 1 1 1 1 0 0 1 0 0 0 0.964 0.744 1.000 168 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(1), AGTR1(2), EGFR(3), JUN(1), MAP2K2(1), MAP2K4(2), MAPK1(1), MEF2B(2), MEF2C(1), PAK1(1), PRKCA(1), PTK2(3), PTK2B(2), RAC1(1), SOS1(2), SYT1(2) 12611197 26 21 26 3 2 6 6 3 9 0 0.0542 0.744 1.000 169 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(1), AGT(1), AGTR1(2), AGTR2(1), KNG1(1), NOS3(3), REN(1) 3588641 10 9 10 3 0 2 2 2 4 0 0.666 0.751 1.000 170 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAS1(1), ALAS2(3), BLVRB(2), COX10(1), CP(4), CPOX(1), EARS2(1), EPRS(2), FTMT(2), GUSB(2), HCCS(1), HMOX1(1), HMOX2(1), PPOX(1), UGT1A10(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT2A3(1), UGT2B11(3), UGT2B15(2), UGT2B17(2), UROD(1), UROS(1) 15245790 38 31 38 5 7 6 12 5 8 0 0.0469 0.752 1.000 171 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(5), EGF(4), EGFR(3), TF(1) 4657749 13 8 13 4 1 6 2 1 3 0 0.400 0.753 1.000 172 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC3(1), CES1(1) 2200691 2 2 2 1 2 0 0 0 0 0 0.733 0.766 1.000 173 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 SEC61A2(1), SRP68(1), SRPR(1) 2736801 3 3 3 1 0 0 1 2 0 0 0.812 0.770 1.000 174 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(1), IARS(1), PDHA2(2), PDHB(1) 3627089 5 5 5 0 0 2 1 1 1 0 0.259 0.772 1.000 175 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 APC(5), AXIN1(1), CCND1(1), DVL1(2), LBP(1), NFKB1(1), PIK3CA(6), PIK3R1(1), RELA(2), TIRAP(1), TLR4(1), TOLLIP(1) 11032897 23 19 22 3 6 4 4 3 6 0 0.0730 0.774 1.000 176 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 CREBBP(4), SET(2) 3823208 6 5 6 1 1 2 1 0 2 0 0.467 0.777 1.000 177 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(1), CPT1A(1), PRKAA2(5), PRKAB2(1) 5263662 8 6 8 1 0 4 3 1 0 0 0.266 0.788 1.000 178 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A2(1) 1386912 1 1 1 0 0 0 0 1 0 0 0.795 0.790 1.000 179 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 TGDS(1), UGDH(2), UGP2(2) 1834327 5 4 5 2 0 2 1 0 2 0 0.778 0.793 1.000 180 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(2) 1753642 2 2 2 0 0 2 0 0 0 0 0.406 0.793 1.000 181 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ARPC1B(1), NCKAP1(2), NTRK1(3), RAC1(1), WASF3(2) 5628375 9 8 9 1 5 2 0 0 2 0 0.211 0.799 1.000 182 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1) 2876523 5 5 5 2 0 0 2 2 1 0 0.820 0.801 1.000 183 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1) 2876523 5 5 5 2 0 0 2 2 1 0 0.820 0.801 1.000 184 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 PRKCA(1), TGM2(1) 1852092 2 2 2 1 1 0 0 0 1 0 0.844 0.801 1.000 185 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 HADHA(1), HSD17B4(1), MECR(1) 3138623 3 3 3 0 0 1 0 1 1 0 0.426 0.808 1.000 186 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMB3(1), PSMB6(1), PSMB9(2) 3182905 4 4 4 1 0 1 3 0 0 0 0.732 0.808 1.000 187 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(1), C1QB(1), C1S(1), C2(1), C3(4), C5(2), C6(6), C7(1), C8A(1), C8B(1), C9(4), MASP1(3) 7667917 26 22 26 7 3 7 4 7 5 0 0.349 0.809 1.000 188 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 IL6R(2), JAK1(1), JAK3(2), JUN(1), PTPN11(3), SOS1(2), SRF(1), STAT3(1) 8838201 13 12 13 2 2 1 4 4 1 1 0.328 0.809 1.000 189 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CAMK2B(1), CAMK2G(1), ESRRA(1), HDAC5(3), MEF2B(2), MEF2C(1), PPARA(1), PPP3CB(1), PPP3CC(2), SLC2A4(1), SYT1(2) 7610070 16 14 16 3 2 4 5 0 5 0 0.215 0.811 1.000 190 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(2), HADHA(1) 2870393 3 3 3 0 0 0 1 2 0 0 0.495 0.813 1.000 191 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ANGPTL2(2), GCA(1), ITGA9(1), ITPKA(1), ITPR1(4), ITPR2(6), ITPR3(2), MAPK1(1), NR1I3(1), PAK1(1), PDE3A(1), PDE3B(5), PI3(1), PIK3C2G(7), PIK3CA(6), PIK3CD(1), PIK3R1(1), VASP(1) 17873338 43 36 42 7 7 4 9 14 9 0 0.0942 0.819 1.000 192 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP8(1) 1338569 1 1 1 1 0 0 1 0 0 0 0.949 0.819 1.000 193 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 CANX(1), CIITA(3), HLA-B(1), HLA-DOA(1), HLA-DOB(1), HLA-DQA2(3), HLA-DRB1(1), HLA-DRB5(1), HLA-E(1), HLA-F(1), HSP90AA1(2), HSP90AB1(4), IFNA1(1), IFNA14(1), IFNA16(1), IFNA17(1), IFNA6(1), IFNA8(1), KIR3DL1(2), KIR3DL2(1), KLRC3(2), LGMN(1) 17044552 32 28 32 4 5 8 9 8 2 0 0.0147 0.822 1.000 194 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(3), ACO2(1), GRHPR(1), HAO1(1), MTHFD1(1), MTHFD1L(1) 4863843 8 7 8 2 0 2 2 1 3 0 0.520 0.832 1.000 195 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 NRF1(1), UBE2C(1), UBE2G2(1), UBE2I(1), UBE2J1(1), UBE3A(1) 3910345 6 6 6 2 0 2 2 1 1 0 0.773 0.834 1.000 196 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5R1(1), DPM2(1), EGR1(1), MAP2K2(1), MAPK1(1), NGFR(1) 3099921 6 6 6 2 2 1 1 1 1 0 0.626 0.837 1.000 197 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 MBTPS1(1), SCAP(4), SREBF1(3), SREBF2(1) 4425899 9 8 9 2 2 2 3 1 1 0 0.366 0.837 1.000 198 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAT1(2), HADHA(1) 3073951 3 3 3 0 0 0 1 2 0 0 0.475 0.837 1.000 199 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD9(2), ADH1A(1), ADH4(2), ADH6(1), ADH7(3), DHRS2(1), DHRSX(1), ESCO2(1), PNPLA3(1), SH3GLB1(1) 8730530 14 11 14 2 1 4 2 1 6 0 0.318 0.845 1.000 200 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ADH1A(1), ADH4(2), ADH6(1), ADH7(3), AKR1C4(1), AKR1D1(2), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), BAAT(1), CEL(5), CYP27A1(1), SOAT2(2) 8499580 24 19 24 5 2 4 5 7 6 0 0.327 0.846 1.000 201 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(2), ACOT11(2), DHRS2(1), DHRSX(1), ESCO2(1), FN3K(1), HADHA(1), PNPLA3(1), SH3GLB1(1), YOD1(1) 9134287 12 12 12 1 2 3 3 3 1 0 0.107 0.848 1.000 202 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS2(2), CARS(1), CARS2(1), DARS(1), EARS2(1), EPRS(2), FARSA(1), FARSB(2), HARS2(1), IARS(1), IARS2(1), KARS(1), MARS(1), MARS2(2), MTFMT(1), QARS(1), RARS(2), SARS(2), TARS(3), TARS2(2), VARS(1), VARS2(1), WARS(1), WARS2(1), YARS(1), YARS2(2) 19648037 36 32 36 4 3 5 16 9 3 0 0.0339 0.849 1.000 203 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(1), JUNB(1), MAP2K3(2), NFATC2(2), PRKACG(1), PRKAR1B(1), PRKAR2B(1) 4388345 9 9 9 3 0 0 6 1 2 0 0.776 0.850 1.000 204 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), UGDH(2) 3110071 7 6 7 3 0 1 3 1 2 0 0.832 0.854 1.000 205 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 JUN(1), PLCG1(1), PRKCA(1), PTK2B(2), SYT1(2) 4975119 7 7 7 2 0 2 1 1 3 0 0.652 0.859 1.000 206 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(1), ALDH18A1(1), ARG2(2), ASL(1), CKMT2(1), PYCR1(2) 6560140 8 8 8 0 2 2 2 0 2 0 0.0749 0.859 1.000 207 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(1), ACPP(1), ENPP1(3), ENPP3(2), FLAD1(2), TYR(2) 3570527 11 11 11 4 0 2 6 0 3 0 0.790 0.859 1.000 208 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 KHK(1), LCT(5), PGM1(1), PYGM(3), TREH(1) 5014463 11 10 11 3 1 4 4 1 1 0 0.399 0.860 1.000 209 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 FOSB(1) 1368893 1 1 1 0 0 0 0 0 1 0 1.000 0.865 1.000 210 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(1), FCGR3A(2), IL6R(2), SELL(1), SPN(1), TGFB1(1), TNF(1), TNFRSF1A(1), TNFRSF8(1) 5071779 11 11 11 3 3 2 2 4 0 0 0.407 0.867 1.000 211 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 DAXX(1), HSPB2(1), MAP2K4(2), MAP2K6(2), MAP3K5(4), MAP3K7(1), MAP3K9(2), MEF2B(2), MEF2C(1), MKNK1(1), MYC(3), PLA2G4A(1), RAC1(1), RIPK1(2), STAT1(2), TGFB1(1), TGFBR1(1), TRADD(1), TRAF2(2) 13690804 31 23 31 3 4 10 6 6 5 0 0.0104 0.871 1.000 212 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 EPX(2), MPO(4), MTHFR(1), TPO(1) 4216368 8 7 8 2 0 5 1 0 2 0 0.202 0.871 1.000 213 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP5O(1), ATP6AP1(2), ATP6V0A4(1), ATP6V1A(2), ATP6V1E1(1), FDXR(2) 5843705 9 7 9 2 2 0 4 2 1 0 0.515 0.872 1.000 214 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(2), GBA(1), MPO(4), TPO(1) 3086376 8 7 8 3 0 5 0 1 2 0 0.346 0.872 1.000 215 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 25 CASP2(1), JUN(1), MAP2K3(2), MAP2K4(2), MAP2K6(2), NFKB1(1), RELA(2), RIPK1(2), TNF(1), TNFRSF1A(1), TRADD(1), TRAF2(2) 8950956 18 18 18 4 3 5 2 4 4 0 0.278 0.874 1.000 216 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 JUN(1), MAPK1(1), NFE2L2(1), PRKCA(1) 3455556 4 4 4 3 0 0 0 1 3 0 0.990 0.875 1.000 217 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(2), HLA-DRB1(1), IL5RA(2) 1934572 5 5 5 3 1 0 1 2 1 0 0.888 0.879 1.000 218 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(1), B4GALT5(2), FUT8(1), MAN1A1(3), MAN1B1(1), MGAT3(1), MGAT5(2), RPN2(2) 7176641 13 9 13 1 2 6 2 1 2 0 0.0327 0.884 1.000 219 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT2(2), FUT1(3), FUT2(1), FUT5(1), FUT9(3) 5729208 10 9 10 2 3 5 1 1 0 0 0.194 0.886 1.000 220 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT2(2), CHST1(2), CHST4(1), FUT8(1) 4349203 6 5 6 1 0 4 2 0 0 0 0.206 0.893 1.000 221 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(5), CAMP(1), CERK(1), EPHB2(1), ITPKA(1), JUN(1), MAP2K4(2), MAP2K7(3), MAPK1(1), MAPK10(2), MAPK8IP3(3) 10213555 21 18 21 4 6 6 1 2 6 0 0.109 0.894 1.000 222 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 CAMP(1), ITPKA(1) 2091289 2 2 2 0 1 1 0 0 0 0 0.405 0.895 1.000 223 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 HADHA(1) 1772393 1 1 1 0 0 0 0 1 0 0 0.778 0.897 1.000 224 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 INPP1(2), INPP4A(2), INPP4B(1), INPP5A(1), INPPL1(1), ITPKA(1), OCRL(1), PIK3C2G(7), PIK3CA(6), PIK3CB(1), PIK3CG(2), PLCB1(5), PLCB2(2), PLCB3(2), PLCB4(3), PLCG1(1), PLCG2(2) 16513155 40 35 39 8 7 9 6 12 6 0 0.118 0.899 1.000 225 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GGT1(1) 1615231 1 1 1 0 0 0 1 0 0 0 0.786 0.899 1.000 226 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 CARS(1), DARS(1), EPRS(2), IARS(1), KARS(1), MARS(1), MARS2(2), QARS(1), RARS(2), SARS(2), TARS(3), WARS(1), WARS2(1), YARS(1) 11528094 20 18 20 3 2 3 7 7 1 0 0.176 0.900 1.000 227 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(1), GNAS(2), PRKACG(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1) 3575137 7 7 7 3 1 0 2 1 3 0 0.905 0.902 1.000 228 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 ST3GAL5(1) 1962197 1 1 1 1 0 0 0 1 0 0 0.935 0.902 1.000 229 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS2(1) 1609349 1 1 1 0 0 0 1 0 0 0 0.842 0.904 1.000 230 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(4), EGFR(3), ERBB3(1) 3731423 8 5 8 3 0 4 2 0 2 0 0.599 0.906 1.000 231 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 EIF4A2(2), EIF4G1(1), EIF4G3(4), IRS1(1), MAPK1(1), MKNK1(1), PABPC1(2), PIK3CA(6), PIK3R1(1), PRKCA(1), PTEN(8) 10234255 28 23 27 5 2 6 4 9 7 0 0.239 0.906 1.000 232 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(1), ATP6AP1(2), ATP6V0A4(1), ATP6V1A(2), ATP6V1E1(1) 5515575 7 6 7 2 1 0 4 1 1 0 0.670 0.909 1.000 233 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(1), ATP6AP1(2), ATP6V0A4(1), ATP6V1A(2), ATP6V1E1(1) 5515575 7 6 7 2 1 0 4 1 1 0 0.670 0.909 1.000 234 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(1), ATP6AP1(2), ATP6V0A4(1), ATP6V1A(2), ATP6V1E1(1) 5515575 7 6 7 2 1 0 4 1 1 0 0.670 0.909 1.000 235 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ERBB4(4), NRG2(1), NRG3(1), PRKCA(1) 3340313 7 6 7 5 2 1 1 1 2 0 0.979 0.909 1.000 236 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 IFNAR1(1), NFKB1(1), RELA(2), TRAF6(2) 4032617 6 6 6 2 1 2 2 1 0 0 0.658 0.914 1.000 237 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 NFKB1(1), NOX1(2), RELA(2), TNF(1) 3653156 6 6 6 2 2 3 1 0 0 0 0.535 0.914 1.000 238 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 APC(5), AXIN1(1), BTRC(2), DVL1(2), NOTCH1(3) 7971545 13 10 13 2 5 3 1 0 3 1 0.121 0.916 1.000 239 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNH(1), CDC25B(1), XPO1(3) 3178232 5 5 4 3 0 2 0 1 2 0 0.935 0.918 1.000 240 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 MAP2K2(1), MAP2K3(2), MAP2K6(2), MAPK1(1), NFATC2(2), NFATC3(1), NFKB1(1), PAK1(1), PIK3C2G(7), PLCB1(5), PPP3CB(1), PPP3CC(2), RAC1(1), RELA(2), SYT1(2) 14201839 31 27 31 6 3 8 9 7 4 0 0.161 0.921 1.000 241 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 CALCR(3), CALCRL(1), CD97(1), CRHR2(4), ELTD1(3), EMR1(4), EMR2(2), GLP1R(2), GLP2R(2), GPR64(1), LPHN1(1), LPHN2(4), LPHN3(2), SCTR(3), VIPR1(3) 10058928 36 27 36 9 4 7 9 11 5 0 0.206 0.923 1.000 242 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ANXA1(3), GNAS(2), NFKB1(1), NOS3(3), PIK3CA(6), PIK3R1(1), RELA(2), SYT1(2) 6663089 20 20 19 5 4 4 3 5 3 1 0.408 0.923 1.000 243 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 BFAR(2), BRAF(1), CAMP(1), MAPK1(1) 4243969 5 4 5 1 0 3 0 1 1 0 0.475 0.924 1.000 244 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMB3(1), PSMB6(1), PSMC3(1), RPN2(2), UBE3A(1) 4842915 6 6 6 0 0 3 1 1 1 0 0.182 0.926 1.000 245 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 APOBEC3B(2), APOBEC3F(1), APOBEC3G(1) 2672657 4 2 4 2 0 1 1 0 2 0 0.642 0.927 1.000 246 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(1) 1763427 1 1 1 1 0 0 1 0 0 0 0.916 0.927 1.000 247 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(3), DNMT1(2), MTNR1A(1), PTAFR(1), PTGER2(2), PTGIR(1) 4070273 10 8 10 3 2 0 3 2 3 0 0.632 0.929 1.000 248 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), HADHA(1) 4405452 6 6 6 2 0 0 2 3 1 0 0.762 0.931 1.000 249 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(2), MAP2(3), PRKACG(1), PRKAR2B(1), PRKCE(2) 6309788 9 8 9 4 0 3 1 0 4 1 0.898 0.932 1.000 250 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLD1(3), POLE(5), POLE2(1), POLE4(1), POLG(1), POLG2(1), POLL(1), POLM(1), POLQ(7), PRIM2(1), REV1(1), REV3L(3) 15074892 26 20 25 3 1 6 13 1 5 0 0.157 0.933 1.000 251 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ALDH1A3(2), AOC3(1), DDC(2), EPX(2), HPD(1), MAOB(1), MPO(4), TAT(2), TPO(1) 8150056 16 14 16 4 4 7 2 0 3 0 0.135 0.938 1.000 252 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(1), DHRS2(1), DHRSX(1), HEMK1(1), PRMT2(2), PRMT3(1), PRMT6(1), PRMT8(1), WBSCR22(1) 5418274 10 8 10 3 1 4 1 2 2 0 0.648 0.938 1.000 253 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 IFNG(1), JUN(1), MAP3K5(4), MAP4K5(1), NFKB1(1), RELA(2), TNFRSF9(2), TRAF2(2) 7239520 14 13 14 4 2 4 1 3 4 0 0.525 0.939 1.000 254 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 