rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(11) 311023 11 11 11 0 3 2 1 1 4 0 0.0397 0.000216 0.133 2 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(1), DCN(8), FMOD(10), KERA(1), LUM(7) 1561475 27 24 27 4 12 4 1 7 3 0 0.0696 0.310 1.000 3 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(3), LIPT1(5) 652455 8 8 7 1 2 3 0 0 3 0 0.274 0.449 1.000 4 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(8), GSTZ1(3), HGD(4) 953469 15 13 14 3 4 3 0 4 4 0 0.377 0.460 1.000 5 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 3 CD28(1), HLA-DRA(8) 632681 9 9 9 2 4 3 0 0 2 0 0.414 0.533 1.000 6 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(6), TPI1(1) 706305 7 7 7 1 2 2 1 1 1 0 0.308 0.600 1.000 7 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 CDK5(2), FOSB(5), GRIA2(23), JUND(2), PPP1R1B(1) 1603188 33 27 33 6 7 10 1 9 6 0 0.0641 0.630 1.000 8 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(6), ALDOA(1), ALDOB(6), ALDOC(6), TPI1(1) 1682865 20 20 20 3 3 7 1 6 3 0 0.117 0.640 1.000 9 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3E(2), CD3G(1) 488715 3 3 3 1 0 1 1 0 1 0 0.822 0.702 1.000 10 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 7 CD28(1), CD80(4), HLA-DRA(8), IL10(2), IL4(1) 1318652 16 16 16 3 8 3 0 2 3 0 0.214 0.706 1.000 11 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL11(1), CCL5(2), CCR3(6), HLA-DRA(8), IL3(1) 1308153 18 16 18 4 9 6 0 2 1 0 0.154 0.711 1.000 12 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(5), CDK2(3), CUL1(22), E2F1(3), RB1(13), RBX1(1), SKP2(5), TFDP1(5), UBE2M(1) 3687047 58 41 56 10 10 21 2 8 17 0 0.0122 0.844 1.000 13 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(10), GLS2(7), GLUD1(2), GLUD2(11) 1951070 30 23 29 5 7 8 0 11 4 0 0.0797 0.857 1.000 14 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(2), SEC61A2(1), SRP19(4), SRP54(6), SRP68(5), SRP72(10), SRP9(1), SRPR(12) 3233319 41 31 41 5 12 12 1 5 11 0 0.0223 0.866 1.000 15 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 7 CCNE1(5), CDC34(2), CDK2(3), CUL1(22), E2F1(3), RB1(13), TFDP1(5) 2829330 53 39 51 10 12 17 2 8 14 0 0.0211 0.880 1.000 16 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 18 ABCB1(26), AKT1(3), ATM(38), BAX(6), CDKN1A(3), CPB2(10), CSNK1A1(3), CSNK1D(2), FHL2(4), HIC1(6), HIF1A(7), HSPA1A(2), IGFBP3(6), MAPK8(5), MDM2(5), NFKBIB(6), NQO1(3) 8554171 135 74 123 27 30 30 4 22 44 5 0.0262 0.915 1.000 17 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(2), FDPS(9), IDI1(2), SQLE(5) 1363502 18 13 17 3 4 4 1 3 6 0 0.191 0.918 1.000 18 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 5 CCR5(4), CD28(1), CD3E(2), CD3G(1) 992068 8 8 8 2 0 4 1 0 3 0 0.626 0.940 1.000 19 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC2(6), AOC3(15), CES1(7), ESD(1) 2594728 29 25 22 6 7 4 0 7 10 1 0.516 0.946 1.000 20 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 14 CD8A(4), CSF1(2), CSF3(2), EPO(1), IL11(3), IL3(1), IL4(1), IL7(1) 2220344 15 15 15 1 5 4 1 2 3 0 0.0446 0.952 1.000 21 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(2), GBA(9), GGT1(6), SHMT1(2), SHMT2(9) 2348712 28 25 26 5 11 3 1 3 10 0 0.112 0.961 1.000 22 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(5), SUCLA2(4) 907276 9 9 9 2 5 0 0 2 2 0 0.459 0.961 1.000 23 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(4), ADH1B(4), ADH4(2), ADH6(7), ADH7(1), ADHFE1(9) 2419403 27 21 26 6 2 7 0 11 6 1 0.300 0.967 1.000 24 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(3), LPL(7), NR3C1(6), PPARG(4), RXRA(6), TNF(3) 2484079 29 27 27 7 7 2 4 8 8 0 0.344 0.974 1.000 25 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALE(1), GALT(1), TGDS(4), UGDH(5), UXS1(5) 1650101 16 14 16 3 5 6 1 2 2 0 0.143 0.975 1.000 26 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALE(1), GALT(1), TGDS(4), UGDH(5), UGP2(7), UXS1(5) 2102519 23 19 21 4 6 6 1 3 7 0 0.146 0.978 1.000 27 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(2), CD36(2), FOS(1), FYN(10), JUN(4), MAPK14(1), THBS1(16) 3182545 36 29 35 7 10 11 1 8 5 1 0.0773 0.978 1.000 28 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(5), ACAT2(4), ACYP1(1), ACYP2(3), EHHADH(7), GCDH(8), HADHA(4), SDHB(4), SDS(4) 3350753 40 29 37 7 9 14 2 3 11 1 0.0439 0.979 1.000 29 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(5), CCL2(1), CSF1(2), LDLR(10), LPL(7) 2287815 25 23 25 7 9 4 1 4 6 1 0.230 0.982 1.000 30 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(5), SLPI(3) 735928 8 7 7 4 3 1 0 1 3 0 0.869 0.983 1.000 31 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 12 CD2(3), CD34(4), CD3E(2), CD3G(1), CD58(6), CD8A(4), CSF3(2), IL3(1), KITLG(3) 2261536 26 20 25 6 3 8 2 3 10 0 0.226 0.984 1.000 32 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(3), BCKDK(8), CBS(6), CTH(2), MUT(6) 2096137 25 22 24 9 5 4 1 2 12 1 0.790 0.987 1.000 33 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 9 CCL11(1), CCR3(6), HLA-DRA(8), IL1B(3), IL4(1), IL5RA(4) 1905414 23 19 23 6 9 6 0 3 5 0 0.241 0.988 1.000 34 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(4), IFNG(2), IL12A(2), IL12B(2), IL18(1) 1274062 11 10 10 4 1 3 1 4 2 0 0.816 0.989 1.000 35 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(2), FDPS(9), GGPS1(1), IDI1(2), IDI2(1), SQLE(5) 1827582 20 14 19 4 4 5 1 3 7 0 0.286 0.991 1.000 36 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 13 AKT1(3), BAD(3), CASP9(3), CHUK(4), GH1(2), GHR(6), NFKB1(7), NFKBIA(1), PDPK1(2), PIK3R1(11), PPP2CA(4), RELA(5), YWHAH(3) 5104423 54 35 53 9 10 15 3 12 13 1 0.0343 0.993 1.000 37 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GGT1(6), SHMT1(2), SHMT2(9) 1767088 17 17 15 5 7 0 0 1 9 0 0.515 0.996 1.000 38 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(6), ERBB4(48), NRG2(8), NRG3(17), PRKCA(5), PSEN1(3) 3865364 87 60 81 23 21 22 8 20 16 0 0.177 0.996 1.000 39 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 8 CCNB1(3), CDC25A(6), CDC25B(4), CSK(7), GRB2(4), PRKCA(5), PTPRA(12), SRC(3) 3538332 44 36 44 9 14 13 0 6 11 0 0.0559 0.996 1.000 40 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(5), ACAT2(4), OXCT1(8) 1450639 17 16 17 7 2 8 0 3 3 1 0.859 0.997 1.000 41 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(1), CSF1(2), IL1B(3), MST1R(14), TNF(3) 2815221 23 19 23 2 5 3 0 7 8 0 0.0528 0.997 1.000 42 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(3), HLCS(5), SPCS1(2), SPCS3(2) 1319135 12 11 12 5 3 1 0 7 1 0 0.793 0.998 1.000 43 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(6), CCNE1(5), CDC34(2), CDK2(3), CUL1(22), E2F1(3), RB1(13), SKP2(5), TFDP1(5) 3668575 64 46 62 15 12 25 2 10 15 0 0.0421 0.999 1.000 44 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 CASP3(2), CASP7(3), DFFA(4), DFFB(3), GZMB(3), HMGB2(4), TOP2A(5), TOP2B(9) 3795203 33 25 32 5 5 9 1 8 9 1 0.190 0.999 1.000 45 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(1), NFYC(2), RB1(13), SP1(6), SP3(3) 2854552 25 21 24 8 3 12 0 3 7 0 0.490 1.000 1.000 46 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(4), MTMR1(8), MTMR2(5), MTMR6(7), PHPT1(3), THTPA(2), TPK1(6) 2754764 35 27 35 9 9 11 1 5 9 0 0.210 1.000 1.000 47 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(2), APEX1(3), CREBBP(40), DFFA(4), DFFB(3), GZMA(3), GZMB(3), HMGB2(4), PRF1(8), SET(5) 4536200 75 49 74 18 22 20 2 15 16 0 0.0724 1.000 1.000 48 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(5), AASDHPPT(1), AASS(7), KARS(5) 2025504 18 14 18 5 4 6 1 5 2 0 0.423 1.000 1.000 49 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(4), MAPK14(1), MAPK8(5), NFKB1(7), RELA(5), TNFRSF13B(5), TNFRSF13C(4), TNFRSF17(1), TNFSF13(3), TNFSF13B(4), TRAF2(4), TRAF3(4), TRAF5(1), TRAF6(6) 6232278 54 42 54 9 9 15 2 10 16 2 0.0527 1.000 1.000 50 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(4), ARG1(2), GLS(10), GLUD1(2), OAT(2) 2367269 20 16 19 5 5 4 0 6 5 0 0.306 1.000 1.000 51 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), MIOX(5), UGDH(5) 3647197 55 39 47 14 10 15 0 13 17 0 0.329 1.000 1.000 52 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(1), FOSL1(1), FOSL2(8), IFNAR1(8), IFNAR2(6), IFNB1(3), MAPK8(5), NFKB1(7), RELA(5), TNFRSF11A(5), TNFSF11(4), TRAF6(6) 4754183 59 44 59 13 14 19 1 10 13 2 0.0700 1.000 1.000 53 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 11 AKT1(3), GRB2(4), KLK2(1), NTRK1(10), PIK3R1(11), PLCG1(19), PRKCA(5), SHC1(7), SOS1(7) 5743632 67 46 65 13 20 17 3 8 18 1 0.0384 1.000 1.000 54 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(5), HADH(3), HADHA(4), HADHB(5), HSD17B4(7), MECR(4), PPT1(6), PPT2(4) 3636190 38 24 37 7 7 14 3 2 12 0 0.0195 1.000 1.000 55 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(3), ACAA2(5), ACAT1(5), ACAT2(4), EHHADH(7), HADHA(4), HADHB(5), SDS(4) 3589460 37 24 36 9 6 15 2 2 11 1 0.170 1.000 1.000 56 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 CREB1(3), FOS(1), JUN(4), KEAP1(10), MAFF(1), MAPK1(3), MAPK14(1), MAPK8(5), NFE2L2(1), PRKCA(5) 3802548 34 27 34 9 9 12 2 3 7 1 0.157 1.000 1.000 57 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(1), CD3E(2), CD3G(1), IFNG(2), IL2RA(3), IL4(1), TGFB1(3), TGFB2(6), TGFB3(8), TGFBR1(4), TGFBR2(14), TGFBR3(7), TOB1(1), TOB2(5) 4545011 58 45 58 14 11 18 6 11 12 0 0.150 1.000 1.000 58 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(31), GNA12(1), PRKACB(4), PRKACG(8), PRKAG1(4), PRKAR2A(2), PRKAR2B(8) 4333423 58 42 53 12 11 15 2 7 21 2 0.143 1.000 1.000 59 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(2), ACADM(4), ACADS(4), ACAT1(5), HADHA(4) 2318194 19 15 18 5 6 5 0 2 5 1 0.319 1.000 1.000 60 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ3(5), COQ5(1), COQ6(3), COQ7(4), NDUFA12(2), NDUFB11(2) 1713010 17 15 17 7 5 4 0 3 5 0 0.782 1.000 1.000 61 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(8), ACO2(9), FH(3), IDH1(2), IDH2(4), MDH1(3), SDHB(4), SUCLA2(4) 3823863 37 26 34 7 15 9 0 5 8 0 0.0769 1.000 1.000 62 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(2), ASL(6), CPS1(22), GLS(10), GLUD1(2), GOT1(3) 3350542 45 37 44 11 14 10 2 14 5 0 0.151 1.000 1.000 63 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(1), EHHADH(7), HADHA(4), SDS(4) 2082074 16 13 15 5 4 4 1 2 5 0 0.418 1.000 1.000 64 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(4), CHRNA1(5), SNAP25(2), STX1A(3), VAMP2(2) 1400328 16 15 15 5 3 2 1 5 5 0 0.708 1.000 1.000 65 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 5 BCL2(3), CASP3(2), CFL1(1), CFLAR(1), PDE6D(1) 1160480 8 7 8 4 2 4 0 1 1 0 0.791 1.000 1.000 66 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(6), F13B(16), HSD17B1(4), HSD17B2(2), HSD17B3(1), HSD17B4(7), HSD17B7(3), HSD3B1(4), HSD3B2(1) 3473806 44 36 44 12 7 14 3 11 9 0 0.184 1.000 1.000 67 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 16 CD28(1), CD3E(2), CD3G(1), CD80(4), CD86(6), CTLA4(3), GRB2(4), HLA-DRA(8), ICOS(2), ITK(6), LCK(4), PIK3R1(11), PTPN11(6) 4558122 58 46 56 13 16 15 2 10 14 1 0.176 1.000 