Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXA2 and FOXA3 transcription factor networks	105.0	4837.0	46.0	-1.248	0.02	1000.0	-1000.0	-0.089	-1000.0
FOXM1 transcription factor network	97.0	4964.0	51.0	0.019	0.743	1000.0	-1000.0	-0.105	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	68.0	2335.0	34.0	-0.243	0.019	1000.0	-1000.0	-0.032	-1000.0
E-cadherin signaling events	62.0	311.0	5.0	-0.207	0.019	1000.0	-1000.0	0.004	-1000.0
TCGA08_retinoblastoma	50.0	405.0	8.0	-0.071	0.188	1000.0	-1000.0	-0.002	-1000.0
ErbB2/ErbB3 signaling events	48.0	3174.0	65.0	-0.338	0.03	1000.0	-1000.0	-0.054	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	46.0	3467.0	74.0	-0.219	0.099	1000.0	-1000.0	-0.072	-1000.0
Signaling mediated by p38-alpha and p38-beta	40.0	1793.0	44.0	-0.314	0.019	1000.0	-1000.0	-0.04	-1000.0
Signaling events mediated by the Hedgehog family	38.0	2021.0	52.0	-0.253	0.099	1000.0	-1000.0	-0.043	-1000.0
EGFR-dependent Endothelin signaling events	38.0	809.0	21.0	-0.209	0.027	1000.0	-1000.0	-0.044	-1000.0
Glypican 2 network	36.0	145.0	4.0	0.049	0.094	1000.0	-1000.0	0.005	-1000.0
E-cadherin signaling in the nascent adherens junction	36.0	2739.0	76.0	-0.207	0.036	1000.0	-1000.0	-0.062	-1000.0
Aurora B signaling	33.0	2211.0	67.0	-0.214	0.211	1000.0	-1000.0	-0.045	-1000.0
TCGA08_p53	32.0	227.0	7.0	-0.016	0.019	1000.0	-1000.0	-0.011	-1000.0
E-cadherin signaling in keratinocytes	32.0	1418.0	43.0	-0.207	0.067	1000.0	-1000.0	-0.041	-1000.0
IL12-mediated signaling events	30.0	2641.0	87.0	-0.113	0.243	1000.0	-1000.0	-0.086	-1000.0
IL4-mediated signaling events	30.0	2781.0	91.0	-1.101	0.549	1000.0	-1000.0	-0.117	-1000.0
Wnt signaling	30.0	214.0	7.0	-0.028	0.08	1000.0	-1000.0	-0.019	-1000.0
TCR signaling in naïve CD8+ T cells	29.0	2780.0	93.0	-0.107	0.106	1000.0	-1000.0	-0.052	-1000.0
Reelin signaling pathway	27.0	1563.0	56.0	-0.184	0.043	1000.0	-1000.0	-0.038	-1000.0
IL23-mediated signaling events	27.0	1624.0	60.0	-0.08	0.084	1000.0	-1000.0	-0.085	-1000.0
PLK1 signaling events	25.0	2157.0	85.0	-0.02	0.141	1000.0	-1000.0	-0.039	-1000.0
Coregulation of Androgen receptor activity	21.0	1620.0	76.0	-0.551	0.189	1000.0	-1000.0	-0.028	-1000.0
BARD1 signaling events	20.0	1174.0	57.0	-0.098	0.128	1000.0	-1000.0	-0.043	-1000.0
Syndecan-1-mediated signaling events	20.0	684.0	34.0	-0.175	0.108	1000.0	-1000.0	-0.044	-1000.0
Osteopontin-mediated events	19.0	738.0	38.0	-0.082	0.027	1000.0	-1000.0	-0.051	-1000.0
amb2 Integrin signaling	19.0	1583.0	82.0	-0.161	0.108	1000.0	-1000.0	-0.039	-1000.0
Signaling events regulated by Ret tyrosine kinase	19.0	1635.0	82.0	-0.143	0.048	1000.0	-1000.0	-0.064	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	19.0	1354.0	68.0	-0.117	0.152	1000.0	-1000.0	-0.089	-1000.0
Thromboxane A2 receptor signaling	18.0	1989.0	105.0	-0.209	0.049	1000.0	-1000.0	-0.049	-1000.0
Calcium signaling in the CD4+ TCR pathway	17.0	529.0	31.0	-0.003	0.092	1000.0	-1000.0	-0.043	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	16.0	898.0	54.0	-0.11	0.097	1000.0	-1000.0	-0.058	-1000.0