EPX(2), MPO(4), TPO(1) 4355125 7 6 7 2 0 5 0 0 2 0 0.249 0.939 1.000 255 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 IGF1R(2), IRS1(1), MAPK1(1), PIK3CA(6), PIK3R1(1), SOS1(2) 6863214 13 12 12 4 2 0 4 4 3 0 0.683 0.940 1.000 256 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1R(2), E2F4(2), ETS1(1), ETV3(2), HDAC5(3), JUN(1), NCOR2(5), SIN3A(1) 9961986 17 15 16 3 3 5 4 3 2 0 0.155 0.940 1.000 257 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 CHST11(1), SULT1A1(1), SULT1E1(1), SULT2A1(1), SUOX(1) 3361833 5 5 5 2 1 1 0 2 1 0 0.794 0.942 1.000 258 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(1), GBA(1), GGT1(1) 2122305 3 3 3 2 0 1 1 1 0 0 0.837 0.943 1.000 259 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 BLVRB(2), CP(4), CPOX(1), EPRS(2), GUSB(2), HCCS(1), HMOX1(1), HMOX2(1), PPOX(1), UGT1A10(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT2B15(2), UROD(1), UROS(1) 9890171 24 21 24 5 5 4 6 2 7 0 0.322 0.944 1.000 260 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), AKR1D1(2), CYP11B1(3), CYP11B2(1), CYP21A2(1), HSD11B1(1), HSD3B1(1), HSD3B2(1) 3614520 11 9 11 9 2 1 2 3 3 0 0.984 0.949 1.000 261 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), AKR1D1(2), CYP11B1(3), CYP11B2(1), CYP21A2(1), HSD11B1(1), HSD3B1(1), HSD3B2(1) 3614520 11 9 11 9 2 1 2 3 3 0 0.984 0.949 1.000 262 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(1), NME2(1), POLD1(3), POLG(1) 4779840 6 6 5 2 0 2 4 0 0 0 0.669 0.949 1.000 263 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTN1(1), CAPN1(1), CAPNS1(1), ITGA1(1), PTK2(3), RAC1(1), SPTAN1(4), TLN1(2) 10456609 14 11 14 1 3 1 2 2 6 0 0.260 0.949 1.000 264 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(2), PARK2(1), SNCAIP(1), UBE2G2(1) 2297950 5 5 5 3 1 2 1 0 1 0 0.880 0.950 1.000 265 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(3), ACO2(1), IDH1(2), IDH3A(1), IDH3B(1), IDH3G(1), PC(1), SDHA(1) 7512166 11 9 11 2 2 3 4 0 2 0 0.219 0.951 1.000 266 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD3G(1), IFNG(1), IL2RA(1), TGFB1(1), TGFBR1(1), TGFBR2(1), TGFBR3(2) 3791044 8 8 8 3 0 1 4 2 1 0 0.804 0.951 1.000 267 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(2), ME1(1), PC(1) 3411882 4 4 4 2 1 1 1 1 0 0 0.775 0.952 1.000 268 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5R1(1), DAB1(3), FYN(1), LRP8(3), RELN(6) 5035368 14 12 14 6 2 3 2 3 4 0 0.744 0.953 1.000 269 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 HDAC9(1), MEF2B(2), MEF2C(1) 3118191 4 3 4 2 1 1 0 0 2 0 0.853 0.954 1.000 270 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(1), ARFGEF2(2), GBF1(4), GPLD1(1) 5863824 8 7 8 2 2 2 3 0 1 0 0.445 0.955 1.000 271 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMB3(1), PSMB6(1), PSMC2(2), PSMC3(1), PSMD1(1) 5837056 6 5 6 0 0 2 2 1 1 0 0.200 0.955 1.000 272 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 GNS(2), GUSB(2), HPSE2(3), IDS(1), IDUA(4), LCT(5), NAGLU(1), SPAM1(2) 7683431 20 18 20 5 6 3 7 1 3 0 0.249 0.956 1.000 273 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(1), FSHR(1), GNAS(2), XPO1(3) 3459802 7 7 6 3 2 0 1 2 2 0 0.887 0.956 1.000 274 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 CPT1B(1), CREBBP(4), DUSP1(1), EP300(2), HSD17B4(1), JUN(1), LPL(2), MAPK1(1), ME1(1), MYC(3), NCOA1(4), NCOR1(1), NCOR2(5), NRIP1(3), PIK3CA(6), PIK3R1(1), PPARA(1), PRKACG(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1), PTGS2(1), RB1(25), RELA(2), RXRA(1), SP1(2), STAT5A(1), TNF(1) 22951391 75 61 74 15 10 9 13 9 32 2 0.136 0.956 1.000 275 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSE(1), GAL3ST1(1), GALC(3), GBA(1), GLA(1), LCT(5), NEU3(2), PPAP2A(1), PPAP2B(2), PPAP2C(1), SMPD2(2), SPTLC1(1) 8779606 21 16 20 9 2 2 4 2 10 1 0.911 0.956 1.000 276 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 IFNG(1), IL1A(1), NR4A3(1), WDR1(1) 3950518 4 4 4 2 1 0 2 1 0 0 0.814 0.957 1.000 277 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA4(1), NDUFB6(1) 2605610 2 2 2 2 0 0 1 0 1 0 0.960 0.957 1.000 278 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(2), HK2(2), IMPA2(1), PGM1(1), TGDS(1) 4334350 7 6 7 2 2 1 3 0 1 0 0.474 0.960 1.000 279 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CDC25B(1), PRKCA(1), PTPRA(2) 3396251 4 4 4 5 0 2 0 0 2 0 0.990 0.960 1.000 280 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 33 GTF2A1L(1), GTF2B(1), GTF2H1(1), STON1(2), TAF1(4), TAF10(1), TAF1L(9), TAF2(1), TAF6(1), TAF6L(3), TAF7L(2), TBPL1(1), TBPL2(1) 13167323 28 19 28 4 7 5 7 3 6 0 0.0739 0.961 1.000 281 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(1), HEMK1(1), PRMT2(2), PRMT3(1), PRMT6(1), PRMT8(1), WBSCR22(1) 5147800 8 6 8 3 1 3 0 2 2 0 0.804 0.961 1.000 282 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(1), SDHA(1) 3434441 2 2 2 0 0 0 1 0 1 0 0.665 0.961 1.000 283 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CD3G(1), FYN(1), JUN(1), LAT(1), LCK(1), MAP2K4(2), NFATC2(2), NFATC3(1), NFKB1(1), PIK3CA(6), PIK3R1(1), PLCG1(1), PPP3CB(1), PPP3CC(2), PRKCA(1), PTPN7(2), RAC1(1), RASA1(3), RELA(2), SOS1(2), SYT1(2), VAV1(3), ZAP70(5) 17363398 43 35 42 8 6 12 9 9 7 0 0.0675 0.961 1.000 284 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(2), JUN(1), MAPK1(1), MYC(3), NFKB1(1), PLCB1(5), PRKCA(1), RELA(2), TNF(1) 5596474 17 13 17 6 3 7 1 2 4 0 0.522 0.962 1.000 285 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(2), ARHGEF1(1), MYLK(3), PLCB1(5), PPP1R12B(1), PRKCA(1), ROCK1(1) 7585600 14 9 14 3 1 4 2 5 2 0 0.354 0.963 1.000 286 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 MST1R(2), TNF(1) 2385049 3 3 3 2 2 0 0 1 0 0 0.864 0.963 1.000 287 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25B(1), CDKN1A(2), NEK1(2), WEE1(1) 2805220 6 5 6 3 2 1 1 1 1 0 0.851 0.964 1.000 288 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(1), GAD1(1), GAD2(2), GGT1(1) 2135444 5 4 5 3 0 1 2 2 0 0 0.848 0.964 1.000 289 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(3), CAPN2(1), CAPNS1(1), EP300(2), NFATC2(2), PPP3CB(1), PPP3CC(2), PRKCA(1), SYT1(2) 8714492 15 15 15 4 1 1 6 3 4 0 0.725 0.965 1.000 290 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAD9(2), ADH1A(1), ADH4(2), ADH6(1), ADH7(3), AKR1B10(1), AKR1C4(1), AKR1D1(2), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), BAAT(1), CEL(5), CYP27A1(1), LIPA(1), SLC27A5(1), SOAT1(1), SOAT2(2) 11745500 30 24 30 7 3 6 7 6 8 0 0.316 0.966 1.000 291 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(2), HK2(2), PGM1(1), TGDS(1) 3777947 6 5 6 2 2 1 2 0 1 0 0.554 0.967 1.000 292 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(1), ACSL3(1), ACSL4(2), CPT1A(1), HADHA(1), SLC25A20(1) 6097115 7 7 7 2 1 1 2 3 0 0 0.613 0.970 1.000 293 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 EPO(1) 2279173 1 1 1 0 0 0 1 0 0 0 0.803 0.970 1.000 294 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 GUSB(2), UCHL3(1), UGDH(2), UGT1A10(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT2B15(2) 6343518 12 12 12 6 4 2 0 1 5 0 0.884 0.970 1.000 295 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 EIF2B3(1), EIF2S2(1), FLT1(3), FLT4(2), HIF1A(1), KDR(4), NOS3(3), PIK3CA(6), PIK3R1(1), PLCG1(1), PRKCA(1), PTK2(3) 12545933 27 26 26 6 3 3 6 10 5 0 0.349 0.970 1.000 296 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ASL(1) 2814992 1 1 1 0 0 0 1 0 0 0 0.840 0.971 1.000 297 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS2(1), DHRSX(1), ESCO2(1), PNPLA3(1), SH3GLB1(1) 5628602 5 5 5 1 0 2 2 0 1 0 0.512 0.971 1.000 298 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(1), ACACA(1), ACADL(1), ACADSB(1), ACAT1(2), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), HADHA(1), LDHB(1), MUT(3) 11998306 16 16 16 3 0 2 5 6 3 0 0.409 0.972 1.000 299 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR2(2), GPR34(1), GPR45(1) 3379606 4 3 4 2 0 1 0 1 2 0 0.738 0.972 1.000 300 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(1), ACACA(1), ACACB(4), ACAT1(2), ACSS2(2), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), HADHA(1), LDHB(1), MUT(3) 14371111 20 20 20 4 2 2 6 6 4 0 0.336 0.972 1.000 301 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 22 IL1A(1), MAP3K7(1), NFKB1(1), RELA(2), RIPK1(2), TLR4(1), TNF(1), TNFRSF1A(1), TRADD(1), TRAF6(2) 8910922 13 13 13 3 3 5 4 1 0 0 0.336 0.973 1.000 302 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 GCK(2), GNE(3), HK2(2) 6237256 7 7 7 2 2 0 4 1 0 0 0.715 0.973 1.000 303 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(5), AXIN1(1), CREBBP(4), DVL1(2), EP300(2), LDB1(1), TRRAP(3) 11792033 18 15 18 3 5 3 1 3 6 0 0.171 0.974 1.000 304 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 FURIN(1), NOTCH1(3) 3694734 4 4 4 2 1 0 1 0 1 1 0.881 0.974 1.000 305 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 IGF1(1), IGF1R(2), IRS1(1), JUN(1), PIK3CA(6), PIK3R1(1), PTPN11(3), RASA1(3), SOS1(2), SRF(1) 9042555 21 18 20 5 3 5 4 5 3 1 0.336 0.975 1.000 306 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 CABIN1(3), HDAC5(3), IGF1(1), IGF1R(2), MAP2K6(2), MAPK7(1), MEF2B(2), MEF2C(1), NFATC2(2), PIK3CA(6), PIK3R1(1), PPP3CB(1), PPP3CC(2), SYT1(2) 12734094 29 25 28 5 4 4 8 7 6 0 0.114 0.975 1.000 307 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AP2A1(2), AP2M1(2), ARF1(1), BTK(1), EEA1(5), LYN(1), PFKL(3), PFKP(2), PLCG1(1), PRKCE(2), RAC1(1), VAV2(3) 9322719 24 17 24 7 3 8 3 2 8 0 0.186 0.975 1.000 308 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(4), EP300(2), LPL(2), NCOA1(4), RXRA(1) 6565269 13 11 13 4 2 2 4 3 2 0 0.735 0.975 1.000 309 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(1), FCER1A(1), JUN(1), LYN(1), MAP2K4(2), MAP2K7(3), MAPK1(1), NFATC2(2), NFATC3(1), PIK3CA(6), PIK3R1(1), PLA2G4A(1), PLCG1(1), PPP3CB(1), PPP3CC(2), SOS1(2), SYK(2), SYT1(2), VAV1(3) 15537290 34 29 33 7 5 5 8 8 8 0 0.199 0.977 1.000 310 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(2), SOS1(2), STAT5A(1) 6559041 5 5 5 1 1 0 4 0 0 0 0.566 0.977 1.000 311 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 AGT(1), AGTR2(1), EDNRA(1), EGF(4), EGFR(3), JUN(1), MYC(3), NFKB1(1), PLCG1(1), PRKCA(1), RELA(2) 7339981 19 14 19 6 2 8 1 2 6 0 0.461 0.979 1.000 312 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 F13B(1), HSD17B1(1), HSD17B2(1), HSD17B4(1), HSD3B1(1), HSD3B2(1) 2901571 6 6 6 5 1 0 1 3 1 0 0.969 0.979 1.000 313 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(4), EP300(2), MAPK1(1) 5243300 7 6 7 3 1 1 0 2 3 0 0.894 0.980 1.000 314 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(2), CYP11B2(1), HSD11B1(1), HSD3B1(1), HSD3B2(1) 2489502 6 5 6 7 1 2 1 1 1 0 0.977 0.981 1.000 315 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ARPC1B(1), RAC1(1) 2993320 2 2 2 0 1 1 0 0 0 0 0.449 0.981 1.000 316 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(2), CARM1(1), CCND1(1), CREBBP(4), EP300(2), GRIP1(3), HDAC3(1), HDAC4(1), HDAC5(3), HDAC6(2), MEF2C(1), NCOR2(5), NR0B1(2), NRIP1(3) 17109588 31 27 31 5 5 6 7 6 7 0 0.118 0.983 1.000 317 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(2), CYP2A13(1), NAT1(1) 2956209 4 4 4 3 1 1 0 1 1 0 0.889 0.983 1.000 318 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 CAPN1(1), CAPN2(1), CAPNS1(1), EGF(4), EGFR(3), ITGA1(1), MAPK1(1), MYLK(3), PRKACG(1), PRKAR1B(1), PRKAR2B(1), PTK2(3), TLN1(2) 12083303 23 18 23 5 3 4 8 1 7 0 0.325 0.984 1.000 319 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(1), FDPS(2), IDI1(1) 4108902 4 4 4 2 0 0 2 0 2 0 0.933 0.984 1.000 320 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 EPHA4(2), EPHB1(2), FYN(1), ITGA1(1), L1CAM(1), LYN(1), SELP(2) 5665133 10 9 10 4 2 3 1 3 1 0 0.660 0.986 1.000 321 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDK2(1), DIAPH2(4), MCM10(3), MCM3(3), MCM4(1), MCM5(1), MCM7(2), NACA(2), POLD1(3), POLE(5), POLE2(1), RPA1(1), RPA4(1), UBB(2) 18294290 30 24 29 4 3 9 10 2 6 0 0.0400 0.986 1.000 322 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 NFKB1(1), PIK3CA(6), PIK3R1(1), RAC1(1), RALGDS(1), RELA(2) 7227662 12 12 11 4 2 3 1 4 2 0 0.550 0.987 1.000 323 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(1), GNAS(2), PRKAA2(5), PRKAB2(1), PRKACG(1), PRKAR1B(1), PRKAR2B(1) 5628747 12 10 12 4 2 4 4 1 1 0 0.594 0.987 1.000 324 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 33 DUSP1(1), MAP2K4(2), MAP2K7(3), MAPK1(1), MAPK10(2), MAPK11(1), MAPK8IP3(3), NFKB1(1), NFKBIL1(1), PIK3CA(6), PIK3CD(1), PIK3R1(1), SYT1(2), TRAF2(2), TRAF6(2) 12720638 29 24 28 7 4 7 6 6 6 0 0.227 0.987 1.000 325 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 ARHGAP5(2), CASP8(1), JUN(1) 4610117 4 4 4 2 0 0 1 2 1 0 0.905 0.988 1.000 326 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(2), IL22RA1(1), JAK1(1), JAK3(2), STAT1(2), STAT3(1), STAT5A(1), TYK2(1) 6946608 11 10 11 4 2 2 2 3 2 0 0.583 0.988 1.000 327 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 DPM2(1), EGFR(3), GNAS(2), IGF1R(2), MAP2K2(1), MAPK1(1), MKNK1(1), MYC(3), NGFR(1), PDGFRA(1), PTPRR(2), RPS6KA1(1), SOS1(2), STAT3(1) 12362648 22 16 22 4 6 5 4 4 3 0 0.129 0.988 1.000 328 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 CARM1(1), CBS(1), CTH(1), GGT1(1), HEMK1(1), MARS(1), MARS2(2), PRMT2(2), PRMT3(1), PRMT6(1), PRMT8(1), SEPHS1(1), WBSCR22(1) 9203641 15 13 15 4 2 3 5 3 2 0 0.556 0.989 1.000 329 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 CASP8(1), SCAP(4), SREBF1(3), SREBF2(1) 6657577 9 8 9 3 1 2 4 1 1 0 0.636 0.989 1.000 330 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ADH1A(1), ADH4(2), ADH6(1), ADH7(3), ALDH1A3(2), AOC3(1), AOX1(2), DBH(1), DCT(3), DDC(2), HPD(1), MAOB(1), TAT(2), TH(1), TPO(1), TYR(2) 11695787 26 20 26 6 5 9 5 2 5 0 0.193 0.990 1.000 331 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(1), LDHB(1) 3314487 2 2 2 3 1 0 0 0 1 0 0.993 0.990 1.000 332 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOB(3), FBP1(1), GPT2(2), ME1(1), ME3(2), PGK2(1), PKLR(2), TKT(1), TKTL1(2), TKTL2(1) 7178839 16 15 16 9 5 0 4 2 5 0 0.900 0.990 1.000 333 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 HLA-DRB1(1), IFNA1(1), IFNG(1), IL1A(1), TGFB1(1), TNF(1) 4930052 6 6 6 3 2 0 2 2 0 0 0.747 0.991 1.000 334 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 CHIT1(1), GNE(3), HK2(2), LHPP(2), MTMR2(1) 10557998 9 8 9 1 2 0 5 1 1 0 0.350 0.991 1.000 335 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(1), GNAS(2), PLCE1(6), PRKACG(1), PRKAR1B(1), PRKAR2B(1) 5352106 12 12 12 6 3 2 3 1 3 0 0.830 0.991 1.000 336 