Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.038 0.147 -9999.0 0.0 -0.537 11.0 11.0 IHH -0.039 0.164 -9999.0 0.0 -0.443 37.0 37.0 SHH Np/Cholesterol/GAS1 -0.013 0.089 -9999.0 0.0 -0.223 40.0 40.0 LRPAP1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.013 0.089 0.222 40.0 -9999.0 0.0 40.0 SMO/beta Arrestin2 -0.029 0.146 -9999.0 0.0 -0.434 17.0 17.0 SMO -0.041 0.143 -9999.0 0.0 -0.454 17.0 17.0 AKT1 -0.026 0.136 -9999.0 0.0 -0.459 17.0 17.0 ARRB2 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.009 0.083 -9999.0 0.0 -0.395 11.0 11.0 ADRBK1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.04 0.142 -9999.0 0.0 -0.448 17.0 17.0 STIL -0.062 0.133 -9999.0 0.0 -0.36 29.0 29.0 DHH N/PTCH2 0.003 0.096 -9999.0 0.0 -0.254 33.0 33.0 DHH N/PTCH1 -0.016 0.12 -9999.0 0.0 -0.396 11.0 11.0 PIK3CA 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.018 0.057 -9999.0 0.0 -0.399 5.0 5.0 PTHLH -0.051 0.178 -9999.0 0.0 -0.654 13.0 13.0 determination of left/right symmetry -0.04 0.142 -9999.0 0.0 -0.448 17.0 17.0 PIK3R1 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.051 0.176 -9999.0 0.0 -0.648 13.0 13.0 IHH N/Hhip -0.077 0.187 -9999.0 0.0 -0.366 75.0 75.0 DHH N/Hhip -0.041 0.14 -9999.0 0.0 -0.289 65.0 65.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.04 0.142 -9999.0 0.0 -0.448 17.0 17.0 pancreas development -0.071 0.178 -9999.0 0.0 -0.398 62.0 62.0 HHAT 0.022 0.037 -9999.0 0.0 -0.399 2.0 2.0 PI3K 0.034 0.013 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.007 0.113 -9999.0 0.0 -0.397 21.0 21.0 somite specification -0.04 0.142 -9999.0 0.0 -0.448 17.0 17.0 SHH Np/Cholesterol/PTCH1 -0.034 0.119 -9999.0 0.0 -0.382 15.0 15.0 SHH Np/Cholesterol/PTCH2 -0.02 0.093 -9999.0 0.0 -0.207 52.0 52.0 SHH Np/Cholesterol/Megalin -0.03 0.1 -9999.0 0.0 -0.209 60.0 60.0 SHH -0.016 0.088 -9999.0 0.0 -0.29 25.0 25.0 catabolic process -0.027 0.123 -9999.0 0.0 -0.41 12.0 12.0 SMO/Vitamin D3 -0.04 0.136 -9999.0 0.0 -0.431 15.0 15.0 SHH Np/Cholesterol/Hhip -0.048 0.129 -9999.0 0.0 -0.257 69.0 69.0 LRP2 -0.038 0.143 -9999.0 0.0 -0.358 45.0 45.0 receptor-mediated endocytosis -0.061 0.14 -9999.0 0.0 -0.411 21.0 21.0 SHH Np/Cholesterol/BOC -0.006 0.083 -9999.0 0.0 -0.224 33.0 33.0 SHH Np/Cholesterol/CDO -0.002 0.074 -9999.0 0.0 -0.216 28.0 28.0 mesenchymal cell differentiation 0.048 0.129 0.255 69.0 -9999.0 0.0 69.0 mol:Vitamin D3 -0.032 0.123 -9999.0 0.0 -0.384 15.0 15.0 IHH N/PTCH2 -0.037 0.134 -9999.0 0.0 -0.272 64.0 64.0 CDON 0.018 0.054 -9999.0 0.0 -0.373 5.0 5.0 IHH N/PTCH1 -0.022 0.128 -9999.0 0.0 -0.414 12.0 12.0 Megalin/LRPAP1 -0.01 0.106 -9999.0 0.0 -0.25 44.0 44.0 PTCH2 -0.013 0.116 -9999.0 0.0 -0.357 28.0 28.0 SHH Np/Cholesterol -0.007 0.069 -9999.0 0.0 -0.219 25.0 25.0 PTCH1 -0.027 0.124 -9999.0 0.0 -0.411 12.0 12.0 HHIP -0.072 0.178 -9999.0 0.0 -0.399 62.0 62.0