Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
BCR signaling pathway	126.0	12498.0	99.0	-0.707	0.045	1000.0	-1000.0	-0.049	-1000.0
IL4-mediated signaling events	124.0	11306.0	91.0	-1.269	1.044	1000.0	-1000.0	-0.06	-1000.0
TCR signaling in naïve CD8+ T cells	106.0	9936.0	93.0	-0.556	0.118	1000.0	-1000.0	-0.029	-1000.0
IL23-mediated signaling events	102.0	6155.0	60.0	-0.764	0.035	1000.0	-1000.0	-0.041	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	80.0	2749.0	34.0	-0.13	0.036	1000.0	-1000.0	-0.026	-1000.0
IL12-mediated signaling events	76.0	6680.0	87.0	-0.673	0.112	1000.0	-1000.0	-0.031	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	63.0	4315.0	68.0	-0.57	0.119	1000.0	-1000.0	-0.04	-1000.0
Caspase cascade in apoptosis	59.0	4405.0	74.0	-0.157	0.121	1000.0	-1000.0	-0.019	-1000.0
Calcium signaling in the CD4+ TCR pathway	58.0	1812.0	31.0	-0.337	0.036	1000.0	-1000.0	-0.025	-1000.0
JNK signaling in the CD4+ TCR pathway	56.0	964.0	17.0	-0.218	0.034	1000.0	-1000.0	-0.019	-1000.0
E-cadherin signaling events	55.0	276.0	5.0	-0.075	0.036	1000.0	-1000.0	0.02	-1000.0
FAS signaling pathway (CD95)	52.0	2448.0	47.0	-0.089	0.075	1000.0	-1000.0	-0.024	-1000.0
IL27-mediated signaling events	51.0	2647.0	51.0	-0.263	0.17	1000.0	-1000.0	-0.036	-1000.0
Ras signaling in the CD4+ TCR pathway	51.0	873.0	17.0	-0.138	0.065	1000.0	-1000.0	-0.011	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	46.0	3411.0	74.0	-0.075	0.082	1000.0	-1000.0	-0.038	-1000.0
E-cadherin signaling in the nascent adherens junction	44.0	3386.0	76.0	-0.089	0.053	1000.0	-1000.0	-0.034	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	43.0	1945.0	45.0	-0.163	0.075	1000.0	-1000.0	-0.022	-1000.0
a4b1 and a4b7 Integrin signaling	41.0	207.0	5.0	-0.025	0.014	1000.0	-1000.0	0.02	-1000.0
amb2 Integrin signaling	39.0	3220.0	82.0	-0.175	0.045	1000.0	-1000.0	-0.013	-1000.0
IL2 signaling events mediated by PI3K	39.0	2277.0	58.0	-0.142	0.062	1000.0	-1000.0	-0.024	-1000.0
Glucocorticoid receptor regulatory network	38.0	4379.0	114.0	-0.424	0.245	1000.0	-1000.0	-0.036	-1000.0
Signaling events regulated by Ret tyrosine kinase	38.0	3165.0	82.0	-0.065	0.036	1000.0	-1000.0	-0.033	-1000.0
Thromboxane A2 receptor signaling	37.0	3948.0	105.0	-0.121	0.059	1000.0	-1000.0	-0.027	-1000.0
IFN-gamma pathway	37.0	2574.0	68.0	-0.113	0.046	1000.0	-1000.0	-0.047	-1000.0
Class I PI3K signaling events	37.0	2736.0	73.0	-0.37	0.07	1000.0	-1000.0	-0.02	-1000.0
Angiopoietin receptor Tie2-mediated signaling	37.0	3334.0	88.0	-0.204	0.047	1000.0	-1000.0	-0.048	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	36.0	1365.0	37.0	-0.208	0.051	1000.0	-1000.0	-0.012	-1000.0
S1P4 pathway	36.0	905.0	25.0	-0.105	0.046	1000.0	-1000.0	-0.008	-1000.0
Syndecan-1-mediated signaling events	35.0	1211.0	34.0	-0.09	0.036	1000.0	-1000.0	-0.013	-1000.0
Endothelins	35.0	3391.0	96.0	-0.159	0.037	1000.0	-1000.0	-0.027	-1000.0
IL2 signaling events mediated by STAT5	35.0	778.0	22.0	-0.156	0.037	1000.0	-1000.0	-0.018	-1000.0