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(1), DHRS2(1), DHRSX(1) 3218589 3 3 3 2 0 1 2 0 0 0 0.819 0.991 1.000 337 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 CES1(1) 4111526 1 1 1 1 1 0 0 0 0 0 0.904 0.992 1.000 338 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(5), CDH1(1), CREBBP(4), EP300(2), MAP3K7(1), SKIL(2), TGFB1(1), TGFBR1(1), TGFBR2(1) 9099210 18 16 18 5 2 3 5 2 6 0 0.633 0.992 1.000 339 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD3G(1), CD86(1), CTLA4(1), HLA-DRB1(1), ITK(1), LCK(1), PIK3CA(6), PIK3R1(1), PTPN11(3) 4617731 16 14 15 5 3 4 3 4 2 0 0.515 0.992 1.000 340 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 31 ANPEP(1), GCLC(1), GGT1(1), GPX5(2), GSTA4(1), GSTM5(1), IDH1(2), MGST1(1) 6773898 10 9 10 3 2 2 3 0 3 0 0.631 0.992 1.000 341 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 CHRNG(2), MUSK(1), PIK3CA(6), PIK3R1(1), PTK2(3), PTK2B(2), TERT(1) 6111194 16 13 15 5 2 2 3 4 5 0 0.475 0.993 1.000 342 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(2), ENPP1(3), ENPP3(2), NMNAT1(1), NT5E(1) 5288067 9 9 9 4 1 3 3 0 2 0 0.781 0.993 1.000 343 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 CAPN1(1), CAPNS1(1), CDK5R1(1), MAPT(1) 3509081 4 4 4 3 1 0 2 0 1 0 0.962 0.993 1.000 344 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(1), ACP6(1), ACPP(1), ALPI(1), ALPL(3), ALPP(1), CYP3A4(3), CYP3A7(2), DHRS2(1), DHRSX(1) 6549669 15 14 15 5 1 4 6 2 2 0 0.537 0.993 1.000 345 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CD3G(1), ETV5(2), IFNG(1), IL12RB1(1), IL12RB2(3), IL18R1(1), JUN(1), MAP2K6(2), STAT4(1), TYK2(1) 6914576 14 13 14 8 0 3 2 5 4 0 0.933 0.993 1.000 346 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 CASP8(1), MAP2K4(2), MAPK1(1), NFKB1(1), NSMAF(1), RELA(2), RIPK1(2), TNFRSF1A(1), TRADD(1), TRAF2(2) 7379044 14 14 14 5 2 5 2 1 4 0 0.580 0.993 1.000 347 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 BAG4(1), CASP2(1), CASP8(1), DAXX(1), LMNB1(1), MAP2K7(3), MAP3K5(4), MDM2(1), NFKB1(1), NUMA1(2), PRKDC(6), PSEN2(1), PTK2(3), RASA1(3), RB1(25), RELA(2), RIPK1(2), SPTAN1(4), TNF(1), TNFRSF1A(1), TRADD(1), TRAF2(2) 25458349 67 55 67 13 5 15 10 3 32 2 0.105 0.993 1.000 348 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 DHCR7(1), FDPS(2), IDI1(1) 4898722 4 4 4 2 0 0 2 0 2 0 0.941 0.994 1.000 349 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOB(3), FBP1(1), GPT2(2), ME1(1), ME3(2), PKLR(2), TKT(1) 6453560 12 12 12 7 5 0 2 1 4 0 0.851 0.994 1.000 350 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD3G(1), ITGAL(2), ITGB2(1), PTPRC(4) 3834888 9 9 9 5 2 1 4 1 1 0 0.887 0.994 1.000 351 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(1), IARS(1), IARS2(1), ILVBL(1), PDHA2(2), PDHB(1), VARS(1), VARS2(1) 6745540 9 9 9 3 0 2 4 1 2 0 0.706 0.994 1.000 352 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B4GALT5(2), FUT8(1) 2817160 3 1 3 0 1 2 0 0 0 0 0.238 0.994 1.000 353 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOB(3), DLAT(1), ENO1(1), ENO2(2), ENO3(1), FBP1(1), GAPDH(1), GCK(2), HK2(2), LDHB(1), PC(1), PDHA2(2), PDHB(1), PDHX(1), PFKL(3), PFKP(2), PGK2(1), PKLR(2), TNFAIP1(1) 15474983 29 25 29 5 7 3 9 4 6 0 0.107 0.994 1.000 354 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(5), CDK4(1), DAZL(1), EGR1(1), ESR2(2), FSHR(1), GJA4(1), INHA(1), LHCGR(6), MLH1(1), NCOR1(1), NRIP1(3), PRLR(4), PTGER2(2) 12502883 30 24 28 8 1 7 8 6 8 0 0.549 0.994 1.000 355 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 16 CREBBP(4), EP300(2), HDAC3(1), NFKB1(1), RELA(2), RIPK1(2), TNF(1), TNFRSF1A(1), TRADD(1), TRAF6(2) 8073375 17 14 17 5 4 6 1 4 2 0 0.490 0.995 1.000 356 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(2), BST1(2), ENPP1(3), ENPP3(2), NADK(1), NMNAT1(1), NT5E(1), NUDT12(1) 7861894 13 12 13 5 2 3 3 1 3 1 0.689 0.995 1.000 357 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(3), F2R(1), ITGA1(1), MAPK1(1), PLA2G4A(1), PLCB1(5), PRKCA(1), PTGS1(1), PTK2(3), SYK(2), TBXAS1(1) 8893130 20 16 20 6 1 5 7 3 4 0 0.559 0.995 1.000 358 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 JUN(1), PRKACG(1), PRKAR1B(1), PRKAR2B(1) 4610753 4 4 4 7 0 0 2 0 2 0 1.000 0.995 1.000 359 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(2), AASDH(1), AASDHPPT(1), AASS(1), ACAT1(2), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), BBOX1(2), DOT1L(1), EHMT1(1), EHMT2(1), HADHA(1), PLOD2(2), PLOD3(1), TMLHE(1) 13493942 22 22 22 5 1 2 6 8 5 0 0.442 0.995 1.000 360 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(1), PRKACG(1), PRKAR2B(1) 3595388 3 3 3 2 0 0 1 1 1 0 0.953 0.995 1.000 361 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(1), CREBBP(4), EP300(2), PRKACG(1), PRKAR1B(1), PRKAR2B(1), RARA(1), RXRA(1) 7395853 12 11 12 5 2 1 3 2 4 0 0.898 0.995 1.000 362 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD3G(1), ITGAL(2), ITGB2(1), PTPRC(4) 4037825 9 9 9 5 2 1 4 1 1 0 0.888 0.995 1.000 363 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(2), APC(5), AXIN1(1), BMP5(1), BMPR2(1), CHRD(2), DVL1(2), GATA4(1), MAP3K7(1), MEF2C(1), NKX2-5(1), TGFB1(1), TGFBR1(1), TGFBR2(1), TGFBR3(2) 13106925 23 18 23 5 3 4 5 3 8 0 0.347 0.995 1.000 364 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL3(1), CCR1(2), CCR3(2), CCR4(1), IFNG(1), IL12RB1(1), IL12RB2(3), IL18R1(1), TGFB1(1) 7298089 13 13 13 5 1 3 4 1 4 0 0.577 0.995 1.000 365 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 ASNS(1), CA12(1), CA2(3), CA3(1), CA4(1), CA9(1), CTH(1), GLS2(1), GLUL(2) 6889549 12 12 12 4 4 2 5 0 1 0 0.582 0.996 1.000 366 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 SNAP29(1), STX16(2), STX7(1), TSNARE1(1), VAMP7(1), YKT6(2) 6240000 8 5 8 2 2 2 2 0 1 1 0.472 0.996 1.000 367 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(1), ACAT1(2), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), DLAT(1), GRHPR(1), LDHB(1), ME1(1), ME3(2), PC(1), PDHA2(2), PDHB(1), PKLR(2) 13440618 20 17 20 4 2 3 7 4 4 0 0.278 0.996 1.000 368 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT6(2), ENPP2(2), PAFAH1B3(1), PAFAH2(2), PLA2G12B(1), PLA2G2D(1), PLA2G4A(1), PLD1(3), PLD2(1), PPAP2A(1), PPAP2B(2), PPAP2C(1) 8656591 18 15 18 7 5 3 3 1 5 1 0.791 0.996 1.000 369 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 ITGAL(2), ITGAM(2), ITGB2(1), SELL(1) 3940335 6 6 6 5 1 1 1 2 1 0 0.931 0.996 1.000 370 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CD2(1), CD3G(1), IFNG(1), IL12RB1(1), IL12RB2(3), STAT4(1), TYK2(1) 5458648 9 9 9 6 0 3 2 2 2 0 0.954 0.996 1.000 371 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(1), IFNAR1(1), JAK1(1), STAT1(2), STAT2(1), TYK2(1) 4029460 7 7 7 6 0 1 3 2 1 0 0.968 0.996 1.000 372 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 NFKB1(1), RELA(2), TRAF2(2), TRAF6(2) 5356275 7 7 7 3 1 2 2 1 1 0 0.804 0.996 1.000 373 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCR3(2), GNAS(2), LIMK1(3), MAPK1(1), NOX1(2), PIK3C2G(7), PLCB1(5), PPP1R12B(1), PRKCA(1), PTK2(3), ROCK2(2) 9331349 29 24 29 9 1 7 9 7 5 0 0.624 0.997 1.000 374 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 MAPK1(1), MAPK7(1), MEF2B(2), MEF2C(1), NTRK1(3), PIK3CA(6), PIK3R1(1), PLCG1(1), RPS6KA1(1) 7168538 17 13 16 5 5 3 1 4 4 0 0.401 0.997 1.000 375 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 GLI2(1), GLI3(1), PRKACG(1), PRKAR1B(1), PRKAR2B(1), SUFU(2) 5994491 7 7 7 3 0 1 2 1 3 0 0.808 0.997 1.000 376 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(4), EGFR(3), NCOR2(5), RARA(1), RXRA(1), THRA(1) 6459561 15 11 15 5 3 6 2 1 3 0 0.396 0.997 1.000 377 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 EGR2(2), MYC(3), NFATC2(2), NFKB1(1), PLCG1(1), PPP3CB(1), PPP3CC(2), PRKACG(1), PRKAR1B(1), PRKAR2B(1), RELA(2), SYT1(2), VIP(1) 9914991 20 18 20 5 3 4 6 3 4 0 0.485 0.998 1.000 378 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 AZIN1(1), CLOCK(1), CRY1(3), CRY2(1), ETV6(1), G0S2(1), HSPA8(1), IDI1(1), MYF6(1), NCKAP1(2), NCOA4(1), NR1D2(1), PER1(3), PER2(1), SF3A3(1), SUMO3(2), UGP2(2), ZFR(1) 13274049 25 24 25 6 1 8 3 4 9 0 0.528 0.998 1.000 379 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(1), DLAT(1), IDH3A(1), IDH3B(1), IDH3G(1), PC(1), PDHA2(2), PDHB(1), PDHX(1), SDHA(1) 10384001 11 10 11 2 1 4 4 1 1 0 0.253 0.998 1.000 380 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 BTK(1), CDKN2A(2), IARS(1), INPP5D(3), PIK3CA(6), PPP1R13B(1), PTEN(8), RPS6KA1(1), SOS1(2), TEC(2), YWHAE(2), YWHAQ(1) 13045211 30 27 28 9 4 6 3 9 8 0 0.653 0.998 1.000 381 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 ALDOB(3), FBP1(1), FPGT(2), GCK(2), GMDS(1), GMPPA(2), HK2(2), KHK(1), PFKFB1(1), PFKFB4(3), PFKP(2) 8801420 20 18 20 6 9 1 5 0 5 0 0.427 0.998 1.000 382 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(1), JAK3(2), MAPK1(1), STAT3(1), TYK2(1) 4446433 6 6 6 4 1 0 1 3 1 0 0.951 0.998 1.000 383 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AP2A1(2), AP2M1(2), DNM1(3), NME2(1), PICALM(1), PPP3CB(1), PPP3CC(2), SYNJ1(2), SYNJ2(1), SYT1(2) 8346889 17 14 17 5 2 5 6 1 3 0 0.464 0.998 1.000 384 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(5), CDC25B(1), MYT1(3), WEE1(1) 4991626 10 9 10 7 0 4 4 1 1 0 0.968 0.998 1.000 385 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3G(1), FYN(1), HLA-DRB1(1), LCK(1), PTPRC(4), ZAP70(5) 3322111 13 11 13 5 4 5 3 1 0 0 0.503 0.998 1.000 386 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 RPL11(1), RPL13A(1), RPL14(2), RPL36A(2), RPL41(1), RPL7(1), RPS20(1), RPS23(1), RPS26(1), RPS6(1), RPS7(1) 8540258 13 13 12 4 5 1 3 1 3 0 0.770 0.998 1.000 387 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ASPH(3), EP300(2), EPO(1), HIF1A(1), JUN(1), NOS3(3) 6235979 11 11 11 8 0 2 3 4 2 0 0.980 0.999 1.000 388 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 52 AGT(1), CREBBP(4), ELSPBP1(2), F2(3), GATA4(1), IGF1(1), MAPK1(1), MEF2C(1), MYH2(6), NFATC2(2), NFATC3(1), NKX2-5(1), PIK3CA(6), PIK3R1(1), PPP3CB(1), PPP3CC(2), PRKACG(1), PRKAR1B(1), PRKAR2B(1), SYT1(2) 18251535 39 32 38 9 4 5 13 5 12 0 0.462 0.999 1.000 389 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(1), DHCR7(1), FDPS(2), GGCX(2), IDI1(1), TM7SF2(1) 7089469 8 8 8 3 1 1 2 1 3 0 0.691 0.999 1.000 390 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(6), COL4A2(3), COL4A3(7), COL4A4(4), COL4A5(3), COL4A6(4), F11(3), F12(1), F2(3), F2R(1), F5(6), F8(4), FGA(2), FGB(2), FGG(2), KLKB1(2), PROS1(1) 16167349 54 38 53 13 2 21 11 9 11 0 0.235 0.999 1.000 391 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 IL2RA(1), IL2RB(5), IL2RG(1), JAK1(1), JAK3(2), JUN(1), LCK(1), SOS1(2), STAT5A(1), SYK(2) 8785940 17 16 17 5 4 3 6 2 2 0 0.374 0.999 1.000 392 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 IFNA1(1), IL1A(1), IL1RN(1), IRAK2(2), IRAK3(2), JUN(1), MAP2K3(2), MAP2K6(2), MAP3K7(1), NFKB1(1), RELA(2), TGFB1(1), TNF(1), TOLLIP(1), TRAF6(2) 10934083 21 20 21 6 3 2 7 7 2 0 0.578 0.999 1.000 393 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F2(3), F2R(1), F5(6), F7(1), FGA(2), FGB(2), FGG(2), PROS1(1), TFPI(1) 5974371 19 18 19 8 1 6 6 4 2 0 0.769 0.999 1.000 394 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(2), ACO1(3), ACO2(1), CLYBL(1), IDH1(2), IDH3A(1), IDH3B(1), IDH3G(1), OGDHL(4), PC(1), SDHA(1) 10840787 18 16 18 5 2 7 4 1 4 0 0.246 0.999 1.000 395 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(1), JAK1(1), PTPRU(8), STAT1(2), STAT2(1), TYK2(1) 4631421 14 14 14 8 3 2 4 4 1 0 0.873 0.999 1.000 396 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 BAIAP2(3), CASP8(1), GAPDH(1), MAGI1(3), MAGI2(3), RERE(2), WWP1(2), WWP2(1) 8458608 16 14 16 5 1 4 3 5 3 0 0.527 0.999 1.000 397 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CREBBP(4), DUSP1(1), EP300(2), MAP2K3(2), MAP2K6(2), MAP3K7(1), MAPK11(1), NFKB1(1), RELA(2), TGFBR1(1), TGFBR2(1), TLR2(3), TNF(1) 10641363 22 19 22 6 4 4 4 7 3 0 0.518 0.999 1.000 398 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(3), CABIN1(3), CAMK2B(1), CD3G(1), CDKN1A(2), CNR1(3), CREBBP(4), CTLA4(1), EGR2(2), EP300(2), FCER1A(1), FCGR3A(2), GATA3(1), GATA4(1), IFNA1(1), IFNG(1), IL2RA(1), ITK(1), JUNB(1), MAP2K7(3), MEF2B(2), MYF5(1), NCK2(1), NFAT5(4), NFATC2(2), NFATC3(1), P2RX7(1), PAK1(1), PIN1(1), PPP3CB(1), PPP3CC(2), PTPRC(4), RELA(2), RPL13A(1), SLA(2), SP1(2), SP3(2), TGFB1(1), TNF(1), TRAF2(2), TRPV6(2), VAV1(3), VAV2(3), VAV3(1), XPO5(1) 33285245 79 57 79 13 12 15 23 14 15 0 0.0169 0.999 1.000 399 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(1), ADH4(2), ADH6(1), ADH7(3), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), CEL(5), DGAT1(1), DGKB(1), DGKD(3), DGKE(1), DGKG(3), DGKH(2), DGKQ(1), DGKZ(1), GLA(1), LCT(5), LIPC(3), LIPF(1), LPL(2), PNLIPRP1(1), PPAP2A(1), PPAP2B(2), PPAP2C(1) 17882073 47 35 46 10 4 9 15 8 10 1 0.199 0.999 1.000 400 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 LCT(5), MAN2C1(1), NEU3(2) 6002669 8 6 8 5 1 1 3 0 2 1 0.856 0.999 1.000 401 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 IL2RA(1), IL2RB(5), IL2RG(1), IRS1(1), JAK1(1), JAK3(2), MAPK1(1), MYC(3), NMI(1), PIK3CA(6), PIK3R1(1), SOS1(2), STAT5A(1), SYK(2) 13392191 28 23 27 7 6 3 8 5 6 0 0.341 0.999 1.000 402 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ALDH1A3(2), AOC3(1), DDC(2), EPX(2), ESCO2(1), HPD(1), MAOB(1), MPO(4), PNPLA3(1), SH3GLB1(1), TAT(2), TPO(1) 12263102 19 15 19 5 4 8 3 0 4 0 0.184 0.999 1.000 403 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(2), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), CYP2C19(2), CYP2C9(2), DHRS2(1), DHRSX(1), ESCO2(1), HADHA(1), PNPLA3(1), SH3GLB1(1), YOD1(1) 10906688 18 17 18 5 2 4 7 3 2 0 0.480 0.999 1.000 404 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 IRS1(1), JUN(1), PIK3CA(6), PIK3R1(1), PTPN11(3), RASA1(3), SLC2A4(1), SOS1(2), SRF(1) 9275979 19 17 18 6 2 5 4 4 3 1 0.539 0.999 1.000 405 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(3), ATP4B(1), ATP5O(1), ATP6AP1(2), ATP6V0A4(1), ATP6V1A(2), ATP6V1E1(1), ATP7A(1), ATP7B(3), COX10(1), COX6A2(1), COX7C(1), NDUFA4(1), NDUFB6(1), SDHA(1), UQCRB(1), UQCRC1(1) 13899298 23 21 23 6 2 3 12 2 4 0 0.437 0.999 1.000 406 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 EGF(4), EGFR(3), MAPK1(1), PTPRB(4), RASA1(3), SOS1(2), SPRY1(1), SPRY3(2) 9144529 20 14 20 6 1 9 5 1 4 0 0.370 0.999 1.000 407 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(1), CFTR(7), GNAS(2), PRKACG(1), PRKAR1B(1), PRKAR2B(1) 4788042 13 12 13 6 3 1 3 5 1 0 0.828 1.000 1.000 408 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CR1(3), CR2(2), FCGR2B(1), HLA-DRB1(1), ITGAL(2), ITGB2(1), PTPRC(4) 