1.000 68 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 16 AKT1(3), CREB1(3), GRB2(4), MAPK1(3), MAPK3(1), MAPK7(6), MEF2A(2), MEF2B(5), MEF2C(4), MEF2D(7), NTRK1(10), PIK3R1(11), PLCG1(19), RPS6KA1(9), SHC1(7) 7178204 94 57 91 19 27 26 6 10 24 1 0.00860 1.000 1.000 69 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(40), EP300(22), ESR1(9), MAPK1(3), MAPK3(1), PELP1(6), SRC(3) 6296008 84 55 82 18 30 22 2 13 16 1 0.0136 1.000 1.000 70 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CCL3(1), CSF3(2), EPO(1), FLT3(10), IGF1(4), IL11(3), IL1A(2), IL3(1), KITLG(3), TGFB1(3), TGFB2(6), TGFB3(8) 3560367 44 33 43 10 12 11 1 12 8 0 0.136 1.000 1.000 71 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(7), ALDH1A2(5), RDH5(2) 1676358 14 14 14 9 4 2 0 4 4 0 0.967 1.000 1.000 72 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(12), PDXK(3), PDXP(2), PSAT1(5) 2075630 22 17 22 9 2 7 0 8 4 1 0.749 1.000 1.000 73 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 12 APC(43), CREBBP(40), EP300(22), MAP2K1(5), MAP3K7(10), MAPK3(1), SKIL(2), TGFB1(3), TGFB2(6), TGFB3(8), TGFBR1(4), TGFBR2(14) 10290478 158 89 152 33 38 43 5 25 38 9 0.0113 1.000 1.000 74 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM1(2), CALM2(2), CAMK1(3), CAMK1G(6), CAMK2A(3), CAMK2B(4), CAMK2D(3), CAMK2G(8), CAMK4(8), ESRRA(2), HDAC5(10), MEF2A(2), MEF2B(5), MEF2C(4), MEF2D(7), PPARA(4), PPP3CA(10), PPP3CB(6), PPP3CC(5), SLC2A4(4), SYT1(4), YWHAH(3) 8662424 105 71 102 24 28 22 6 21 28 0 0.0200 1.000 1.000 75 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(7), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4) 3425297 57 36 49 18 12 13 0 11 21 0 0.624 1.000 1.000 76 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(7), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4) 3425297 57 36 49 18 12 13 0 11 21 0 0.624 1.000 1.000 77 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM1(2), CALM2(2), CCL2(1), CCR5(4), CXCR4(1), FOS(1), GNAQ(4), JUN(4), MAPK14(1), MAPK8(5), PLCG1(19), PRKCA(5), PTK2B(16), SYT1(4) 5936561 69 50 67 15 23 18 3 10 14 1 0.0303 1.000 1.000 78 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(3), GOT2(2), TAT(5) 1128324 10 10 10 7 4 3 0 2 1 0 0.925 1.000 1.000 79 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(26), ABCB11(9), ABCB4(23), ABCC1(16), ABCC3(11), GSTP1(1) 6158288 86 59 83 21 21 19 3 17 24 2 0.0784 1.000 1.000 80 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 11 APAF1(8), ARHGAP5(18), ARHGDIB(1), CASP1(4), CASP10(6), CASP3(2), CASP9(3), GZMB(3), JUN(4), PRF1(8) 5030725 57 41 49 12 11 10 3 11 21 1 0.313 1.000 1.000 81 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(12), APOBEC1(3), APOBEC2(3), APOBEC3A(1), APOBEC3B(3), APOBEC3F(1), APOBEC3G(3), APOBEC4(1) 3143328 27 20 27 6 9 6 3 5 4 0 0.241 1.000 1.000 82 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(5), COASY(3), DPYD(16), DPYS(7), ENPP1(7), ENPP3(8), PANK1(9), PANK2(4), PANK3(2), PANK4(3), PPCS(2), UPB1(4) 5982354 70 45 67 14 12 18 3 19 18 0 0.0217 1.000 1.000 83 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 13 ARF1(5), CCND1(1), CDK2(3), CDKN1A(3), CFL1(1), E2F1(3), E2F2(4), MDM2(5), NXT1(2), PRB1(4) 3015642 31 24 30 8 8 12 1 3 6 1 0.254 1.000 1.000 84 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(4), CAMP(2), DAG1(13), GNAQ(4), ITPKA(2), ITPKB(11) 2599369 36 28 35 10 13 9 0 8 6 0 0.226 1.000 1.000 85 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(3), CREM(4), FOS(1), JUN(4), MAPK3(1), OPRK1(14), POLR2A(19), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8) 5533905 77 54 72 19 19 24 2 14 18 0 0.0612 1.000 1.000 86 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(4), ADH1B(4), ADH4(2), ADH5(3), ADH6(7), ADH7(1), ADHFE1(9), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4) 5671490 75 47 66 19 12 19 0 20 23 1 0.267 1.000 1.000 87 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(9), ACO1(8), ACO2(9), ACSS1(12), ACSS2(10), FH(3), IDH1(2), IDH2(4), MDH1(3), SUCLA2(4) 5715576 64 41 60 14 22 13 3 10 16 0 0.0685 1.000 1.000 88 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(14), AP2A1(9), AP2M1(7), BIN1(4), CALM1(2), CALM2(2), DNM1(5), EPN1(5), EPS15(2), NME2(3), PICALM(2), PPP3CA(10), PPP3CB(6), PPP3CC(5), SYNJ1(10), SYNJ2(18), SYT1(4) 9305231 108 66 100 22 30 21 3 22 32 0 0.0120 1.000 1.000 89 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 20 CSNK2A1(5), ELK1(3), FOS(1), GRB2(4), INSR(14), IRS1(24), JUN(4), MAP2K1(5), MAPK3(1), MAPK8(5), PIK3R1(11), PTPN11(6), RAF1(10), RASA1(17), SHC1(7), SLC2A4(4), SOS1(7), SRF(2) 10000033 130 70 122 29 34 32 3 18 40 3 0.0196 1.000 1.000 90 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA1(1), NDUFA10(4), NDUFA8(5), NDUFB2(1), NDUFB4(1), NDUFB5(1), NDUFB6(1), NDUFB7(1), NDUFS1(7), NDUFS2(5), NDUFV1(5) 2969101 32 25 31 7 6 8 1 8 9 0 0.418 1.000 1.000 91 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(22), CPT1A(10), LEP(2), LEPR(13), PRKAA1(6), PRKAA2(7), PRKAB1(6), PRKAB2(4), PRKAG1(4), PRKAG2(5) 6213129 79 49 77 16 21 14 3 21 18 2 0.0892 1.000 1.000 92 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 8 CCNB1(3), CCNH(2), CDC25A(6), CDC25B(4), MNAT1(3), SHH(4), XPO1(7) 3272546 29 18 29 8 7 10 1 7 4 0 0.311 1.000 1.000 93 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(10), PARK2(10), SNCA(1), SNCAIP(13), UBE2F(3), UBE2G2(2), UBE2L3(1), UBE2L6(1) 2761315 41 32 40 14 11 12 1 8 8 1 0.422 1.000 1.000 94 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(8), BAD(3), BAK1(4), BAX(6), BCL10(2), BCL2(3), BCL2L11(1), BID(2), CASP9(3), CES1(7) 4675335 39 27 34 8 14 9 1 6 9 0 0.176 1.000 1.000 95 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(4), PAPSS1(6), PAPSS2(5), SULT1A2(5), SULT1E1(2), SULT2A1(3), SUOX(3) 2625444 28 23 28 7 11 10 0 3 4 0 0.289 1.000 1.000 96 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 19 AKT1(3), APAF1(8), ATM(38), BAD(3), BAX(6), BCL2(3), BID(2), CASP3(2), CASP6(1), CASP7(3), CASP9(3), EIF2S1(2), PRKCA(5), PTK2(11), PXN(4), STAT1(10), TLN1(23) 11394930 127 72 116 27 35 32 6 16 35 3 0.0254 1.000 1.000 97 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(2), CDK5R1(4), DAB1(9), FYN(10), LRP8(6), RELN(47), VLDLR(6) 6019362 84 55 83 23 23 30 3 16 12 0 0.0561 1.000 1.000 98 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 17 APAF1(8), BAK1(4), BAX(6), BCL2(3), BID(2), BIRC2(3), BIRC3(6), CASP3(2), CASP6(1), CASP7(3), CASP9(3), DFFA(4), DFFB(3), DIABLO(1) 5257789 49 35 43 10 13 14 0 9 13 0 0.184 1.000 1.000 99 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 14 AKT1(3), BCAR1(8), GRB2(4), ILK(8), ITGB1(10), MAPK1(3), MAPK3(1), PDPK1(2), PIK3R1(11), PTK2(11), SHC1(7), SOS1(7) 6969290 75 47 70 15 20 17 4 11 21 2 0.0526 1.000 1.000 100 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(5), PLCG1(19), PRKCA(5), PTK2B(16) 2899870 45 37 44 12 20 8 2 4 11 0 0.199 1.000 1.000 101 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(3), GRB2(4), PTK2B(16), SHC1(7), SOS1(7), SRC(3) 3796620 40 29 40 10 12 10 0 8 10 0 0.296 1.000 1.000 102 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(11), BMPR1A(5), BMPR1B(7), BMPR2(16) 2689015 39 33 36 10 9 8 2 3 15 2 0.469 1.000 1.000 103 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 10 ATM(38), CDC25A(6), CDC25B(4), CDK2(3), CHEK1(4), MYT1(19), RB1(13), WEE1(4), YWHAH(3) 6778483 94 62 87 21 18 26 3 18 26 3 0.156 1.000 1.000 104 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(6), CYSLTR2(1), GPR161(12), GPR171(2), GPR18(3), GPR39(9), GPR45(12), GPR65(2), GPR68(3), GPR75(5) 4226763 55 40 50 16 21 8 4 8 14 0 0.316 1.000 1.000 105 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(4), CR1(27), CR2(22), FCGR2B(1), HLA-DRA(8), ICAM1(2), ITGAL(16), ITGB2(6), PTPRC(19) 6527237 105 65 92 29 26 31 0 22 26 0 0.183 1.000 1.000 106 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 17 CSNK2A1(5), ELK1(3), FOS(1), GRB2(4), JUN(4), KLK2(1), MAP2K1(5), MAPK3(1), MAPK8(5), NGFR(4), PIK3R1(11), PLCG1(19), RAF1(10), SHC1(7), SOS1(7) 7265976 87 54 82 21 26 21 3 16 19 2 0.0616 1.000 1.000 107 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(5), BCAT2(6), COASY(3), DPYD(16), DPYS(7), ENPP1(7), ENPP3(8), ILVBL(5), PANK1(9), PANK2(4), PANK3(2), PANK4(3), PPCDC(1), PPCS(2), UPB1(4), VNN1(4) 7431209 86 51 83 17 21 20 3 23 19 0 0.00994 1.000 1.000 108 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 CHUK(4), DNAJC3(3), EIF2S1(2), EIF2S2(2), NFKB1(7), NFKBIA(1), RELA(5) 3842638 24 18 24 5 4 6 0 8 6 0 0.330 1.000 1.000 109 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 29 AGPAT1(3), AGPAT2(2), AGPAT3(4), AGPAT4(5), AGPAT6(5), AGPS(2), CHPT1(3), ENPP2(9), ENPP6(6), PAFAH1B1(12), PAFAH1B2(2), PAFAH1B3(2), PAFAH2(3), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6), PLD1(19), PLD2(16), PPAP2A(3), PPAP2B(1), PPAP2C(4) 9818237 135 65 130 25 40 38 4 25 28 0 0.00123 1.000 1.000 110 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 15 APAF1(8), ATM(38), BAX(6), BCL2(3), CCND1(1), CCNE1(5), CDK2(3), CDKN1A(3), E2F1(3), MDM2(5), PCNA(2), RB1(13), TIMP3(6) 7424035 96 59 83 22 18 25 2 15 32 4 0.263 1.000 1.000 111 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 14 APAF1(8), BIRC2(3), BIRC3(6), CASP10(6), CASP3(2), CASP7(3), CASP9(3), DFFA(4), DFFB(3), GZMB(3), PRF1(8), SCAP(13), SREBF1(12), SREBF2(11) 7274561 85 56 80 18 26 19 2 17 20 1 0.0790 1.000 1.000 112 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BET1(1), BNIP1(5), GOSR1(2), GOSR2(2), SNAP25(2), SNAP29(1), STX10(3), STX11(7), STX12(2), STX16(8), STX17(2), STX18(2), STX19(3), STX2(6), STX3(2), STX4(4), STX5(1), STX6(7), STX7(2), STX8(5), TSNARE1(7), USE1(3), VAMP2(2), VAMP4(1), VAMP5(1), VAMP7(5), VTI1A(3), VTI1B(4), YKT6(1) 7168770 94 53 90 20 32 23 2 14 22 1 0.0358 1.000 1.000 113 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 25 AKT1(3), APC(43), AXIN1(9), CCND1(1), CD14(2), CTNNB1(22), DVL1(7), FZD1(10), GJA1(11), GNAI1(1), GSK3B(5), IRAK1(6), LBP(1), LEF1(8), LY96(4), MYD88(2), NFKB1(7), PDPK1(2), PIK3R1(11), PPP2CA(4), RELA(5), TIRAP(1), TLR4(21), TOLLIP(5), WNT1(8) 12240489 199 109 185 46 40 46 6 42 55 10 0.0220 1.000 1.000 114 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(8), IFNB1(3), JAK1(12), PTPRU(25), REG1A(4), STAT1(10), STAT2(10), TYK2(9) 5357141 81 52 75 21 24 18 0 9 30 0 0.239 1.000 1.000 115 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(10), F13A1(14), F2(9), F2R(3), FGA(9), FGB(4), FGG(3), PLAT(7), PLG(14), SERPINB2(7), SERPINE1(3) 5760920 83 55 79 25 25 13 7 23 15 0 0.287 1.000 1.000 116 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(4), CDO1(1), CSAD(8), GAD1(7), GAD2(9), GGT1(6) 2466206 35 29 34 12 14 4 1 6 10 0 0.382 1.000 1.000 117 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(2), LDLR(10), MBTPS1(12), MBTPS2(5), SCAP(13), SREBF1(12), SREBF2(11) 5077584 65 44 62 18 21 14 1 10 18 1 0.233 1.000 1.000 118 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(3), IFNG(2), IFNGR1(6), JAK1(12), JAK2(13), PLA2G2A(2), PTPRU(25), REG1A(4), STAT1(10) 