Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.027 0.102 -9999.0 0.0 -0.2 92.0 92.0 epithelial cell differentiation 0.001 0.118 -9999.0 0.0 -0.2 91.0 91.0 CYFIP2 0.016 0.086 -9999.0 0.0 -0.4 15.0 15.0 ENAH -0.03 0.073 0.277 3.0 -0.248 1.0 4.0 EGFR 0.024 0.04 -9999.0 0.0 -0.4 2.0 2.0 EPHA2 0.031 0.046 -9999.0 0.0 -0.4 4.0 4.0 MYO6 -0.03 0.099 0.215 7.0 -0.192 91.0 98.0 CTNNB1 0.036 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.052 0.063 -9999.0 0.0 -0.231 15.0 15.0 AQP5 -0.027 0.086 -9999.0 0.0 -0.345 2.0 2.0 CTNND1 0.036 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.027 0.098 0.21 7.0 -0.191 89.0 96.0 regulation of calcium-dependent cell-cell adhesion -0.033 0.102 0.21 7.0 -0.194 96.0 103.0 EGF 0.001 0.11 -9999.0 0.0 -0.4 25.0 25.0 NCKAP1 0.036 0.003 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.072 0.157 0.312 2.0 -0.401 49.0 51.0 cortical microtubule organization 0.001 0.118 -9999.0 0.0 -0.2 91.0 91.0 GO:0000145 -0.044 0.085 0.184 10.0 -0.182 87.0 97.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.005 0.122 -9999.0 0.0 -0.202 91.0 91.0 MLLT4 0.026 0.025 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.048 0.07 -9999.0 0.0 -0.179 77.0 77.0 ARF6 0.036 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.075 0.044 -9999.0 0.0 -0.216 3.0 3.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.028 0.084 0.228 4.0 -0.235 3.0 7.0 PVRL2 0.036 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.025 0.095 0.217 6.0 -0.193 81.0 87.0 ARF6/GTP 0.082 0.047 -9999.0 0.0 -0.202 3.0 3.0 CDH1 -0.075 0.188 -9999.0 0.0 -0.4 92.0 92.0 EGFR/EGFR/EGF/EGF -0.026 0.12 -9999.0 0.0 -0.205 103.0 103.0 RhoA/GDP 0.004 0.116 -9999.0 0.0 -0.191 91.0 91.0 actin cytoskeleton organization -0.036 0.094 0.199 7.0 -0.192 82.0 89.0 IGF-1R heterotetramer 0.035 0.006 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.035 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.035 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.03 0.041 -9999.0 0.0 -0.4 3.0 3.0 DIAPH1 -0.014 0.217 -9999.0 0.0 -0.561 36.0 36.0 Wnt receptor signaling pathway -0.001 0.118 0.2 91.0 -9999.0 0.0 91.0 RHOA 0.036 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.049 0.07 -9999.0 0.0 -0.179 81.0 81.0 CTNNA1 0.034 0.009 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.037 0.095 0.2 7.0 -0.196 82.0 89.0 EFNA1 0.033 0.011 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.047 0.087 0.194 9.0 -0.187 87.0 96.0 Ephrin A1/EPHA2 -0.002 0.106 -9999.0 0.0 -0.191 81.0 81.0 SEC6/SEC8 -0.03 0.08 -9999.0 0.0 -0.183 69.0 69.0 MGAT3 -0.033 0.103 0.212 7.0 -0.197 96.0 103.0 HGF/MET -0.017 0.122 -9999.0 0.0 -0.212 93.0 93.0 HGF 0.024 0.057 -9999.0 0.0 -0.4 6.0 6.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.027 0.103 -9999.0 0.0 -0.201 92.0 92.0 actin cable formation 0.007 0.106 0.269 20.0 -0.252 7.0 27.0 KIAA1543 -0.052 0.091 0.186 10.0 -0.187 102.0 112.0 KIFC3 -0.03 0.098 0.218 6.0 -0.193 91.0 97.0 NCK1 0.035 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.033 0.011 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.029 0.1 0.21 8.0 -0.193 89.0 97.0 NCK1/GIT1 0.051 0.013 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.001 0.118 -9999.0 0.0 -0.2 91.0 91.0 EXOC4 0.032 0.012 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.028 0.1 0.21 8.0 -0.193 91.0 99.0 PIP5K1C -0.027 0.099 0.212 7.0 -0.193 89.0 96.0 LIMA1 0.036 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.033 0.011 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.022 0.102 0.394 5.0 -0.286 1.0 6.0 adherens junction assembly -0.037 0.099 0.302 3.0 -0.353 6.0 9.0 IGF-1R heterotetramer/IGF1 -0.004 0.11 -9999.0 0.0 -0.188 92.0 92.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.041 0.027 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.007 0.099 -9999.0 0.0 -0.4 20.0 20.0 PLEKHA7 -0.036 0.105 0.212 7.0 -0.196 102.0 109.0 mol:GTP 0.073 0.043 -9999.0 0.0 -0.215 3.0 3.0 establishment of epithelial cell apical/basal polarity -0.01 0.118 0.326 11.0 -9999.0 0.0 11.0 cortical actin cytoskeleton stabilization -0.027 0.102 -9999.0 0.0 -0.2 92.0 92.0 regulation of cell-cell adhesion -0.036 0.094 0.199 7.0 -0.192 82.0 89.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.027 0.103 -9999.0 0.0 -0.201 92.0 92.0