5552076 14 12 14 7 3 5 4 1 1 0 0.743 1.000 1.000 409 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 FN3K(1), IMPA2(1), INPP1(2), INPP4A(2), INPP4B(1), INPP5A(1), INPP5B(3), INPPL1(1), ITPK1(2), ITPKA(1), OCRL(1), PI4KA(4), PI4KB(1), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIP5K1A(1), PIP5K1B(1), PLCB1(5), PLCB2(2), PLCB3(2), PLCB4(3), PLCD3(1), PLCE1(6), PLCG1(1), PLCG2(2), PLCZ1(1), PTEN(8), SYNJ1(2), SYNJ2(1) 27356232 67 47 66 12 14 17 8 14 14 0 0.0104 1.000 1.000 410 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(1), CAMK2B(1), CAMK2G(1), GNAS(2), MAPK1(1), PIK3CA(6), PIK3R1(1), PRKACG(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1), RAC1(1), RPS6KA1(1), SOS1(2) 10664146 21 20 20 6 3 2 6 4 6 0 0.573 1.000 1.000 411 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ADCY1(1), GNAS(2), MAPK1(1), MYT1(3), PIN1(1), PRKACG(1), PRKAR1B(1), PRKAR2B(1), RPS6KA1(1) 7483966 12 10 12 7 2 3 3 1 3 0 0.897 1.000 1.000 412 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(1), ABCC2(3), CES1(1), CYP3A4(3), UGT1A10(1), UGT1A4(1), UGT1A5(2), UGT1A6(1) 8230653 13 13 13 9 4 2 2 2 3 0 0.959 1.000 1.000 413 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLRMT(1) 4965190 1 1 1 3 0 0 0 0 1 0 1.000 1.000 1.000 414 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 32 JUN(1), MAP2K3(2), MAP2K4(2), MAP2K6(2), MAP3K7(1), NFKB1(1), PPARA(1), RELA(2), TIRAP(1), TLR2(3), TLR3(2), TLR4(1), TLR9(3), TOLLIP(1), TRAF6(2) 13328791 25 22 25 7 2 4 6 9 4 0 0.477 1.000 1.000 415 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 ABAT(1), ADSL(1), AGXT(1), AGXT2(1), ASL(1), ASNS(1), ASPA(1), CAD(4), DARS(1), GAD1(1), GAD2(2), GPT2(2), PC(1) 9520031 18 16 18 7 2 4 5 3 4 0 0.702 1.000 1.000 416 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOB(3), DERA(1), FBP1(1), H6PD(2), PFKL(3), PFKP(2), PGM1(1), TKT(1), TKTL1(2), TKTL2(1) 8874984 17 13 17 9 4 2 5 1 5 0 0.843 1.000 1.000 417 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(2), ANAPC2(3), ANAPC4(2), ANAPC5(1), BTRC(2), CDC20(1), CUL1(3), CUL3(1), FZR1(2), SMURF2(1), UBA1(1), UBE2C(1), WWP1(2), WWP2(1) 14898061 23 19 23 5 5 4 3 9 2 0 0.232 1.000 1.000 418 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 ITGA4(2), ITGAL(2), ITGAM(2), ITGB2(1), SELL(1), SELP(2) 5959207 10 10 10 7 2 1 3 3 1 0 0.934 1.000 1.000 419 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 GUSB(2), UGDH(2), UGP2(2), UGT1A10(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT2A3(1), UGT2B11(3), UGT2B15(2), UGT2B17(2) 9825650 19 17 19 7 5 5 3 2 4 0 0.687 1.000 1.000 420 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(2), ACTB(3), ARHGEF2(2), ARPC5(1), CDH1(1), CLDN1(2), CTTN(3), EZR(1), FYN(1), HCLS1(3), KRT18(1), NCK2(1), OCLN(1), PRKCA(1), ROCK1(1), ROCK2(2), TLR4(1), TLR5(2), TUBA3C(3), TUBA3D(1), TUBA3E(1), TUBA4A(1), TUBA8(1), TUBAL3(2), TUBB2B(2), TUBB8(3), YWHAQ(1) 19185241 44 35 43 10 5 8 11 9 11 0 0.224 1.000 1.000 421 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(2), ACTB(3), ARHGEF2(2), ARPC5(1), CDH1(1), CLDN1(2), CTTN(3), EZR(1), FYN(1), HCLS1(3), KRT18(1), NCK2(1), OCLN(1), PRKCA(1), ROCK1(1), ROCK2(2), TLR4(1), TLR5(2), TUBA3C(3), TUBA3D(1), TUBA3E(1), TUBA4A(1), TUBA8(1), TUBAL3(2), TUBB2B(2), TUBB8(3), YWHAQ(1) 19185241 44 35 43 10 5 8 11 9 11 0 0.224 1.000 1.000 422 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(1), ACACB(4), ACAT1(2), ACSS2(2), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), DLAT(1), GRHPR(1), LDHB(1), ME1(1), ME3(2), PC(1), PDHA2(2), PDHB(1), PKLR(2) 16943621 26 23 26 6 4 3 9 5 5 0 0.274 1.000 1.000 423 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(1), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), AOC3(1), DPYD(6), GAD1(1), GAD2(2), HADHA(1) 9778521 17 13 17 7 1 5 3 4 4 0 0.658 1.000 1.000 424 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 37 ANPEP(1), GCLC(1), GGT1(1), GPX5(2), GSTA4(1), GSTM5(1), IDH1(2), MGST1(1) 8255982 10 9 10 6 2 2 3 0 3 0 0.926 1.000 1.000 425 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(1), CD3G(1), CREBBP(4), GNAS(2), HLA-DRB1(1), LCK(1), PRKACG(1), PRKAR1B(1), PRKAR2B(1), PTPRC(4), ZAP70(5) 8368487 22 20 22 8 7 5 5 2 3 0 0.598 1.000 1.000 426 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(1), CD3G(1), CREBBP(4), GNAS(2), HLA-DRB1(1), LCK(1), PRKACG(1), PRKAR1B(1), PRKAR2B(1), PTPRC(4), ZAP70(5) 8368487 22 20 22 8 7 5 5 2 3 0 0.598 1.000 1.000 427 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(1), DLG4(1), EPHB2(1), F2(3), F2RL2(1), JUN(1), MAP2K5(1), MAPK1(1), MAPK7(1), PLD1(3), PLD2(1), PTK2(3), RASAL1(1), TEC(2), VAV1(3) 10110544 24 21 24 8 6 3 7 4 4 0 0.649 1.000 1.000 428 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2B(1), CAMK2G(1), ITPKA(1), ITPR1(4), ITPR2(6), ITPR3(2), NFAT5(4), PDE6A(1), PDE6B(3), PDE6C(1), PDE6H(1), SLC6A13(1), TF(1) 13084564 27 23 27 7 9 4 4 3 7 0 0.232 1.000 1.000 429 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 ACHE(3), CHAT(2), DBH(1), DDC(2), GAD1(1), GAD2(2), HDC(3), PAH(1), TH(1) 5322099 16 14 16 9 7 5 0 3 1 0 0.731 1.000 1.000 430 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(1), ALPL(3), ALPP(1), ASCC3(2), ATP13A2(1), DDX18(2), DDX23(2), DDX4(1), DDX41(1), DDX50(1), DDX51(1), DDX52(1), DDX56(1), EP400(3), FPGS(2), GGH(1), IFIH1(1), MOV10L1(1), QDPR(2), RAD54B(1), RAD54L(1), RUVBL2(2), SETX(3), SMARCA2(2), SMARCA5(2) 23094349 39 32 39 9 6 10 12 4 7 0 0.168 1.000 1.000 431 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B4GALNT1(4), LCT(5), ST3GAL5(1), ST6GALNAC3(1), ST6GALNAC5(1), ST6GALNAC6(1) 5843211 13 11 13 7 3 1 6 2 1 0 0.900 1.000 1.000 432 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ARHGAP5(2), ARHGAP6(1), ARHGEF1(1), ARHGEF11(2), ARHGEF5(1), ARPC1B(1), BAIAP2(3), DIAPH1(2), LIMK1(3), MYLK(3), OPHN1(1), PIP5K1A(1), PIP5K1B(1), PPP1R12B(1), ROCK1(1), TLN1(2) 16840224 26 20 26 5 6 4 7 5 4 0 0.215 1.000 1.000 433 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5R1(1), DRD1(1), DRD2(1), GRM1(1), PLCB1(5), PRKACG(1), PRKAR1B(1), PRKAR2B(1) 5703949 12 9 12 5 1 4 3 3 1 0 0.698 1.000 1.000 434 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 ANKHD1(1), EEF1G(2), EEF2(1), EIF2AK3(2), EIF2B3(1), EIF2S2(1), EIF4A2(2), EIF4G1(1), EIF4G3(4), EIF5B(1), GSPT2(1), PABPC1(2), PABPC3(3), PAIP1(1), SLC35A4(1) 16257785 24 20 24 5 3 8 2 6 5 0 0.236 1.000 1.000 435 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 IRS1(1), MAPK1(1), PIK3CA(6), PIK3R1(1), PLCG1(1), PRKCA(1), RPS6KA1(1), SLC2A4(1), SOS1(2), SRF(1), STAT5A(1) 12039323 17 16 16 6 2 2 4 4 4 1 0.725 1.000 1.000 436 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT1(2), CHPF(1), CHST11(1), CHST14(1), CHST3(1), DSE(2), XYLT1(1), XYLT2(2) 5189556 11 8 11 5 2 6 0 2 1 0 0.532 1.000 1.000 437 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(1), ADH4(2), ADH6(1), ADH7(3), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), ALDOB(3), DLAT(1), ENO1(1), ENO2(2), ENO3(1), FBP1(1), GAPDH(1), GCK(2), HK2(2), LDHB(1), PDHA2(2), PDHB(1), PFKP(2), PGM1(1), PKLR(2) 17865584 35 26 35 9 7 5 9 5 9 0 0.369 1.000 1.000 438 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(1), ADH4(2), ADH6(1), ADH7(3), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), ALDOB(3), DLAT(1), ENO1(1), ENO2(2), ENO3(1), FBP1(1), GAPDH(1), GCK(2), HK2(2), LDHB(1), PDHA2(2), PDHB(1), PFKP(2), PGM1(1), PKLR(2) 17865584 35 26 35 9 7 5 9 5 9 0 0.369 1.000 1.000 439 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(4), DPYD(6), DTYMK(1), ENTPD1(1), NME2(1), NT5E(1), POLD1(3), POLE(5), POLG(1), POLL(1), POLQ(7), POLRMT(1), RRM2(1), TXNRD1(4), UMPS(1) 21093456 38 27 37 7 2 10 14 5 7 0 0.108 1.000 1.000 440 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(1), GPLD1(1), PGAP1(2), PIGB(1), PIGC(2), PIGG(2), PIGN(3), PIGS(2), PIGT(1) 9057052 15 13 15 5 1 7 2 3 2 0 0.438 1.000 1.000 441 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACADL(1), ACADSB(1), ACAT1(2), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), AOX1(2), BCAT1(1), BCKDHA(1), HADHA(1), MCCC1(1), MUT(3) 13123762 18 16 18 5 0 4 4 7 3 0 0.527 1.000 1.000 442 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 LCT(5), MAN2B2(1), MAN2C1(1), NEU3(2) 7408902 9 7 9 5 2 1 3 0 2 1 0.777 1.000 1.000 443 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AOC3(1), CES1(1), ESCO2(1), LIPA(1), PLA1A(2), PNPLA3(1), SH3GLB1(1) 8956790 8 7 8 3 3 3 1 0 1 0 0.535 1.000 1.000 444 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(1), ACADL(1), ACADSB(1), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), AOC3(1), DPYD(6), GAD1(1), GAD2(2), HADHA(1) 10508406 19 15 19 7 1 5 3 6 4 0 0.589 1.000 1.000 445 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(1), AGTR2(1), CAMK2B(1), CAMK2G(1), F2(3), FYN(1), GNA11(1), MAP2K2(1), MAPK1(1), MAPT(1), MYLK(3), PLCG1(1), PRKCA(1), PTK2B(2), SOS1(2), STAT1(2), STAT3(1), STAT5A(1), SYT1(2) 15383357 27 21 27 7 3 6 9 3 6 0 0.296 1.000 1.000 446 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 CASP2(1), CASP4(2), CASP8(1), LMNB1(1) 6982543 5 5 5 3 0 3 1 0 1 0 0.882 1.000 1.000 447 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(2), BTK(1), JUN(1), LYN(1), NFATC2(2), NFATC3(1), PLCG1(1), PPP3CB(1), PPP3CC(2), PRKCA(1), RAC1(1), SOS1(2), SYK(2), SYT1(2), VAV1(3) 13816409 23 22 23 9 4 2 8 3 6 0 0.786 1.000 1.000 448 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOB(3), FBP1(1), H6PD(2), PFKP(2), PGM1(1), TAL1(1), TKT(1) 7335752 11 9 11 7 3 1 5 0 2 0 0.891 1.000 1.000 449 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(1), ACAT1(2), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), AOX1(2), BCAT1(1), BCKDHA(1), DBT(1), HADHA(1), HMGCS2(2), HSD17B4(1), MCCC1(1), MUT(3), OXCT2(1) 15822118 22 20 22 7 2 4 4 5 7 0 0.623 1.000 1.000 450 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTN1(1), BCAR1(2), BCR(2), CAPN1(1), CAPNS1(1), FYN(1), ITGA1(1), JUN(1), MAP2K2(1), MAPK1(1), PPP1R12B(1), PTK2(3), RAP1A(1), ROCK1(1), SOS1(2), TLN1(2) 17533414 22 20 22 5 3 3 6 5 5 0 0.401 1.000 1.000 451 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(1), ABAT(1), ACAT1(2), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), GAD1(1), GAD2(2), HADHA(1), PDHA2(2), PDHB(1) 9391041 16 14 16 6 0 4 4 6 2 0 0.665 1.000 1.000 452 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 IRS1(1), JAK1(1), JAK3(2), MAP4K1(3), MAPK1(1), PIK3CA(6), PIK3CD(1), PIK3R1(1), PPP1R13B(1), SOS1(2) 13342134 19 17 18 8 4 0 5 4 6 0 0.849 1.000 1.000 453 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 35 ARHGEF11(2), DLG4(1), MAP2K4(2), MAP3K5(4), NFKB1(1), NFKBIL1(1), PHKA2(2), PI3(1), PIK3CB(1), PLD1(3), PLD2(1), PTK2(3), RDX(1), ROCK1(1), ROCK2(2), SERPINA4(1), SRF(1) 18312773 28 24 28 7 5 6 4 9 3 1 0.417 1.000 1.000 454 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 28 BAG4(1), CASP8(1), JUN(1), MAP2K4(2), MAP3K7(1), NFKB1(1), NFKBIL1(1), RIPK1(2), TNF(1), TNFRSF1A(1), TRADD(1), TRAF2(2) 10249352 15 15 15 5 2 5 4 1 3 0 0.567 1.000 1.000 455 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(3), ATP4B(1), ATP5B(1), ATP5C1(1), ATP5J2(1), ATP5O(1), ATP6AP1(2), ATP6V0A4(1), ATP6V1A(2), ATP6V1E1(1), COX10(1), COX6A2(1), COX7C(1), LHPP(2), NDUFA13(1), NDUFA4(1), NDUFA7(2), NDUFB6(1), NDUFV3(1), SDHA(1), TCIRG1(1), UQCRB(1), UQCRC1(1) 20665347 29 28 29 7 4 4 13 2 6 0 0.348 1.000 1.000 456 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(1), ALOX12(2), ALOX15(1), ALOX5(2), CBR3(1), CYP4F2(2), EPX(2), GGT1(1), MPO(4), PLA2G4A(1), PTGIS(1), PTGS1(1), PTGS2(1), TBXAS1(1), TPO(1) 10522708 22 17 22 7 3 8 5 2 4 0 0.299 1.000 1.000 457 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 43 DAXX(1), EGF(4), EGFR(3), ETS1(1), JUN(1), MAP2K3(2), MAP2K4(2), MAP2K6(2), MAP2K7(3), MAP3K5(4), MAPK1(1), NFKB1(1), PRKCA(1), PRKCE(2), PRKCG(1), PRKCH(1), PRKCQ(3), RELA(2), RIPK1(2), SP1(2), TNF(1), TNFRSF1A(1), TRAF2(2) 17862368 43 31 43 10 5 16 7 5 10 0 0.0888 1.000 1.000 458 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 27 ADRBK1(1), ITPKA(1), ITPR1(4), ITPR2(6), ITPR3(2), NFKB1(1), NFKBIL1(1), PHKA2(2), PIK3CB(1), PLD1(3), PLD2(1), VN1R1(1) 16805137 24 22 24 6 8 5 3 4 4 0 0.292 1.000 1.000 459 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 GBA(1), GNS(2), GUSB(2), HPSE2(3), IDS(1), IDUA(4), LCT(5), MAN2B2(1), MAN2C1(1), NAGLU(1), NEU3(2), SPAM1(2) 12823598 25 20 25 9 7 3 7 2 5 1 0.419 1.000 1.000 460 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 18 DUSP1(1), IKBKAP(2), NFKB1(1), RELA(2), RIPK1(2), TRAF2(2) 8232383 10 10 10 6 1 5 2 1 1 0 0.876 1.000 1.000 461 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(1), ALG11(2), ALG13(1), ALG14(1), ALG2(1), ALG3(1), ALG6(1), ALG9(1), DHDDS(1), FUT8(1), GANAB(1), MAN1A1(3), MAN1B1(1), MAN1C1(2), MGAT3(1), MGAT5(2), MGAT5B(2), RPN2(2) 15623630 25 20 25 7 3 7 6 3 5 1 0.315 1.000 1.000 462 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 ASNS(1), ASRGL1(1), CA12(1), CA2(3), CA3(1), CA4(1), CA9(1), CTH(1), GLS2(1), GLUL(2) 7679478 13 13 13 5 4 3 5 0 1 0 0.639 1.000 1.000 463 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 EPO(1), JUN(1), PLCG1(1), SOS1(2), STAT5A(1) 8060821 6 6 6 3 1 0 3 1 1 0 0.852 1.000 1.000 464 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(2), GPRC5B(1), GPRC5C(3), GRM1(1), GRM3(5), GRM4(1), GRM5(4), GRM7(2), GRM8(2) 7419426 21 15 21 9 6 7 3 4 1 0 0.483 1.000 1.000 465 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B10(1), ALDOB(3), FBP1(1), FPGT(2), GMDS(1), GMPPA(2), HK2(2), KHK(1), LHPP(2), MTMR2(1), PFKFB1(1), PFKFB2(1), PFKFB4(3), PFKL(3), PFKP(2) 13897798 26 23 26 8 10 1 8 0 7 0 0.368 1.000 1.000 466 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(1) 8352425 1 1 1 3 0 0 0 0 1 0 0.998 1.000 1.000 467 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ACY1(1), AGMAT(1), ALDH18A1(1), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), AMD1(1), AOC3(1), ARG2(2), ASL(1), MAOB(1) 10791388 14 13 14 6 2 3 4 1 4 0 0.760 1.000 1.000 468 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA2C(1), CHRM1(1), CHRM2(2), CHRM4(1), CHRM5(1), DRD1(1), DRD2(1), DRD3(2), HTR1A(1), HTR1B(1), HTR1D(2), HTR2A(1), HTR4(1), HTR6(1) 9192732 17 15 17 7 3 7 5 2 0 0 0.335 1.000 1.000 469 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 CDK5R1(1), CHN1(1), LIMK1(3), MYLK(3), PAK1(1), PDGFRA(1), PIK3CA(6), PIK3R1(1), PLD1(3), PPP1R12B(1), RAC1(1), TRIO(4), VAV1(3) 12699503 29 24 28 9 7 3 8 8 3 0 0.527 1.000 1.000 470 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(2), APOA4(1), CETP(1), DGAT1(1), LIPC(3), LPL(2), LRP1(4), SCARB1(1), SOAT1(1) 9937050 16 