4913590 77 52 76 21 20 21 2 11 22 1 0.221 1.000 1.000 119 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(4), CHST11(4), CHST12(5), CHST13(4), PAPSS1(6), PAPSS2(5), SULT1A1(6), SULT1A2(5), SULT1E1(2), SULT2A1(3), SUOX(3) 3956462 47 34 46 13 22 12 1 8 4 0 0.152 1.000 1.000 120 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(6), CDKN1A(3), EPO(1), EPOR(3), GRIN1(8), HIF1A(7), JAK2(13), NFKB1(7), NFKBIA(1), RELA(5), SOD2(1) 5428608 55 37 54 14 8 16 2 10 18 1 0.285 1.000 1.000 121 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 7 ATM(38), CDC25A(6), CDC25B(4), CHEK1(4), MYT1(19), WEE1(4), YWHAH(3) 5492608 78 55 72 21 18 19 2 16 20 3 0.401 1.000 1.000 122 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 16 ADRB2(8), AKT1(3), ANXA1(2), CALM1(2), CALM2(2), GNAS(29), GNB1(1), GNGT1(3), NFKB1(7), NOS3(10), NPPA(2), NR3C1(6), PIK3R1(11), RELA(5), SYT1(4) 6765194 95 64 88 21 36 21 0 18 19 1 0.0668 1.000 1.000 123 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 7 B3GAT3(4), B4GALT7(5), HS3ST1(3), HS3ST2(10), HS3ST3A1(2), HS3ST3B1(4), XYLT1(12) 2142388 40 33 38 13 18 11 1 5 5 0 0.270 1.000 1.000 124 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 7 B3GAT3(4), B4GALT7(5), HS3ST1(3), HS3ST2(10), HS3ST3A1(2), HS3ST3B1(4), XYLT1(12) 2142388 40 33 38 13 18 11 1 5 5 0 0.270 1.000 1.000 125 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 28 CSF1(2), CSF3(2), HLA-DRA(8), IFNA1(1), IFNB1(3), IFNG(2), IL10(2), IL11(3), IL12A(2), IL12B(2), IL13(2), IL1A(2), IL3(1), IL4(1), IL7(1), LTA(4), PDGFA(2), TGFB1(3), TGFB2(6), TGFB3(8), TNF(3) 5328049 60 44 60 18 18 16 2 13 11 0 0.293 1.000 1.000 126 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(7), ST3GAL1(4), ST3GAL2(6), ST3GAL4(6), ST3GAL5(3), ST6GALNAC2(1), ST6GALNAC4(2), ST8SIA1(7) 2426528 36 33 35 13 18 4 2 8 4 0 0.535 1.000 1.000 127 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(7), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), EHHADH(7), HADHA(4), SDS(4) 5216751 72 40 63 23 16 17 0 13 26 0 0.530 1.000 1.000 128 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(14), GABRA2(9), GABRA3(10), GABRA4(9), GABRA5(7), GABRA6(10), PRKCE(14) 3377064 73 49 72 27 18 14 8 26 7 0 0.543 1.000 1.000 129 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(15), EIF2AK4(10), EIF2B5(9), EIF2S1(2), EIF2S2(2), EIF5(6), GSK3B(5), PPP1CA(2) 4952517 51 40 51 13 10 15 1 14 11 0 0.262 1.000 1.000 130 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(1), EHHADH(7), HADH(3), HADHA(4), HSD17B4(7), NTAN1(5), SIRT1(6), SIRT2(3), SIRT5(4), SIRT7(3), VNN2(3) 5090453 46 28 43 12 12 10 4 4 16 0 0.210 1.000 1.000 131 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(4), ALAS1(3), ALAS2(12), CPO(5), FECH(6), GATA1(3), HBB(2), HMBS(3), UROD(1), UROS(4) 3377482 43 34 43 11 9 11 2 11 10 0 0.303 1.000 1.000 132 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(3), FOS(1), JUN(4), MAP2K1(5), MAPK1(3), MAPK3(1), MYC(5), NFKB1(7), NFKBIA(1), PLCB1(19), PRKCA(5), RAF1(10), RELA(5), TNF(3) 6678768 72 50 69 19 20 15 1 18 18 0 0.165 1.000 1.000 133 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(6), ASPH(6), COPS5(3), CREB1(3), EDN1(3), EP300(22), EPO(1), HIF1A(7), JUN(4), LDHA(3), NOS3(10), P4HB(4), VHL(2) 7285971 74 48 70 17 17 17 5 13 21 1 0.107 1.000 1.000 134 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(30), C5(11), C6(12), C7(3), C8A(5), C9(7) 5387439 68 43 64 19 21 17 3 14 13 0 0.201 1.000 1.000 135 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 22 BCAR1(8), CXCR4(1), GNAI1(1), GNAQ(4), GNB1(1), GNGT1(3), MAP2K1(5), MAPK1(3), MAPK3(1), NFKB1(7), PIK3C2G(10), PIK3R1(11), PLCG1(19), PRKCA(5), PTK2(11), PTK2B(16), PXN(4), RAF1(10), RELA(5) 10890758 125 71 119 29 36 24 5 21 38 1 0.0354 1.000 1.000 136 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(5), CHPT1(3), HEMK1(1), LCMT1(1), LCMT2(11), METTL6(3), PCYT1A(9), PCYT1B(6), PRMT2(8), PRMT3(5), PRMT5(3), PRMT6(4), PRMT7(6), PRMT8(9), WBSCR22(6) 6030990 80 47 75 20 19 23 3 13 21 1 0.131 1.000 1.000 137 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(16), KHK(2), LCT(23), MPI(3), PGM1(2), PYGL(8), PYGM(14), TPI1(1), TREH(1) 5752710 70 52 70 20 32 17 2 8 11 0 0.123 1.000 1.000 138 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(1), IFNAR1(8), IFNAR2(6), IFNB1(3), JAK1(12), STAT1(10), STAT2(10), TYK2(9) 4649991 59 40 54 17 13 15 0 8 23 0 0.476 1.000 1.000 139 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(9), GBA(9), LPO(9), MPO(7), PRDX6(2), TPO(24) 3585382 60 50 59 18 21 12 3 15 8 1 0.329 1.000 1.000 140 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 20 AKT1(3), EIF4A1(3), EIF4A2(6), EIF4E(2), EIF4EBP1(2), EIF4G1(23), EIF4G2(7), EIF4G3(17), GHR(6), IRS1(24), MAPK1(3), MAPK14(1), MAPK3(1), MKNK1(3), PABPC1(2), PDPK1(2), PIK3R1(11), PRKCA(5), RPS6KB1(5) 10790254 126 72 119 27 30 32 5 21 36 2 0.0520 1.000 1.000 141 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(2), DHRS3(2), DHRS7(6), DHRSX(5), ESCO1(7), ESCO2(8), NAT6(3), PNPLA3(2), SH3GLB1(3) 7112853 38 33 37 9 10 7 1 5 14 1 0.415 1.000 1.000 142 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(5), ACP2(4), ACP5(2), ACP6(3), ACPP(3), ACPT(4), ENPP1(7), ENPP3(8), FLAD1(4), LHPP(4), MTMR1(8), MTMR2(5), MTMR6(7), PHPT1(3), RFK(1), TYR(9) 6452624 77 52 73 20 16 22 4 14 21 0 0.137 1.000 1.000 143 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(6), ALOX15(7), ALOX15B(3), ALOX5(10), ALOX5AP(3), DPEP1(2), GGT1(6), LTA4H(5), PLA2G2A(2), PLA2G6(6), PTGDS(1), PTGIS(6), PTGS1(12), PTGS2(7), TBXAS1(6) 6445417 82 53 81 20 33 15 4 13 17 0 0.0308 1.000 1.000 144 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 13 DHCR7(6), FDFT1(2), FDPS(9), HMGCR(7), IDI1(2), LSS(9), MVD(2), NQO1(3), NQO2(3), PMVK(1), SQLE(5), VKORC1(1) 4376286 50 31 47 15 14 12 1 12 11 0 0.356 1.000 1.000 145 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(4), ACAD9(6), ADH1A(4), ADH1B(4), ADH4(2), ADH5(3), ADH6(7), ADH7(1), ADHFE1(9), DHRS1(2), DHRS3(2), DHRS7(6), DHRSX(5), ESCO1(7), ESCO2(8), NAT6(3), PNPLA3(2), SH3GLB1(3) 10717969 78 49 76 16 17 21 2 16 20 2 0.0614 1.000 1.000 146 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(2), ACADM(4), ACADS(4), ACADVL(1), ACSL1(3), ACSL3(8), ACSL4(4), CPT1A(10), CPT2(5), EHHADH(7), HADHA(4), PECR(1), SCP2(5), SLC25A20(2) 7219115 60 40 58 16 17 11 5 11 16 0 0.131 1.000 1.000 147 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(4), ALAS1(3), ALAS2(12), CPOX(2), FECH(6), HMBS(3), PPOX(5), UROD(1), UROS(4) 3258406 40 34 40 10 7 12 2 10 9 0 0.304 1.000 1.000 148 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(5), AOC2(6), AOC3(15), CES1(7), DDHD1(9), ESCO1(7), ESCO2(8), LIPA(3), NAT6(3), PLA1A(2), PNPLA3(2), PPME1(1), PRDX6(2), SH3GLB1(3) 10873015 73 52 64 15 16 12 2 17 25 1 0.288 1.000 1.000 149 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(3), CAMK1G(6), HDAC9(8), MEF2A(2), MEF2B(5), MEF2C(4), MEF2D(7), MYOD1(6), YWHAH(3) 3317406 44 37 43 16 14 7 4 6 13 0 0.512 1.000 1.000 150 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 21 APC(43), AXIN1(9), BTRC(9), CCND1(1), CREBBP(40), CSNK1A1(3), CSNK1D(2), CSNK2A1(5), CTBP1(3), CTNNB1(22), DVL1(7), FZD1(10), GSK3B(5), HDAC1(5), MAP3K7(10), MYC(5), PPARD(8), PPP2CA(4), TLE1(9), WIF1(2), WNT1(8) 12204299 210 106 194 52 62 43 6 31 59 9 0.0405 1.000 1.000 151 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(4), BFAR(5), BRAF(16), CAMP(2), CREB1(3), CREB5(5), MAPK1(3), RAF1(10), SNX13(7), SRC(3), TERF2IP(5) 4797663 63 46 57 18 17 12 1 14 19 0 0.433 1.000 1.000 152 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(6), ENO1(3), GPI(5), HK1(16), PFKL(5), PGK1(4), PKLR(7), TPI1(1) 3978561 47 37 47 15 15 14 2 11 5 0 0.263 1.000 1.000 153 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 14 ACOX1(5), ACOX3(11), FADS2(5), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6) 4222162 55 42 53 18 23 10 3 14 5 0 0.407 1.000 1.000 154 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(3), B4GALT1(2), B4GALT2(7), B4GALT3(2), B4GALT5(6), FUT8(7), ST3GAL1(4), ST3GAL2(6), ST3GAL3(2), ST3GAL4(6) 3390971 45 37 44 13 20 11 0 6 8 0 0.353 1.000 1.000 155 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(4), NFKB1(7), NFKBIA(1), PLCB1(19), PRKCA(5), RELA(5) 3539135 41 33 40 13 11 8 0 9 13 0 0.516 1.000 1.000 156 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(4), GALNT10(7), GALNT2(5), GALNT3(4), GALNT4(5), GALNT6(6), GALNT7(2), GALNT8(6), GALNT9(3), ST3GAL1(4), ST3GAL2(6), ST3GAL4(6), WBSCR17(25) 6199575 83 57 80 24 33 14 4 14 17 1 0.346 1.000 1.000 157 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 20 BAD(3), BAX(6), BCL2(3), FADD(1), MAP2K1(5), MAP2K4(8), MAP3K1(11), MAPK1(3), MAPK3(1), MAPK8(5), NFKB1(7), NSMAF(9), RAF1(10), RELA(5), RIPK1(2), SMPD1(6), TNFRSF1A(6), TRADD(2), TRAF2(4) 8297031 97 57 89 25 32 20 2 11 29 3 0.125 1.000 1.000 158 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(3), PSMA2(1), PSMA3(3), PSMA4(4), PSMA6(5), PSMA7(4), PSMB1(2), PSMB10(1), PSMB2(2), PSMB3(2), PSMB4(3), PSMB5(1), PSMB6(3), PSMB8(5), PSMB9(1) 3747289 40 26 39 13 13 12 2 7 6 0 0.351 1.000 1.000 159 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(5), ELK1(3), EPO(1), EPOR(3), FOS(1), GRB2(4), JAK2(13), JUN(4), MAP2K1(5), MAPK3(1), MAPK8(5), PLCG1(19), PTPN6(4), RAF1(10), SHC1(7), SOS1(7), STAT5A(3), STAT5B(14) 9231320 109 60 103 28 28 31 3 21 24 2 0.0966 1.000 1.000 160 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 21 CSNK2A1(5), FOS(1), GRB2(4), JAK2(13), JUN(4), MAP2K1(5), MAPK3(1), MPL(5), PIK3R1(11), PLCG1(19), PRKCA(5), RAF1(10), RASA1(17), SHC1(7), SOS1(7), STAT1(10), STAT3(7), STAT5A(3), STAT5B(14), THPO(6) 11933697 154 80 145 31 36 38 5 29 44 2 0.00968 1.000 1.000 161 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(3), ENO2(3), ENO3(4), FARS2(7), GOT1(3), GOT2(2), PAH(6), TAT(5), YARS(6) 3566422 39 28 39 12 12 11 0 9 7 0 0.378 1.000 1.000 162 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(3), GNAS(29), GNB1(1), GNGT1(3), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PRKCA(5) 4145607 72 50 67 21 35 11 1 9 16 0 0.397 1.000 1.000 163 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(3), PSMA2(1), PSMA3(3), PSMA4(4), PSMA6(5), PSMA7(4), PSMB1(2), PSMB2(2), PSMB3(2), PSMB4(3), PSMB5(1), PSMB6(3), PSMC2(6), PSMC3(8), PSMD1(6), PSMD11(3), PSMD12(4), PSMD13(2), PSMD2(14), PSMD6(2) 6859759 78 46 77 18 22 23 4 14 15 0 0.0755 1.000 1.000 164 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(22), ACACB(35), FASN(19), MCAT(3), OXSM(4) 6763071 83 49 80 24 23 19 4 20 16 1 0.192 1.000 1.000 165 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 ANPEP(9), G6PD(5), GCLC(3), GCLM(3), GGT1(6), GPX2(3), GPX3(1), GPX5(2), GSS(3), GSTA1(3), GSTA2(2), GSTA3(1), GSTA4(2), GSTM2(1), GSTM3(2), GSTM4(3), GSTM5(2), GSTO2(3), GSTP1(1), GSTZ1(3), IDH1(2), IDH2(4), MGST1(3), MGST2(3), MGST3(3), PGD(6) 7719621 79 51 74 20 20 17 1 19 22 0 0.253 1.000 1.000 166 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 