Pathway Name Avg Num Perturbations Total Perturbations Num Entities Min Mean Truth Max Mean Truth Min Mean Within Max Mean Within Min Mean Any Max Mean Within FOXA2 and FOXA3 transcription factor networks 109.0 5039.0 46.0 -1.49 0.01 1000.0 -1000.0 -0.06 -1000.0 Nephrin/Neph1 signaling in the kidney podocyte 78.0 2671.0 34.0 -0.369 0.0 1000.0 -1000.0 -0.066 -1000.0 E-cadherin signaling events 67.0 335.0 5.0 -0.345 0.0 1000.0 -1000.0 -0.042 -1000.0 Stabilization and expansion of the E-cadherin adherens junction 53.0 3964.0 74.0 -0.349 0.194 1000.0 -1000.0 -0.096 -1000.0 IL4-mediated signaling events 49.0 4462.0 91.0 -1.313 0.77 1000.0 -1000.0 -0.145 -1000.0 EGFR-dependent Endothelin signaling events 45.0 952.0 21.0 -0.315 0.0 1000.0 -1000.0 -0.063 -1000.0 ErbB2/ErbB3 signaling events 43.0 2828.0 65.0 -0.521 0.026 1000.0 -1000.0 -0.071 -1000.0 Signaling mediated by p38-alpha and p38-beta 43.0 1927.0 44.0 -0.405 0.0 1000.0 -1000.0 -0.054 -1000.0 Signaling events mediated by the Hedgehog family 38.0 2025.0 52.0 -0.373 0.176 1000.0 -1000.0 -0.082 -1000.0 Glypican 2 network 38.0 155.0 4.0 -0.104 -0.095 1000.0 -1000.0 -0.03 -1000.0 E-cadherin signaling in the nascent adherens junction 36.0 2763.0 76.0 -0.345 0.0 1000.0 -1000.0 -0.08 -1000.0 TCGA08_retinoblastoma 35.0 282.0 8.0 -0.252 0.053 1000.0 -1000.0 -0.022 -1000.0 Wnt signaling 33.0 237.0 7.0 -0.088 -0.01 1000.0 -1000.0 -0.048 -1000.0 Reelin signaling pathway 30.0 1723.0 56.0 -0.274 0.0 1000.0 -1000.0 -0.093 -1000.0 TCGA08_p53 28.0 201.0 7.0 -0.164 0.031 1000.0 -1000.0 -0.02 -1000.0 Signaling events regulated by Ret tyrosine kinase 25.0 2121.0 82.0 -0.265 0.0 1000.0 -1000.0 -0.085 -1000.0 Syndecan-1-mediated signaling events 24.0 818.0 34.0 -0.291 0.0 1000.0 -1000.0 -0.08 -1000.0 amb2 Integrin signaling 23.0 1919.0 82.0 -0.298 0.004 1000.0 -1000.0 -0.078 -1000.0 Aurora B signaling 21.0 1435.0 67.0 -0.314 0.001 1000.0 -1000.0 -0.065 -1000.0 Osteopontin-mediated events 19.0 751.0 38.0 -0.15 0.0 1000.0 -1000.0 -0.105 -1000.0 E-cadherin signaling in keratinocytes 18.0 787.0 43.0 -0.345 0.084 1000.0 -1000.0 -0.076 -1000.0 Lissencephaly gene (LIS1) in neuronal migration and development 17.0 968.0 54.0 -0.198 0.019 1000.0 -1000.0 -0.09 -1000.0 Thromboxane A2 receptor signaling 17.0 1856.0 105.0 -0.315 0.014 1000.0 -1000.0 -0.073 -1000.0 BMP receptor signaling 17.0 1445.0 81.0 -0.397 0.028 1000.0 -1000.0 -0.089 -1000.0 Integrins in angiogenesis 17.0 1503.0 84.0 -0.444 0.006 1000.0 -1000.0 -0.096 -1000.0 Coregulation of Androgen receptor activity 16.0 1222.0 76.0 -0.699 0.027 1000.0 -1000.0 -0.049 -1000.0 Aurora C signaling 16.0 115.0 7.0 -0.133 0.0 1000.0 -1000.0 -0.043 -1000.0 LPA4-mediated signaling events 15.0 180.0 12.0 -0.191 0.017 1000.0 -1000.0 -0.02 -1000.0 Noncanonical Wnt signaling pathway 15.0 415.0 26.0 -0.088 0.0 1000.0 -1000.0 -0.082 -1000.0 TCR signaling in naïve CD8+ T cells 15.0 1458.0 93.0 -0.214 0.105 1000.0 -1000.0 -0.07 -1000.0 Ephrin A reverse signaling 14.0 100.0 7.0 -0.072 0.0 1000.0 -1000.0 -0.047 -1000.0 Arf6 signaling events 14.0 901.0 62.0 -0.315 0.012 1000.0 -1000.0 -0.066 -1000.0 PDGFR-alpha signaling pathway 14.0 638.0 44.0 -0.108 0.007 1000.0 -1000.0 -0.062 -1000.0 Endothelins 14.0 1349.0 96.0 -0.491 0.024 1000.0 -1000.0 -0.081 -1000.0 Syndecan-4-mediated signaling events 14.0 963.0 67.0 -0.178 0.036 1000.0 -1000.0 -0.091 -1000.0 Angiopoietin receptor Tie2-mediated signaling 14.0 1237.0 88.0 -0.241 0.021 1000.0 -1000.0 -0.105 -1000.0 p75(NTR)-mediated signaling 13.0 1660.0 125.0 -0.481 0.026 1000.0 -1000.0 -0.098 -1000.0 Fc-epsilon receptor I signaling in mast cells 13.0 1322.0 97.0 -0.144 0.026 1000.0 -1000.0 -0.087 -1000.0 S1P1 pathway 13.0 498.0 36.0 -0.228 0.012 1000.0 -1000.0 -0.069 -1000.0 IL23-mediated signaling events 13.0 800.0 60.0 -0.239 0.014 1000.0 -1000.0 -0.153 -1000.0 FOXM1 transcription factor network 13.0 700.0 51.0 -0.237 0.014 1000.0 -1000.0 -0.178 -1000.0 Visual signal transduction: Cones 11.0 425.0 38.0 -0.14 0.0 1000.0 -1000.0 -0.056 -1000.0 Calcium signaling in the CD4+ TCR pathway 11.0 352.0 31.0 -0.245 0.0 1000.0 -1000.0 -0.104 -1000.0 Calcineurin-regulated NFAT-dependent transcription in lymphocytes 11.0 781.0 68.0 -0.211 0.026 1000.0 -1000.0 -0.119 -1000.0 Hypoxic and oxygen homeostasis regulation of HIF-1-alpha 11.0 378.0 33.0 -0.243 0.0 1000.0 -1000.0 -0.06 -1000.0 Class IB PI3K non-lipid kinase events 11.0 33.0 3.0 -0.034 -1000.0 1000.0 -1000.0 -0.023 -1000.0 ErbB4 signaling events 10.0 744.0 69.0 -0.103 0.04 1000.0 -1000.0 -0.082 -1000.0 Signaling events mediated by PTP1B 10.0 789.0 76.0 -0.317 0.036 1000.0 -1000.0 -0.078 -1000.0 PLK1 signaling events 10.0 904.0 85.0 -0.168 0.011 1000.0 -1000.0 -0.052 -1000.0 RXR and RAR heterodimerization with other nuclear receptor 10.0 533.0 52.0 -0.173 0.042 1000.0 -1000.0 -0.065 -1000.0 Nongenotropic Androgen signaling 10.0 562.0 52.0 -0.103 0.009 1000.0 -1000.0 -0.058 -1000.0 IL2 signaling events mediated by STAT5 10.0 222.0 22.0 -0.094 0.028 1000.0 -1000.0 -0.062 -1000.0 IL12-mediated signaling events 9.0 830.0 87.0 -0.099 0.023 1000.0 -1000.0 -0.116 -1000.0 HIF-1-alpha transcription factor network 9.0 685.0 76.0 -0.367 0.061 1000.0 -1000.0 -0.141 -1000.0 Glypican 1 network 9.0 463.0 48.0 -0.245 0.007 1000.0 -1000.0 -0.056 -1000.0 Glucocorticoid receptor regulatory network 9.0 1064.0 114.0 -0.234 0.179 1000.0 -1000.0 -0.083 -1000.0 Visual signal transduction: Rods 9.0 507.0 52.0 -0.14 0.0 1000.0 -1000.0 -0.071 -1000.0 S1P4 pathway 9.0 243.0 25.0 -0.103 0.0 1000.0 -1000.0 -0.057 -1000.0 Signaling events mediated by Stem cell factor receptor (c-Kit) 9.0 765.0 78.0 -0.087 0.037 1000.0 -1000.0 -0.106 -1000.0 Regulation of Androgen receptor activity 9.0 657.0 70.0 -0.733 0.012 1000.0 -1000.0 -0.075 -1000.0 Regulation of nuclear SMAD2/3 signaling 8.0 1130.0 136.0 -0.367 0.066 1000.0 -1000.0 -0.091 -1000.0 Presenilin action in Notch and Wnt signaling 8.0 518.0 61.0 -0.131 0.042 1000.0 -1000.0 -0.069 -1000.0 S1P5 pathway 8.0 150.0 17.0 -0.103 0.059 1000.0 -1000.0 -0.052 -1000.0 Signaling mediated by p38-gamma and p38-delta 8.0 134.0 15.0 -0.142 0.02 1000.0 -1000.0 -0.048 -1000.0 Sphingosine 1-phosphate (S1P) pathway 7.0 222.0 28.0 -0.103 0.0 1000.0 -1000.0 -0.055 -1000.0 Nectin adhesion pathway 7.0 449.0 63.0 -0.345 0.034 1000.0 -1000.0 -0.075 -1000.0 Ephrin B reverse signaling 7.0 360.0 48.0 -0.051 0.03 1000.0 -1000.0 -0.069 -1000.0 FoxO family signaling 7.0 491.0 64.0 -0.403 0.039 1000.0 -1000.0 -0.082 -1000.0 LPA receptor mediated events 7.0 755.0 102.0 -0.147 0.027 1000.0 -1000.0 -0.09 -1000.0 Insulin Pathway 7.0 582.0 74.0 -0.259 0.031 1000.0 -1000.0 -0.09 -1000.0 Plasma membrane estrogen receptor signaling 7.0 679.0 86.0 -0.115 0.03 1000.0 -1000.0 -0.079 -1000.0 S1P3 pathway 7.0 310.0 42.0 -0.103 0.001 1000.0 -1000.0 -0.056 -1000.0 Neurotrophic factor-mediated Trk receptor signaling 7.0 952.0 120.0 -0.167 0.053 1000.0 -1000.0 -0.073 -1000.0 Canonical Wnt signaling pathway 6.0 348.0 51.0 -0.131 0.04 1000.0 -1000.0 -0.063 -1000.0 Effects of Botulinum toxin 6.0 164.0 26.0 -0.104 0.0 1000.0 -1000.0 -0.059 -1000.0 Regulation of Telomerase 6.0 711.0 102.0 -0.355 0.016 1000.0 -1000.0 -0.095 -1000.0 PLK2 and PLK4 events 5.0 15.0 3.0 -0.017 0.005 1000.0 -1000.0 -0.024 -1000.0 Syndecan-2-mediated signaling events 5.0 348.0 69.0 -0.185 0.032 1000.0 -1000.0 -0.064 -1000.0 