Noncanonical Wnt signaling pathway	16.0	431.0	26.0	-0.034	0.08	1000.0	-1000.0	-0.04	-1000.0
BMP receptor signaling	16.0	1329.0	81.0	-0.208	0.057	1000.0	-1000.0	-0.044	-1000.0
Endothelins	16.0	1626.0	96.0	-0.415	0.082	1000.0	-1000.0	-0.045	-1000.0
Integrins in angiogenesis	16.0	1412.0	84.0	-0.272	0.128	1000.0	-1000.0	-0.058	-1000.0
Fc-epsilon receptor I signaling in mast cells	15.0	1530.0	97.0	-0.077	0.035	1000.0	-1000.0	-0.055	-1000.0
Effects of Botulinum toxin	15.0	405.0	26.0	-0.004	0.091	1000.0	-1000.0	-0.01	-1000.0
Aurora C signaling	14.0	103.0	7.0	-0.0	0.105	1000.0	-1000.0	-0.023	-1000.0
PDGFR-alpha signaling pathway	14.0	643.0	44.0	-0.074	0.02	1000.0	-1000.0	-0.033	-1000.0
Syndecan-4-mediated signaling events	14.0	949.0	67.0	-0.106	0.134	1000.0	-1000.0	-0.034	-1000.0
LPA4-mediated signaling events	13.0	167.0	12.0	-0.133	0.004	1000.0	-1000.0	-0.023	-1000.0
Ephrin A  reverse signaling	13.0	96.0	7.0	0.0	0.062	1000.0	-1000.0	-0.027	-1000.0
Arf6 signaling events	13.0	842.0	62.0	-0.209	0.044	1000.0	-1000.0	-0.032	-1000.0
S1P1 pathway	13.0	475.0	36.0	-0.226	0.023	1000.0	-1000.0	-0.047	-1000.0
IL2 signaling events mediated by STAT5	13.0	292.0	22.0	-0.026	0.088	1000.0	-1000.0	-0.053	-1000.0
Angiopoietin receptor Tie2-mediated signaling	13.0	1181.0	88.0	-0.155	0.062	1000.0	-1000.0	-0.074	-1000.0
S1P4 pathway	13.0	345.0	25.0	-0.051	0.035	1000.0	-1000.0	-0.026	-1000.0
p75(NTR)-mediated signaling	12.0	1544.0	125.0	-0.271	0.09	1000.0	-1000.0	-0.067	-1000.0
S1P5 pathway	12.0	212.0	17.0	-0.051	0.034	1000.0	-1000.0	-0.013	-1000.0
IL27-mediated signaling events	12.0	660.0	51.0	-0.154	0.168	1000.0	-1000.0	-0.044	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	12.0	410.0	33.0	-0.083	0.184	1000.0	-1000.0	-0.033	-1000.0
Signaling events mediated by PTP1B	11.0	900.0	76.0	-0.21	0.051	1000.0	-1000.0	-0.035	-1000.0
Aurora A signaling	11.0	693.0	60.0	-0.025	0.131	1000.0	-1000.0	-0.031	-1000.0
Nongenotropic Androgen signaling	11.0	618.0	52.0	-0.082	0.031	1000.0	-1000.0	-0.032	-1000.0
Visual signal transduction: Cones	10.0	394.0	38.0	-0.062	0.051	1000.0	-1000.0	-0.027	-1000.0
Glucocorticoid receptor regulatory network	10.0	1181.0	114.0	-0.143	0.07	1000.0	-1000.0	-0.061	-1000.0
FoxO family signaling	10.0	674.0	64.0	-0.393	0.161	1000.0	-1000.0	-0.058	-1000.0
LPA receptor mediated events	10.0	1036.0	102.0	-0.105	0.109	1000.0	-1000.0	-0.065	-1000.0
Insulin Pathway	10.0	744.0	74.0	-0.168	0.058	1000.0	-1000.0	-0.052	-1000.0
Class IB PI3K non-lipid kinase events	10.0	30.0	3.0	-0.004	-1000.0	1000.0	-1000.0	-0.01	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	10.0	786.0	78.0	-0.057	0.032	1000.0	-1000.0	-0.058	-1000.0
Regulation of Androgen receptor activity	10.0	722.0	70.0	-0.638	0.022	1000.0	-1000.0	-0.044	-1000.0
ErbB4 signaling events	9.0	678.0	69.0	-0.092	0.048	1000.0	-1000.0	-0.042	-1000.0
Sphingosine 1-phosphate (S1P) pathway	9.0	261.0	28.0	-0.051	0.078	1000.0	-1000.0	-0.023	-1000.0