ceramide signaling pathway	32.0	1572.0	49.0	-0.096	0.051	1000.0	-1000.0	-0.015	-1000.0
Fc-epsilon receptor I signaling in mast cells	31.0	3091.0	97.0	-0.101	0.061	1000.0	-1000.0	-0.045	-1000.0
E-cadherin signaling in keratinocytes	31.0	1351.0	43.0	-0.075	0.038	1000.0	-1000.0	-0.015	-1000.0
FOXA2 and FOXA3 transcription factor networks	29.0	1342.0	46.0	-0.423	0.041	1000.0	-1000.0	-0.041	-1000.0
Syndecan-4-mediated signaling events	28.0	1925.0	67.0	-0.164	0.047	1000.0	-1000.0	-0.027	-1000.0
HIF-1-alpha transcription factor network	27.0	2071.0	76.0	-0.092	0.104	1000.0	-1000.0	-0.005	-1000.0
LPA receptor mediated events	27.0	2807.0	102.0	-0.079	0.046	1000.0	-1000.0	-0.046	-1000.0
Visual signal transduction: Cones	25.0	982.0	38.0	-0.137	0.042	1000.0	-1000.0	-0.006	-1000.0
Glypican 1 network	24.0	1177.0	48.0	-0.213	0.036	1000.0	-1000.0	-0.021	-1000.0
Osteopontin-mediated events	23.0	876.0	38.0	-0.035	0.051	1000.0	-1000.0	-0.01	-1000.0
TRAIL signaling pathway	23.0	1139.0	48.0	-0.026	0.056	1000.0	-1000.0	-0.012	-1000.0
Atypical NF-kappaB pathway	23.0	741.0	31.0	-0.129	0.05	1000.0	-1000.0	-0.006	-1000.0
Regulation of p38-alpha and p38-beta	23.0	1248.0	54.0	-0.224	0.074	1000.0	-1000.0	-0.036	-1000.0
Visual signal transduction: Rods	23.0	1224.0	52.0	-0.137	0.04	1000.0	-1000.0	-0.007	-1000.0
Aurora C signaling	21.0	148.0	7.0	-0.051	0.033	1000.0	-1000.0	-0.006	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	21.0	1121.0	52.0	-0.172	0.069	1000.0	-1000.0	-0.022	-1000.0
Ephrin A  reverse signaling	20.0	140.0	7.0	-0.009	0.026	1000.0	-1000.0	-0.0	-1000.0
Arf6 signaling events	20.0	1241.0	62.0	-0.097	0.075	1000.0	-1000.0	-0.033	-1000.0
Ceramide signaling pathway	20.0	1566.0	76.0	-0.096	0.082	1000.0	-1000.0	-0.024	-1000.0
IL6-mediated signaling events	20.0	1513.0	75.0	-0.185	0.059	1000.0	-1000.0	-0.038	-1000.0
Paxillin-dependent events mediated by a4b1	19.0	717.0	36.0	-0.043	0.061	1000.0	-1000.0	-0.03	-1000.0
EPHB forward signaling	18.0	1569.0	85.0	-0.054	0.067	1000.0	-1000.0	-0.039	-1000.0
Plasma membrane estrogen receptor signaling	18.0	1616.0	86.0	-0.054	0.064	1000.0	-1000.0	-0.027	-1000.0
Signaling events mediated by PTP1B	16.0	1260.0	76.0	-0.236	0.064	1000.0	-1000.0	-0.015	-1000.0
EPO signaling pathway	16.0	933.0	55.0	-0.034	0.056	1000.0	-1000.0	-0.014	-1000.0
Signaling events mediated by the Hedgehog family	15.0	785.0	52.0	-0.194	0.056	1000.0	-1000.0	-0.016	-1000.0
Nectin adhesion pathway	15.0	986.0	63.0	-0.166	0.065	1000.0	-1000.0	-0.028	-1000.0
Integrins in angiogenesis	15.0	1342.0	84.0	-0.129	0.075	1000.0	-1000.0	-0.021	-1000.0
PDGFR-beta signaling pathway	15.0	1475.0	97.0	-0.294	0.089	1000.0	-1000.0	-0.026	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	14.0	1244.0	85.0	-0.034	0.075	1000.0	-1000.0	-0.028	-1000.0
BMP receptor signaling	14.0	1137.0	81.0	-0.136	0.074	1000.0	-1000.0	-0.013	-1000.0
Sphingosine 1-phosphate (S1P) pathway	13.0	379.0	28.0	-0.105	0.067	1000.0	-1000.0	-0.012	-1000.0
Cellular roles of Anthrax toxin	13.0	534.0	39.0	-0.12	0.042	1000.0	-1000.0	-0.013	-1000.0
