E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.087 0.193 -9999.0 0.0 -0.388 102.0 102.0 KLHL20 -0.011 0.096 0.211 7.0 -0.216 23.0 30.0 CYFIP2 0.016 0.086 -9999.0 0.0 -0.4 15.0 15.0 Rac1/GDP -0.03 0.124 0.255 1.0 -0.241 74.0 75.0 ENAH -0.082 0.187 -9999.0 0.0 -0.379 99.0 99.0 AP1M1 0.036 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.035 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.035 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.036 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.008 0.09 -9999.0 0.0 -0.169 67.0 67.0 ABI1/Sra1/Nap1 -0.035 0.051 -9999.0 0.0 -0.147 31.0 31.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.026 0.157 -9999.0 0.0 -0.237 123.0 123.0 RAPGEF1 -0.064 0.17 0.239 3.0 -0.348 88.0 91.0 CTNND1 0.036 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.083 0.203 -9999.0 0.0 -0.403 101.0 101.0 CRK -0.074 0.181 -9999.0 0.0 -0.374 90.0 90.0 E-cadherin/gamma catenin/alpha catenin -0.013 0.132 -9999.0 0.0 -0.237 91.0 91.0 alphaE/beta7 Integrin 0.007 0.111 -9999.0 0.0 -0.278 48.0 48.0 IQGAP1 0.035 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.036 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.052 0.033 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.085 0.195 -9999.0 0.0 -0.395 100.0 100.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.023 0.056 -9999.0 0.0 -0.13 68.0 68.0 MLLT4 0.026 0.025 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.049 0.067 -9999.0 0.0 -0.213 21.0 21.0 PI3K -0.024 0.074 -9999.0 0.0 -0.163 68.0 68.0 ARF6 0.036 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.036 0.144 -9999.0 0.0 -0.282 92.0 92.0 TIAM1 0.01 0.101 -9999.0 0.0 -0.4 21.0 21.0 E-cadherin(dimer)/Ca2+ 0.005 0.122 -9999.0 0.0 -0.202 91.0 91.0 AKT1 -0.006 0.056 0.168 5.0 -9999.0 0.0 5.0 PIK3R1 0.035 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.075 0.188 -9999.0 0.0 -0.4 92.0 92.0 RhoA/GDP -0.024 0.133 0.28 4.0 -0.242 77.0 81.0 actin cytoskeleton organization -0.006 0.074 0.174 9.0 -0.158 23.0 32.0 CDC42/GDP -0.026 0.133 0.28 4.0 -0.241 78.0 82.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.034 0.102 -9999.0 0.0 -0.207 93.0 93.0 ITGB7 -0.023 0.148 -9999.0 0.0 -0.4 49.0 49.0 RAC1 0.032 0.012 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.006 0.131 -9999.0 0.0 -0.215 91.0 91.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.008 0.112 -9999.0 0.0 -0.2 91.0 91.0 mol:GDP -0.045 0.14 0.281 4.0 -0.274 79.0 83.0 CDC42/GTP/IQGAP1 0.047 0.011 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.033 0.017 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP -0.017 0.139 0.274 3.0 -0.247 76.0 79.0 RAC1/GTP/IQGAP1 0.042 0.017 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.053 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.036 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.036 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.034 0.009 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.003 0.056 0.143 12.0 -0.107 18.0 30.0 NME1 0.035 0.006 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.087 0.195 -9999.0 0.0 -0.397 99.0 99.0 regulation of cell-cell adhesion -0.016 0.073 -9999.0 0.0 -0.151 68.0 68.0 WASF2 -0.004 0.043 0.103 5.0 -0.095 7.0 12.0 Rap1/GTP -0.01 0.099 0.184 11.0 -0.186 68.0 79.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.017 0.156 -9999.0 0.0 -0.223 123.0 123.0 CCND1 0.002 0.066 0.163 12.0 -0.129 19.0 31.0 VAV2 -0.089 0.242 0.353 1.0 -0.655 27.0 28.0 RAP1/GDP -0.009 0.115 0.259 5.0 -0.201 76.0 81.0 adherens junction assembly -0.084 0.189 -9999.0 0.0 -0.385 99.0 99.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.033 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.036 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.024 0.143 -9999.0 0.0 -0.217 120.0 120.0 E-cadherin/beta catenin -0.067 0.141 -9999.0 0.0 -0.303 95.0 95.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.083 0.189 -9999.0 0.0 -0.382 100.0 100.0 PIK3CA 0.035 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.056 0.122 -9999.0 0.0 -0.345 27.0 27.0 E-cadherin/beta catenin/alpha catenin -0.011 0.132 -9999.0 0.0 -0.237 91.0 91.0 ITGAE 0.034 0.01 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.085 0.207 -9999.0 0.0 -0.411 101.0 101.0