15 16 8 2 4 7 1 2 0 0.739 1.000 1.000 471 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B10(1), G6PC2(1), GAA(1), GALK1(1), GCK(2), GLA(1), HK2(2), LCT(5), MGAM(5), PFKL(3), PFKP(2), PGM1(1), UGP2(2) 14253402 27 23 27 9 7 7 9 1 3 0 0.385 1.000 1.000 472 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 144 APC(5), AXIN1(1), AXIN2(2), BTRC(2), CAMK2B(1), CAMK2G(1), CCND1(1), CHD8(4), CREBBP(4), CTBP1(3), CTBP2(1), CUL1(3), DAAM1(1), DAAM2(1), DKK2(1), DVL1(2), DVL2(1), EP300(2), FZD10(1), FZD2(2), FZD3(2), FZD5(1), FZD6(1), JUN(1), LRP5(2), MAP3K7(1), MAPK10(2), MMP7(1), MYC(3), NFAT5(4), NFATC2(2), NFATC3(1), NKD2(2), PLCB1(5), PLCB2(2), PLCB3(2), PLCB4(3), PORCN(2), PPP2R1A(2), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R2C(2), PPP3CB(1), PPP3CC(2), PRICKLE1(1), PRKACA(2), PRKACG(1), PRKCA(1), PRKCG(1), RAC1(1), ROCK1(1), ROCK2(2), RUVBL1(1), SFRP4(1), SMAD3(2), SOX17(1), TBL1Y(2), TCF7L1(1), TCF7L2(1), TP53(89), VANGL1(2), WIF1(4), WNT10B(1), WNT2(1), WNT2B(1), WNT5A(1), WNT7B(1), WNT8A(1), WNT8B(1) 58315564 208 123 194 35 28 36 42 35 67 0 7.47e-05 1.000 1.000 473 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(1), GNAS(2), JUN(1), NFATC2(2), NFATC3(1), PLCG1(1), PPP3CB(1), PPP3CC(2), PRKACG(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1), SYT1(2) 12664412 17 16 17 6 3 1 7 2 4 0 0.785 1.000 1.000 474 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 GTF2B(1), HDAC3(1), NCOA1(4), NCOR2(5), RARA(1), RXRA(1) 9194027 13 12 13 5 3 3 3 3 1 0 0.649 1.000 1.000 475 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 70 ADH1A(1), ADH4(2), ADH6(1), ADH7(3), AKR1C3(1), AKR1C4(1), ALDH1A3(2), CYP1A2(2), CYP2C18(3), CYP2C19(2), CYP2C9(2), CYP2E1(3), CYP2F1(2), CYP2S1(2), CYP3A4(3), CYP3A7(2), DHDH(1), EPHX1(2), GSTA4(1), GSTM5(1), MGST1(1), UGT1A10(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT2A3(1), UGT2B11(3), UGT2B15(2), UGT2B17(2) 21106766 51 35 51 13 8 11 10 9 13 0 0.204 1.000 1.000 476 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 99 CASP8(1), CCL3(1), CD86(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA17(1), IFNA6(1), IFNA8(1), IFNAR1(1), IRF3(1), IRF5(1), JUN(1), LBP(1), MAP2K2(1), MAP2K3(2), MAP2K4(2), MAP2K6(2), MAP2K7(3), MAP3K7(1), MAPK1(1), MAPK10(2), MAPK11(1), NFKB1(1), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), RAC1(1), RELA(2), RIPK1(2), STAT1(2), TICAM1(2), TIRAP(1), TLR1(1), TLR2(3), TLR3(2), TLR4(1), TLR5(2), TLR8(1), TLR9(3), TNF(1), TOLLIP(1), TRAF6(2) 32386445 69 47 68 13 11 16 14 16 12 0 0.0217 1.000 1.000 477 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(1), ADH4(2), ADH6(1), ADH7(3), AGK(1), AGPAT6(2), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), CEL(5), DGAT1(1), DGKB(1), DGKD(3), DGKE(1), DGKG(3), DGKH(2), DGKI(1), DGKQ(1), DGKZ(1), GK2(2), GLA(1), GPAM(1), LCT(5), LIPA(1), LIPC(3), LIPF(1), LPL(2), PNLIPRP1(1), PNPLA3(1), PPAP2A(1), PPAP2B(2), PPAP2C(1) 21699876 56 41 55 15 5 10 17 10 13 1 0.407 1.000 1.000 478 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACADL(1), ACADSB(1), ACAT1(2), ACSL3(1), ACSL4(2), ACSL6(4), ADH1A(1), ADH4(2), ADH6(1), ADH7(3), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), CPT1A(1), CPT1B(1), CYP4A11(1), HADHA(1), HSD17B4(1) 17834756 28 25 28 9 4 1 8 9 6 0 0.726 1.000 1.000 479 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG2(1), ADCY3(1), ADCY9(1), ARF1(1), ARL4D(1), ATP6V0A4(1), ATP6V1A(2), ATP6V1E1(1), GNAS(2), PDIA4(1), PLCG1(1), PLCG2(2), PRKCA(1), SEC61A2(1), SEC61B(1) 13493111 18 16 18 8 2 5 4 4 3 0 0.771 1.000 1.000 480 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 37 CCNH(1), GTF2B(1), GTF2H1(1), POLR1A(1), POLR3E(1), TAF6(1) 12672490 6 6 6 5 1 1 1 0 3 0 0.956 1.000 1.000 481 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 CASP8(1), GAS2(1), NFKB1(1), RELA(2), RIPK1(2), SPTAN1(4), TNFRSF10B(1), TNFSF10(1), TRADD(1), TRAF2(2) 12204229 16 13 16 7 2 5 5 0 4 0 0.894 1.000 1.000 482 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 BCR(2), BTK(1), CD19(1), CDKN2A(2), GAB1(1), ITPR1(4), ITPR2(6), ITPR3(2), LYN(1), PIK3CA(6), PLCG2(2), PPP1R13B(1), PREX1(2), PTEN(8), PTPRC(4), RPS6KA1(1), SAG(1), SYK(2), TEC(2), VAV1(3) 20510509 52 47 51 14 13 5 11 13 10 0 0.312 1.000 1.000 483 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 GAA(1), GALK1(1), GANAB(1), GCK(2), GLA(1), HK2(2), LCT(5), MGAM(5), PFKP(2), PGM1(1) 11957090 21 18 21 8 6 6 7 1 1 0 0.544 1.000 1.000 484 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(1), EGFR(3), ERBB2(1), ERBB4(4), ETS1(1), ETV6(1), ETV7(1), FMN2(7), KRAS(2), MAPK1(1), NOTCH1(3), NOTCH2(2), NOTCH3(5), NOTCH4(6), PIWIL1(3), PIWIL2(1), PIWIL3(1), PIWIL4(1), SOS1(2), SPIRE1(2) 19515802 48 37 48 13 10 8 16 6 7 1 0.283 1.000 1.000 485 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 BRAF(1), DUSP9(1), MAP2K2(1), MAPK1(1), MKNK1(1), NFKB1(1), RAP1A(1), RPS6KA1(1), SOS1(2) 10901705 10 9 10 9 1 3 4 1 1 0 0.987 1.000 1.000 486 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 APC(5), CAMP(1), CAV3(1), DLG4(1), EPHB2(1), ITPR1(4), ITPR2(6), ITPR3(2), KCNJ3(1), KCNJ5(2), KCNJ9(1), MAPK1(1), RAC1(1), RHO(1), RYR1(16) 16875637 44 32 43 13 13 14 4 4 9 0 0.0830 1.000 1.000 487 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 63 CDK2(1), CDKN2A(2), ERBB4(4), F2RL2(1), GAB1(1), IGF1(1), INPPL1(1), IRS1(1), IRS4(3), MET(4), MYC(3), NOLC1(1), PAK1(1), PAK3(3), PAK4(1), PAK7(1), PIK3CA(6), PIK3CD(1), PPP1R13B(1), PREX1(2), PTEN(8), PTK2(3), PTPN1(1), RPS6KA1(1), SLC2A4(1), SOS1(2), TSC1(1), TSC2(4), YWHAE(2), YWHAQ(1) 27977825 63 51 61 15 10 14 11 14 14 0 0.218 1.000 1.000 488 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ADH1A(1), ADH4(2), ADH6(1), ADH7(3), ALDH1A3(2), AOC3(1), AOX1(2), CARM1(1), DBH(1), DCT(3), DDC(2), ESCO2(1), HEMK1(1), HPD(1), MAOB(1), PNPLA3(1), PRMT2(2), PRMT3(1), PRMT6(1), PRMT8(1), SH3GLB1(1), TAT(2), TH(1), TPO(1), TYR(2), WBSCR22(1) 21554841 37 26 37 10 6 13 6 4 8 0 0.325 1.000 1.000 489 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 BTK(1), FCER1A(1), FYN(1), INPP5D(3), KRAS(2), LAT(1), LCP2(2), LYN(1), MAP2K2(1), MAP2K3(2), MAP2K4(2), MAP2K6(2), MAP2K7(3), MAPK1(1), MAPK10(2), MAPK11(1), MS4A2(3), NRAS(1), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PLA2G12B(1), PLA2G2D(1), PLA2G4A(1), PLCG1(1), PLCG2(2), PRKCA(1), PRKCE(2), RAC1(1), SOS1(2), SYK(2), TNF(1), VAV1(3), VAV2(3), VAV3(1) 26529400 64 44 63 17 9 16 9 19 11 0 0.168 1.000 1.000 490 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS2(2), ADH1A(1), ADH4(2), ADH6(1), ADH7(3), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), ALDOB(3), DLAT(1), ENO1(1), ENO2(2), ENO3(1), FBP1(1), G6PC2(1), GAPDH(1), GCK(2), HK2(2), LDHB(1), PDHA2(2), PDHB(1), PFKL(3), PFKP(2), PGK2(1), PGM1(1), PKLR(2) 21366271 42 32 42 10 8 5 12 5 12 0 0.249 1.000 1.000 491 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 CASP2(1), CASP4(2), CASP8(1), CD40LG(1), DAXX(1), FAS(1), NFKB1(1), NGFR(1), NTRK1(3), RIPK1(2), TNF(1), TNFRSF1A(1), TRADD(1), TRAF2(2), TRAF6(2) 15953942 21 18 21 8 6 7 4 1 3 0 0.670 1.000 1.000 492 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AMY2B(4), ENPP1(3), ENPP3(2), GAA(1), GANAB(1), GBE1(4), GCK(2), GUSB(2), GYS2(1), HK2(2), MGAM(5), PGM1(1), PYGB(2), PYGM(3), RNPC3(2), SI(4), UCHL3(1), UGDH(2), UGT1A10(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT2B15(2) 21178895 49 35 48 12 11 15 6 6 11 0 0.160 1.000 1.000 493 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 CREBBP(4), CTBP1(3), CTBP2(1), DLL3(1), DTX1(3), DTX2(3), DTX3(2), DTX4(2), DVL1(2), DVL2(1), EP300(2), JAG1(4), JAG2(1), MAML1(1), MAML2(2), MAML3(4), NCOR2(5), NCSTN(1), NOTCH1(3), NOTCH2(2), NOTCH3(5), NOTCH4(6), NUMBL(9), PSEN2(1), SNW1(2) 26373326 70 45 62 19 15 15 8 8 23 1 0.249 1.000 1.000 494 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(3), AGPAT6(2), CDIPT(1), CDS1(1), CHAT(2), DGKB(1), DGKD(3), DGKE(1), DGKG(3), DGKH(2), DGKI(1), DGKQ(1), DGKZ(1), ESCO2(1), ETNK2(1), GPAM(1), GPD2(2), PLA2G12B(1), PLA2G2D(1), PLA2G4A(1), PLD1(3), PLD2(1), PNPLA3(1), PPAP2A(1), PPAP2B(2), PPAP2C(1), SH3GLB1(1) 24037933 40 31 39 10 9 8 11 4 7 1 0.232 1.000 1.000 495 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 BCAR1(2), CAPN1(1), CAPN10(1), CAPN11(4), CAPN2(1), CAPN3(1), CAPN5(1), CAPN7(2), CAPN9(2), CAPNS1(1), CAV3(1), DOCK1(3), FYN(1), ITGA10(4), ITGA11(1), ITGA2(1), ITGA2B(2), ITGA3(2), ITGA4(2), ITGA6(3), ITGA7(1), ITGA8(1), ITGA9(1), ITGAD(3), ITGAE(1), ITGAL(2), ITGAM(2), ITGAV(3), ITGAX(1), ITGB2(1), ITGB4(4), ITGB6(2), ITGB7(2), ITGB8(1), MAP2K2(1), MAP2K3(2), MAP2K6(2), MAPK10(2), MAPK6(2), MAPK7(1), MYLK2(2), PAK1(1), PAK3(3), PAK4(1), PTK2(3), RAC1(1), RAPGEF1(1), RHO(1), ROCK1(1), ROCK2(2), SHC3(1), SORBS1(2), SOS1(2), TLN1(2), TNS1(1), VASP(1), VAV2(3), VAV3(1) 49803016 100 72 100 20 15 25 28 17 15 0 0.0101 1.000 1.000 496 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 CISH(2), IARS(1), IL2RG(1), INPP5D(3), JAK1(1), JAK3(2), PI3(1), PIK3CA(6), PPP1R13B(1), SERPINA4(1), SOS1(2), TYK2(1) 13550892 22 19 21 9 3 4 6 8 1 0 0.819 1.000 1.000 497 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ADORA3(3), ALG6(1), CCKBR(2), CCR3(2), CELSR1(7), CELSR2(4), CELSR3(4), CHRM2(2), CIDEB(1), EDNRA(1), EMR2(2), EMR3(1), F2R(1), FSHR(1), GPR116(3), GPR132(1), GPR133(1), GPR135(1), GPR143(3), GPR55(1), GPR88(1), GRM1(1), GRPR(1), LGR6(1), LPHN2(4), LPHN3(2), NTSR1(2), OR2M4(1), P2RY11(1), VN1R1(1) 24025239 57 41 57 15 11 14 14 13 5 0 0.0575 1.000 1.000 498 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 BRAF(1), CAB39(2), FIGF(1), HIF1A(1), IGF1(1), MAPK1(1), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PRKAA2(5), RICTOR(3), RPS6(1), RPS6KA1(1), TSC1(1), TSC2(4), ULK1(3), ULK2(2), ULK3(1), VEGFC(1) 19702923 41 30 40 11 6 13 7 7 7 1 0.264 1.000 1.000 499 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 93 CARD11(3), CBLB(2), CBLC(1), CD3G(1), CD40LG(1), CDK4(1), CTLA4(1), FYN(1), GRAP2(2), IFNG(1), ITK(1), JUN(1), KRAS(2), LAT(1), LCK(1), LCP2(2), NCK2(1), NFAT5(4), NFATC2(2), NFATC3(1), NFKB1(1), NRAS(1), PAK1(1), PAK3(3), PAK4(1), PAK7(1), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PLCG1(1), PPP3CB(1), PPP3CC(2), PRKCQ(3), PTPRC(4), SOS1(2), TEC(2), TNF(1), VAV1(3), VAV2(3), VAV3(1), ZAP70(5) 37120582 78 55 77 16 12 19 20 14 13 0 0.0339 1.000 1.000 500 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(2), ACTN1(1), ANGPTL2(2), ARHGEF6(2), ARHGEF7(1), BCAR1(2), BRAF(1), CDKN2A(2), CSE1L(1), DOCK1(3), EPHB2(1), FYN(1), ITGA1(1), ITGA10(4), ITGA11(1), ITGA2(1), ITGA3(2), ITGA4(2), ITGA6(3), ITGA7(1), ITGA8(1), ITGA9(1), MAP2K4(2), MAP2K7(3), MAP3K11(1), MAPK1(1), MAPK10(2), MAPK8IP3(3), MYLK(3), MYLK2(2), PAK1(1), PAK3(3), PAK4(1), PAK7(1), PIK3CA(6), PIK3CB(1), PKLR(2), PLCG1(1), PLCG2(2), PTEN(8), PTK2(3), RHO(1), ROCK1(1), ROCK2(2), SOS1(2), TLN1(2), TLN2(6), VASP(1) 44906677 97 73 96 21 15 22 22 22 16 0 0.0549 1.000 1.000 501 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 63 BLNK(2), BTK(1), CARD11(3), CD19(1), CD22(1), CD72(1), CD81(1), CR2(2), FCGR2B(1), INPP5D(3), JUN(1), KRAS(2), LILRB3(1), LYN(1), NFAT5(4), NFATC2(2), NFATC3(1), NFKB1(1), NRAS(1), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PLCG2(2), PPP3CB(1), PPP3CC(2), RAC1(1), SYK(2), VAV1(3), VAV2(3), VAV3(1) 27199129 57 40 56 15 7 14 15 8 13 0 0.213 1.000 1.000 502 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ANGPTL2(2), ARHGEF11(2), BTK(1), GDI1(1), INPPL1(1), ITPR1(4), ITPR2(6), ITPR3(2), LIMK1(3), MYLK(3), MYLK2(2), PAK1(1), PAK3(3), PAK4(1), PAK7(1), PIK3CA(6), PIK3CD(1), PIK3CG(2), PIK3R1(1), PPP1R13B(1), PTEN(8), RHO(1), ROCK1(1), ROCK2(2), SAG(1) 25702166 57 45 56 15 11 11 11 15 9 0 0.261 1.000 1.000 503 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 85 BRAF(1), DAXX(1), JUN(1), MAP2K2(1), MAP2K3(2), MAP2K4(2), MAP2K5(1), MAP2K6(2), MAP2K7(3), MAP3K11(1), MAP3K12(1), MAP3K13(1), MAP3K4(1), MAP3K5(4), MAP3K6(3), MAP3K7(1), MAP3K9(2), MAP4K1(3), MAP4K4(1), MAP4K5(1), MAPK1(1), MAPK10(2), MAPK11(1), MAPK6(2), MAPK7(1), MEF2B(2), MEF2C(1), MKNK1(1), MYC(3), NFKB1(1), PAK1(1), RAC1(1), RELA(2), RIPK1(2), RPS6KA1(1), SP1(2), STAT1(2), TGFB1(1), TGFBR1(1), TRADD(1), TRAF2(2) 36041521 64 41 64 14 9 21 12 12 10 0 0.0361 1.000 1.000 504 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 84 ANPEP(1), CD19(1), CD1A(1), CD1C(1), CD2(1), CD22(1), CD33(1), CD34(1), CD3G(1), CD55(1), CR1(3), CR2(2), CSF1R(2), CSF2RA(1), CSF3R(1), DNTT(1), EPO(1), FCER2(2), FLT3(2), HLA-DRB1(1), HLA-DRB5(1), IL1A(1), IL2RA(1), IL5RA(2), IL6R(2), IL7R(1), IL9R(2), ITGA1(1), ITGA2(1), ITGA2B(2), ITGA3(2), ITGA4(2), ITGA6(3), ITGAM(2), KIT(5), KITLG(1), MME(3), MS4A1(1), TNF(1), TPO(1) 30160592 61 43 61 16 7 15 18 8 12 1 0.225 1.000 1.000 505 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(2), ABL2(1), BRAF(1), BTC(1), CAMK2B(1), CAMK2G(1), CBLB(2), CBLC(1), CDKN1A(2), EGF(4), EGFR(3), ERBB2(1), ERBB3(1), ERBB4(4), GAB1(1), JUN(1), KRAS(2), MAP2K2(1), MAP2K4(2), MAP2K7(3), MAPK1(1), MAPK10(2), MYC(3), NCK2(1), NRAS(1), NRG2(1), NRG3(1), PAK1(1), PAK3(3), PAK4(1), PAK7(1), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PLCG1(1), PLCG2(2), PRKCA(1), PRKCG(1), PTK2(3), SHC3(1), SHC4(2), SOS1(2), STAT5A(1) 37897208 77 54 76 19 12 18 17 13 17 0 0.124 1.000 1.000 506 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CDIPT(1), CDS1(1), DGKB(1), DGKD(3), DGKE(1), DGKG(3), DGKH(2), DGKI(1), DGKQ(1), DGKZ(1), FN3K(1), IMPA2(1), INPP1(2), INPP4A(2), INPP4B(1), INPP5A(1), INPP5B(3), INPP5D(3), INPPL1(1), ITPK1(2), ITPKA(1), ITPR1(4), ITPR2(6), ITPR3(2), OCRL(1), PI4KA(4), PI4KB(1), PIK3C2G(7), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PIP5K1A(1), PIP5K1B(1), PLCB1(5), PLCB2(2), PLCB3(2), PLCB4(3), PLCD3(1), PLCE1(6), PLCG1(1), PLCG2(2), PLCZ1(1), PRKCA(1), PRKCG(1), PTEN(8), SYNJ1(2), SYNJ2(1) 46349610 108 71 106 25 20 25 19 22 22 0 0.0311 1.000 1.000 507 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 BRAF(1), CD48(1), FAS(1), FCGR3A(2), FYN(1), HCST(1), HLA-B(1), HLA-E(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA17(1), IFNA6(1), IFNA8(1), IFNAR1(1), IFNG(1), ITGAL(2), ITGB2(1), KIR3DL1(2), KIR3DL2(1), KLRC3(2), KRAS(2), LAT(1), LCK(1), LCP2(2), MAP2K2(1), MAPK1(1), MICA(1), MICB(1), NFAT5(4), NFATC2(2), NFATC3(1), NRAS(1), PAK1(1), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PLCG1(1), PLCG2(2), PPP3CB(1), PPP3CC(2), PRKCA(1), PRKCG(1), PTK2B(2), PTPN11(3), RAC1(1), SHC3(1), SHC4(2), SOS1(2), SYK(2), TNF(1), TNFRSF10B(1), TNFRSF10D(1), TNFSF10(1), ULBP1(1), VAV1(3), VAV2(3), VAV3(1), ZAP70(5) 41567290 94 64 93 