17 AKT1(3), EIF2B5(9), EIF2S1(2), EIF2S2(2), EIF4E(2), EIF4EBP1(2), GSK3B(5), IGF1(4), IGF1R(16), INPPL1(24), PDPK1(2), PIK3R1(11), PPP2CA(4), RPS6(1), RPS6KB1(5) 7140971 92 53 85 24 25 23 2 15 25 2 0.255 1.000 1.000 167 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(3), JAK1(12), JAK2(13), JAK3(13), PIAS1(12), PIAS3(7), PTPRU(25), REG1A(4), SOAT1(7) 5871529 96 54 88 27 24 22 2 14 33 1 0.471 1.000 1.000 168 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 15 AKT1(3), CREB1(3), MAP2K1(5), MAP2K2(3), MAP2K3(4), MAP2K6(1), MAP3K1(11), MAPK1(3), MAPK14(1), MAPK3(1), NFKB1(7), PIK3R1(11), RB1(13), RELA(5), SP1(6) 7383016 77 53 72 20 13 27 1 11 24 1 0.187 1.000 1.000 169 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 15 BCL2(3), CREBBP(40), EP300(22), FYN(10), IL2RG(6), IL7(1), IL7R(9), JAK1(12), JAK3(13), LCK(4), NMI(1), PIK3R1(11), PTK2B(16), STAT5A(3), STAT5B(14) 11051291 165 73 156 34 42 44 1 30 46 2 0.00888 1.000 1.000 170 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 15 B3GAT1(7), B3GAT2(6), B3GAT3(4), B4GALT7(5), CHPF(2), CHST11(4), CHST12(5), CHST13(4), CHST14(1), CHST3(3), CHST7(7), CHSY1(6), DSE(6), UST(9), XYLT1(12) 5331889 81 48 79 24 38 22 2 12 7 0 0.100 1.000 1.000 171 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 17 IL18(1), ITGB1(10), KLRC1(3), KLRC3(2), KLRD1(3), LAT(3), MAP2K1(5), MAPK3(1), PAK1(5), PIK3R1(11), PTK2B(16), PTPN6(4), SYK(7), VAV1(9) 6626596 80 58 75 23 17 24 0 18 20 1 0.315 1.000 1.000 172 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(5), GABRA1(14), GABRA2(9), GABRA3(10), GABRA4(9), GABRA5(7), GABRA6(10), GPHN(11), NSF(1), SRC(3), UBQLN1(5) 5132607 84 52 83 29 16 19 10 30 9 0 0.508 1.000 1.000 173 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM1(2), CALM2(2), CAMK1(3), CAMK1G(6), CAMK2A(3), CAMK2B(4), CAMK2D(3), CAMK2G(8), CAMK4(8), CAMKK1(5), CAMKK2(2), CREB1(3), SYT1(4) 4950394 53 39 52 18 13 17 4 7 12 0 0.320 1.000 1.000 174 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(5), ACP2(4), ACP5(2), ACPP(3), ACPT(4), ENPP1(7), ENPP3(8), FLAD1(4), RFK(1), TYR(9) 4164477 47 35 43 14 7 14 3 9 14 0 0.448 1.000 1.000 175 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(7), CYB5R3(4), GCK(4), GFPT1(4), GNE(7), GNPDA1(4), GNPDA2(6), HEXA(2), HEXB(3), HK1(16), HK2(10), HK3(6), PGM3(7), RENBP(2), UAP1(5) 7274408 87 58 87 24 28 25 4 15 15 0 0.103 1.000 1.000 176 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(3), CHUK(4), IFNG(2), IKBKB(8), IL4(1), JUN(4), MAP3K1(11), MAP3K5(5), MAP4K5(1), MAPK14(1), MAPK8(5), NFKB1(7), NFKBIA(1), RELA(5), TNFRSF9(11), TRAF2(4) 8291564 73 45 67 18 20 10 3 13 25 2 0.280 1.000 1.000 177 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(3), CAT(5), EPX(9), LPO(9), MPO(7), MTHFR(9), PRDX6(2), SHMT1(2), SHMT2(9), TPO(24) 4968930 79 60 77 23 28 10 4 18 18 1 0.315 1.000 1.000 178 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSR(5), GSS(3), NFKB1(7), NOX1(6), RELA(5), TNF(3), XDH(14) 4262484 43 28 43 14 7 14 2 10 10 0 0.486 1.000 1.000 179 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 21 ATP6AP1(6), ATP6V0A1(5), ATP6V0A4(10), ATP6V0B(4), ATP6V0D1(8), ATP6V1A(6), ATP6V1B2(5), ATP6V1C1(2), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(2), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), FDXR(7), SHMT1(2) 6417659 84 56 81 24 24 21 4 15 20 0 0.229 1.000 1.000 180 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 20 ATP6AP1(6), ATP6V0A1(5), ATP6V0A4(10), ATP6V0B(4), ATP6V0D1(8), ATP6V1A(6), ATP6V1B2(5), ATP6V1C1(2), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(2), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), SHMT1(2) 6005714 77 53 74 23 21 19 3 15 19 0 0.346 1.000 1.000 181 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 20 ATP6AP1(6), ATP6V0A1(5), ATP6V0A4(10), ATP6V0B(4), ATP6V0D1(8), ATP6V1A(6), ATP6V1B2(5), ATP6V1C1(2), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(2), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), SHMT1(2) 6005714 77 53 74 23 21 19 3 15 19 0 0.346 1.000 1.000 182 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 20 ATP6AP1(6), ATP6V0A1(5), ATP6V0A4(10), ATP6V0B(4), ATP6V0D1(8), ATP6V1A(6), ATP6V1B2(5), ATP6V1C1(2), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(2), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), SHMT1(2) 6005714 77 53 74 23 21 19 3 15 19 0 0.346 1.000 1.000 183 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 19 AKT1(3), BAD(3), CASP9(3), CDC42(1), CHUK(4), ELK1(3), MAP2K1(5), MAPK3(1), NFKB1(7), PIK3R1(11), RAF1(10), RALBP1(8), RALGDS(11), RELA(5) 7080019 75 48 71 21 22 20 2 11 19 1 0.195 1.000 1.000 184 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(5), DHRS1(2), DHRS3(2), DHRS7(6), DHRSX(5), HEMK1(1), LCMT1(1), LCMT2(11), METTL6(3), PRMT2(8), PRMT3(5), PRMT5(3), PRMT6(4), PRMT7(6), PRMT8(9), WBSCR22(6) 6443426 77 46 72 23 19 20 3 11 22 2 0.319 1.000 1.000 185 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(1), CD86(6), HLA-DRA(8), IFNG(2), IFNGR1(6), IFNGR2(2), IL12A(2), IL12B(2), IL12RB1(5), IL12RB2(11), IL18(1), IL18R1(4), IL2RA(3), IL4(1), IL4R(3) 5432805 57 37 57 21 14 12 3 12 16 0 0.586 1.000 1.000 186 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 189 ACTB(8), ACTG1(1), ACTN1(7), ACTN2(23), ACTN4(11), AKT1(3), AKT2(8), AKT3(6), ARHGAP5(18), BAD(3), BCAR1(8), BCL2(3), BIRC2(3), BIRC3(6), BRAF(16), CAPN2(8), CAV1(4), CAV2(2), CAV3(2), CCND1(1), CCND2(3), CCND3(2), CDC42(1), CHAD(6), COL11A1(34), COL11A2(16), COL1A1(12), COL1A2(30), COL2A1(16), COL3A1(12), COL4A1(29), COL4A2(13), COL4A4(15), COL4A6(9), COL5A1(29), COL5A2(17), COL5A3(15), COL6A1(9), COL6A2(19), COL6A3(41), COL6A6(34), COMP(3), CRKL(1), CTNNB1(22), DIAPH1(11), DOCK1(17), EGF(10), EGFR(15), ELK1(3), ERBB2(15), FARP2(4), FIGF(4), FLNA(26), FLNB(32), FLNC(26), FLT1(16), FN1(29), FYN(10), GRB2(4), GSK3B(5), HGF(15), IBSP(2), IGF1(4), IGF1R(16), ILK(8), ITGA1(8), ITGA10(9), ITGA11(10), ITGA2(8), ITGA2B(9), ITGA3(11), ITGA4(12), ITGA5(5), ITGA6(6), ITGA7(16), ITGA8(6), ITGA9(8), ITGAV(13), ITGB1(10), ITGB3(7), ITGB4(18), ITGB5(7), ITGB6(4), ITGB7(6), ITGB8(14), JUN(4), KDR(13), LAMA1(45), LAMA2(33), LAMA3(24), LAMA4(26), LAMA5(29), LAMB1(18), LAMB2(24), LAMB3(20), LAMB4(19), LAMC1(21), LAMC2(12), LAMC3(18), MAP2K1(5), MAPK1(3), MAPK10(5), MAPK3(1), MAPK8(5), MAPK9(3), MET(8), MYL2(8), MYL7(1), MYL9(2), MYLK(22), MYLK2(4), PAK1(5), PAK2(7), PAK3(5), PAK4(8), PAK6(9), PAK7(9), PARVA(2), PARVB(4), PARVG(3), PDGFA(2), PDGFB(4), PDGFC(7), PDGFD(9), PDGFRA(11), PDGFRB(14), PDPK1(2), PGF(1), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(11), PIK3R3(8), PIK3R5(8), PIP5K1C(11), PPP1CA(2), PPP1CB(1), PPP1CC(5), PPP1R12A(2), PRKCA(5), PRKCG(17), PTK2(11), PXN(4), RAC2(2), RAC3(4), RAF1(10), RAP1A(2), RAP1B(6), RAPGEF1(9), RELN(47), ROCK1(18), ROCK2(12), SHC1(7), SHC2(2), SHC3(10), SHC4(4), SOS1(7), SOS2(19), SPP1(4), SRC(3), THBS1(16), THBS2(15), THBS3(9), THBS4(13), TLN1(23), TLN2(27), TNC(25), TNN(22), TNR(23), TNXB(43), VASP(2), VAV1(9), VAV2(12), VAV3(10), VCL(6), VEGFB(1), VEGFC(9), VTN(8), VWF(28), ZYX(7) 157862481 2078 246 1990 752 646 480 71 426 426 29 0.438 1.000 1.000 187 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 165 ADCY1(19), ADCY2(17), ADCY3(12), ADCY4(9), ADCY7(16), ADCY8(31), ADCY9(13), ADORA2A(1), ADORA2B(1), ADRA1A(16), ADRA1B(5), ADRA1D(4), ADRB1(7), ADRB2(8), ADRB3(5), AGTR1(2), ATP2A1(16), ATP2A2(5), ATP2A3(6), ATP2B1(12), ATP2B2(18), ATP2B3(21), ATP2B4(8), AVPR1A(14), AVPR1B(3), BDKRB1(2), BDKRB2(4), BST1(3), CACNA1A(24), CACNA1B(24), CACNA1C(37), CACNA1D(35), CACNA1E(44), CACNA1F(11), CACNA1G(23), CACNA1H(25), CACNA1I(18), CACNA1S(17), CALM1(2), CALM2(2), CALML3(1), CAMK2A(3), CAMK2B(4), CAMK2D(3), CAMK2G(8), CAMK4(8), CCKAR(5), CCKBR(9), CD38(4), CHRM1(4), CHRM2(17), CHRM3(11), CHRM5(2), CHRNA7(4), CYSLTR1(6), CYSLTR2(1), DRD1(3), EDNRA(4), EGFR(15), ERBB2(15), ERBB4(48), F2R(3), GNA11(6), GNA14(4), GNA15(3), GNAL(2), GNAQ(4), GNAS(29), GRIN1(8), GRIN2A(16), GRIN2C(6), GRIN2D(7), GRM1(31), GRM5(26), GRPR(6), HRH1(5), HRH2(8), HTR2A(6), HTR2B(5), HTR2C(6), HTR4(5), HTR5A(9), HTR6(7), HTR7(10), ITPKA(2), ITPKB(11), ITPR1(24), ITPR2(30), ITPR3(36), LHCGR(11), LTB4R2(4), MYLK(22), MYLK2(4), NOS1(28), NOS3(10), NTSR1(7), OXTR(7), P2RX1(3), P2RX2(7), P2RX3(6), P2RX4(6), P2RX5(5), P2RX7(1), PDE1A(7), PDE1B(6), PDE1C(11), PDGFRA(11), PDGFRB(14), PHKA1(10), PHKA2(10), PHKB(6), PHKG1(2), PLCB1(19), PLCB2(8), PLCB3(12), PLCB4(13), PLCD1(4), PLCD3(9), PLCD4(5), PLCE1(14), PLCG1(19), PLCG2(15), PLCZ1(6), PPID(3), PPP3CA(10), PPP3CB(6), PPP3CC(5), PPP3R1(2), PRKACA(4), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(17), PRKX(5), PTAFR(5), PTGER3(5), PTGFR(5), PTK2B(16), RYR1(61), RYR2(82), RYR3(68), SLC25A4(3), SLC25A5(3), SLC25A6(5), SLC8A1(14), SLC8A2(13), SLC8A3(9), SPHK1(6), SPHK2(3), TACR1(3), TACR2(1), TACR3(15), TBXA2R(8), TNNC1(3), TRHR(5), TRPC1(8), VDAC1(3), VDAC2(1), VDAC3(3) 113564038 1769 239 1697 613 655 404 75 337 288 10 0.0111 1.000 1.000 188 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 233 ADCYAP1R1(7), ADORA1(5), ADORA2A(1), ADORA2B(1), ADORA3(5), ADRA1A(16), ADRA1B(5), ADRA2A(7), ADRA2B(7), ADRA2C(5), ADRB1(7), ADRB2(8), ADRB3(5), AGTR1(2), AGTR2(4), AVPR1A(14), AVPR1B(3), AVPR2(6), BDKRB1(2), BDKRB2(4), BRS3(3), C3AR1(8), C5AR1(5), CALCR(6), CALCRL(8), CCKAR(5), CCKBR(9), CGA(1), CHRM1(4), CHRM2(17), CHRM3(11), CHRM4(2), CHRM5(2), CNR1(11), CRHR1(11), CRHR2(4), CTSG(3), CYSLTR1(6), CYSLTR2(1), DRD1(3), DRD2(9), DRD3(7), DRD4(3), DRD5(10), EDNRA(4), F2(9), F2R(3), F2RL1(2), F2RL2(3), F2RL3(3), FPR1(6), FSHB(1), GABBR1(16), GABBR2(11), GABRA1(14), GABRA2(9), GABRA3(10), GABRA4(9), GABRA5(7), GABRA6(10), GABRB1(8), GABRB2(5), GABRB3(9), GABRD(7), GABRE(7), GABRG1(4), GABRG2(13), GABRG3(6), GABRP(4), GABRQ(12), GABRR1(6), GABRR2(4), GALR1(6), GALR2(10), GALR3(2), GH1(2), GH2(1), GHR(6), GHRHR(4), GHSR(9), GIPR(4), GLP1R(1), GLP2R(8), GLRA1(4), GLRA2(5), GLRA3(6), GLRB(8), GNRHR(4), GPR156(5), GPR35(4), GPR50(11), GPR63(2), GPR83(5), GRIA1(20), GRIA2(23), GRIA3(8), GRIA4(10), GRID1(24), GRID2(16), GRIK1(11), GRIK2(18), GRIK3(16), GRIK4(14), GRIK5(10), GRIN1(8), GRIN2A(16), GRIN2B(23), GRIN2C(6), GRIN2D(7), GRIN3A(18), GRIN3B(6), GRM1(31), GRM2(23), GRM3(17), GRM4(11), GRM5(26), GRM6(10), GRM7(20), GRM8(22), GRPR(6), GZMA(3), HCRTR1(5), HCRTR2(10), HRH1(5), HRH2(8), HRH3(5), HRH4(3), HTR1A(11), HTR1B(10), HTR1D(4), HTR1E(10), HTR1F(8), HTR2A(6), HTR2B(5), HTR2C(6), HTR4(5), HTR5A(9), HTR6(7), HTR7(10), LEP(2), LEPR(13), LHB(1), LHCGR(11), LTB4R(2), LTB4R2(4), MAS1(2), MC1R(6), MC2R(2), MC3R(9), MC4R(5), MC5R(5), MCHR1(6), MCHR2(4), MLNR(4), MTNR1A(5), MTNR1B(6), NMBR(4), NMUR1(5), NMUR2(5), NPBWR1(13), NPBWR2(8), NPFFR1(1), NPFFR2(10), NPY1R(4), NPY2R(6), NPY5R(4), NR3C1(6), NTSR1(7), NTSR2(4), OPRD1(2), OPRK1(14), OPRL1(6), OPRM1(4), OXTR(7), P2RX1(3), P2RX2(7), P2RX3(6), P2RX4(6), P2RX5(5), P2RX7(1), P2RY1(3), P2RY10(10), P2RY13(4), P2RY14(4), P2RY2(5), P2RY4(5), P2RY6(8), P2RY8(7), PARD3(11), PRL(1), PRLHR(7), PRLR(4), PRSS1(1), PRSS3(3), PTAFR(5), PTGDR(7), PTGER2(5), PTGER3(5), PTGER4(8), PTGFR(5), PTH2R(8), RXFP1(9), RXFP2(10), SCTR(3), SSTR1(9), SSTR2(4), SSTR3(8), SSTR4(14), SSTR5(4), TAAR1(4), TAAR2(3), TAAR5(6), TAAR6(7), TACR1(3), TACR2(1), TACR3(15), TBXA2R(8), THRA(6), THRB(9), TRHR(5), TRPV1(8), TSHB(3), TSHR(10), UTS2R(3), VIPR1(3), VIPR2(3) 