Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.031 0.068 -9999.0 0.0 -0.423 4.0 4.0 IHH 0.04 0.038 -9999.0 0.0 -0.157 4.0 4.0 SHH Np/Cholesterol/GAS1 0.023 0.014 -9999.0 0.0 -9999.0 0.0 0.0 LRPAP1 0.035 0.008 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.023 0.014 -9999.0 0.0 -9999.0 0.0 0.0 SMO/beta Arrestin2 0.056 0.083 -9999.0 0.0 -0.334 6.0 6.0 SMO 0.025 0.071 -9999.0 0.0 -0.349 6.0 6.0 AKT1 0.032 0.08 -9999.0 0.0 -0.339 10.0 10.0 ARRB2 0.034 0.009 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.034 0.012 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.035 0.007 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.025 0.07 -9999.0 0.0 -0.344 6.0 6.0 STIL 0.043 0.079 0.221 35.0 -0.294 2.0 37.0 DHH N/PTCH2 0.035 0.063 -9999.0 0.0 -0.282 12.0 12.0 DHH N/PTCH1 0.036 0.076 -9999.0 0.0 -0.25 17.0 17.0 PIK3CA 0.035 0.006 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.018 0.076 -9999.0 0.0 -0.4 11.0 11.0 PTHLH 0.022 0.102 -9999.0 0.0 -0.618 7.0 7.0 determination of left/right symmetry 0.025 0.07 -9999.0 0.0 -0.344 6.0 6.0 PIK3R1 0.035 0.007 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.022 0.101 -9999.0 0.0 -0.612 7.0 7.0 IHH N/Hhip 0.038 0.027 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/Hhip 0.025 0.058 -9999.0 0.0 -0.288 11.0 11.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.025 0.07 -9999.0 0.0 -0.344 6.0 6.0 pancreas development 0.017 0.002 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.031 0.025 -9999.0 0.0 -0.4 1.0 1.0 PI3K 0.05 0.014 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.032 0.025 -9999.0 0.0 -0.4 1.0 1.0 somite specification 0.025 0.07 -9999.0 0.0 -0.344 6.0 6.0 SHH Np/Cholesterol/PTCH1 0.024 0.043 -9999.0 0.0 -0.251 4.0 4.0 SHH Np/Cholesterol/PTCH2 0.023 0.02 -9999.0 0.0 -0.219 1.0 1.0 SHH Np/Cholesterol/Megalin -0.082 0.119 -9999.0 0.0 -0.218 157.0 157.0 SHH -0.011 0.005 -9999.0 0.0 -9999.0 0.0 0.0 catabolic process 0.031 0.065 -9999.0 0.0 -0.407 6.0 6.0 SMO/Vitamin D3 0.034 0.067 -9999.0 0.0 -0.277 4.0 4.0 SHH Np/Cholesterol/Hhip 0.015 0.008 -9999.0 0.0 -9999.0 0.0 0.0 LRP2 -0.194 0.217 -9999.0 0.0 -0.4 193.0 193.0 receptor-mediated endocytosis -0.057 0.114 -9999.0 0.0 -0.35 13.0 13.0 SHH Np/Cholesterol/BOC 0.024 0.014 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/CDO 0.023 0.014 -9999.0 0.0 -9999.0 0.0 0.0 mesenchymal cell differentiation -0.015 0.008 -9999.0 0.0 -9999.0 0.0 0.0 mol:Vitamin D3 0.056 0.086 0.241 41.0 -0.253 4.0 45.0 IHH N/PTCH2 0.05 0.036 -9999.0 0.0 -0.309 1.0 1.0 CDON 0.033 0.011 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.041 0.07 -9999.0 0.0 -0.409 6.0 6.0 Megalin/LRPAP1 -0.122 0.165 -9999.0 0.0 -0.281 190.0 190.0 PTCH2 0.033 0.026 -9999.0 0.0 -0.4 1.0 1.0 SHH Np/Cholesterol 0.015 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PTCH1 0.031 0.066 -9999.0 0.0 -0.408 6.0 6.0 HHIP 0.017 0.002 -9999.0 0.0 -9999.0 0.0 0.0