24 13 22 23 21 15 0 0.103 1.000 1.000 508 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 109 ACTN1(1), ACTN4(3), ARHGAP5(2), BCAR1(2), CDH5(1), CLDN1(2), CLDN10(1), CLDN15(1), CLDN2(2), CLDN20(1), CLDN4(1), CLDN6(1), CLDN8(1), CTNNA1(2), CTNNA2(5), CTNNA3(3), CTNND1(4), CYBB(1), EZR(1), F11R(4), ITGA4(2), ITGAL(2), ITGAM(2), ITGB2(1), ITK(1), MAPK11(1), MLLT4(1), MMP2(2), MMP9(1), MYL5(1), NCF4(1), NOX1(2), OCLN(1), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PLCG1(1), PLCG2(2), PRKCA(1), PRKCG(1), PTK2(3), PTK2B(2), PTPN11(3), RAC1(1), RAP1A(1), RAPGEF4(1), ROCK1(1), ROCK2(2), SIPA1(1), TXK(1), VASP(1), VAV1(3), VAV2(3), VAV3(1), VCAM1(1) 45756268 99 62 98 22 15 26 19 23 16 0 0.0147 1.000 1.000 509 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 KDR(4), KRAS(2), MAP2K2(1), MAPK1(1), MAPK11(1), NFAT5(4), NFATC2(2), NFATC3(1), NOS3(3), NRAS(1), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PLA2G12B(1), PLA2G2D(1), PLA2G4A(1), PLCG1(1), PLCG2(2), PPP3CB(1), PPP3CC(2), PRKCA(1), PRKCG(1), PTGS2(1), PTK2(3), RAC1(1), SPHK2(2) 26614616 50 42 49 15 6 7 14 12 11 0 0.517 1.000 1.000 510 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(3), CDIPT(1), CDS1(1), CHAT(2), CPT1B(1), DGKB(1), DGKD(3), DGKE(1), DGKG(3), DGKH(2), DGKQ(1), DGKZ(1), GPD2(2), PAFAH2(2), PLA2G4A(1), PLCB2(2), PLCG1(1), PLCG2(2), PPAP2A(1), PPAP2B(2), PPAP2C(1) 18532497 34 29 33 11 7 7 8 7 4 1 0.479 1.000 1.000 511 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 BRAF(1), DRD2(1), EGFR(3), EPHB2(1), ITPKA(1), ITPR1(4), ITPR2(6), ITPR3(2), KCNJ3(1), KCNJ5(2), KCNJ9(1), MAPK1(1), PI3(1), PIK3CB(1), PLCB1(5), PLCB2(2), PLCB3(2), PLCB4(3), SOS1(2), STAT3(1) 21397845 41 26 41 13 9 12 4 11 5 0 0.304 1.000 1.000 512 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 89 ACVR1(2), ACVR1B(1), ACVR2B(1), AMHR2(1), BMP5(1), BMP6(1), BMPR2(1), CHRD(2), COMP(3), CREBBP(4), CUL1(3), E2F4(2), E2F5(1), EP300(2), FST(1), GDF6(1), ID3(1), ID4(1), IFNG(1), INHBA(2), LTBP1(4), MAPK1(1), MYC(3), PPP2R1A(2), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R2C(2), ROCK1(1), ROCK2(2), SMAD3(2), SMURF2(1), SP1(2), TFDP1(1), TGFB1(1), TGFBR1(1), TGFBR2(1), THBS1(3), THBS3(2), TNF(1), ZFYVE9(4) 35900428 70 47 70 19 11 15 16 13 15 0 0.244 1.000 1.000 513 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP5(1), BMP6(1), BTRC(2), CSNK1G3(1), DHH(2), GLI1(4), GLI2(1), GLI3(1), HHIP(2), LRP2(12), PRKACA(2), PRKACG(1), PTCH1(1), PTCH2(1), STK36(3), SUFU(2), WNT10B(1), WNT2(1), WNT2B(1), WNT5A(1), WNT7B(1), WNT8A(1), WNT8B(1), ZIC2(1) 21829985 45 33 45 15 5 10 12 11 7 0 0.354 1.000 1.000 514 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 248 ACVR1B(1), ARRB1(1), BRAF(1), CACNA1A(7), CACNA1B(7), CACNA1C(4), CACNA1D(2), CACNA1E(4), CACNA1F(5), CACNA1G(3), CACNA1H(4), CACNA1I(3), CACNA1S(6), CACNA2D1(2), CACNA2D3(2), CACNA2D4(1), CACNB1(1), CACNB2(1), CACNB4(1), CACNG3(2), CACNG5(2), CACNG6(1), CACNG8(2), CDC25B(1), DAXX(1), DUSP1(1), DUSP5(1), DUSP7(3), DUSP9(1), ECSIT(2), EGF(4), EGFR(3), FAS(1), FGF13(3), FGF17(1), FGF18(1), FGF23(1), FGF3(2), FGFR1(3), FGFR2(1), FGFR3(1), FGFR4(2), FLNA(4), FLNB(2), FLNC(3), IL1A(1), JUN(1), KRAS(2), MAP2K2(1), MAP2K3(2), MAP2K4(2), MAP2K5(1), MAP2K6(2), MAP2K7(3), MAP3K12(1), MAP3K13(1), MAP3K4(1), MAP3K5(4), MAP3K6(3), MAP3K7(1), MAP4K1(3), MAP4K4(1), MAPK1(1), MAPK10(2), MAPK11(1), MAPK7(1), MAPK8IP3(3), MAPT(1), MEF2C(1), MKNK1(1), MYC(3), NF1(11), NFATC2(2), NFKB1(1), NR4A1(1), NRAS(1), NTRK1(3), NTRK2(3), PAK1(1), PDGFB(1), PDGFRA(1), PDGFRB(2), PLA2G12B(1), PLA2G2D(1), PLA2G4A(1), PPP3CB(1), PPP3CC(2), PPP5C(1), PRKACA(2), PRKACG(1), PRKCA(1), PRKCG(1), PTPN5(2), PTPN7(2), PTPRR(2), RAC1(1), RAP1A(1), RAPGEF2(2), RASA1(3), RASGRF1(4), RASGRF2(4), RPS6KA1(1), RRAS(1), SOS1(2), SRF(1), STK4(1), TAOK1(2), TAOK2(1), TGFB1(1), TGFBR1(1), TGFBR2(1), TNF(1), TNFRSF1A(1), TP53(89), TRAF2(2), TRAF6(2), ZAK(4) 108546471 320 162 305 81 50 67 64 55 83 1 0.00287 1.000 1.000 515 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTB(3), ACTN1(1), ACTN4(3), ARHGAP5(2), BCAR1(2), BRAF(1), CAPN2(1), CAV3(1), CCND1(1), CHAD(1), COL11A1(3), COL11A2(9), COL1A1(3), COL1A2(1), COL2A1(1), COL4A1(6), COL4A2(3), COL4A4(4), COL4A6(4), COL5A2(1), COL5A3(10), COL6A1(2), COL6A3(4), COL6A6(4), COMP(3), DIAPH1(2), DOCK1(3), EGF(4), EGFR(3), ERBB2(1), FARP2(2), FIGF(1), FLNA(4), FLNB(2), FLNC(3), FLT1(3), FN1(3), FYN(1), HGF(2), IGF1(1), IGF1R(2), ITGA1(1), ITGA10(4), ITGA11(1), ITGA2(1), ITGA2B(2), ITGA3(2), ITGA4(2), ITGA6(3), ITGA7(1), ITGA8(1), ITGA9(1), ITGAV(3), ITGB4(4), ITGB6(2), ITGB7(2), ITGB8(1), JUN(1), KDR(4), LAMA1(7), LAMA2(5), LAMA3(5), LAMA4(2), LAMA5(6), LAMB1(2), LAMB2(1), LAMB3(3), LAMB4(1), LAMC1(3), LAMC2(2), LAMC3(3), MAPK1(1), MAPK10(2), MET(4), MYL5(1), MYLK(3), MYLK2(2), PAK1(1), PAK3(3), PAK4(1), PAK7(1), PARVG(1), PDGFB(1), PDGFD(3), PDGFRA(1), PDGFRB(2), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PPP1R12A(2), PRKCA(1), PRKCG(1), PTEN(8), PTK2(3), RAC1(1), RAP1A(1), RAPGEF1(1), RELN(6), ROCK1(1), ROCK2(2), SHC3(1), SHC4(2), SOS1(2), THBS1(3), THBS3(2), TLN1(2), TLN2(6), TNC(6), TNN(2), TNR(8), TNXB(6), VASP(1), VAV1(3), VAV2(3), VAV3(1), VEGFC(1), VTN(3), VWF(4) 137353830 309 141 308 87 42 90 64 60 52 1 0.0125 1.000 1.000 516 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(1), ADCY2(3), ADCY3(1), ADCY4(1), ADCY7(1), ADCY8(2), ADCY9(1), ADORA2A(1), AGTR1(2), ATP2A1(1), ATP2A2(2), ATP2A3(3), ATP2B1(3), ATP2B2(2), ATP2B4(1), BDKRB1(1), BST1(2), CACNA1A(7), CACNA1B(7), CACNA1C(4), CACNA1D(2), CACNA1E(4), CACNA1F(5), CACNA1G(3), CACNA1H(4), CACNA1I(3), CACNA1S(6), CAMK2B(1), CAMK2G(1), CCKAR(1), CCKBR(2), CHRM1(1), CHRM2(2), CHRM5(1), CHRNA7(1), CYSLTR2(2), DRD1(1), EDNRA(1), EGFR(3), ERBB2(1), ERBB3(1), ERBB4(4), F2R(1), GNA11(1), GNAL(1), GNAS(2), GRIN1(2), GRIN2A(3), GRIN2D(2), GRM1(1), GRM5(4), GRPR(1), HTR2A(1), HTR4(1), HTR6(1), ITPKA(1), ITPR1(4), ITPR2(6), ITPR3(2), LHCGR(6), MYLK(3), MYLK2(2), NOS1(7), NOS3(3), NTSR1(2), P2RX2(1), P2RX7(1), PDE1A(2), PDE1B(3), PDE1C(4), PDGFRA(1), PDGFRB(2), PHKA1(4), PHKA2(2), PHKB(2), PHKG1(1), PLCB1(5), PLCB2(2), PLCB3(2), PLCB4(3), PLCD3(1), PLCE1(6), PLCG1(1), PLCG2(2), PLCZ1(1), PPP3CB(1), PPP3CC(2), PRKACA(2), PRKACG(1), PRKCA(1), PRKCG(1), PTAFR(1), PTK2B(2), RYR1(16), RYR2(16), RYR3(7), SLC8A1(2), SLC8A2(3), SLC8A3(5), SPHK2(2), TACR1(2), TRHR(1), TRPC1(1), VDAC1(1) 101535747 266 129 262 96 53 69 54 38 51 1 0.114 1.000 1.000 517 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 202 ACTN1(1), ACTN4(3), APC(5), ARHGEF1(1), ARHGEF12(2), ARHGEF4(1), ARHGEF6(2), ARHGEF7(1), ARPC1B(1), ARPC5(1), BAIAP2(3), BCAR1(2), BDKRB1(1), BRAF(1), CHRM1(1), CHRM2(2), CHRM4(1), CHRM5(1), CYFIP1(1), CYFIP2(3), DIAPH1(2), DIAPH2(4), DOCK1(3), EGF(4), EGFR(3), EZR(1), F2(3), F2R(1), FGD1(1), FGD3(4), FGF13(3), FGF17(1), FGF18(1), FGF23(1), FGF3(2), FGFR1(3), FGFR2(1), FGFR3(1), FGFR4(2), FN1(3), IQGAP1(4), IQGAP3(2), ITGA1(1), ITGA10(4), ITGA11(1), ITGA2(1), ITGA2B(2), ITGA3(2), ITGA4(2), ITGA6(3), ITGA7(1), ITGA8(1), ITGA9(1), ITGAD(3), ITGAE(1), ITGAL(2), ITGAM(2), ITGAV(3), ITGAX(1), ITGB2(1), ITGB4(4), ITGB6(2), ITGB7(2), ITGB8(1), KRAS(2), LIMK1(3), MAP2K2(1), MAPK1(1), MYH10(3), MYH14(4), MYH9(4), MYL5(1), MYLK(3), MYLK2(2), NCKAP1(2), NCKAP1L(1), NRAS(1), PAK1(1), PAK3(3), PAK4(1), PAK7(1), PDGFB(1), PDGFRA(1), PDGFRB(2), PFN2(1), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PIP5K1A(1), PIP5K1B(1), PPP1R12A(2), PPP1R12B(1), PTK2(3), RAC1(1), RDX(1), ROCK1(1), ROCK2(2), RRAS(1), SCIN(1), SLC9A1(1), SOS1(2), SSH1(2), SSH3(2), TIAM1(1), TIAM2(1), VAV1(3), VAV2(3), VAV3(1) 102660588 207 114 206 53 30 52 58 31 36 0 0.0122 1.000 1.000 518 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(3), CHAD(1), COL11A1(3), COL11A2(9), COL17A1(4), COL1A1(3), COL1A2(1), COL2A1(1), COL4A1(6), COL4A2(3), COL4A4(4), COL4A6(4), COL5A2(1), COL5A3(10), COL6A1(2), COL6A3(4), COL6A6(4), COMP(3), DSC3(3), DSG1(1), DSG2(4), DSG3(1), DSG4(2), FN1(3), GJA4(1), GJA5(2), GJA8(1), GJB1(1), GJB2(1), GJD2(2), INA(1), ITGA6(3), ITGB4(4), KRT1(2), KRT10(2), KRT12(1), KRT14(4), KRT15(1), KRT16(1), KRT18(1), KRT20(1), KRT23(1), KRT27(1), KRT3(2), KRT33B(2), KRT36(1), KRT4(3), KRT5(3), KRT6A(1), KRT6B(1), KRT6C(2), KRT71(1), KRT72(1), KRT73(1), KRT74(1), KRT75(2), KRT76(1), KRT77(2), KRT78(1), KRT79(1), KRT8(1), KRT81(1), KRT82(1), KRT84(1), KRT85(2), KRT86(1), LAMA1(7), LAMA2(5), LAMA3(5), LAMA4(2), LAMA5(6), LAMB1(2), LAMB2(1), LAMB3(3), LAMB4(1), LAMC1(3), LAMC2(2), LAMC3(3), LMNB1(1), NES(2), RELN(6), THBS1(3), THBS3(2), TNC(6), TNN(2), TNR(8), TNXB(6), VTN(3), VWF(4) 91990074 227 113 227 82 38 75 40 34 38 2 0.274 1.000 1.000 519 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 237 ADORA2A(1), ADORA3(3), ADRA2B(1), ADRA2C(1), AGTR1(2), AGTR2(1), BDKRB1(1), C3AR1(1), CALCR(3), CALCRL(1), CCKAR(1), CCKBR(2), CHRM1(1), CHRM2(2), CHRM4(1), CHRM5(1), CNR1(3), CRHR2(4), CTSG(1), CYSLTR2(2), DRD1(1), DRD2(1), DRD3(2), EDNRA(1), F2(3), F2R(1), F2RL2(1), FSHR(1), GABRA1(1), GABRA2(2), GABRA4(1), GABRA5(2), GABRA6(2), GABRB2(1), GABRD(2), GABRE(1), GABRG1(2), GABRG3(1), GABRP(1), GABRQ(1), GABRR1(5), GHSR(2), GLP1R(2), GLP2R(2), GLRA1(3), GLRA3(2), GPR156(3), GPR50(2), GPR63(1), GPR83(3), GRIA1(6), GRIA3(1), GRIA4(2), GRID1(1), GRID2(3), GRIK1(2), GRIK2(2), GRIK3(4), GRIK4(3), GRIK5(2), GRIN1(2), GRIN2A(3), GRIN2D(2), GRIN3A(4), GRIN3B(1), GRM1(1), GRM3(5), GRM4(1), GRM5(4), GRM7(2), GRM8(2), GRPR(1), HCRTR2(1), HRH3(1), HTR1A(1), HTR1B(1), HTR1D(2), HTR2A(1), HTR4(1), HTR6(1), LHCGR(6), MC4R(1), MTNR1A(1), NMUR1(1), NMUR2(2), NPBWR2(1), NTSR1(2), NTSR2(1), OPRM1(1), P2RX2(1), P2RX7(1), P2RY10(1), P2RY11(1), P2RY2(1), P2RY4(1), P2RY6(1), PRLHR(4), PRLR(4), PRSS1(2), PTAFR(1), PTGER2(2), PTGIR(1), PTH2R(2), RXFP1(1), RXFP2(4), SCTR(3), SSTR3(1), TAAR2(1), TAAR6(1), TACR1(2), THRA(1), TRHR(1), VIPR1(3) 79677068 206 105 204 79 40 55 53 37 21 0 0.264 1.000 1.000 520 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 130 ACTB(3), ACTN1(1), ACTN4(3), ASH1L(3), CDK4(1), CGN(1), CLDN1(2), CLDN10(1), CLDN15(1), CLDN2(2), CLDN20(1), CLDN4(1), CLDN6(1), CLDN8(1), CTNNA1(2), CTNNA2(5), CTNNA3(3), CTTN(3), EPB41(1), EPB41L1(1), EPB41L3(1), F11R(4), HCLS1(3), KRAS(2), LLGL2(1), MAGI1(3), MAGI2(3), MAGI3(2), MLLT4(1), MPDZ(3), MPP5(1), MYH1(4), MYH10(3), MYH11(5), MYH13(3), MYH14(4), MYH15(4), MYH2(6), MYH3(4), MYH4(6), MYH6(2), MYH7(7), MYH7B(4), MYH8(1), MYH9(4), MYL5(1), NRAS(1), OCLN(1), PARD6B(1), PPP2R1A(2), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R2C(2), PPP2R3A(1), PPP2R3B(1), PRKCA(1), PRKCE(2), PRKCG(1), PRKCH(1), PRKCI(1), PRKCQ(3), PTEN(8), RRAS(1), SPTAN1(4), SYMPK(2), TJAP1(1), TJP1(1), TJP2(5), TJP3(2), YES1(1), ZAK(4) 71725725 170 102 170 44 24 36 42 28 40 0 0.106 1.000 1.000 521 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(2), ABLIM1(1), ABLIM2(1), ARHGEF12(2), DCC(7), DPYSL5(2), EFNB3(1), EPHA1(1), EPHA2(2), EPHA3(3), EPHA4(2), EPHA5(4), EPHA6(3), EPHA7(4), EPHA8(4), EPHB1(2), EPHB2(1), EPHB4(1), EPHB6(3), FES(1), FYN(1), KRAS(2), L1CAM(1), LIMK1(3), LRRC4C(1), MAPK1(1), MET(4), NCK2(1), NFAT5(4), NFATC2(2), NFATC3(1), NGEF(1), NRAS(1), NTN1(1), NTN4(1), PAK1(1), PAK3(3), PAK4(1), PAK7(1), PLXNA1(2), PLXNA2(3), PLXNA3(1), PLXNB1(5), PLXNB2(1), PLXNB3(3), PPP3CB(1), PPP3CC(2), PTK2(3), RAC1(1), RASA1(3), ROBO1(1), ROBO2(3), ROBO3(5), ROCK1(1), ROCK2(2), SEMA3A(2), SEMA3C(1), SEMA3D(1), SEMA3F(1), SEMA4B(1), SEMA4D(2), SEMA4F(1), SEMA5A(2), SEMA5B(2), SEMA6A(2), SEMA6B(1), SEMA6D(3), SLIT2(4), SLIT3(4), SRGAP1(3), SRGAP3(4), UNC5A(4), UNC5B(3), UNC5C(2), UNC5D(1) 72084020 159 100 159 52 25 35 49 25 25 0 0.368 1.000 1.000 522 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(1), CHAD(1), COL11A1(3), COL11A2(9), COL1A1(3), COL1A2(1), COL2A1(1), COL4A1(6), COL4A2(3), COL4A4(4), COL4A6(4), COL5A2(1), COL5A3(10), COL6A1(2), COL6A3(4), COL6A6(4), FN1(3), GP6(1), HMMR(1), HSPG2(6), ITGA1(1), ITGA10(4), ITGA11(1), ITGA2(1), ITGA2B(2), ITGA3(2), ITGA4(2), ITGA6(3), ITGA7(1), ITGA8(1), ITGA9(1), ITGAV(3), ITGB4(4), ITGB6(2), ITGB7(2), ITGB8(1), LAMA1(7), LAMA2(5), LAMA3(5), LAMA4(2), LAMA5(6), LAMB1(2), LAMB2(1), LAMB3(3), LAMB4(1), LAMC1(3), LAMC2(2), LAMC3(3), RELN(6), SV2A(1), SV2B(3), SV2C(3), THBS1(3), THBS3(2), TNC(6), TNN(2), TNR(8), TNXB(6), VTN(3), VWF(4) 83157689 186 100 186 61 29 52 42 31 31 1 0.224 1.000 1.000 523 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(1), ADCY2(3), ADCY3(1), ADCY4(1), ADCY5(1), ADCY7(1), ADCY8(2), ADCY9(1), ANXA6(2), ARRB1(1), ATP1A4(3), ATP1B2(1), ATP2A2(2), ATP2A3(3), ATP2B1(3), ATP2B2(2), CACNA1A(7), CACNA1B(7), CACNA1C(4), CACNA1D(2), CACNA1E(4), CACNA1S(6), CACNB1(1), CAMK2B(1), CAMK2G(1), CHRM1(1), CHRM2(2), CHRM4(1), CHRM5(1), GJA4(1), GJA5(2), GJB1(1), GJB2(1), GNA11(1), GNAO1(1), GNAZ(2), GNB2(1), GRK4(1), GRK5(1), ITPR1(4), ITPR2(6), ITPR3(2), KCNB1(1), KCNJ3(1), KCNJ5(2), PKIB(1), PLCB3(2), PRKACA(2), PRKAR1B(1), PRKAR2B(1), PRKCA(1), PRKCE(2), PRKCG(1), PRKCH(1), PRKCQ(3), PRKD1(1), RGS11(1), RGS17(1), RGS18(1), RGS2(1), RGS6(1), RGS7(2), RYR1(16), RYR2(16), RYR3(7), SLC8A1(2), SLC8A3(5), YWHAQ(1) 70820375 164 88 162 64 30 48 35 19 32 0 0.244 1.000 1.000 524 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 131 ACACA(1), ACACB(4), BRAF(1), CBLB(2), CBLC(1), EXOC7(2), FASN(5), FBP1(1), G6PC2(1), GCK(2), GYS2(1), INPP5D(3), IRS1(1), IRS4(3), KRAS(2), MAP2K2(1), MAPK1(1), MAPK10(2), MKNK1(1), NRAS(1), PDE3A(1), PDE3B(5), PFKL(3), PFKP(2), PHKA1(4), PHKA2(2), PHKB(2), PHKG1(1), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PKLR(2), PPARGC1A(1), PPP1R3A(6), PRKAA2(5), PRKAB2(1), PRKACA(2), PRKACG(1), PRKAR1B(1), PRKAR2B(1), PRKCI(1), PTPN1(1), PTPRF(2), PYGB(2), PYGM(3), RAPGEF1(1), RPS6(1), SHC3(1), SHC4(2), SLC2A4(1), SOCS2(1), SORBS1(2), SOS1(2), SREBF1(3), TRIP10(1), TSC1(1), TSC2(4) 59157530 117 86 116 34 14 25 31 28 19 0 0.248 1.000 1.000 525 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 251 ACVR1(2), ACVR1B(1), ACVR2B(1), AMHR2(1), BMPR2(1), CCL15(1), CCL16(1), CCL23(1), CCL3(1), CCR1(2), CCR3(2), CCR4(1), CD40LG(1), CNTFR(1), CSF1R(2), CSF2RA(1), CSF2RB(2), CSF3R(1), CX3CL1(3), CXCL14(2), CXCL5(1), CXCR6(2), EDA2R(1), EGF(4), EGFR(3), EPO(1), FAS(1), FLT1(3), FLT3(2), FLT4(2), HGF(2), IFNA1(1), IFNA14(1), IFNA16(1), IFNA17(1), IFNA6(1), IFNA8(1), IFNAR1(1), IFNG(1), IFNW1(2), IL10RA(2), IL12RB1(1), IL12RB2(3), IL17A(1), IL17B(1), IL17RA(2), IL18R1(1), IL18RAP(2), IL1A(1), IL20RA(1), IL21R(1), IL22RA1(1), IL23A(1), IL23R(1), IL25(1), IL26(1), IL2RA(1), IL2RB(5), IL2RG(1), IL5RA(2), IL6R(2), IL7R(1), IL9R(2), INHBA(2), KDR(4), KIT(5), KITLG(1), LIFR(1), MET(4), NGFR(1), PDGFB(1), PDGFRA(1), PDGFRB(2), PLEKHO2(1), PRLR(4), TGFB1(1), TGFBR1(1), TGFBR2(1), TNF(1), TNFRSF10B(1), TNFRSF10D(1), TNFRSF19(1), TNFRSF1A(1), TNFRSF21(3), TNFRSF8(1), TNFRSF9(2), TNFSF10(1), TNFSF15(1), TNFSF18(1), TPO(1), VEGFC(1), XCR1(1) 