94196153 1621 227 1570 553 598 362 68 379 211 3 0.00114 1.000 1.000 189 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(8), ACTG1(1), CHAD(6), COL11A1(34), COL11A2(16), COL17A1(10), COL1A1(12), COL1A2(30), COL2A1(16), COL3A1(12), COL4A1(29), COL4A2(13), COL4A4(15), COL4A6(9), COL5A1(29), COL5A2(17), COL5A3(15), COL6A1(9), COL6A2(19), COL6A3(41), COL6A6(34), COMP(3), DES(1), DSC1(2), DSC2(12), DSC3(5), DSG1(5), DSG2(6), DSG3(10), DSG4(8), FN1(29), GJA1(11), GJA10(3), GJA3(2), GJA4(4), GJA5(8), GJA8(8), GJA9(3), GJB1(1), GJB3(4), GJB4(4), GJB5(2), GJB6(5), GJB7(2), GJC1(3), GJC2(3), GJD2(5), GJD4(6), IBSP(2), INA(7), ITGA6(6), ITGB4(18), KRT1(6), KRT10(6), KRT12(3), KRT13(9), KRT14(2), KRT15(3), KRT16(8), KRT17(5), KRT18(2), KRT19(2), KRT2(10), KRT20(4), KRT23(11), KRT24(6), KRT25(7), KRT27(8), KRT28(10), KRT3(8), KRT31(6), KRT32(7), KRT33A(9), KRT33B(4), KRT34(6), KRT35(4), KRT36(6), KRT37(3), KRT38(4), KRT39(8), KRT4(7), KRT40(1), KRT5(4), KRT6A(9), KRT6B(3), KRT6C(7), KRT7(3), KRT71(2), KRT72(6), KRT73(15), KRT74(4), KRT75(5), KRT76(4), KRT77(2), KRT78(3), KRT79(5), KRT8(6), KRT81(3), KRT82(3), KRT83(3), KRT84(6), KRT85(3), KRT86(3), KRT9(1), LAMA1(45), LAMA2(33), LAMA3(24), LAMA4(26), LAMA5(29), LAMB1(18), LAMB2(24), LAMB3(20), LAMB4(19), LAMC1(21), LAMC2(12), LAMC3(18), LMNA(6), LMNB1(4), LMNB2(6), NES(12), PRPH(3), RELN(47), SPP1(4), THBS1(16), THBS2(15), THBS3(9), THBS4(13), TNC(25), TNN(22), TNR(23), TNXB(43), VIM(10), VTN(8), VWF(28) 107036911 1421 221 1387 574 435 324 55 320 271 16 0.971 1.000 1.000 190 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 240 ACVR1B(13), ACVR1C(5), AKT1(3), AKT2(8), AKT3(6), ARRB1(3), ARRB2(1), ATF2(3), ATF4(2), BDNF(8), BRAF(16), CACNA1A(24), CACNA1B(24), CACNA1C(37), CACNA1D(35), CACNA1E(44), CACNA1F(11), CACNA1G(23), CACNA1H(25), CACNA1I(18), CACNA1S(17), CACNA2D1(10), CACNA2D2(9), CACNA2D3(17), CACNA2D4(9), CACNB1(1), CACNB2(15), CACNB3(2), CACNB4(6), CACNG1(5), CACNG2(2), CACNG3(5), CACNG4(3), CACNG5(9), CACNG6(3), CACNG7(11), CACNG8(3), CASP3(2), CD14(2), CDC25B(4), CDC42(1), CHUK(4), CRKL(1), DAXX(10), DDIT3(4), DUSP1(2), DUSP10(8), DUSP14(3), DUSP16(9), DUSP2(2), DUSP3(1), DUSP4(1), DUSP5(8), DUSP6(3), DUSP8(1), DUSP9(5), ECSIT(4), EGF(10), EGFR(15), ELK1(3), ELK4(1), FAS(3), FASLG(3), FGF1(3), FGF10(5), FGF11(1), FGF12(8), FGF14(6), FGF16(1), FGF17(5), FGF18(2), FGF19(1), FGF2(2), FGF20(3), FGF21(1), FGF22(2), FGF23(2), FGF3(2), FGF5(5), FGF6(6), FGF7(1), FGF8(1), FGF9(6), FGFR1(13), FGFR2(11), FGFR3(6), FGFR4(9), FLNA(26), FLNB(32), FLNC(26), FOS(1), GADD45B(1), GNA12(1), GRB2(4), IKBKB(8), IL1A(2), IL1B(3), IL1R1(4), IL1R2(10), JUN(4), JUND(2), MAP2K1(5), MAP2K2(3), MAP2K3(4), MAP2K4(8), MAP2K5(1), MAP2K6(1), MAP3K1(11), MAP3K10(8), MAP3K12(15), MAP3K13(9), MAP3K2(4), MAP3K3(8), MAP3K4(21), MAP3K5(5), MAP3K6(8), MAP3K7(10), MAP4K1(4), MAP4K2(8), MAP4K3(4), MAP4K4(10), MAPK1(3), MAPK10(5), MAPK11(1), MAPK13(3), MAPK14(1), MAPK3(1), MAPK7(6), MAPK8(5), MAPK8IP1(4), MAPK8IP2(4), MAPK8IP3(13), MAPK9(3), MAPKAPK2(1), MAPKAPK3(5), MAPKAPK5(3), MAPT(7), MAX(3), MEF2C(4), MKNK1(3), MKNK2(7), MOS(11), MRAS(2), MYC(5), NF1(26), NFATC2(17), NFATC4(16), NFKB1(7), NFKB2(7), NR4A1(4), NRAS(3), NTF3(5), NTRK1(10), NTRK2(13), PAK1(5), PAK2(7), PDGFA(2), PDGFB(4), PDGFRA(11), PDGFRB(14), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6), PPM1A(4), PPM1B(10), PPP3CA(10), PPP3CB(6), PPP3CC(5), PPP3R1(2), PPP5C(8), PRKACA(4), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(17), PRKX(5), PTPN5(6), PTPN7(7), PTPRR(11), RAC2(2), RAC3(4), RAF1(10), RAP1A(2), RAP1B(6), RAPGEF2(14), RASA1(17), RASA2(8), RASGRF1(16), RASGRF2(12), RASGRP1(8), RASGRP2(7), RASGRP3(5), RASGRP4(4), RPS6KA1(9), RPS6KA2(9), RPS6KA3(4), RPS6KA4(6), RPS6KA5(3), RPS6KA6(15), RRAS(1), RRAS2(3), SOS1(7), SOS2(19), SRF(2), STK3(5), STK4(3), STMN1(2), TAOK1(11), TAOK2(19), TAOK3(11), TGFB1(3), TGFB2(6), TGFB3(8), TGFBR1(4), TGFBR2(14), TNF(3), TNFRSF1A(6), TRAF2(4), TRAF6(6), ZAK(9) 120700455 1623 220 1555 507 550 369 62 279 345 18 0.000766 1.000 1.000 191 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 198 ABI2(6), ACTN1(7), ACTN2(23), ACTN4(11), APC(43), APC2(15), ARAF(11), ARHGEF1(11), ARHGEF12(14), ARHGEF4(8), ARHGEF6(13), ARHGEF7(8), ARPC1A(3), ARPC2(3), ARPC4(2), ARPC5L(1), BAIAP2(5), BCAR1(8), BDKRB1(2), BDKRB2(4), BRAF(16), CD14(2), CDC42(1), CFL1(1), CFL2(1), CHRM1(4), CHRM2(17), CHRM3(11), CHRM4(2), CHRM5(2), CRKL(1), CSK(7), CYFIP1(11), CYFIP2(16), DIAPH1(11), DIAPH2(7), DIAPH3(13), DOCK1(17), EGF(10), EGFR(15), EZR(6), F2(9), F2R(3), FGD1(12), FGD3(12), FGF1(3), FGF10(5), FGF11(1), FGF12(8), FGF14(6), FGF16(1), FGF17(5), FGF18(2), FGF19(1), FGF2(2), FGF20(3), FGF21(1), FGF22(2), FGF23(2), FGF3(2), FGF5(5), FGF6(6), FGF7(1), FGF8(1), FGF9(6), FGFR1(13), FGFR2(11), FGFR3(6), FGFR4(9), FN1(29), GIT1(3), GNA12(1), GNA13(5), GSN(11), IQGAP1(14), IQGAP2(10), IQGAP3(14), ITGA1(8), ITGA10(9), ITGA11(10), ITGA2(8), ITGA2B(9), ITGA3(11), ITGA4(12), ITGA5(5), ITGA6(6), ITGA7(16), ITGA8(6), ITGA9(8), ITGAD(12), ITGAE(12), ITGAL(16), ITGAM(9), ITGAV(13), ITGAX(14), ITGB1(10), ITGB2(6), ITGB3(7), ITGB4(18), ITGB5(7), ITGB6(4), ITGB7(6), ITGB8(14), LIMK1(5), LIMK2(2), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), MOS(11), MRAS(2), MSN(9), MYH10(36), MYH14(18), MYH9(34), MYL2(8), MYL7(1), MYL9(2), MYLK(22), MYLK2(4), NCKAP1(9), NCKAP1L(14), NRAS(3), PAK1(5), PAK2(7), PAK3(5), PAK4(8), PAK6(9), PAK7(9), PDGFA(2), PDGFB(4), PDGFRA(11), PDGFRB(14), PFN2(2), PFN3(3), PFN4(1), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(11), PIK3R3(8), PIK3R5(8), PIP4K2A(6), PIP4K2B(4), PIP4K2C(2), PIP5K1A(4), PIP5K1B(1), PIP5K1C(11), PPP1CA(2), PPP1CB(1), PPP1CC(5), PPP1R12A(2), PPP1R12B(15), PTK2(11), PXN(4), RAC2(2), RAC3(4), RAF1(10), RDX(7), ROCK1(18), ROCK2(12), RRAS(1), RRAS2(3), SCIN(6), SLC9A1(10), SOS1(7), SOS2(19), SSH1(9), SSH2(22), SSH3(8), TIAM1(32), TIAM2(23), VAV1(9), VAV2(12), VAV3(10), VCL(6), WAS(3), WASF1(5), WASF2(5), WASL(3) 116837455 1519 219 1466 535 507 337 54 293 304 24 0.429 1.000 1.000 192 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 136 ADCY1(19), ADCY2(17), ADCY3(12), ADCY4(9), ADCY5(13), ADCY6(14), ADCY7(16), ADCY8(31), ADCY9(13), ADRA1A(16), ADRA1B(5), ADRA1D(4), ADRB1(7), ADRB2(8), ADRB3(5), ANXA6(2), ARRB1(3), ARRB2(1), ATP1A4(19), ATP1B1(6), ATP1B2(3), ATP1B3(4), ATP2A2(5), ATP2A3(6), ATP2B1(12), ATP2B2(18), ATP2B3(21), CACNA1A(24), CACNA1B(24), CACNA1C(37), CACNA1D(35), CACNA1E(44), CACNA1S(17), CACNB1(1), CACNB3(2), CALM1(2), CALM2(2), CALR(5), CAMK1(3), CAMK2A(3), CAMK2B(4), CAMK2D(3), CAMK2G(8), CAMK4(8), CASQ1(6), CASQ2(3), CHRM1(4), CHRM2(17), CHRM3(11), CHRM4(2), CHRM5(2), GJA1(11), GJA4(4), GJA5(8), GJB1(1), GJB3(4), GJB4(4), GJB5(2), GJB6(5), GNA11(6), GNAI2(3), GNAI3(7), GNAO1(1), GNAQ(4), GNAZ(17), GNB1(1), GNB2(3), GNB3(1), GNB4(3), GNB5(1), GNG13(2), GNGT1(3), GRK4(5), GRK5(1), GRK6(5), ITPR1(24), ITPR2(30), ITPR3(36), KCNB1(12), KCNJ5(5), MIB1(4), NME7(1), PKIA(2), PKIG(2), PLCB3(12), PRKACA(4), PRKACB(4), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PRKCA(5), PRKCD(7), PRKCE(14), PRKCG(17), PRKCH(6), PRKCQ(10), PRKD1(20), RGS1(2), RGS10(3), RGS11(2), RGS14(3), RGS16(3), RGS17(4), RGS18(6), RGS19(3), RGS2(3), RGS20(6), RGS3(13), RGS4(6), RGS5(3), RGS6(14), RGS7(2), RGS9(10), RYR1(61), RYR2(82), RYR3(68), SFN(1), SLC8A1(14), SLC8A3(9), USP5(6), YWHAB(2), YWHAH(3), YWHAQ(2) 79896656 1223 214 1189 438 447 279 53 238 195 11 0.0714 1.000 1.000 193 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(15), CD36(2), CD44(5), CHAD(6), COL11A1(34), COL11A2(16), COL1A1(12), COL1A2(30), COL2A1(16), COL3A1(12), COL4A1(29), COL4A2(13), COL4A4(15), COL4A6(9), COL5A1(29), COL5A2(17), COL5A3(15), COL6A1(9), COL6A2(19), COL6A3(41), COL6A6(34), DAG1(13), FN1(29), FNDC1(15), FNDC3A(8), FNDC4(2), FNDC5(2), GP5(7), GP6(3), GP9(3), HMMR(7), HSPG2(35), IBSP(2), ITGA1(8), ITGA10(9), ITGA11(10), ITGA2(8), ITGA2B(9), ITGA3(11), ITGA4(12), ITGA5(5), ITGA6(6), ITGA7(16), ITGA8(6), ITGA9(8), ITGAV(13), ITGB1(10), ITGB3(7), ITGB4(18), ITGB5(7), ITGB6(4), ITGB7(6), ITGB8(14), LAMA1(45), LAMA2(33), LAMA3(24), LAMA4(26), LAMA5(29), LAMB1(18), LAMB2(24), LAMB3(20), LAMB4(19), LAMC1(21), LAMC2(12), LAMC3(18), RELN(47), SDC1(2), SDC2(2), SDC3(5), SDC4(3), SPP1(4), SV2A(13), SV2B(5), SV2C(9), THBS1(16), THBS2(15), THBS3(9), THBS4(13), TNC(25), TNN(22), TNR(23), TNXB(43), VTN(8), VWF(28) 96226801 1272 214 1229 489 395 271 44 288 256 18 0.828 1.000 1.000 194 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 128 ACTB(8), ACTG1(1), ACTN1(7), ACTN2(23), ACTN4(11), AKT1(3), AKT2(8), AKT3(6), AMOTL1(8), ASH1L(39), CASK(6), CDC42(1), CGN(12), CLDN1(3), CLDN10(2), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(4), CLDN17(6), CLDN18(2), CLDN19(6), CLDN2(1), CLDN20(4), CLDN22(3), CLDN23(3), CLDN3(1), CLDN4(6), CLDN5(2), CLDN6(7), CLDN8(2), CLDN9(7), CSNK2A1(5), CSNK2A2(6), CSNK2B(1), CTNNA1(15), CTNNA2(19), CTNNA3(16), CTNNB1(22), CTTN(7), EPB41(11), EPB41L1(6), EPB41L2(9), EPB41L3(27), EXOC3(3), EXOC4(8), F11R(2), GNAI1(1), GNAI2(3), GNAI3(7), HCLS1(3), IGSF5(3), INADL(16), JAM2(2), JAM3(7), LLGL1(9), LLGL2(6), MAGI1(20), MAGI2(27), MAGI3(9), MLLT4(24), MPDZ(23), MPP5(2), MRAS(2), MYH1(20), MYH10(36), MYH11(29), MYH13(23), MYH14(18), MYH15(17), MYH2(29), MYH3(27), MYH4(22), MYH6(27), MYH7(23), MYH7B(18), MYH8(18), MYH9(34), MYL2(8), MYL7(1), MYL9(2), NRAS(3), OCLN(6), PARD3(11), PARD6A(1), PARD6B(3), PARD6G(3), PPM1J(2), PPP2CA(4), PPP2CB(3), PPP2R1A(11), PPP2R1B(6), PPP2R2A(6), PPP2R2B(8), PPP2R2C(8), PPP2R3A(9), PPP2R3B(15), PPP2R4(4), PRKCA(5), PRKCD(7), PRKCE(14), PRKCG(17), PRKCH(6), PRKCI(8), PRKCQ(10), RAB13(2), RAB3B(3), RRAS(1), RRAS2(3), SPTAN1(21), SRC(3), SYMPK(7), TJAP1(2), TJP1(21), TJP2(15), TJP3(11), VAPA(3), YES1(2), ZAK(9) 82619342 1143 207 1105 353 372 261 39 247 215 9 0.0177 1.000 1.000 195 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 124 ABL1(7), ABLIM1(12), ABLIM2(11), ABLIM3(6), ARHGEF12(14), CDC42(1), CDK5(2), CFL1(1), CFL2(1), CXCR4(1), DCC(32), DPYSL2(2), DPYSL5(10), EFNA1(1), EFNA2(1), EFNA4(2), EFNA5(4), EFNB1(1), EFNB2(3), EFNB3(7), EPHA1(13), EPHA2(25), EPHA3(23), EPHA4(17), EPHA5(29), EPHA7(6), EPHA8(13), EPHB1(23), EPHB2(12), EPHB3(13), EPHB4(9), EPHB6(14), FES(11), FYN(10), GNAI1(1), GNAI2(3), GNAI3(7), GSK3B(5), ITGB1(10), L1CAM(16), LIMK1(5), LIMK2(2), LRRC4C(5), MAPK1(3), MAPK3(1), MET(8), NCK1(6), NCK2(5), NFAT5(10), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), NGEF(6), NRAS(3), NRP1(14), NTN1(7), NTN4(2), NTNG1(19), PAK1(5), PAK2(7), PAK3(5), PAK4(8), PAK6(9), PAK7(9), PLXNA1(33), PLXNA2(25), PLXNA3(20), PLXNB1(19), PLXNB2(17), PLXNB3(12), PLXNC1(20), PPP3CA(10), PPP3CB(6), PPP3CC(5), PPP3R1(2), PTK2(11), RAC2(2), RAC3(4), RASA1(17), RGS3(13), RHOD(2), RND1(3), ROBO1(30), ROBO2(33), ROBO3(11), ROCK1(18), ROCK2(12), SEMA3A(15), SEMA3C(7), SEMA3D(12), SEMA3E(12), SEMA3F(11), SEMA3G(5), SEMA4A(9), SEMA4B(3), SEMA4C(9), SEMA4D(15), SEMA4F(8), SEMA4G(4), SEMA5A(24), SEMA5B(20), SEMA6A(18), SEMA6B(6), SEMA6C(10), SEMA6D(20), SEMA7A(7), SLIT1(11), SLIT2(27), SLIT3(15), SRGAP1(12), SRGAP2(6), SRGAP3(13), UNC5A(10), UNC5B(10), UNC5C(16), UNC5D(16) 