Insulin-mediated glucose transport 5.0 160.0 32.0 -0.16 0.019 1000.0 -1000.0 -0.064 -1000.0 Ceramide signaling pathway 5.0 414.0 76.0 -0.315 0.105 1000.0 -1000.0 -0.07 -1000.0 IL2 signaling events mediated by PI3K 5.0 325.0 58.0 -0.076 0.049 1000.0 -1000.0 -0.073 -1000.0 IL27-mediated signaling events 5.0 264.0 51.0 -0.136 0.005 1000.0 -1000.0 -0.088 -1000.0 Signaling events mediated by PRL 5.0 183.0 34.0 -0.177 0.027 1000.0 -1000.0 -0.065 -1000.0 BARD1 signaling events 4.0 246.0 57.0 -0.159 0.103 1000.0 -1000.0 -0.059 -1000.0 JNK signaling in the CD4+ TCR pathway 4.0 71.0 17.0 -0.025 0.036 1000.0 -1000.0 -0.052 -1000.0 IL1-mediated signaling events 4.0 296.0 62.0 -0.091 0.024 1000.0 -1000.0 -0.097 -1000.0 FAS signaling pathway (CD95) 4.0 217.0 47.0 -0.115 0.017 1000.0 -1000.0 -0.056 -1000.0 Retinoic acid receptors-mediated signaling 4.0 236.0 58.0 -0.058 0.032 1000.0 -1000.0 -0.071 -1000.0 IL6-mediated signaling events 4.0 348.0 75.0 -0.075 0.081 1000.0 -1000.0 -0.098 -1000.0 BCR signaling pathway 4.0 405.0 99.0 -0.068 0.037 1000.0 -1000.0 -0.077 -1000.0 Ras signaling in the CD4+ TCR pathway 4.0 73.0 17.0 -0.033 0.02 1000.0 -1000.0 -0.064 -1000.0 Caspase cascade in apoptosis 3.0 247.0 74.0 -0.129 0.037 1000.0 -1000.0 -0.059 -1000.0 Cellular roles of Anthrax toxin 3.0 144.0 39.0 -0.106 0.018 1000.0 -1000.0 -0.029 -1000.0 Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met) 3.0 333.0 85.0 -0.049 0.037 1000.0 -1000.0 -0.072 -1000.0 Aurora A signaling 3.0 239.0 60.0 -0.159 0.016 1000.0 -1000.0 -0.057 -1000.0 IFN-gamma pathway 3.0 217.0 68.0 -0.086 0.047 1000.0 -1000.0 -0.095 -1000.0 Class I PI3K signaling events mediated by Akt 3.0 259.0 68.0 -0.213 0.037 1000.0 -1000.0 -0.07 -1000.0 Paxillin-independent events mediated by a4b1 and a4b7 3.0 133.0 37.0 -0.065 0.0 1000.0 -1000.0 -0.081 -1000.0 TRAIL signaling pathway 3.0 177.0 48.0 -0.036 0.037 1000.0 -1000.0 -0.066 -1000.0 Role of Calcineurin-dependent NFAT signaling in lymphocytes 3.0 273.0 83.0 -0.091 0.017 1000.0 -1000.0 -0.082 -1000.0 Syndecan-3-mediated signaling events 3.0 125.0 35.0 -0.064 0.0 1000.0 -1000.0 -0.068 -1000.0 EPHB forward signaling 3.0 284.0 85.0 -0.137 0.045 1000.0 -1000.0 -0.09 -1000.0 Regulation of p38-alpha and p38-beta 3.0 171.0 54.0 -0.07 0.037 1000.0 -1000.0 -0.076 -1000.0 Arf6 trafficking events 3.0 254.0 71.0 -0.355 0.08 1000.0 -1000.0 -0.082 -1000.0 IGF1 pathway 3.0 182.0 57.0 -0.059 0.034 1000.0 -1000.0 -0.092 -1000.0 Rapid