HIF-1-alpha transcription factor network	9.0	714.0	76.0	-0.24	0.115	1000.0	-1000.0	-0.073	-1000.0
Glypican 1 network	9.0	446.0	48.0	-0.086	0.033	1000.0	-1000.0	-0.03	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	9.0	505.0	52.0	-0.103	0.054	1000.0	-1000.0	-0.035	-1000.0
Ephrin B reverse signaling	9.0	457.0	48.0	-0.067	0.071	1000.0	-1000.0	-0.028	-1000.0
Signaling mediated by p38-gamma and p38-delta	9.0	139.0	15.0	-0.113	0.018	1000.0	-1000.0	-0.032	-1000.0
Plasma membrane estrogen receptor signaling	9.0	784.0	86.0	-0.137	0.042	1000.0	-1000.0	-0.056	-1000.0
S1P3 pathway	9.0	393.0	42.0	-0.052	0.031	1000.0	-1000.0	-0.045	-1000.0
Visual signal transduction: Rods	9.0	486.0	52.0	-0.062	0.051	1000.0	-1000.0	-0.047	-1000.0
Regulation of nuclear SMAD2/3 signaling	8.0	1102.0	136.0	-0.255	0.154	1000.0	-1000.0	-0.044	-1000.0
JNK signaling in the CD4+ TCR pathway	8.0	137.0	17.0	-0.016	0.066	1000.0	-1000.0	-0.039	-1000.0
Syndecan-2-mediated signaling events	8.0	588.0	69.0	-0.136	0.062	1000.0	-1000.0	-0.042	-1000.0
Nectin adhesion pathway	8.0	544.0	63.0	-0.207	0.042	1000.0	-1000.0	-0.041	-1000.0
Ceramide signaling pathway	8.0	677.0	76.0	-0.209	0.086	1000.0	-1000.0	-0.038	-1000.0
HIF-2-alpha transcription factor network	8.0	351.0	43.0	-0.126	0.128	1000.0	-1000.0	-0.06	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	8.0	986.0	120.0	-0.079	0.043	1000.0	-1000.0	-0.054	-1000.0
Presenilin action in Notch and Wnt signaling	7.0	461.0	61.0	-0.033	0.067	1000.0	-1000.0	-0.051	-1000.0
IFN-gamma pathway	7.0	517.0	68.0	-0.044	0.067	1000.0	-1000.0	-0.061	-1000.0
IL2 signaling events mediated by PI3K	7.0	447.0	58.0	-0.037	0.072	1000.0	-1000.0	-0.054	-1000.0
Canonical Wnt signaling pathway	7.0	365.0	51.0	-0.033	0.065	1000.0	-1000.0	-0.057	-1000.0
Caspase cascade in apoptosis	6.0	445.0	74.0	-0.128	0.045	1000.0	-1000.0	-0.036	-1000.0
IL1-mediated signaling events	6.0	386.0	62.0	-0.037	0.076	1000.0	-1000.0	-0.057	-1000.0
ceramide signaling pathway	6.0	335.0	49.0	-0.018	0.038	1000.0	-1000.0	-0.039	-1000.0
FAS signaling pathway (CD95)	6.0	287.0	47.0	-0.114	0.052	1000.0	-1000.0	-0.043	-1000.0
IL6-mediated signaling events	6.0	465.0	75.0	-0.029	0.093	1000.0	-1000.0	-0.064	-1000.0
Regulation of Telomerase	6.0	666.0	102.0	-0.216	0.116	1000.0	-1000.0	-0.062	-1000.0
BCR signaling pathway	6.0	606.0	99.0	-0.038	0.06	1000.0	-1000.0	-0.059	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	5.0	465.0	85.0	-0.051	0.038	1000.0	-1000.0	-0.042	-1000.0
Hedgehog signaling events mediated by Gli proteins	5.0	357.0	65.0	-0.054	0.039	1000.0	-1000.0	-0.051	-1000.0
Insulin-mediated glucose transport	5.0	175.0	32.0	-0.168	0.035	1000.0	-1000.0	-0.036	-1000.0
Class I PI3K signaling events mediated by Akt	5.0	397.0	68.0	-0.113	0.061	1000.0	-1000.0	-0.041	-1000.0
EPHB forward signaling	5.0	493.0	85.0	-0.077	0.077	1000.0	-1000.0	-0.068	-1000.0
Arf6 trafficking events	5.0	406.0	71.0	-0.22	0.057	1000.0	-1000.0	-0.03	-1000.0
Signaling events mediated by PRL	5.0	194.0	34.0	-0.095	0.03	1000.0	-1000.0	-0.041	-1000.0