65289890 142 82 142 37 23 38 33 23 24 1 0.0181 1.000 1.000 526 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA2(2), ADCY1(1), ADCY2(3), ADCY3(1), ADCY4(1), ADCY5(1), ADCY7(1), ADCY8(2), ADCY9(1), ARRB1(1), ATP2A2(2), ATP2A3(3), CAMK2B(1), CAMK2G(1), CNN1(1), CNN2(1), CORIN(2), DGKZ(1), GBA2(3), GNB2(1), GRK4(1), GRK5(1), GUCY1A3(1), IGFBP4(1), ITPR1(4), ITPR2(6), ITPR3(2), JUN(1), MYLK2(2), NFKB1(1), NOS1(7), NOS3(3), PDE4B(1), PDE4D(2), PKIB(1), PLCB3(2), PLCG1(1), PLCG2(2), PRKACA(2), PRKAR1B(1), PRKAR2B(1), PRKCA(1), PRKCE(2), PRKCH(1), PRKCQ(3), PRKD1(1), RGS11(1), RGS17(1), RGS18(1), RGS2(1), RGS6(1), RGS7(2), RLN1(1), RYR1(16), RYR2(16), RYR3(7), SLC8A1(2), SP1(2), TNXB(6), YWHAQ(1) 64988122 139 81 138 60 23 43 30 15 28 0 0.605 1.000 1.000 527 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 BRAF(1), CACNA1A(7), GNA11(1), GNAO1(1), GNAS(2), GNAZ(2), GRIA1(6), GRIA3(1), GRID2(3), GRM1(1), GRM5(4), GUCY1A3(1), GUCY1B3(2), GUCY2C(2), IGF1(1), IGF1R(2), ITPR1(4), ITPR2(6), ITPR3(2), KRAS(2), LYN(1), MAP2K2(1), MAPK1(1), NOS1(7), NOS3(3), NPR2(1), NRAS(1), PLA2G12B(1), PLA2G2D(1), PLA2G4A(1), PLCB1(5), PLCB2(2), PLCB3(2), PLCB4(3), PPP2R1A(2), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R2C(2), PRKCA(1), PRKCG(1), PRKG1(1), PRKG2(1), RYR1(16) 41193234 109 73 107 34 26 30 19 15 19 0 0.0873 1.000 1.000 528 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADORA2A(1), ADORA3(3), ADRA2C(1), AGTR1(2), AGTR2(1), BDKRB1(1), C3AR1(1), CCKAR(1), CCKBR(2), CCR1(2), CCR3(2), CCR4(1), CHML(1), CHRM1(1), CHRM2(2), CHRM4(1), CHRM5(1), CMKLR1(1), CNR1(3), DRD1(1), DRD2(1), DRD3(2), EDNRA(1), F2R(1), F2RL2(1), FSHR(1), GHSR(2), GPR37(2), GPR37L1(1), GPR50(2), GPR63(1), GPR83(3), GRPR(1), HCRTR2(1), HRH3(1), HTR1A(1), HTR1B(1), HTR1D(2), HTR2A(1), HTR4(1), HTR6(1), LHCGR(6), MC4R(1), MTNR1A(1), NMUR1(1), NMUR2(2), NTSR1(2), NTSR2(1), OPN1SW(1), OPRM1(1), OR10A5(1), OR11A1(2), OR1C1(2), OR1F1(1), OR2H1(2), OR5V1(3), OR7A5(2), OR7C1(1), OR8B8(1), P2RY10(1), P2RY11(1), P2RY12(1), P2RY2(1), P2RY6(1), PTAFR(1), PTGER2(2), PTGIR(1), RGR(1), RHO(1), SSTR3(1), SUCNR1(1), TRHR(1) 42653628 102 71 100 48 15 25 30 16 16 0 0.825 1.000 1.000 529 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 129 CD2(1), CD22(1), CD276(1), CD34(1), CD40LG(1), CD58(1), CD86(1), CDH1(1), CDH15(2), CDH3(1), CDH4(3), CDH5(1), CLDN1(2), CLDN10(1), CLDN15(1), CLDN2(2), CLDN20(1), CLDN4(1), CLDN6(1), CLDN8(1), CNTN2(1), CNTNAP1(1), CTLA4(1), F11R(4), GLG1(1), HLA-B(1), HLA-DOA(1), HLA-DOB(1), HLA-DQA2(3), HLA-DRB1(1), HLA-DRB5(1), HLA-E(1), HLA-F(1), ITGA4(2), ITGA6(3), ITGA8(1), ITGA9(1), ITGAL(2), ITGAM(2), ITGAV(3), ITGB2(1), ITGB7(2), ITGB8(1), L1CAM(1), MADCAM1(1), MAG(2), NCAM1(1), NCAM2(2), NEGR1(2), NFASC(1), NLGN1(1), NLGN2(1), NLGN3(1), NRCAM(1), NRXN1(5), NRXN2(2), NRXN3(2), OCLN(1), PTPRC(4), PTPRF(2), PTPRM(6), PVRL2(1), PVRL3(1), SELL(1), SELP(2), SELPLG(1), SIGLEC1(2), SPN(1), VCAM1(1), VCAN(1) 53767564 108 69 108 37 19 29 25 24 11 0 0.247 1.000 1.000 530 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 152 CBLB(2), CBLC(1), CCND1(1), CISH(2), CNTFR(1), CREBBP(4), CSF2RA(1), CSF2RB(2), CSF3R(1), EP300(2), EPO(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA17(1), IFNA6(1), IFNA8(1), IFNAR1(1), IFNG(1), IFNW1(2), IL10RA(2), IL12RB1(1), IL12RB2(3), IL13RA2(1), IL20RA(1), IL21R(1), IL22RA1(1), IL23A(1), IL23R(1), IL26(1), IL2RA(1), IL2RB(5), IL2RG(1), IL5RA(2), IL6R(2), IL7R(1), IL9R(2), IRF9(1), JAK1(1), JAK3(2), LIFR(1), MYC(3), PIAS1(3), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PIM1(1), PRLR(4), PTPN11(3), SOCS2(1), SOS1(2), SPRED1(2), SPRED2(1), SPRY1(1), SPRY3(2), STAT1(2), STAT2(1), STAT3(1), STAT4(1), STAT5A(1), TPO(1), TYK2(1) 53330786 103 64 102 25 14 24 26 24 15 0 0.0914 1.000 1.000 531 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(3), BDKRB1(1), C1QA(1), C1QB(1), C1S(1), C2(1), C3(4), C3AR1(1), C4BPA(2), C4BPB(1), C5(2), C6(6), C7(1), C8A(1), C8B(1), C9(4), CD55(1), CFH(4), CR1(3), CR2(2), F11(3), F12(1), F13A1(3), F13B(1), F2(3), F2R(1), F5(6), F7(1), F8(4), FGA(2), FGB(2), FGG(2), KLKB1(2), KNG1(1), MASP1(3), MASP2(1), MBL2(1), PLG(1), PROS1(1), SERPINA1(1), SERPINA5(1), SERPIND1(1), SERPINF2(1), TFPI(1), VWF(4) 32947310 89 63 89 35 7 28 21 20 12 1 0.803 1.000 1.000 532 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(1), ADCY2(3), ADCY3(1), ADCY4(1), ADCY5(1), ADCY7(1), ADCY8(2), ADCY9(1), CACNA1C(4), CACNA1D(2), CACNA1F(5), CACNA1S(6), CAMK2B(1), CAMK2G(1), EGFR(3), GNA11(1), GNAS(2), GNRH2(1), ITPR1(4), ITPR2(6), ITPR3(2), JUN(1), KRAS(2), MAP2K2(1), MAP2K3(2), MAP2K4(2), MAP2K6(2), MAP2K7(3), MAP3K4(1), MAPK1(1), MAPK10(2), MAPK11(1), MAPK7(1), MMP2(2), NRAS(1), PLA2G12B(1), PLA2G2D(1), PLA2G4A(1), PLCB1(5), PLCB2(2), PLCB3(2), PLCB4(3), PLD1(3), PLD2(1), PRKACA(2), PRKACG(1), PRKCA(1), PTK2B(2), SOS1(2) 47890492 98 62 98 38 19 24 16 20 19 0 0.536 1.000 1.000 533 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(2), ABCA10(1), ABCA12(2), ABCA13(11), ABCA2(2), ABCA3(2), ABCA4(2), ABCA5(2), ABCA6(3), ABCA7(2), ABCA8(3), ABCA9(5), ABCB1(1), ABCB11(2), ABCB4(3), ABCB5(6), ABCB6(1), ABCB7(1), ABCC1(1), ABCC10(2), ABCC11(1), ABCC12(4), ABCC2(3), ABCC3(6), ABCC5(1), ABCC6(1), ABCC8(6), ABCC9(1), ABCD1(1), ABCD3(1), ABCD4(1), ABCG1(2), ABCG5(1), CFTR(7) 43801721 90 60 90 35 8 26 22 18 15 1 0.391 1.000 1.000 534 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(1), ADCY2(3), ADCY3(1), ADCY4(1), ADCY5(1), ADCY7(1), ADCY8(2), ADCY9(1), DRD1(1), DRD2(1), EGF(4), EGFR(3), GJD2(2), GNA11(1), GNAS(2), GRM1(1), GRM5(4), GUCY1A3(1), GUCY1B3(2), GUCY2C(2), HTR2A(1), ITPR1(4), ITPR2(6), ITPR3(2), KRAS(2), MAP2K2(1), MAP2K5(1), MAPK1(1), MAPK7(1), NPR2(1), NRAS(1), PDGFB(1), PDGFD(3), PDGFRA(1), PDGFRB(2), PLCB1(5), PLCB2(2), PLCB3(2), PLCB4(3), PRKACA(2), PRKACG(1), PRKCA(1), PRKCG(1), PRKG1(1), PRKG2(1), SOS1(2), TJP1(1), TUBA3C(3), TUBA3D(1), TUBA3E(1), TUBA4A(1), TUBA8(1), TUBAL3(2), TUBB2B(2), TUBB8(3) 48706929 99 60 98 44 18 29 17 22 13 0 0.759 1.000 1.000 535 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1(2), ACVR1B(1), AURKB(1), BMPR2(1), BUB1(1), CDIPT(1), CDKL2(1), CDS1(1), CLK1(1), CLK4(1), COL4A3BP(2), DGKB(1), DGKD(3), DGKE(1), DGKG(3), DGKH(2), DGKQ(1), DGKZ(1), INPP1(2), INPP4A(2), INPP4B(1), INPP5A(1), INPPL1(1), ITPKA(1), NEK1(2), OCRL(1), PAK4(1), PIK3C2G(7), PIK3CA(6), PIK3CB(1), PIK3CG(2), PIM2(3), PLCB1(5), PLCB2(2), PLCB3(2), PLCB4(3), PLCG1(1), PLCG2(2), PRKACA(2), PRKACG(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1), PRKCE(2), PRKCG(1), PRKCH(1), PRKCQ(3), PRKD1(1), PRKG1(1), RPS6KA1(1), TGFBR1(1), VRK1(1) 42301178 89 60 87 28 12 21 20 18 18 0 0.421 1.000 1.000 536 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADCY1(1), ADCY2(3), ADCY3(1), ADCY4(1), ADCY5(1), ADCY7(1), ADCY8(2), ADCY9(1), ADK(2), ADSL(1), ADSSL1(1), AK2(1), AK5(3), AK7(1), AMPD1(2), AMPD3(1), APRT(1), ENPP1(3), ENPP3(2), ENTPD1(1), ENTPD3(1), ENTPD8(2), GART(2), GMPR2(1), GMPS(1), GUCY1A3(1), GUCY1B3(2), GUCY2C(2), IMPDH2(1), NME2(1), NME6(2), NPR2(1), NT5E(1), PDE10A(2), PDE11A(1), PDE1A(2), PDE1C(4), PDE2A(1), PDE3B(5), PDE4A(3), PDE4B(1), PDE4C(2), PDE4D(2), PDE5A(1), PDE6H(1), PFAS(1), PKLR(2), PNPT1(2), POLD1(3), POLE(5), POLE2(1), POLE4(1), POLR1A(1), PPAT(1), PRIM2(1), RRM2(1) 60093641 92 58 91 37 8 22 29 12 21 0 0.850 1.000 1.000 537 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AMY2B(4), ASCC3(2), ATP13A2(1), DDX18(2), DDX23(2), DDX4(1), DDX41(1), DDX50(1), DDX51(1), DDX52(1), DDX56(1), ENPP1(3), ENPP3(2), EP400(3), G6PC2(1), GAA(1), GBA(1), GBE1(4), GCK(2), GUSB(2), GYS2(1), HK2(2), IFIH1(1), MGAM(5), MOV10L1(1), PGM1(1), PYGB(2), PYGM(3), RAD54B(1), RAD54L(1), RUVBL2(2), SETX(3), SI(4), SMARCA2(2), SMARCA5(2), TREH(1), UGDH(2), UGP2(2), UGT1A10(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT2A3(1), UGT2B11(3), UGT2B15(2), UGT2B17(2) 45735222 85 58 85 22 17 25 17 11 15 0 0.103 1.000 1.000 538 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACP1(1), ACTB(3), ACTN1(1), ACTN4(3), ACVR1B(1), BAIAP2(3), CDH1(1), CREBBP(4), CTNNA1(2), CTNNA2(5), CTNNA3(3), CTNND1(4), EGFR(3), EP300(2), ERBB2(1), FARP2(2), FER(2), FGFR1(3), FYN(1), IGF1R(2), IQGAP1(4), LMO7(6), MAP3K7(1), MAPK1(1), MET(4), MLLT4(1), PTPN1(1), PTPRB(4), PTPRF(2), PTPRJ(3), PTPRM(6), PVRL2(1), PVRL3(1), RAC1(1), SMAD3(2), SNAI1(2), SORBS1(2), SSX2IP(1), TCF7L1(1), TCF7L2(1), TGFBR1(1), TGFBR2(1), TJP1(1), WASF3(2), YES1(1) 43921628 98 58 98 28 12 32 22 13 19 0 0.153 1.000 1.000 539 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 98 ADCY1(1), ADCY2(3), ADCY3(1), ADCY4(1), ADCY5(1), ADCY7(1), ADCY8(2), ADCY9(1), ASIP(1), CAMK2B(1), CAMK2G(1), CREB3L1(1), CREB3L3(1), CREBBP(4), DCT(3), DVL1(2), DVL2(1), EP300(2), FZD10(1), FZD2(2), FZD3(2), FZD5(1), FZD6(1), GNAO1(1), GNAS(2), KIT(5), KITLG(1), KRAS(2), MAP2K2(1), MAPK1(1), NRAS(1), PLCB1(5), PLCB2(2), PLCB3(2), PLCB4(3), POMC(1), PRKACA(2), PRKACG(1), PRKCA(1), PRKCG(1), TCF7L1(1), TCF7L2(1), TYR(2), WNT10B(1), WNT2(1), WNT2B(1), WNT5A(1), WNT7B(1), WNT8A(1), WNT8B(1) 39618243 78 58 78 32 12 22 13 16 14 1 0.682 1.000 1.000 540 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(1), ADCY2(3), ADCY3(1), ADCY4(1), ADCY5(1), ADCY7(1), ADCY8(2), ADCY9(1), AKAP10(1), AKAP11(3), AKAP12(2), AKAP2(2), AKAP3(1), AKAP4(1), AKAP5(1), AKAP6(3), AKAP8(1), AKAP9(2), ARHGEF1(1), GNA11(1), GNAL(1), GNAO1(1), GNAZ(2), GNB2(1), ITPR1(4), KCNJ3(1), KRAS(2), NRAS(1), PDE1A(2), PDE1B(3), PDE1C(4), PDE4A(3), PDE4B(1), PDE4C(2), PDE4D(2), PLCB3(2), PPP3CC(2), PRKACA(2), PRKACG(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1), PRKCE(2), PRKCG(1), PRKCH(1), PRKCI(1), PRKCQ(3), PRKD1(1), PRKD3(2), RRAS(1), SLC9A1(1) 42529061 83 57 83 29 12 18 17 10 25 1 0.603 1.000 1.000 541 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA2(2), ACTN4(3), DMD(9), MYBPC2(1), MYBPC3(3), MYH3(4), MYH6(2), MYH7(7), MYH8(1), NEB(7), TNNT3(1), TTN(45) 50662900 85 53 85 41 15 21 23 8 16 2 0.980 1.000 1.000 542 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(1), ADCY8(2), BRAF(1), CACNA1C(4), CAMK2B(1), CAMK2G(1), CREBBP(4), EP300(2), GRIA1(6), GRIN1(2), GRIN2A(3), GRIN2D(2), GRM1(1), GRM5(4), ITPR1(4), ITPR2(6), ITPR3(2), KRAS(2), MAP2K2(1), MAPK1(1), NRAS(1), PLCB1(5), PLCB2(2), PLCB3(2), PLCB4(3), PPP1R12A(2), PPP1R1A(2), PPP3CB(1), PPP3CC(2), PRKACA(2), PRKACG(1), PRKCA(1), PRKCG(1), RAP1A(1), RPS6KA1(1) 37267657 77 52 77 26 14 18 12 20 13 0 0.340 1.000 1.000 543 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 ALG1(1), ALG11(2), ALG13(1), ALG14(1), ALG2(1), ALG3(1), ALG6(1), ALG9(1), B3GNT2(2), B4GALT5(2), CHPF(1), CHST1(2), CHST11(1), CHST14(1), CHST3(1), CHST4(1), EXT1(1), EXTL2(1), EXTL3(2), FUT11(1), FUT8(1), GALNT10(1), GALNT13(1), GALNT14(3), GALNT3(1), GALNT5(1), GALNT7(1), GALNT8(3), GALNT9(1), GALNTL5(1), GANAB(1), HS3ST1(1), HS3ST3A1(1), HS3ST3B1(1), HS3ST5(2), HS6ST1(2), MAN1A1(3), MAN1B1(1), MAN1C1(2), MGAT3(1), MGAT5(2), MGAT5B(2), NDST3(4), NDST4(3), OGT(1), RPN2(2), ST6GALNAC1(1), WBSCR17(3), XYLT1(1), XYLT2(2) 40330126 75 47 74 33 9 29 17 10 9 1 0.660 1.000 1.000 544 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 BCR(2), BLNK(2), BTK(1), CD19(1), CD22(1), CD81(1), CR2(2), INPP5D(3), ITPR1(4), ITPR2(6), ITPR3(2), LYN(1), MAP4K1(3), MAPK1(1), NFATC2(2), PIK3CA(6), PIK3CD(1), PIK3R1(1), PLCG2(2), PPP1R13B(1), PPP3CB(1), PPP3CC(2), PTPRC(4), SOS1(2), SYK(2), VAV1(3) 26928115 57 47 56 20 12 7 18 8 12 0 0.617 1.000 1.000 545 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 71 ACACB(4), ACSL3(1), ACSL4(2), ACSL6(4), ADIPOR1(1), CAMKK1(2), CPT1A(1), CPT1B(1), G6PC2(1), IRS1(1), IRS4(3), JAK1(1), JAK3(2), MAPK10(2), NFKB1(1), POMC(1), PPARA(1), PPARGC1A(1), PRKAA2(5), PRKAB2(1), PRKCQ(3), PTPN11(3), RELA(2), RXRA(1), RXRG(1), SLC2A4(1), STAT3(1), TNF(1), TNFRSF1A(1), TRADD(1), TRAF2(2), TYK2(1) 30474872 54 45 54 22 13 11 14 12 4 0 0.691 1.000 1.000 546 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADCY1(1), ADCY2(3), ADCY3(1), ADCY4(1), ADCY5(1), ADCY7(1), ADCY8(2), ADK(2), ADSL(1), AK2(1), AK5(3), AMPD1(2), AMPD3(1), APRT(1), ATP5B(1), ATP5C1(1), ATP5J2(1), ENPP1(3), ENPP3(2), ENTPD1(1), GART(2), GMPS(1), GUCY1A3(1), GUCY1B3(2), GUCY2C(2), IMPDH2(1), NME2(1), NPR2(1), NT5E(1), PDE1A(2), PDE4A(3), PDE4B(1), PDE4C(2), PDE4D(2), PDE5A(1), PDE6B(3), PDE6C(1), PFAS(1), PKLR(2), POLD1(3), POLE(5), POLG(1), POLL(1), POLQ(7), POLRMT(1), PPAT(1), RRM2(1) 47120757 80 45 79 28 9 23 30 6 12 0 0.500 1.000 1.000 547 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 57 ASH1L(3), CARM1(1), CTCFL(2), DOT1L(1), EED(1), EHMT1(1), EHMT2(1), HCFC1(5), HSF4(1), MEN1(2), NSD1(1), OGT(1), PAXIP1(6), PRDM2(3), PRDM6(1), PRDM7(1), PRDM9(4), PRMT1(1), PRMT6(1), PRMT8(1), SATB1(3), SETD1A(4), SETD1B(4), SETD2(2), SETD8(1), SMYD3(1), SUV39H1(1), SUZ12(2), WHSC1(3) 45830407 59 43 59 20 6 20 10 5 18 0 0.694 1.000 1.000 548 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 66 ATP6AP1(2), ATP6V0A4(1), ATP6V1A(2), ATP6V1E1(1), EGFR(3), F11R(4), JUN(1), LYN(1), MAP2K4(2), MAPK10(2), MAPK11(1), MET(4), NFKB1(1), NOD1(3), PAK1(1), PLCG1(1), PLCG2(2), PTPN11(3), PTPRZ1(6), RAC1(1), RELA(2), TCIRG1(1), TJP1(1) 25724130 46 38 46 16 7 13 10 7 9 0 0.504 1.000 1.000 549 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(1), ADCY8(2), CACNA1A(7), CACNA1B(7), GNAS(2), GRM4(1), ITPR3(2), KCNB1(1), PDE1A(2), PLCB2(2), PRKACA(2), PRKACG(1), SCNN1A(1), SCNN1B(1), SCNN1G(3), TAS1R1(2), TAS1R2(1), TAS1R3(1), TAS2R38(1), TAS2R39(1), TAS2R40(1), TAS2R5(1), TAS2R7(1), TAS2R9(1), TRPM5(6) 21272706 51 37 50 24 12 10 12 8 9 0 0.644 1.000 1.000 550 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CDC40(1), CLK4(1), COL2A1(1), CPSF1(1), CPSF3(1), CSTF2(1), DDX1(1), DHX15(1), DHX38(2), DHX8(3), DICER1(3), DNAJC8(1), NUDT21(2), NXF1(1), PABPN1(1), PAPOLA(1), PRPF18(1), PRPF4B(1), PRPF8(4), PTBP1(1), RBM17(1), RNMT(1), SF3A1(1), SF3A2(1), SF3A3(1), SF3B1(3), SF3B2(1), SNRPB2(1), SNRPE(1), SRPK1(2), SRPK2(2), SRRM1(3), SUPT5H(2), U2AF2(1) 38695611 50 34 50 13 3 14 11 9 13 0 0.374 1.000 1.000 551 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACADL(1), ACOX2(1), ACSL3(1), ACSL4(2), ACSL6(4), ANGPTL4(1), APOA5(1), CPT1A(1), CPT1B(1), CYP27A1(1), CYP4A11(1), CYP8B1(1), FABP4(1), FABP6(1), FABP7(1), FADS2(1), GK2(2), HMGCS2(2), LPL(2), ME1(1), MMP1(2), PLTP(1), PPARA(1), RXRA(1), RXRG(1), SCD(1), SLC27A4(1), SLC27A5(1), SLC27A6(1), SORBS1(2) 