83217476 1244 206 1205 421 384 266 65 263 252 14 0.193 1.000 1.000 196 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 125 ALCAM(10), CADM3(11), CD2(3), CD22(5), CD226(2), CD274(2), CD276(6), CD28(1), CD34(4), CD40(3), CD40LG(5), CD58(6), CD6(9), CD80(4), CD86(6), CD8A(4), CD8B(1), CD99(1), CDH15(6), CDH2(19), CDH3(10), CDH4(22), CDH5(10), CLDN1(3), CLDN10(2), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(4), CLDN17(6), CLDN18(2), CLDN19(6), CLDN2(1), CLDN20(4), CLDN22(3), CLDN23(3), CLDN3(1), CLDN4(6), CLDN5(2), CLDN6(7), CLDN8(2), CLDN9(7), CNTN1(19), CNTN2(10), CNTNAP1(18), CNTNAP2(40), CTLA4(3), ESAM(5), F11R(2), GLG1(13), HLA-C(6), HLA-DMA(1), HLA-DMB(3), HLA-DOA(2), HLA-DOB(2), HLA-DPA1(2), HLA-DPB1(3), HLA-DQA1(1), HLA-DQA2(3), HLA-DQB1(1), HLA-DRA(8), HLA-E(5), HLA-F(7), HLA-G(5), ICAM1(2), ICAM2(3), ICAM3(1), ICOS(2), ICOSLG(2), ITGA4(12), ITGA6(6), ITGA8(6), ITGA9(8), ITGAL(16), ITGAM(9), ITGAV(13), ITGB1(10), ITGB2(6), ITGB7(6), ITGB8(14), JAM2(2), JAM3(7), L1CAM(16), MAG(14), MPZ(2), MPZL1(2), NCAM1(4), NCAM2(24), NEGR1(7), NEO1(14), NFASC(18), NLGN1(16), NLGN2(10), NLGN3(13), NRCAM(11), NRXN1(39), NRXN2(25), NRXN3(28), OCLN(6), PDCD1(2), PDCD1LG2(1), PTPRC(19), PTPRF(18), PTPRM(28), PVR(3), PVRL1(1), PVRL2(5), PVRL3(6), SDC1(2), SDC2(2), SDC3(5), SDC4(3), SELE(5), SELL(4), SELP(10), SELPLG(7), SIGLEC1(18), SPN(4), VCAM1(10), VCAN(41) 61274097 941 201 906 343 300 244 29 203 157 8 0.165 1.000 1.000 197 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 139 APC(43), APC2(15), AXIN1(9), AXIN2(15), BTRC(9), CACYBP(2), CAMK2A(3), CAMK2B(4), CAMK2D(3), CAMK2G(8), CCND1(1), CCND2(3), CCND3(2), CER1(2), CHD8(19), CREBBP(40), CSNK1A1(3), CSNK1A1L(6), CSNK1E(8), CSNK2A1(5), CSNK2A2(6), CSNK2B(1), CTBP1(3), CTBP2(8), CTNNB1(22), CTNNBIP1(1), CUL1(22), CXXC4(2), DAAM1(11), DAAM2(13), DKK1(9), DKK2(5), DKK4(3), DVL1(7), DVL2(6), DVL3(12), EP300(22), FBXW11(10), FOSL1(1), FZD1(10), FZD10(18), FZD2(7), FZD3(11), FZD4(6), FZD5(4), FZD6(9), FZD7(7), FZD8(10), FZD9(2), GSK3B(5), JUN(4), LEF1(8), LRP5(22), LRP6(7), MAP3K7(10), MAPK10(5), MAPK8(5), MAPK9(3), MMP7(2), MYC(5), NFAT5(10), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), NKD1(10), NKD2(1), PLCB1(19), PLCB2(8), PLCB3(12), PLCB4(13), PORCN(5), PPARD(8), PPP2CA(4), PPP2CB(3), PPP2R1A(11), PPP2R1B(6), PPP2R2A(6), PPP2R2B(8), PPP2R2C(8), PPP3CA(10), PPP3CB(6), PPP3CC(5), PPP3R1(2), PRICKLE1(16), PRICKLE2(16), PRKACA(4), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(17), PRKX(5), PSEN1(3), RAC2(2), RAC3(4), RBX1(1), ROCK1(18), ROCK2(12), RUVBL1(8), SENP2(4), SFRP1(4), SFRP2(6), SFRP4(5), SFRP5(1), SIAH1(2), SMAD2(9), SMAD3(5), SOX17(11), TBL1X(6), TBL1XR1(6), TBL1Y(1), TCF7(8), TCF7L1(5), TCF7L2(11), VANGL1(2), VANGL2(9), WIF1(2), WNT1(8), WNT10A(5), WNT10B(2), WNT11(2), WNT2(4), WNT2B(10), WNT3(5), WNT3A(6), WNT4(2), WNT5A(6), WNT5B(4), WNT6(3), WNT7A(5), WNT7B(7), WNT8A(1), WNT8B(1), WNT9A(8), WNT9B(4) 67539649 1032 198 983 300 355 238 27 165 232 15 0.000181 1.000 1.000 198 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 135 ACTA1(3), ACTA2(6), ADCY1(19), ADCY2(17), ADCY3(12), ADCY4(9), ADCY5(13), ADCY6(14), ADCY7(16), ADCY8(31), ADCY9(13), ADM(2), ARRB1(3), ARRB2(1), ATF2(3), ATF3(1), ATF4(2), ATF5(3), ATP2A2(5), ATP2A3(6), CACNB3(2), CALCA(2), CALM1(2), CALM2(2), CAMK2A(3), CAMK2B(4), CAMK2D(3), CAMK2G(8), CNN1(3), CNN2(1), CORIN(13), CRHR1(11), DGKZ(8), ETS2(4), FOS(1), GABPA(2), GABPB2(3), GBA2(4), GJA1(11), GNAQ(4), GNB1(1), GNB2(3), GNB3(1), GNB4(3), GNB5(1), GNG13(2), GNGT1(3), GRK4(5), GRK5(1), GRK6(5), GUCA2A(1), GUCA2B(1), GUCY1A3(15), IGFBP2(5), IGFBP3(6), IGFBP4(1), IGFBP6(1), IL1B(3), ITPR1(24), ITPR2(30), ITPR3(36), JUN(4), MAFF(1), MIB1(4), MYL2(8), MYLK2(4), NFKB1(7), NOS1(28), NOS3(10), OXT(1), OXTR(7), PDE4B(5), PDE4D(4), PKIA(2), PKIG(2), PLCB3(12), PLCD1(4), PLCG1(19), PLCG2(15), PRKACA(4), PRKACB(4), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PRKCA(5), PRKCD(7), PRKCE(14), PRKCH(6), PRKCQ(10), PRKD1(20), RAMP2(2), RAMP3(3), RGS1(2), RGS10(3), RGS11(2), RGS14(3), RGS16(3), RGS17(4), RGS18(6), RGS19(3), RGS2(3), RGS20(6), RGS3(13), RGS4(6), RGS5(3), RGS6(14), RGS7(2), RGS9(10), RLN1(3), RYR1(61), RYR2(82), RYR3(68), SFN(1), SLC8A1(14), SP1(6), TNXB(43), USP5(6), YWHAB(2), YWHAH(3), YWHAQ(2) 74010410 1023 193 993 376 361 214 44 221 173 10 0.335 1.000 1.000 199 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 249 ACVR1(5), ACVR1B(13), ACVR2A(8), ACVR2B(5), AMHR2(4), BMP2(5), BMP7(7), BMPR1A(5), BMPR1B(7), BMPR2(16), CCL1(2), CCL11(1), CCL15(2), CCL16(1), CCL18(2), CCL19(2), CCL2(1), CCL20(2), CCL22(1), CCL23(1), CCL24(1), CCL25(1), CCL27(1), CCL3(1), CCL5(2), CCL7(1), CCL8(2), CCR1(5), CCR2(6), CCR3(6), CCR5(4), CCR6(1), CCR7(3), CCR8(3), CCR9(3), CD27(2), CD40(3), CD40LG(5), CD70(2), CLCF1(2), CNTF(3), CNTFR(3), CRLF2(2), CSF1(2), CSF1R(15), CSF2RA(9), CSF2RB(9), CSF3(2), CSF3R(13), CX3CL1(7), CX3CR1(3), CXCL10(1), CXCL2(2), CXCL9(2), CXCR3(1), CXCR4(1), CXCR6(2), EDA(2), EDA2R(3), EDAR(9), EGF(10), EGFR(15), EPO(1), EPOR(3), FAS(3), FASLG(3), FLT1(16), FLT3(10), FLT3LG(1), FLT4(24), GDF5(11), GH1(2), GH2(1), GHR(6), HGF(15), IFNA1(1), IFNA10(4), IFNA13(1), IFNA16(4), IFNA2(1), IFNA4(1), IFNA5(2), IFNA6(3), IFNA7(4), IFNA8(1), IFNAR1(8), IFNAR2(6), IFNB1(3), IFNG(2), IFNGR1(6), IFNGR2(2), IFNK(1), IFNW1(4), IL10(2), IL10RA(5), IL10RB(3), IL11(3), IL11RA(3), IL12A(2), IL12B(2), IL12RB1(5), IL12RB2(11), IL13(2), IL13RA1(4), IL15RA(3), IL17B(4), IL17RA(7), IL17RB(6), IL18(1), IL18R1(4), IL18RAP(2), IL19(1), IL1A(2), IL1B(3), IL1R1(4), IL1R2(10), IL1RAP(7), IL20(1), IL20RA(8), IL21(4), IL21R(9), IL22(1), IL22RA1(2), IL22RA2(1), IL23A(3), IL23R(7), IL25(4), IL26(4), IL2RA(3), IL2RB(2), IL2RG(6), IL3(1), IL3RA(5), IL4(1), IL4R(3), IL5RA(4), IL6R(2), IL6ST(6), IL7(1), IL7R(9), IL9R(2), INHBA(12), INHBB(10), INHBC(6), INHBE(2), KDR(13), KIT(12), KITLG(3), LEP(2), LEPR(13), LIF(2), LIFR(13), LTA(4), LTBR(2), MET(8), MPL(5), NGFR(4), OSM(5), OSMR(8), PDGFB(4), PDGFC(7), PDGFRA(11), PDGFRB(14), PF4V1(1), PLEKHO2(3), PRL(1), PRLR(4), RELT(6), TGFB1(3), TGFB2(6), TGFB3(8), TGFBR1(4), TGFBR2(14), TNF(3), TNFRSF10A(1), TNFRSF10B(2), TNFRSF10C(3), TNFRSF10D(3), TNFRSF11A(5), TNFRSF11B(3), TNFRSF13B(5), TNFRSF13C(4), TNFRSF14(1), TNFRSF17(1), TNFRSF19(9), TNFRSF1A(6), TNFRSF1B(3), TNFRSF21(5), TNFRSF25(4), TNFRSF4(3), TNFRSF8(4), TNFRSF9(11), TNFSF10(5), TNFSF11(4), TNFSF13(3), TNFSF13B(4), TNFSF14(3), TNFSF15(2), TNFSF18(2), TNFSF4(1), TNFSF8(3), TPO(24), TSLP(1), VEGFB(1), VEGFC(9), XCL1(1), XCR1(4) 75871830 948 191 912 328 260 235 36 203 206 8 0.271 1.000 1.000 200 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(3), ACTA2(6), ACTN2(23), ACTN4(11), DES(1), DMD(62), MYBPC1(7), MYBPC2(10), MYBPC3(6), MYH3(27), MYH6(27), MYH7(23), MYH8(18), MYL1(1), MYL2(8), MYL3(3), MYL9(2), MYOM1(11), NEB(63), TMOD1(4), TNNI1(2), TNNI2(6), TNNT1(5), TNNT2(2), TNNT3(2), TPM1(4), TPM3(3), TPM4(3), TTN(480), VIM(10) 58405619 833 191 816 247 219 219 47 251 81 16 0.00889 1.000 1.000 201 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 159 ADORA1(5), ADORA2A(1), ADORA2B(1), ADORA3(5), ADRA1A(16), ADRA1B(5), ADRA1D(4), ADRA2A(7), ADRA2C(5), ADRB1(7), ADRB2(8), ADRB3(5), AGTR1(2), AGTR2(4), AVPR1A(14), AVPR1B(3), AVPR2(6), BDKRB1(2), BDKRB2(4), BRS3(3), C3AR1(8), CCKAR(5), CCKBR(9), CCR1(5), CCR10(1), CCR2(6), CCR3(6), CCR5(4), CCR6(1), CCR7(3), CCR8(3), CCR9(3), CCRL2(1), CHML(4), CHRM1(4), CHRM2(17), CHRM3(11), CHRM4(2), CHRM5(2), CMKLR1(4), CNR1(11), CX3CR1(3), CXCR3(1), CXCR4(1), DRD1(3), DRD2(9), DRD3(7), DRD4(3), DRD5(10), EDNRA(4), F2R(3), F2RL1(2), F2RL2(3), F2RL3(3), FPR1(6), GALR1(6), GALR2(10), GALR3(2), GALT(1), GHSR(9), GNB2L1(4), GPR17(5), GPR173(5), GPR174(3), GPR27(5), GPR3(4), GPR35(4), GPR37(10), GPR37L1(5), GPR4(3), GPR50(11), GPR6(11), GPR63(2), GPR83(5), GPR85(4), GPR87(5), GRPR(6), HCRTR1(5), HCRTR2(10), HRH1(5), HRH2(8), HRH3(5), HTR1A(11), HTR1B(10), HTR1D(4), HTR1E(10), HTR1F(8), HTR2A(6), HTR2B(5), HTR2C(6), HTR4(5), HTR5A(9), HTR6(7), HTR7(10), LHCGR(11), LTB4R(2), MAS1(2), MC1R(6), MC3R(9), MC4R(5), MC5R(5), MLNR(4), MTNR1A(5), MTNR1B(6), NMBR(4), NMUR1(5), NMUR2(5), NPY1R(4), NPY2R(6), NPY5R(4), NTSR1(7), NTSR2(4), OPN1SW(1), OPN3(4), OPRD1(2), OPRK1(14), OPRL1(6), OPRM1(4), OR10A5(5), OR11A1(5), OR12D3(4), OR1C1(5), OR1F1(4), OR1Q1(5), OR2H1(2), OR5V1(7), OR7C1(6), OR8B8(5), OXTR(7), P2RY1(3), P2RY10(10), P2RY12(6), P2RY13(4), P2RY14(4), P2RY2(5), P2RY6(8), PTAFR(5), PTGDR(7), PTGER2(5), PTGER4(8), PTGFR(5), RGR(3), RHO(7), RRH(3), SSTR1(9), SSTR2(4), SSTR3(8), SSTR4(14), SUCNR1(4), TBXA2R(8), TRHR(5) 51266770 834 187 807 317 314 203 33 174 107 3 0.0969 1.000 1.000 202 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 141 ADA(5), ADCY1(19), ADCY2(17), ADCY3(12), ADCY4(9), ADCY5(13), ADCY6(14), ADCY7(16), ADCY8(31), ADCY9(13), ADK(4), ADSL(5), ADSS(5), ADSSL1(8), AK1(1), AK5(4), AK7(4), ALLC(5), AMPD1(9), AMPD2(13), AMPD3(20), APRT(3), ATIC(6), CANT1(4), DGUOK(2), ENPP1(7), ENPP3(8), ENTPD1(5), ENTPD2(4), ENTPD3(5), ENTPD4(8), ENTPD5(3), ENTPD6(4), ENTPD8(6), GART(9), GDA(4), GMPR(1), GMPR2(3), GMPS(7), GUCY1A2(10), GUCY1A3(15), GUCY1B3(8), GUCY2C(12), GUCY2D(12), GUCY2F(15), GUK1(4), IMPDH1(5), ITPA(1), NME2(3), NME6(3), NME7(1), NPR1(11), NPR2(8), NT5C(1), NT5C1A(5), NT5C1B(6), NT5C2(8), NT5E(2), NUDT2(4), NUDT9(2), PAICS(1), PAPSS1(6), PAPSS2(5), PDE10A(13), PDE11A(8), PDE1A(7), PDE1C(11), PDE2A(15), PDE3B(20), PDE4A(7), PDE4B(5), PDE4C(6), PDE4D(4), PDE5A(7), PDE6D(1), PDE6G(1), PDE7A(5), PDE7B(3), PDE8A(10), PDE8B(5), PDE9A(7), PFAS(9), PKLR(7), PNPT1(5), POLA1(6), POLA2(4), POLD1(15), POLD2(4), POLD3(7), POLE(24), POLE2(4), POLE3(3), POLR1A(15), POLR1B(8), POLR1C(3), POLR1D(4), POLR2A(19), POLR2B(11), POLR2C(4), POLR2E(2), POLR2F(4), POLR2G(1), POLR2I(2), POLR2K(1), POLR3A(17), POLR3B(13), POLR3G(2), POLR3K(1), PPAT(5), PRIM1(2), PRIM2(1), PRPS1(3), PRPS1L1(2), PRPS2(3), PRUNE(4), RFC5(1), RRM1(5), RRM2(4), RRM2B(4), XDH(14), ZNRD1(1) 69850220 843 181 822 282 264 212 28 176 157 6 0.195 1.000 1.000 203 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 91 