PLK2 and PLK4 events	4.0	14.0	3.0	-0.006	0.032	1000.0	-1000.0	-0.023	-1000.0
Cellular roles of Anthrax toxin	4.0	185.0	39.0	-0.061	0.026	1000.0	-1000.0	-0.02	-1000.0
Arf6 downstream pathway	4.0	177.0	43.0	-0.051	0.053	1000.0	-1000.0	-0.027	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	4.0	337.0	83.0	-0.04	0.036	1000.0	-1000.0	-0.04	-1000.0
Syndecan-3-mediated signaling events	4.0	170.0	35.0	-0.016	0.044	1000.0	-1000.0	-0.03	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	4.0	188.0	45.0	-0.014	0.05	1000.0	-1000.0	-0.046	-1000.0
Regulation of p38-alpha and p38-beta	4.0	247.0	54.0	-0.02	0.063	1000.0	-1000.0	-0.054	-1000.0
PDGFR-beta signaling pathway	4.0	391.0	97.0	-0.077	0.079	1000.0	-1000.0	-0.066	-1000.0
Ras signaling in the CD4+ TCR pathway	4.0	82.0	17.0	-0.008	0.03	1000.0	-1000.0	-0.03	-1000.0
Canonical NF-kappaB pathway	3.0	129.0	39.0	-0.014	0.039	1000.0	-1000.0	-0.037	-1000.0
mTOR signaling pathway	3.0	196.0	53.0	-0.022	0.022	1000.0	-1000.0	-0.041	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	3.0	146.0	37.0	-0.041	0.061	1000.0	-1000.0	-0.037	-1000.0
TRAIL signaling pathway	3.0	151.0	48.0	-0.02	0.041	1000.0	-1000.0	-0.041	-1000.0
Retinoic acid receptors-mediated signaling	3.0	215.0	58.0	-0.022	0.038	1000.0	-1000.0	-0.048	-1000.0
TCGA08_rtk_signaling	3.0	92.0	26.0	-0.026	0.044	1000.0	-1000.0	-0.014	-1000.0
Class I PI3K signaling events	3.0	263.0	73.0	-0.023	0.052	1000.0	-1000.0	-0.042	-1000.0
IGF1 pathway	3.0	180.0	57.0	-0.026	0.043	1000.0	-1000.0	-0.058	-1000.0
Signaling events mediated by HDAC Class II	2.0	219.0	75.0	-0.091	0.044	1000.0	-1000.0	-0.032	-1000.0
Signaling events mediated by HDAC Class III	2.0	109.0	40.0	-0.088	0.033	1000.0	-1000.0	-0.029	-1000.0
Signaling events mediated by HDAC Class I	2.0	237.0	104.0	-0.091	0.043	1000.0	-1000.0	-0.041	-1000.0
Rapid glucocorticoid signaling	2.0	56.0	20.0	-0.016	0.026	1000.0	-1000.0	-0.014	-1000.0
Circadian rhythm pathway	1.0	24.0	22.0	-0.003	0.037	1000.0	-1000.0	-0.033	-1000.0
a4b1 and a4b7 Integrin signaling	1.0	8.0	5.0	0.018	0.033	1000.0	-1000.0	0.004	-1000.0
EPO signaling pathway	1.0	87.0	55.0	-0.015	0.043	1000.0	-1000.0	-0.049	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	51.0	36.0	-0.036	0.038	1000.0	-1000.0	-0.045	-1000.0
Atypical NF-kappaB pathway	1.0	47.0	31.0	-0.016	0.043	1000.0	-1000.0	-0.027	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	1.0	152.0	125.0	-0.024	0.041	1000.0	-1000.0	-0.065	-1000.0
VEGFR1 specific signals	1.0	70.0	56.0	-0.016	0.045	1000.0	-1000.0	-0.05	-1000.0
p38 MAPK signaling pathway	1.0	81.0	44.0	-0.002	0.04	1000.0	-1000.0	-0.032	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	20.0	23.0	-0.016	0.037	1000.0	-1000.0	-0.029	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	4.0	27.0	-0.016	0.035	1000.0	-1000.0	-0.042	-1000.0
Arf1 pathway	0.0	31.0	54.0	-0.008	0.039	1000.0	-1000.0	-0.019	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.048	1000.0	-1000.0	0.0	-1000.0
Total	1862	100324	7203	-15.8414835984	-990.234386219	131000	-131000	-5.60575302706	-131000