23750730 39 33 39 23 7 7 10 8 7 0 0.985 1.000 1.000 552 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 CHRM1(1), FLT1(3), FLT4(2), KDR(4), NOS3(3), PDE2A(1), PDE3A(1), PDE3B(5), PRKACG(1), PRKAR1B(1), PRKAR2B(1), PRKG1(1), PRKG2(1), RYR2(16), SYT1(2) 15168083 43 33 43 16 3 11 8 13 8 0 0.607 1.000 1.000 553 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 CDKN2A(2), F2RL2(1), INPPL1(1), IRS1(1), IRS4(3), LNPEP(3), MAPK1(1), PIK3CA(6), PIK3CD(1), PIK3R1(1), PTEN(8), PTPN1(1), RPS6KA1(1), SERPINB6(1), SLC2A4(1), SORBS1(2), SOS1(2), YWHAE(2), YWHAQ(1) 21315951 39 33 37 13 2 6 10 10 11 0 0.775 1.000 1.000 554 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(1), AKR1D1(2), ARSE(1), CARM1(1), CYP11B1(3), CYP11B2(1), CYP19A1(1), HEMK1(1), HSD11B1(1), HSD17B1(1), HSD17B12(2), HSD17B2(1), HSD3B1(1), HSD3B2(1), PRMT2(2), PRMT3(1), PRMT6(1), PRMT8(1), STS(1), SULT1E1(1), SULT2A1(1), UGT1A10(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT2A3(1), UGT2B11(3), UGT2B15(2), UGT2B17(2), WBSCR22(1) 18265347 40 32 40 17 7 7 5 11 10 0 0.884 1.000 1.000 555 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 BCR(2), BLNK(2), BTK(1), CD19(1), EPHB2(1), ITPKA(1), LYN(1), MAP2K2(1), MAPK1(1), NFAT5(4), NFKB1(1), NFKBIL1(1), PI3(1), PIK3CA(6), PIK3CD(1), PIK3R1(1), PLCG2(2), PPP1R13B(1), SERPINA4(1), SOS1(2), SYK(2), VAV1(3) 19502623 37 32 36 15 8 4 9 7 9 0 0.826 1.000 1.000 556 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 CAD(4), DPYD(6), DTYMK(1), ENTPD1(1), ENTPD3(1), ENTPD8(2), NME2(1), NME6(2), NT5E(1), PNPT1(2), POLD1(3), POLE(5), POLE2(1), POLE4(1), POLR1A(1), PRIM2(1), RRM2(1), TXNRD1(4), TXNRD2(2), UMPS(1), UPP2(1) 29929462 42 31 41 14 2 11 10 7 12 0 0.711 1.000 1.000 557 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(2), AASDHPPT(1), AASS(1), ACAT1(2), AKR1B10(1), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), BBOX1(2), DOT1L(1), EHMT1(1), EHMT2(1), HADHA(1), HSD17B4(1), NSD1(1), OGDHL(4), PLOD2(2), PLOD3(1), SETD1A(4), SUV39H1(1), TMLHE(1) 21122637 33 31 33 15 2 7 9 6 9 0 0.872 1.000 1.000 558 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(2), ACAT1(2), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), AOC3(1), AOX1(2), CARM1(1), CYP1A2(2), DDC(2), HADHA(1), HEMK1(1), HSD17B4(1), INMT(1), KYNU(2), LNX1(1), MAOB(1), OGDHL(4), PRMT2(2), PRMT3(1), PRMT6(1), PRMT8(1), TPH2(3), WARS(1), WARS2(1), WBSCR22(1) 22212882 40 31 40 15 7 12 5 8 8 0 0.634 1.000 1.000 559 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CTLA4(1), DTYMK(1), EPHB2(1), GRAP2(2), ITK(1), ITPKA(1), LAT(1), LCK(1), LCP2(2), MAPK1(1), NFAT5(4), NFKB1(1), NFKBIL1(1), PAK1(1), PAK3(3), PAK4(1), PAK7(1), PLCG1(1), PTPRC(4), SOS1(2), VAV1(3), ZAP70(5) 20858987 39 31 39 13 7 13 7 7 5 0 0.452 1.000 1.000 560 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 ACAT1(2), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), AOC3(1), AOX1(2), CYP19A1(1), CYP1A2(2), CYP2A13(1), CYP2C18(3), CYP2C19(2), CYP2C9(2), CYP2E1(3), CYP2F1(2), CYP2J2(2), CYP3A4(3), CYP3A7(2), CYP4B1(1), DDC(2), HADHA(1), KYNU(2), MAOB(1), WARS(1), WARS2(1) 20264018 42 31 42 17 8 11 8 9 6 0 0.604 1.000 1.000 561 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(5), AXIN1(1), CCND1(1), DVL1(2), DVL2(1), FZD10(1), FZD2(2), FZD3(2), FZD5(1), FZD6(1), JUN(1), MAPK10(2), MYC(3), PPP2R5C(2), PPP2R5E(1), PRKCA(1), PRKCE(2), PRKCG(1), PRKCH(1), PRKCI(1), PRKCQ(3), PRKD1(1), RAC1(1), SFRP4(1), WNT10B(1), WNT2(1), WNT2B(1), WNT5A(1), WNT7B(1) 21607923 43 30 43 16 7 10 6 5 15 0 0.528 1.000 1.000 562 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F11(3), F12(1), F13B(1), F2(3), F5(6), F7(1), F8(4), FGA(2), FGB(2), FGG(2), PLG(1), SERPINF2(1), VWF(4) 12690612 31 29 31 18 2 9 8 7 4 1 0.984 1.000 1.000 563 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 50 AKR1C3(1), ALOX12(2), ALOX12B(4), ALOX15(1), ALOX5(2), CBR3(1), CYP2C18(3), CYP2C19(2), CYP2C9(2), CYP2E1(3), CYP2J2(2), CYP4A11(1), CYP4F2(2), GGT1(1), GPX5(2), PLA2G12B(1), PLA2G2D(1), PLA2G4A(1), PTGIS(1), PTGS1(1), PTGS2(1), TBXAS1(1) 14765817 36 29 36 12 6 7 14 3 6 0 0.476 1.000 1.000 564 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(2), AGTR2(1), ATP8A1(4), BDKRB1(1), C3AR1(1), CCKAR(1), CCKBR(2), CCR1(2), CCR3(2), CCR4(1), CXCR6(2), EDNRA(1), FSHR(1), GHSR(2), GRPR(1), LHCGR(6), MC4R(1), NTSR1(2), NTSR2(1), OPRM1(1), SSTR3(1), TACR1(2), TRHR(1) 18326786 39 29 37 21 5 9 8 4 13 0 0.939 1.000 1.000 565 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(3), AR(5), ESR2(2), ESRRA(1), HNF4A(2), NR0B1(2), NR1D1(1), NR1D2(1), NR1I3(1), NR2E1(1), NR4A1(1), PPARA(1), RARA(1), RARB(4), RORC(1), RXRA(1), RXRG(1), THRA(1) 15243118 30 28 29 13 4 5 7 6 8 0 0.859 1.000 1.000 566 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG2(1), ANGPTL2(2), FLNA(4), FLNC(3), FSCN3(1), GDI1(1), LIMK1(3), MYH2(6), MYLK(3), MYLK2(2), PAK1(1), PAK3(3), PAK4(1), PAK7(1), PFN2(1), RHO(1), ROCK1(1), ROCK2(2), VASP(1) 17633746 38 26 38 16 5 11 13 5 4 0 0.729 1.000 1.000 567 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 31 ANKRD6(1), APC(5), AXIN1(1), AXIN2(2), DACT1(1), DKK2(1), DVL1(2), FSTL1(2), LRP1(4), MVP(1), NKD2(2), PIN1(1), PTPRA(2), WIF1(4) 14984319 29 26 29 14 5 5 5 3 11 0 0.846 1.000 1.000 568 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 AGMAT(1), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), AMD1(1), AOC3(1), ARG2(2), ASL(1), CKMT2(1), MAOB(1), NOS1(7), NOS3(3), P4HA2(1), P4HA3(1), PYCR1(2), RARS(2) 16324615 29 25 29 11 5 8 8 2 6 0 0.533 1.000 1.000 569 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 AGXT(1), AGXT2(1), ALAS1(1), ALAS2(3), AOC3(1), CBS(1), CHDH(1), CPT1B(1), CTH(1), DMGDH(1), MAOB(1), PLCB2(2), PLCG1(1), PLCG2(2), PSPH(1), SARDH(3), SARS(2), TARS(3) 15728079 27 25 27 12 2 8 8 7 2 0 0.733 1.000 1.000 570 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 B3GNT2(2), B4GALNT1(4), FUT1(3), FUT2(1), FUT5(1), FUT9(3), PIGB(1), PIGC(2), PIGG(2), PIGN(3), PIGS(2), PIGT(1), ST3GAL5(1), ST6GALNAC3(1), ST6GALNAC5(1), ST6GALNAC6(1) 17864285 29 25 29 11 6 10 6 4 3 0 0.465 1.000 1.000 571 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(1), ACPP(1), ALPI(1), ALPL(3), ALPP(1), CYP19A1(1), CYP1A2(2), CYP2A13(1), CYP2C18(3), CYP2C19(2), CYP2C9(2), CYP2E1(3), CYP2F1(2), CYP2J2(2), CYP3A4(3), CYP3A7(2), CYP4B1(1) 10839534 31 23 31 12 4 9 9 4 5 0 0.464 1.000 1.000 572 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(4), C5(2), C6(6), C7(1), IL1A(1), ITGA4(2), ITGAL(2), ITGB2(1), SELP(2), SELPLG(1), TNF(1), VCAM1(1) 9068561 24 23 24 10 4 3 7 8 2 0 0.711 1.000 1.000 573 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(3), DGKI(1), MRPL19(1), RPL11(1), RPL13A(1), RPL14(2), RPL17(1), RPL36(1), RPL4(1), RPL41(1), RPL5(3), RPL7(1), RPS20(1), RPS23(1), RPS26(1), RPS6(1), RPS6KA1(1), RPS7(1), SLC36A2(2), UBB(2) 19504484 27 23 26 11 3 9 7 2 6 0 0.746 1.000 1.000 574 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS2(2), ABAT(1), ADSL(1), ADSSL1(1), AGXT(1), AGXT2(1), ASL(1), ASNS(1), ASPA(1), ASRGL1(1), CAD(4), DARS(1), DLAT(1), GAD1(1), GAD2(2), GPT2(2), PC(1), PDHA2(2), PDHB(1) 13886257 26 22 26 10 2 9 6 3 6 0 0.587 1.000 1.000 575 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ARG2(2), ASL(1), CKMT2(1), EPRS(2), LAP3(2), NOS1(7), NOS3(3), P4HA2(1), P4HA3(1), PRODH(2), PYCR1(2), RARS(2) 13389358 26 22 26 10 6 9 7 0 4 0 0.443 1.000 1.000 576 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), AOC3(1), ASPA(1), CARM1(1), DDC(2), FTCD(2), HARS2(1), HDC(3), HEMK1(1), MAOB(1), PRMT2(2), PRMT3(1), PRMT6(1), PRMT8(1), UROC1(2), WBSCR22(1) 14717888 26 22 26 15 7 6 5 4 4 0 0.951 1.000 1.000 577 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSE(1), CERK(1), GAL3ST1(1), GALC(3), GBA(1), GLA(1), LCT(5), NEU3(2), PPAP2A(1), PPAP2B(2), PPAP2C(1), SGMS1(1), SGPP1(2), SMPD2(2), SMPD3(2), SMPD4(1), SPHK2(2), SPTLC1(1), UGT8(2) 13093874 32 22 31 14 4 6 7 3 11 1 0.860 1.000 1.000 578 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(1), ABAT(1), ACAT1(2), AKR1B10(1), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), BDH2(2), GAD1(1), GAD2(2), HADHA(1), HMGCS2(2), HSD17B4(1), ILVBL(1), OXCT2(1), PDHA2(2), PDHB(1), PLA1A(2) 14944155 26 22 26 12 3 6 8 5 4 0 0.797 1.000 1.000 579 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 AGXT(1), AGXT2(1), AKR1B10(1), ALAS1(1), ALAS2(3), AOC3(1), CBS(1), CHDH(1), CTH(1), DMGDH(1), MAOB(1), PSPH(1), SARDH(3), SARS(2), TARS(3), TARS2(2) 16138840 24 21 24 10 2 7 8 5 2 0 0.618 1.000 1.000 580 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 DLG4(1), GRIN1(2), GRIN2A(3), GRIN2D(2), NOS1(7), PPP3CB(1), PPP3CC(2), PRKACG(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1), SYT1(2) 9237365 24 21 24 10 4 6 8 2 4 0 0.697 1.000 1.000 581 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 BCR(2), BLNK(2), JUN(1), LYN(1), MAPK1(1), MAPK8IP3(3), PAPPA(6), RAC1(1), RPS6KA1(1), SOS1(2), SYK(2), VAV1(3), VAV2(3), VAV3(1) 11934491 29 21 29 11 5 6 7 4 7 0 0.582 1.000 1.000 582 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(1), ALOX15(1), ALOX5(2), CYP1A2(2), CYP2C18(3), CYP2C19(2), CYP2C9(2), CYP2E1(3), CYP2J2(2), CYP3A4(3), CYP3A7(2), PLA2G12B(1), PLA2G2D(1), PLA2G4A(1) 8979329 26 20 26 11 5 6 7 4 4 0 0.619 1.000 1.000 583 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(1), AKR1D1(2), ARSE(1), CYP11B1(3), CYP11B2(1), HSD11B1(1), HSD17B2(1), HSD3B1(1), HSD3B2(1), STS(1), SULT1E1(1), SULT2A1(1), UGT1A10(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT2B15(2) 9915105 22 19 22 13 4 1 3 7 7 0 0.975 1.000 1.000 584 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(1), CAD(4), EARS2(1), EPRS(2), GAD1(1), GAD2(2), GCLC(1), GLS2(1), GLUL(2), GMPS(1), GPT2(2), PPAT(1), QARS(1) 14348556 20 17 20 12 4 2 7 3 4 0 0.963 1.000 1.000 585 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(1), EXTL2(1), EXTL3(2), GLCE(2), HS3ST1(1), HS3ST3A1(1), HS3ST3B1(1), HS3ST5(2), HS6ST1(2), NDST3(4), NDST4(3) 7627157 20 17 19 10 3 6 4 4 3 0 0.833 1.000 1.000 586 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(1), CAMK2B(1), CAMK2G(1), CLCA1(1), CLCA2(1), CNGA3(4), CNGB1(1), GNAL(1), GUCA1C(1), PDE1C(4), PRKACA(2), PRKACG(1), PRKG1(1), PRKG2(1) 11147247 21 17 21 10 2 5 6 4 4 0 0.797 1.000 1.000 587 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 DUSP1(1), MAP2K3(2), MAP2K4(2), MAP2K6(2), MAP3K4(1), MAP3K5(4), MAP3K7(1), MAPK1(1), MAPK11(1), MKNK1(1), NFKB1(1), SRF(1), TRAF6(2) 12481785 20 17 20 11 2 4 5 6 2 1 0.921 1.000 1.000 588 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(1), CAD(4), EPRS(2), GAD1(1), GAD2(2), GCLC(1), GLS2(1), GLUL(2), GMPS(1), GPT2(2), PPAT(1), QARS(1) 12030926 19 16 19 12 4 2 6 3 4 0 0.974 1.000 1.000 589 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B4GALT5(2), GALNT10(1), GALNT13(1), GALNT14(3), GALNT3(1), GALNT5(1), GALNT7(1), GALNT8(3), GALNT9(1), GALNTL5(1), OGT(1), ST6GALNAC1(1), WBSCR17(3) 11775073 20 14 20 10 3 10 4 1 2 0 0.666 1.000 1.000 590 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), AOC3(1), ASPA(1), DDC(2), HDC(3), MAOB(1) 8973023 13 12 13 10 5 2 2 3 1 0 0.972 1.000 1.000 591 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 CDKN1A(2), EPO(1), GRIN1(2), HIF1A(1), NFKB1(1), RELA(2) 4676614 9 9 9 5 2 3 2 2 0 0 0.843 1.000 1.000 592 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 13 DUSP1(1), IKBKAP(2), NFKB1(1), RELA(2), TRAF6(2) 6746232 8 7 8 4 1 3 2 2 0 0 0.791 1.000 1.000 593 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST1(1), HS3ST3A1(1), HS3ST3B1(1), XYLT1(1), XYLT2(2) 2478737 6 6 6 4 1 2 1 2 0 0 0.841 1.000 1.000 594 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST1(1), HS3ST3A1(1), HS3ST3B1(1), XYLT1(1), XYLT2(2) 2478737 6 6 6 4 1 2 1 2 0 0 0.841 1.000 1.000 595 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 ITGA4(2), ITGAL(2), ITGB2(1), SELL(1) 4506207 6 6 6 4 2 0 2 2 0 0 0.901 1.000 1.000 596 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(1), GAD1(1), HDC(3), TH(1) 2204291 6 6 6 4 2 3 0 1 0 0 0.833 1.000 1.000 597 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 IL2RG(1), IRS1(1), JAK1(1), JAK3(2) 5439985 5 5 5 3 1 0 3 1 0 0 0.878 1.000 1.000 598 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 CD3G(1), ITGAL(2), ITGB2(1) 3137330 4 4 4 4 1 0 2 1 0 0 0.962 1.000 1.000 599 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 FADS2(1), PLA2G12B(1), PLA2G2D(1), PLA2G4A(1) 3919090 4 4 4 5 1 2 1 0 0 0 0.981 1.000 1.000 600 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 GREB1(2), HSPB2(1), PDZK1(1), TUBA8(1) 4154701 5 4 5 4 2 0 0 3 0 0 0.889 1.000 1.000 601 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 HMGB1(1), TOP2A(1), TOP2B(1) 3873946 3 3 3 3 0 0 1 2 0 0 0.979 1.000 1.000 602 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(2), PGLYRP2(1) 634153 3 3 3 3 2 0 1 0 0 0 0.959 1.000 1.000 603 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA2(1), JAK1(1), TYK2(1) 3868047 3 3 3 4 0 1 1 1 0 0 0.987 1.000 1.000 604 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA2(1), JAK1(1), TYK2(1) 3868047 3 3 3 4 0 1 1 1 0 0 0.987 1.000 1.000 605 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 PRODH(2) 2141785 2 2 2 2 1 1 0 0 0 0 0.873 1.000 1.000 606 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(1), BMPR2(1) 2218155 2 2 2 3 0 2 0 0 0 0 0.956 1.000 1.000 607 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 HLA-DRB1(1) 1428643 1 1 1 2 1 0 0 0 0 0 0.945 1.000 1.000 608 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(1) 1151471 1 1 1 2 0 0 0 1 0 0 0.981 1.000 1.000 609 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(1) 799416 1 1 1 3 0 0 1 0 0 0 0.991 1.000 1.000 610 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 CASP8(1) 4958152 1 1 1 2 0 0 1 0 0 0 0.985 1.000 1.000 611 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 582152 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 612 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 259063 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 613 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 185349 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 614 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 812817 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 615 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 1110624 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 616 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 545786 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000