ADCY1(19), ADCY2(17), ADCY3(12), ADCY4(9), ADCY5(13), ADCY6(14), ADCY7(16), ADCY8(31), ADCY9(13), ADRB1(7), CSNK1D(2), DRD1(3), DRD2(9), EGF(10), EGFR(15), GJA1(11), GJD2(5), GNA11(6), GNAI1(1), GNAI2(3), GNAI3(7), GNAQ(4), GNAS(29), GRB2(4), GRM1(31), GRM5(26), GUCY1A2(10), GUCY1A3(15), GUCY1B3(8), GUCY2C(12), GUCY2D(12), GUCY2F(15), HTR2A(6), HTR2B(5), HTR2C(6), ITPR1(24), ITPR2(30), ITPR3(36), MAP2K1(5), MAP2K2(3), MAP2K5(1), MAP3K2(4), MAPK1(3), MAPK3(1), MAPK7(6), NPR1(11), NPR2(8), NRAS(3), PDGFA(2), PDGFB(4), PDGFC(7), PDGFD(9), PDGFRA(11), PDGFRB(14), PLCB1(19), PLCB2(8), PLCB3(12), PLCB4(13), PRKACA(4), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(17), PRKG1(10), PRKG2(13), PRKX(5), RAF1(10), SOS1(7), SOS2(19), SRC(3), TJP1(21), TUBA1A(2), TUBA1B(1), TUBA1C(1), TUBA3C(8), TUBA3D(7), TUBA3E(8), TUBA4A(1), TUBA8(5), TUBAL3(5), TUBB1(5), TUBB2A(3), TUBB2B(3), TUBB3(7), TUBB6(7), TUBB8(2) 56543534 831 178 807 292 275 197 33 183 138 5 0.282 1.000 1.000 204 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 72 ARAF(11), BRAF(16), CACNA1A(24), CRHR1(11), GNA11(6), GNA12(1), GNA13(5), GNAI1(1), GNAI2(3), GNAI3(7), GNAO1(1), GNAQ(4), GNAS(29), GNAZ(17), GRIA1(20), GRIA2(23), GRIA3(8), GRID2(16), GRM1(31), GRM5(26), GUCY1A2(10), GUCY1A3(15), GUCY1B3(8), GUCY2C(12), GUCY2D(12), GUCY2F(15), IGF1(4), IGF1R(16), ITPR1(24), ITPR2(30), ITPR3(36), LYN(5), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), NOS1(28), NOS3(10), NPR1(11), NPR2(8), NRAS(3), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6), PLCB1(19), PLCB2(8), PLCB3(12), PLCB4(13), PPP2CA(4), PPP2CB(3), PPP2R1A(11), PPP2R1B(6), PPP2R2A(6), PPP2R2B(8), PPP2R2C(8), PRKCA(5), PRKCG(17), PRKG1(10), PRKG2(13), RAF1(10), RYR1(61) 46960385 767 175 736 232 273 169 28 177 115 5 0.0115 1.000 1.000 205 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 149 AKT1(3), AKT2(8), AKT3(6), CBL(3), CBLB(3), CBLC(5), CCND1(1), CCND2(3), CCND3(2), CISH(3), CLCF1(2), CNTF(3), CNTFR(3), CREBBP(40), CRLF2(2), CSF2RA(9), CSF2RB(9), CSF3(2), CSF3R(13), EP300(22), EPO(1), EPOR(3), GH1(2), GH2(1), GHR(6), GRB2(4), IFNA1(1), IFNA10(4), IFNA13(1), IFNA16(4), IFNA2(1), IFNA4(1), IFNA5(2), IFNA6(3), IFNA7(4), IFNA8(1), IFNAR1(8), IFNAR2(6), IFNB1(3), IFNG(2), IFNGR1(6), IFNGR2(2), IFNK(1), IFNW1(4), IL10(2), IL10RA(5), IL10RB(3), IL11(3), IL11RA(3), IL12A(2), IL12B(2), IL12RB1(5), IL12RB2(11), IL13(2), IL13RA1(4), IL13RA2(6), IL15RA(3), IL19(1), IL20(1), IL20RA(8), IL21(4), IL21R(9), IL22(1), IL22RA1(2), IL22RA2(1), IL23A(3), IL23R(7), IL26(4), IL2RA(3), IL2RB(2), IL2RG(6), IL3(1), IL3RA(5), IL4(1), IL4R(3), IL5RA(4), IL6R(2), IL6ST(6), IL7(1), IL7R(9), IL9R(2), IRF9(7), JAK1(12), JAK2(13), JAK3(13), LEP(2), LEPR(13), LIF(2), LIFR(13), MPL(5), MYC(5), OSM(5), OSMR(8), PIAS1(12), PIAS2(11), PIAS3(7), PIAS4(7), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(11), PIK3R3(8), PIK3R5(8), PIM1(2), PRL(1), PRLR(4), PTPN11(6), PTPN6(4), SOCS1(1), SOCS2(2), SOCS3(3), SOCS4(6), SOCS5(6), SOCS7(3), SOS1(7), SOS2(19), SPRED1(13), SPRED2(7), SPRY1(3), SPRY3(6), SPRY4(5), STAM(7), STAM2(5), STAT1(10), STAT2(10), STAT3(7), STAT4(6), STAT5A(3), STAT5B(14), STAT6(3), TPO(24), TSLP(1), TYK2(9) 61234552 765 173 722 231 194 192 26 155 192 6 0.0849 1.000 1.000 206 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 71 ACP1(5), ACTB(8), ACTG1(1), ACTN1(7), ACTN2(23), ACTN4(11), ACVR1B(13), ACVR1C(5), BAIAP2(5), CDC42(1), CREBBP(40), CSNK2A1(5), CSNK2A2(6), CSNK2B(1), CTNNA1(15), CTNNA2(19), CTNNA3(16), CTNNB1(22), CTNND1(19), EGFR(15), EP300(22), ERBB2(15), FARP2(4), FER(13), FGFR1(13), FYN(10), IGF1R(16), INSR(14), IQGAP1(14), LEF1(8), LMO7(14), MAP3K7(10), MAPK1(3), MAPK3(1), MET(8), MLLT4(24), PARD3(11), PTPN1(3), PTPN6(4), PTPRB(21), PTPRF(18), PTPRJ(27), PTPRM(28), PVRL1(1), PVRL2(5), PVRL3(6), PVRL4(7), RAC2(2), RAC3(4), SMAD2(9), SMAD3(5), SNAI1(3), SNAI2(11), SORBS1(9), SRC(3), SSX2IP(9), TCF7(8), TCF7L1(5), TCF7L2(11), TGFBR1(4), TGFBR2(14), TJP1(21), VCL(6), WAS(3), WASF1(5), WASF2(5), WASF3(13), WASL(3), YES1(2) 49675833 712 169 679 217 199 190 22 124 168 9 0.0304 1.000 1.000 207 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 87 ADCY1(19), ADCY2(17), ADCY3(12), ADCY4(9), ADCY5(13), ADCY6(14), ADCY7(16), ADCY8(31), ADCY9(13), AKAP1(3), AKAP10(3), AKAP11(16), AKAP12(18), AKAP2(10), AKAP3(12), AKAP4(11), AKAP5(1), AKAP6(23), AKAP7(3), AKAP8(10), AKAP9(38), ARHGEF1(11), CALM1(2), CALM2(2), CHMP1B(1), GNA11(6), GNA12(1), GNA13(5), GNA14(4), GNA15(3), GNAI2(3), GNAI3(7), GNAL(2), GNAO1(1), GNAQ(4), GNAZ(17), GNB1(1), GNB2(3), GNB3(1), GNB5(1), GNG10(1), GNG13(2), GNGT1(3), GNGT2(2), ITPR1(24), NRAS(3), PALM2(6), PDE1A(7), PDE1B(6), PDE1C(11), PDE4A(7), PDE4B(5), PDE4C(6), PDE4D(4), PDE7A(5), PDE7B(3), PDE8A(10), PDE8B(5), PLCB3(12), PPP3CA(10), PPP3CC(5), PRKACA(4), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PRKCA(5), PRKCD(7), PRKCE(14), PRKCG(17), PRKCH(6), PRKCI(8), PRKCQ(10), PRKD1(20), PRKD3(5), RRAS(1), SLC9A1(10), USP5(6) 49267882 648 168 621 233 187 165 22 137 130 7 0.465 1.000 1.000 208 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 126 ACACA(22), ACACB(35), AKT1(3), AKT2(8), AKT3(6), ARAF(11), BAD(3), BRAF(16), CALM1(2), CALM2(2), CALML3(1), CBL(3), CBLB(3), CBLC(5), CRKL(1), EIF4EBP1(2), ELK1(3), EXOC7(11), FASN(19), FBP1(4), FBP2(5), FLOT1(2), FLOT2(5), FOXO1(4), G6PC2(1), GCK(4), GRB2(4), GSK3B(5), GYS1(6), GYS2(6), IKBKB(8), INPP5D(4), INSR(14), IRS1(24), IRS2(6), IRS4(27), LIPE(6), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK10(5), MAPK3(1), MAPK8(5), MAPK9(3), MKNK1(3), MKNK2(7), NRAS(3), PCK1(11), PCK2(9), PDE3A(14), PDE3B(20), PDPK1(2), PFKL(5), PFKM(2), PFKP(14), PHKA1(10), PHKA2(10), PHKB(6), PHKG1(2), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(11), PIK3R3(8), PIK3R5(8), PKLR(7), PPARGC1A(10), PPP1CA(2), PPP1CB(1), PPP1CC(5), PPP1R3B(7), PPP1R3C(4), PPP1R3D(3), PRKAA1(6), PRKAA2(7), PRKAB1(6), PRKAB2(4), PRKACA(4), PRKACB(4), PRKACG(8), PRKAG1(4), PRKAG2(5), PRKAG3(3), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PRKCI(8), PRKX(5), PTPN1(3), PTPRF(18), PYGB(10), PYGL(8), PYGM(14), RAF1(10), RAPGEF1(9), RHEB(1), RPS6(1), RPS6KB1(5), RPS6KB2(4), SH2B2(4), SHC1(7), SHC2(2), SHC3(10), SHC4(4), SLC2A4(4), SOCS1(1), SOCS2(2), SOCS3(3), SOCS4(6), SORBS1(9), SOS1(7), SOS2(19), SREBF1(12), TRIP10(9), TSC1(7), TSC2(12) 66047110 840 167 797 297 273 184 24 141 208 10 0.558 1.000 1.000 209 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 109 ADA(5), ADCY1(19), ADCY2(17), ADCY3(12), ADCY4(9), ADCY5(13), ADCY6(14), ADCY7(16), ADCY8(31), ADK(4), ADSL(5), ADSS(5), AK1(1), AK5(4), ALLC(5), AMPD1(9), AMPD2(13), AMPD3(20), APRT(3), ATIC(6), ATP1B1(6), ATP5A1(2), ATP5B(7), ATP5C1(3), ATP5F1(1), ATP5G2(1), ATP5G3(1), ATP5J(1), ATP5J2(1), CANT1(4), DGUOK(2), ENPP1(7), ENPP3(8), ENTPD1(5), ENTPD2(4), GART(9), GDA(4), GMPS(7), GUCY1A2(10), GUCY1A3(15), GUCY1B3(8), GUCY2C(12), GUCY2D(12), GUCY2F(15), GUK1(4), IMPDH1(5), ITPA(1), NME2(3), NPR1(11), NPR2(8), NT5C(1), NT5E(2), NUDT2(4), PAICS(1), PAPSS1(6), PAPSS2(5), PDE1A(7), PDE4A(7), PDE4B(5), PDE4C(6), PDE4D(4), PDE5A(7), PDE6B(10), PDE6C(4), PDE6G(1), PDE7B(3), PDE8A(10), PDE9A(7), PFAS(9), PKLR(7), POLB(4), POLD1(15), POLD2(4), POLE(24), POLG(8), POLL(3), POLQ(29), POLR1B(8), POLR2A(19), POLR2B(11), POLR2C(4), POLR2E(2), POLR2F(4), POLR2G(1), POLR2I(2), POLR2K(1), POLRMT(9), PPAT(5), PRPS1(3), PRPS1L1(2), PRPS2(3), PRUNE(4), RRM1(5), RRM2(4) 54802177 668 166 650 222 195 172 25 149 122 5 0.240 1.000 1.000 210 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 108 ACTN1(7), ACTN2(23), ACTN4(11), ARHGAP5(18), BCAR1(8), CD99(1), CDC42(1), CDH5(10), CLDN1(3), CLDN10(2), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(4), CLDN17(6), CLDN18(2), CLDN19(6), CLDN2(1), CLDN20(4), CLDN22(3), CLDN23(3), CLDN3(1), CLDN4(6), CLDN5(2), CLDN6(7), CLDN8(2), CLDN9(7), CTNNA1(15), CTNNA2(19), CTNNA3(16), CTNNB1(22), CTNND1(19), CXCR4(1), CYBB(8), ESAM(5), EZR(6), F11R(2), GNAI1(1), GNAI2(3), GNAI3(7), ICAM1(2), ITGA4(12), ITGAL(16), ITGAM(9), ITGB1(10), ITGB2(6), ITK(6), JAM2(2), JAM3(7), MAPK11(1), MAPK13(3), MAPK14(1), MLLT4(24), MMP2(6), MMP9(17), MSN(9), MYL2(8), MYL7(1), MYL9(2), NCF1(3), NCF2(4), NCF4(1), NOX1(6), NOX3(5), OCLN(6), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(11), PIK3R3(8), PIK3R5(8), PLCG1(19), PLCG2(15), PRKCA(5), PRKCG(17), PTK2(11), PTK2B(16), PTPN11(6), PXN(4), RAC2(2), RAP1A(2), RAP1B(6), RAPGEF3(2), RAPGEF4(8), RASSF5(4), RHOH(1), ROCK1(18), ROCK2(12), SIPA1(4), THY1(1), TXK(2), VASP(2), VAV1(9), VAV2(12), VAV3(10), VCAM1(10), VCL(6) 52183069 721 162 681 253 219 161 29 126 174 12 0.572 1.000 1.000 211 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 66 ADCY1(19), ADCY8(31), ARAF(11), ATF4(2), BRAF(16), CACNA1C(37), CALM1(2), CALM2(2), CALML3(1), CAMK2A(3), CAMK2B(4), CAMK2D(3), CAMK2G(8), CAMK4(8), CREBBP(40), EP300(22), GNAQ(4), GRIA1(20), GRIA2(23), GRIN1(8), GRIN2A(16), GRIN2B(23), GRIN2C(6), GRIN2D(7), GRM1(31), GRM5(26), ITPR1(24), ITPR2(30), ITPR3(36), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), NRAS(3), PLCB1(19), PLCB2(8), PLCB3(12), PLCB4(13), PPP1CA(2), PPP1CB(1), PPP1CC(5), PPP1R12A(2), PPP1R1A(1), PPP3CA(10), PPP3CB(6), PPP3CC(5), PPP3R1(2), PRKACA(4), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(17), PRKX(5), RAF1(10), RAP1A(2), RAP1B(6), RAPGEF3(2), RPS6KA1(9), RPS6KA2(9), RPS6KA3(4), RPS6KA6(15) 42454473 664 162 640 211 213 165 18 132 132 4 0.0230 1.000 1.000 212 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 92 ADCY1(19), ADCY2(17), ADCY3(12), ADCY4(9), ADCY5(13), ADCY6(14), ADCY7(16), ADCY8(31), ADCY9(13), ATF4(2), CACNA1C(37), CACNA1D(35), CACNA1F(11), CACNA1S(17), CALM1(2), CALM2(2), CALML3(1), CAMK2A(3), CAMK2B(4), CAMK2D(3), CAMK2G(8), CDC42(1), CGA(1), EGFR(15), ELK1(3), FSHB(1), GNA11(6), GNAQ(4), GNAS(29), GNRH1(1), GNRH2(2), GNRHR(4), GRB2(4), HBEGF(1), ITPR1(24), ITPR2(30), ITPR3(36), JUN(4), LHB(1), MAP2K1(5), MAP2K2(3), MAP2K3(4), MAP2K4(8), MAP2K6(1), MAP3K1(11), MAP3K2(4), MAP3K3(8), MAP3K4(21), MAPK1(3), MAPK10(5), MAPK11(1), MAPK13(3), MAPK14(1), MAPK3(1), MAPK7(6), MAPK8(5), MAPK9(3), MMP14(6), MMP2(6), NRAS(3), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6), PLCB1(19), PLCB2(8), PLCB3(12), PLCB4(13), PLD1(19), PLD2(16), PRKACA(4), PRKACB(4), PRKACG(8), PRKCA(5), PRKCD(7), PRKX(5), PTK2B(16), RAF1(10), SOS1(7), SOS2(19), SRC(3) 53966587 753 162 733 245 267 175 27 137 140 7 0.0424 1.000 1.000 213 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 104 ABL1(7), ANAPC1(13), ANAPC10(2), ANAPC11(1), ANAPC2(7), ANAPC5(4), ANAPC7(6), ATM(38), ATR(18), BUB1(12), BUB1B(10), BUB3(4), CCNA1(6), CCNA2(1), CCNB1(3), CCNB2(1), CCNB3(20), CCND1(1), CCND2(3), CCND3(2), CCNE1(5), CCNE2(3), CCNH(2), CDC14B(4), CDC16(7), CDC20(5), CDC23(6), CDC25A(6), CDC25B(4), CDC26(1), CDC27(3), CDC6(8), CDC7(4), CDK2(3), CDK6(4), CDKN1A(3), CDKN2D(3), CHEK1(4), CHEK2(8), CREBBP(40), CUL1(22), DBF4(7), E2F1(3), E2F2(4), E2F3(3), EP300(22), ESPL1(15), FZR1(7), GADD45B(1), GSK3B(5), HDAC1(5), HDAC2(2), MAD1L1(8), MAD2L1(3), MAD2L2(1), MCM2(14), MCM3(6), MCM4(13), MCM5(8), MCM6(8), MCM7(7), MDM2(5), PCNA(2), PKMYT1(3), PLK1(9), PRKDC(40), PTTG1(1), RB1(13), RBL1(11), RBL2(8), RBX1(1), SFN(1), SKP2(5), SMAD2(9), SMAD3(5), SMC1A(7), SMC1B(6), TFDP1(5), TGFB1(3), TGFB2(6), TGFB3(8), WEE1(4), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(3), YWHAQ(2), YWHAZ(3) 