p75(NTR)-mediated signaling	13.0	1711.0	125.0	-0.096	0.09	1000.0	-1000.0	-0.03	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	13.0	1097.0	83.0	-0.091	0.068	1000.0	-1000.0	-0.011	-1000.0
LPA4-mediated signaling events	12.0	146.0	12.0	-0.045	0.01	1000.0	-1000.0	-0.012	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	12.0	1537.0	120.0	-0.07	0.086	1000.0	-1000.0	-0.028	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	12.0	985.0	78.0	-0.077	0.08	1000.0	-1000.0	-0.032	-1000.0
Noncanonical Wnt signaling pathway	11.0	311.0	26.0	-0.007	0.039	1000.0	-1000.0	-0.026	-1000.0
Syndecan-2-mediated signaling events	11.0	826.0	69.0	-0.164	0.059	1000.0	-1000.0	-0.019	-1000.0
Ephrin B reverse signaling	11.0	545.0	48.0	-0.1	0.046	1000.0	-1000.0	-0.026	-1000.0
ErbB2/ErbB3 signaling events	10.0	710.0	65.0	-0.024	0.061	1000.0	-1000.0	-0.031	-1000.0
IL1-mediated signaling events	10.0	667.0	62.0	-0.029	0.085	1000.0	-1000.0	-0.02	-1000.0
Canonical Wnt signaling pathway	10.0	510.0	51.0	-0.025	0.073	1000.0	-1000.0	-0.03	-1000.0
EGFR-dependent Endothelin signaling events	10.0	223.0	21.0	-0.021	0.051	1000.0	-1000.0	-0.03	-1000.0
Presenilin action in Notch and Wnt signaling	9.0	600.0	61.0	-0.062	0.091	1000.0	-1000.0	-0.025	-1000.0
TCGA08_retinoblastoma	9.0	75.0	8.0	-0.01	0.036	1000.0	-1000.0	-0.004	-1000.0
mTOR signaling pathway	8.0	446.0	53.0	-0.019	0.055	1000.0	-1000.0	-0.021	-1000.0
Signaling mediated by p38-gamma and p38-delta	8.0	126.0	15.0	-0.004	0.035	1000.0	-1000.0	-0.017	-1000.0
Aurora B signaling	8.0	556.0	67.0	-0.091	0.092	1000.0	-1000.0	-0.022	-1000.0
Canonical NF-kappaB pathway	7.0	295.0	39.0	-0.05	0.075	1000.0	-1000.0	-0.014	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	7.0	389.0	54.0	-0.073	0.059	1000.0	-1000.0	-0.011	-1000.0
Signaling events mediated by HDAC Class I	7.0	784.0	104.0	-0.066	0.083	1000.0	-1000.0	-0.037	-1000.0
Effects of Botulinum toxin	7.0	186.0	26.0	-0.025	0.046	1000.0	-1000.0	-0.002	-1000.0
Glypican 2 network	6.0	27.0	4.0	0.026	0.037	1000.0	-1000.0	0.022	-1000.0
TCGA08_rtk_signaling	6.0	164.0	26.0	-0.042	0.083	1000.0	-1000.0	-0.01	-1000.0
Insulin Pathway	6.0	463.0	74.0	-0.058	0.085	1000.0	-1000.0	-0.026	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	6.0	210.0	33.0	-0.013	0.08	1000.0	-1000.0	-0.013	-1000.0
Class IB PI3K non-lipid kinase events	6.0	18.0	3.0	-0.028	0.028	1000.0	-1000.0	-0.023	-1000.0
FoxO family signaling	5.0	343.0	64.0	-0.41	0.099	1000.0	-1000.0	-0.031	-1000.0
Signaling mediated by p38-alpha and p38-beta	5.0	230.0	44.0	-0.008	0.048	1000.0	-1000.0	-0.009	-1000.0
Wnt signaling	5.0	41.0	7.0	-0.007	0.032	1000.0	-1000.0	0.002	-1000.0
Regulation of Telomerase	5.0	584.0	102.0	-0.105	0.079	1000.0	-1000.0	-0.024	-1000.0
S1P3 pathway	5.0	225.0	42.0	-0.033	0.056	1000.0	-1000.0	-0.019	-1000.0
Regulation of Androgen receptor activity	5.0	391.0	70.0	-0.053	0.049	1000.0	-1000.0	-0.026	-1000.0
Regulation of nuclear SMAD2/3 signaling	4.0	589.0	136.0	-0.119	0.124	1000.0	-1000.0	-0.036	-1000.0