glucocorticoid signaling 3.0 61.0 20.0 -0.041 0.006 1000.0 -1000.0 -0.039 -1000.0 Signaling events mediated by HDAC Class II 2.0 219.0 75.0 -0.143 0.002 1000.0 -1000.0 -0.058 -1000.0 Hedgehog signaling events mediated by Gli proteins 2.0 161.0 65.0 -0.103 0.037 1000.0 -1000.0 -0.077 -1000.0 Signaling events mediated by HDAC Class III 2.0 111.0 40.0 -0.165 0.025 1000.0 -1000.0 -0.047 -1000.0 HIV-1 Nef: Negative effector of Fas and TNF-alpha 2.0 104.0 45.0 -0.059 0.055 1000.0 -1000.0 -0.083 -1000.0 TCGA08_rtk_signaling 2.0 67.0 26.0 -0.075 0.032 1000.0 -1000.0 -0.027 -1000.0 Class I PI3K signaling events 2.0 169.0 73.0 -0.046 0.043 1000.0 -1000.0 -0.067 -1000.0 PDGFR-beta signaling pathway 2.0 252.0 97.0 -0.137 0.05 1000.0 -1000.0 -0.084 -1000.0 a4b1 and a4b7 Integrin signaling 1.0 8.0 5.0 -0.007 -0.002 1000.0 -1000.0 -0.033 -1000.0 HIF-2-alpha transcription factor network 1.0 78.0 43.0 -0.084 0.101 1000.0 -1000.0 -0.09 -1000.0 Signaling events mediated by HDAC Class I 1.0 201.0 104.0 -0.143 0.0 1000.0 -1000.0 -0.072 -1000.0 Paxillin-dependent events mediated by a4b1 1.0 55.0 36.0 -0.065 0.019 1000.0 -1000.0 -0.076 -1000.0 Atypical NF-kappaB pathway 1.0 47.0 31.0 -0.039 0.019 1000.0 -1000.0 -0.066 -1000.0 Sumoylation by RanBP2 regulates transcriptional repression 1.0 53.0 27.0 -0.062 0.0 1000.0 -1000.0 -0.05 -1000.0 p38 MAPK signaling pathway 1.0 54.0 44.0 -0.03 0.029 1000.0 -1000.0 -0.062 -1000.0 Regulation of cytoplasmic and nuclear SMAD2/3 signaling 0.0 14.0 23.0 -0.012 0.031 1000.0 -1000.0 -0.07 -1000.0 Canonical NF-kappaB pathway 0.0 27.0 39.0 -0.016 0.066 1000.0 -1000.0 -0.084 -1000.0 Circadian rhythm pathway 0.0 14.0 22.0 -0.011 0.035 1000.0 -1000.0 -0.075 -1000.0 Arf6 downstream pathway 0.0 8.0 43.0 -0.012 0.018 1000.0 -1000.0 -0.054 -1000.0 EPO signaling pathway 0.0 18.0 55.0 -0.007 0.067 1000.0 -1000.0 -0.086 -1000.0 mTOR signaling pathway 0.0 19.0 53.0 -0.004 0.027 1000.0 -1000.0 -0.059 -1000.0 ceramide signaling pathway 0.0 16.0 49.0 -0.011 0.044 1000.0 -1000.0 -0.057 -1000.0 Signaling events mediated by VEGFR1 and VEGFR2 0.0 100.0 125.0 -0.034 0.079 1000.0 -1000.0 -0.098 -1000.0 VEGFR1 specific signals 0.0 43.0 56.0 -0.016 0.048 1000.0 -1000.0 -0.077 -1000.0 Arf1 pathway 0.0 7.0 54.0 -0.007 0.016 1000.0 -1000.0 -0.042 -1000.0 Alternative NF-kappaB pathway 0.0 0.0 13.0 0.0 0.0 1000.0 -1000.0 -0.057 -1000.0 Total 1582 84162 7203 -25.2874513674 -995.468461542 131000 -131000 -9.45599002691 -131000