E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.005 0.081 -9999.0 0.0 -0.347 10.0 10.0 KLHL20 0.022 0.057 0.161 4.0 -0.2 1.0 5.0 CYFIP2 0.019 0.05 -9999.0 0.0 -0.388 4.0 4.0 Rac1/GDP 0.031 0.075 0.251 7.0 -9999.0 0.0 7.0 ENAH 0.009 0.075 -9999.0 0.0 -0.367 8.0 8.0 AP1M1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.024 0.024 -9999.0 0.0 -0.355 1.0 1.0 CDC42/GTP 0.016 0.036 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.009 0.028 -9999.0 0.0 -0.146 2.0 2.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.051 0.049 -9999.0 0.0 -0.21 7.0 7.0 RAPGEF1 0.012 0.089 0.231 2.0 -0.329 8.0 10.0 CTNND1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.01 0.088 -9999.0 0.0 -0.354 12.0 12.0 CRK 0.0 0.074 -9999.0 0.0 -0.339 10.0 10.0 E-cadherin/gamma catenin/alpha catenin 0.039 0.049 -9999.0 0.0 -0.28 5.0 5.0 alphaE/beta7 Integrin 0.035 0.022 -9999.0 0.0 -0.282 1.0 1.0 IQGAP1 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.045 0.017 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 0.006 0.081 -9999.0 0.0 -0.354 10.0 10.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 0.001 0.023 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.029 0.025 -9999.0 0.0 -0.194 3.0 3.0 PI3K 0.004 0.03 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.028 0.052 -9999.0 0.0 -0.328 5.0 5.0 TIAM1 0.021 0.042 -9999.0 0.0 -0.37 3.0 3.0 E-cadherin(dimer)/Ca2+ 0.049 0.043 -9999.0 0.0 -0.203 5.0 5.0 AKT1 0.003 0.035 0.101 1.0 -9999.0 0.0 1.0 PIK3R1 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.017 0.057 -9999.0 0.0 -0.399 5.0 5.0 RhoA/GDP 0.037 0.08 0.253 9.0 -9999.0 0.0 9.0 actin cytoskeleton organization 0.023 0.051 0.152 12.0 -0.147 1.0 13.0 CDC42/GDP 0.036 0.081 0.253 9.0 -9999.0 0.0 9.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.012 0.038 -9999.0 0.0 -0.245 5.0 5.0 ITGB7 0.024 0.026 -9999.0 0.0 -0.399 1.0 1.0 RAC1 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.053 0.046 -9999.0 0.0 -0.217 5.0 5.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.036 0.038 -9999.0 0.0 -0.193 6.0 6.0 mol:GDP 0.026 0.087 0.259 9.0 -0.274 5.0 14.0 CDC42/GTP/IQGAP1 0.033 0.011 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.023 0.027 -9999.0 0.0 -0.399 1.0 1.0 p120 catenin/RhoA/GDP 0.046 0.08 0.262 8.0 -9999.0 0.0 8.0 RAC1/GTP/IQGAP1 0.032 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.037 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.019 0.037 0.126 8.0 -0.143 1.0 9.0 NME1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.005 0.083 -9999.0 0.0 -0.352 11.0 11.0 regulation of cell-cell adhesion 0.01 0.03 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.012 0.024 0.068 5.0 -9999.0 0.0 5.0 Rap1/GTP 0.031 0.057 0.211 1.0 -9999.0 0.0 1.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.056 0.055 -9999.0 0.0 -0.391 1.0 1.0 CCND1 0.021 0.043 0.144 8.0 -0.175 1.0 9.0 VAV2 0.017 0.121 -9999.0 0.0 -0.531 5.0 5.0 RAP1/GDP 0.041 0.073 0.262 7.0 -9999.0 0.0 7.0 adherens junction assembly 0.006 0.081 -9999.0 0.0 -0.342 11.0 11.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.047 0.056 -9999.0 0.0 -0.378 1.0 1.0 E-cadherin/beta catenin 0.004 0.045 -9999.0 0.0 -0.285 6.0 6.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.004 0.082 -9999.0 0.0 -0.352 11.0 11.0 PIK3CA 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.017 0.056 -9999.0 0.0 -0.299 3.0 3.0 E-cadherin/beta catenin/alpha catenin 0.041 0.044 -9999.0 0.0 -0.229 6.0 6.0 ITGAE 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.006 0.088 -9999.0 0.0 -0.361 12.0 12.0