ErbB4 signaling events	4.0	281.0	69.0	-0.039	0.056	1000.0	-1000.0	-0.015	-1000.0
PLK1 signaling events	4.0	421.0	85.0	-0.008	0.071	1000.0	-1000.0	-0.023	-1000.0
Class I PI3K signaling events mediated by Akt	4.0	303.0	68.0	-0.053	0.068	1000.0	-1000.0	-0.018	-1000.0
HIF-2-alpha transcription factor network	4.0	201.0	43.0	-0.152	0.155	1000.0	-1000.0	-0.042	-1000.0
S1P1 pathway	4.0	179.0	36.0	-0.003	0.038	1000.0	-1000.0	-0.019	-1000.0
Signaling events mediated by PRL	4.0	149.0	34.0	-0.054	0.078	1000.0	-1000.0	-0.024	-1000.0
p38 MAPK signaling pathway	4.0	185.0	44.0	-0.01	0.059	1000.0	-1000.0	-0.01	-1000.0
Hedgehog signaling events mediated by Gli proteins	3.0	207.0	65.0	-0.003	0.083	1000.0	-1000.0	-0.019	-1000.0
Arf6 downstream pathway	3.0	151.0	43.0	-0.052	0.065	1000.0	-1000.0	-0.03	-1000.0
Reelin signaling pathway	3.0	176.0	56.0	-0.013	0.079	1000.0	-1000.0	-0.014	-1000.0
Retinoic acid receptors-mediated signaling	3.0	198.0	58.0	-0.031	0.069	1000.0	-1000.0	-0.028	-1000.0
Syndecan-3-mediated signaling events	3.0	134.0	35.0	-0.015	0.09	1000.0	-1000.0	-0.017	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	3.0	469.0	125.0	-0.07	0.087	1000.0	-1000.0	-0.019	-1000.0
IGF1 pathway	3.0	179.0	57.0	-0.025	0.086	1000.0	-1000.0	-0.024	-1000.0
Arf1 pathway	3.0	202.0	54.0	-0.006	0.052	1000.0	-1000.0	-0.011	-1000.0
Coregulation of Androgen receptor activity	2.0	223.0	76.0	-0.02	0.062	1000.0	-1000.0	-0.016	-1000.0
Insulin-mediated glucose transport	2.0	67.0	32.0	-0.0	0.066	1000.0	-1000.0	-0.006	-1000.0
PDGFR-alpha signaling pathway	2.0	119.0	44.0	-0.022	0.071	1000.0	-1000.0	-0.026	-1000.0
Signaling events mediated by HDAC Class III	2.0	100.0	40.0	-0.058	0.059	1000.0	-1000.0	-0.037	-1000.0
Nongenotropic Androgen signaling	2.0	147.0	52.0	-0.037	0.058	1000.0	-1000.0	-0.015	-1000.0
Arf6 trafficking events	2.0	205.0	71.0	-0.055	0.066	1000.0	-1000.0	-0.032	-1000.0
FOXM1 transcription factor network	2.0	116.0	51.0	-0.016	0.249	1000.0	-1000.0	-0.059	-1000.0
Signaling events mediated by HDAC Class II	1.0	149.0	75.0	-0.04	0.092	1000.0	-1000.0	-0.015	-1000.0
Aurora A signaling	1.0	94.0	60.0	-0.0	0.076	1000.0	-1000.0	-0.007	-1000.0
S1P5 pathway	1.0	25.0	17.0	-0.03	0.04	1000.0	-1000.0	-0.007	-1000.0
VEGFR1 specific signals	1.0	106.0	56.0	-0.044	0.086	1000.0	-1000.0	-0.025	-1000.0
Rapid glucocorticoid signaling	1.0	36.0	20.0	-0.009	0.042	1000.0	-1000.0	-0.0	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	6.0	23.0	0.007	0.071	1000.0	-1000.0	-0.013	-1000.0
BARD1 signaling events	0.0	50.0	57.0	-0.08	0.093	1000.0	-1000.0	-0.035	-1000.0
PLK2 and PLK4 events	0.0	2.0	3.0	0.018	-1000.0	1000.0	-1000.0	-0.003	-1000.0
Circadian rhythm pathway	0.0	6.0	22.0	-0.012	0.083	1000.0	-1000.0	-0.016	-1000.0
TCGA08_p53	0.0	1.0	7.0	-0.011	0.032	1000.0	-1000.0	-0.004	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	5.0	27.0	-0.0	0.084	1000.0	-1000.0	-0.018	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.092	1000.0	-1000.0	-0.0	-1000.0
Total	2744	171450	7203	-15.7125607227	-990.305480113	131000	-131000	-2.77298993347	-131000