56189777 611 161 588 186 164 157 15 126 145 4 0.183 1.000 1.000 214 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 81 ABL1(7), ABL2(12), AKT1(3), AKT2(8), AKT3(6), ARAF(11), BAD(3), BRAF(16), BTC(2), CAMK2A(3), CAMK2B(4), CAMK2D(3), CAMK2G(8), CBL(3), CBLB(3), CBLC(5), CDKN1A(3), CRKL(1), EGF(10), EGFR(15), EIF4EBP1(2), ELK1(3), ERBB2(15), ERBB4(48), EREG(2), GAB1(3), GRB2(4), GSK3B(5), HBEGF(1), JUN(4), MAP2K1(5), MAP2K2(3), MAP2K4(8), MAPK1(3), MAPK10(5), MAPK3(1), MAPK8(5), MAPK9(3), MYC(5), NCK1(6), NCK2(5), NRAS(3), NRG1(14), NRG2(8), NRG3(17), NRG4(2), PAK1(5), PAK2(7), PAK3(5), PAK4(8), PAK6(9), PAK7(9), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(11), PIK3R3(8), PIK3R5(8), PLCG1(19), PLCG2(15), PRKCA(5), PRKCG(17), PTK2(11), RAF1(10), RPS6KB1(5), RPS6KB2(4), SHC1(7), SHC2(2), SHC3(10), SHC4(4), SOS1(7), SOS2(19), SRC(3), STAT5A(3), STAT5B(14), TGFA(2) 41543809 589 160 551 188 178 136 27 108 135 5 0.189 1.000 1.000 215 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 81 ACVR1(5), ACVR1B(13), ACVRL1(5), AKT1(3), AURKB(5), BMPR1A(5), BMPR2(16), BUB1(12), CDIPT(1), CDKL2(3), CDS1(6), CDS2(2), CLK1(4), CLK2(11), CLK4(4), COL4A3BP(3), CSNK2A1(5), CSNK2A2(6), CSNK2B(1), DGKA(7), DGKB(11), DGKD(6), DGKE(7), DGKG(4), DGKH(10), DGKQ(2), DGKZ(8), IMPA1(4), INPP1(1), INPP4A(6), INPP4B(7), INPP5A(8), INPPL1(24), ITPKA(2), ITPKB(11), MAP3K10(8), MOS(11), NEK1(4), NEK3(3), OCRL(9), PAK4(8), PIK3C2A(14), PIK3C2B(19), PIK3C2G(10), PIK3CB(13), PIK3CG(21), PIM2(3), PLCB1(19), PLCB2(8), PLCB3(12), PLCB4(13), PLCD1(4), PLCG1(19), PLCG2(15), PLK3(6), PRKACA(4), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PRKCA(5), PRKCD(7), PRKCE(14), PRKCG(17), PRKCH(6), PRKCQ(10), PRKD1(20), PRKG1(10), RAF1(10), RPS6KA1(9), RPS6KA2(9), RPS6KA3(4), RPS6KA4(6), RPS6KB1(5), STK11(3), TGFBR1(4), VRK1(1) 47406894 622 159 589 179 177 144 23 120 150 8 0.0564 1.000 1.000 216 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(3), AKT3(6), BCAR1(8), CAPN1(5), CAPN10(7), CAPN11(6), CAPN2(8), CAPN3(9), CAPN5(9), CAPN6(7), CAPN7(8), CAPN9(4), CAPNS1(2), CAV1(4), CAV2(2), CAV3(2), CDC42(1), CSK(7), DOCK1(17), FYN(10), GIT2(2), GRB2(4), ILK(8), ITGA10(9), ITGA11(10), ITGA2(8), ITGA2B(9), ITGA3(11), ITGA4(12), ITGA5(5), ITGA6(6), ITGA7(16), ITGA8(6), ITGA9(8), ITGAD(12), ITGAE(12), ITGAL(16), ITGAM(9), ITGAV(13), ITGAX(14), ITGB1(10), ITGB2(6), ITGB3(7), ITGB4(18), ITGB5(7), ITGB6(4), ITGB7(6), ITGB8(14), MAP2K1(5), MAP2K2(3), MAP2K3(4), MAP2K6(1), MAPK10(5), MAPK4(6), MAPK6(1), MAPK7(6), MYLK2(4), PAK1(5), PAK2(7), PAK3(5), PAK4(8), PAK6(9), PDPK1(2), PIK3R2(11), PTK2(11), PXN(4), RAC2(2), RAC3(4), RAP1B(6), RAPGEF1(9), RHO(7), ROCK1(18), ROCK2(12), SDCCAG8(5), SEPP1(1), SHC1(7), SHC3(10), SORBS1(9), SOS1(7), SRC(3), TLN1(23), TNS1(27), VASP(2), VAV2(12), VAV3(10), VCL(6), ZYX(7) 57422581 671 158 648 234 213 153 29 121 143 12 0.382 1.000 1.000 217 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 96 ADCY1(19), ADCY2(17), ADCY3(12), ADCY4(9), ADCY5(13), ADCY6(14), ADCY7(16), ADCY8(31), ADCY9(13), ASIP(2), CALM1(2), CALM2(2), CALML3(1), CAMK2A(3), CAMK2B(4), CAMK2D(3), CAMK2G(8), CREB1(3), CREB3L1(4), CREB3L2(4), CREB3L3(4), CREB3L4(2), CREBBP(40), CTNNB1(22), DCT(13), DVL1(7), DVL2(6), DVL3(12), EDN1(3), EP300(22), FZD1(10), FZD10(18), FZD2(7), FZD3(11), FZD4(6), FZD5(4), FZD6(9), FZD7(7), FZD8(10), FZD9(2), GNAI1(1), GNAI2(3), GNAI3(7), GNAO1(1), GNAQ(4), GNAS(29), GSK3B(5), KIT(12), KITLG(3), LEF1(8), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), MC1R(6), MITF(10), NRAS(3), PLCB1(19), PLCB2(8), PLCB3(12), PLCB4(13), POMC(8), PRKACA(4), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(17), PRKX(5), RAF1(10), TCF7(8), TCF7L1(5), TCF7L2(11), TYR(9), TYRP1(4), WNT1(8), WNT10A(5), WNT10B(2), WNT11(2), WNT2(4), WNT2B(10), WNT3(5), WNT3A(6), WNT4(2), WNT5A(6), WNT5B(4), WNT6(3), WNT7A(5), WNT7B(7), WNT8A(1), WNT8B(1), WNT9A(8), WNT9B(4) 45852713 732 157 700 253 270 176 21 127 135 3 0.0524 1.000 1.000 218 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 71 CALM1(2), CALM2(2), CALML3(1), CDIPT(1), CDS1(6), CDS2(2), DGKA(7), DGKB(11), DGKD(6), DGKE(7), DGKG(4), DGKH(10), DGKI(16), DGKQ(2), DGKZ(8), FN3K(3), IMPA1(4), IMPA2(2), INPP1(1), INPP4A(6), INPP4B(7), INPP5A(8), INPP5B(7), INPP5D(4), INPP5E(6), INPPL1(24), ITPK1(4), ITPKA(2), ITPKB(11), ITPR1(24), ITPR2(30), ITPR3(36), OCRL(9), PI4KA(14), PI4KB(5), PIK3C2A(14), PIK3C2B(19), PIK3C2G(10), PIK3C3(14), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(11), PIK3R3(8), PIK3R5(8), PIP4K2A(6), PIP4K2B(4), PIP4K2C(2), PIP5K1A(4), PIP5K1B(1), PIP5K1C(11), PLCB1(19), PLCB2(8), PLCB3(12), PLCB4(13), PLCD1(4), PLCD3(9), PLCD4(5), PLCE1(14), PLCG1(19), PLCG2(15), PLCZ1(6), PRKCA(5), PRKCG(17), PTPMT1(1), SYNJ1(10), SYNJ2(18) 52075445 635 156 599 193 208 145 20 113 141 8 0.0458 1.000 1.000 219 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(20), BDKRB1(2), BDKRB2(4), C1QA(5), C1QB(1), C1QC(2), C1R(5), C1S(7), C2(1), C3(30), C3AR1(8), C4BPA(3), C4BPB(3), C5(11), C5AR1(5), C6(12), C7(3), C8A(5), C8B(14), C9(7), CD46(3), CD55(3), CFB(6), CFH(20), CFI(13), CPB2(10), CR1(27), CR2(22), F10(7), F11(4), F12(3), F13A1(14), F13B(16), F2(9), F2R(3), F3(1), F5(21), F7(10), F8(22), F9(9), FGA(9), FGB(4), FGG(3), KLKB1(7), KNG1(9), MASP1(1), MASP2(6), MBL2(4), PLAT(7), PLAUR(4), PLG(14), PROC(3), PROS1(9), SERPINA1(7), SERPINA5(7), SERPINC1(4), SERPIND1(5), SERPINE1(3), SERPINF2(8), SERPING1(7), TFPI(4), THBD(1), VWF(28) 38840565 525 153 495 147 131 127 23 120 122 2 0.0282 1.000 1.000 220 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 86 ACVR1(5), ACVR1B(13), ACVR1C(5), ACVR2A(8), ACVR2B(5), ACVRL1(5), AMHR2(4), BMP2(5), BMP4(6), BMP5(11), BMP6(10), BMP7(7), BMP8A(1), BMP8B(2), BMPR1A(5), BMPR1B(7), BMPR2(16), CHRD(9), COMP(3), CREBBP(40), CUL1(22), DCN(8), E2F5(1), EP300(22), FST(4), GDF5(11), GDF6(15), GDF7(4), ID1(1), ID3(1), IFNG(2), INHBA(12), INHBB(10), INHBC(6), INHBE(2), LEFTY1(2), LTBP1(20), MAPK1(3), MAPK3(1), MYC(5), NOG(1), PITX2(6), PPP2CA(4), PPP2CB(3), PPP2R1A(11), PPP2R1B(6), PPP2R2A(6), PPP2R2B(8), PPP2R2C(8), RBL1(11), RBL2(8), RBX1(1), ROCK1(18), ROCK2(12), RPS6KB1(5), RPS6KB2(4), SMAD1(4), SMAD2(9), SMAD3(5), SMAD5(2), SMAD6(5), SMAD7(5), SMAD9(9), SMURF1(6), SMURF2(5), SP1(6), TFDP1(5), TGFB1(3), TGFB2(6), TGFB3(8), TGFBR1(4), TGFBR2(14), THBS1(16), THBS2(15), THBS3(9), THBS4(13), TNF(3), ZFYVE16(11), ZFYVE9(8) 41763099 602 152 581 199 187 140 27 98 141 9 0.168 1.000 1.000 221 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 74 ABL1(7), ACTN1(7), ACTR2(2), ACTR3(2), AKT1(3), AKT2(8), AKT3(6), ANGPTL2(4), ARHGEF6(13), ARHGEF7(8), BCAR1(8), BRAF(16), CAV1(4), CDC42(1), CSE1L(5), DOCK1(17), EPHB2(12), FYN(10), GRB2(4), GRB7(6), ILK(8), ITGA1(8), ITGA10(9), ITGA11(10), ITGA2(8), ITGA3(11), ITGA4(12), ITGA5(5), ITGA6(6), ITGA7(16), ITGA8(6), ITGA9(8), ITGB3BP(1), MAP2K4(8), MAP3K11(7), MAPK1(3), MAPK10(5), MAPK8(5), MAPK8IP1(4), MAPK8IP2(4), MAPK8IP3(13), MAPK9(3), MRAS(2), MYLK(22), MYLK2(4), P4HB(4), PAK1(5), PAK2(7), PAK3(5), PAK4(8), PAK6(9), PAK7(9), PIK3CB(13), PKLR(7), PLCG1(19), PLCG2(15), PTK2(11), RAF1(10), RHO(7), ROCK1(18), ROCK2(12), SHC1(7), SOS1(7), SOS2(19), SRC(3), TERF2IP(5), TLN1(23), TLN2(27), VASP(2), WAS(3), ZYX(7) 50636122 593 152 576 197 195 131 20 102 133 12 0.334 1.000 1.000 222 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 88 AKT1(3), AKT2(8), AKT3(6), BCL10(2), CARD11(20), CBL(3), CBLB(3), CBLC(5), CD247(3), CD28(1), CD3E(2), CD3G(1), CD40LG(5), CD8A(4), CD8B(1), CDC42(1), CHUK(4), CTLA4(3), FOS(1), FYN(10), GRAP2(4), GRB2(4), ICOS(2), IFNG(2), IKBKB(8), IL10(2), IL4(1), ITK(6), JUN(4), LAT(3), LCK(4), LCP2(7), MALT1(4), NCK1(6), NCK2(5), NFAT5(10), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), NFKB1(7), NFKB2(7), NFKBIA(1), NFKBIB(6), NRAS(3), PAK1(5), PAK2(7), PAK3(5), PAK4(8), PAK6(9), PAK7(9), PDCD1(2), PDK1(3), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(11), PIK3R3(8), PIK3R5(8), PLCG1(19), PPP3CA(10), PPP3CB(6), PPP3CC(5), PPP3R1(2), PRKCQ(10), PTPN6(4), PTPRC(19), RASGRP1(8), SOS1(7), SOS2(19), TEC(4), TNF(3), VAV1(9), VAV2(12), VAV3(10), ZAP70(14) 41851337 524 149 504 169 164 127 17 99 114 3 0.165 1.000 1.000 223 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 43 ABCA1(18), ABCA10(19), ABCA12(31), ABCA13(52), ABCA2(18), ABCA3(17), ABCA4(17), ABCA5(21), ABCA6(16), ABCA7(13), ABCA8(14), ABCA9(16), ABCB1(26), ABCB10(12), ABCB11(9), ABCB4(23), ABCB5(16), ABCB6(9), ABCB7(4), ABCB8(8), ABCB9(4), ABCC1(16), ABCC10(10), ABCC11(16), ABCC12(17), ABCC2(12), ABCC3(11), ABCC4(18), ABCC5(11), ABCC6(15), ABCC8(17), ABCD1(6), ABCD2(4), ABCD3(5), ABCD4(8), ABCG1(10), ABCG2(6), ABCG4(4), ABCG5(2), ABCG8(5), CFTR(14), TAP1(4), TAP2(6) 49136307 580 146 554 185 161 152 18 113 127 9 0.0567 1.000 1.000 224 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 76 ABL1(7), ATM(38), BUB1(12), BUB1B(10), BUB3(4), CCNA1(6), CCNA2(1), CCNB1(3), CCNB2(1), CCNB3(20), CCND2(3), CCND3(2), CCNE1(5), CCNE2(3), CCNH(2), CDAN1(12), CDC14B(4), CDC20(5), CDC25A(6), CDC25B(4), CDC6(8), CDC7(4), CDK2(3), CDKN1A(3), CHEK1(4), CHEK2(8), DTX4(7), E2F1(3), E2F2(4), E2F3(3), E2F5(1), E2F6(2), EP300(22), ESPL1(15), GSK3B(5), HDAC1(5), HDAC2(2), HDAC3(6), HDAC4(25), HDAC5(10), HDAC6(7), HDAC8(3), MAD1L1(8), MAD2L1(3), MAD2L2(1), MCM2(14), MCM3(6), MCM4(13), MCM5(8), MCM6(8), MCM7(7), MDM2(5), MPEG1(10), MPL(5), PCNA(2), PLK1(9), PRKDC(40), PTPRA(12), PTTG1(1), RB1(13), RBL1(11), SKP2(5), TBC1D8(9), TFDP1(5), TGFB1(3), WEE1(4) 44349286 500 145 479 154 138 126 17 103 112 4 0.200 1.000 1.000 225 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 59 AKT1(3), AKT2(8), AKT3(6), BAD(3), CDC42(1), CDK2(3), CREB1(3), CREB5(5), EBP(1), ERBB4(48), F2RL2(3), GAB1(3), GRB2(4), GSK3A(3), GSK3B(5), IFI27(1), IGF1(4), INPPL1(24), IRS1(24), IRS2(6), IRS4(27), MET(8), MYC(5), NOLC1(9), PAK1(5), PAK2(7), PAK3(5), PAK4(8), PAK6(9), PAK7(9), PARD3(11), PARD6A(1), PDK1(3), PIK3CD(11), PPP1R13B(11), PREX1(16), PTK2(11), PTPN1(3), RPS6KA1(9), RPS6KA2(9), RPS6KA3(4), RPS6KB1(5), SFN(1), SHC1(7), SLC2A4(4), SOS1(7), SOS2(19), TSC1(7), TSC2(12), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(3), YWHAQ(2), YWHAZ(3) 31497999 414 145 388 121 133 89 18 68 102 4 0.0718 1.000 1.000 226 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 94 AKT1(3), AKT2(8), AKT3(6), CCL3(1), CCL5(2), CD14(2), CD40(3), CD80(4), CD86(6), CHUK(4), CXCL10(1), CXCL9(2), FADD(1), FOS(1), IFNA1(1), IFNA10(4), IFNA13(1), IFNA16(4), IFNA2(1), IFNA4(1), IFNA5(2), IFNA6(3), IFNA7(4), IFNA8(1), IFNAR1(8), IFNAR2(6), IFNB1(3), IKBKB(8), IKBKE(12), IL12A(2), IL12B(2), IL1B(3), IRAK1(6), IRAK4(3), IRF3(3), IRF5(4), IRF7(1), JUN(4), LBP(1), LY96(4), MAP2K1(5), MAP2K2(3), MAP2K3(4), MAP2K4(8), MAP2K6(1), MAP3K7(10), MAPK1(3), MAPK10(5), MAPK11(1), MAPK13(3), MAPK14(1), MAPK3(1), MAPK8(5), MAPK9(3), MYD88(2), NFKB1(7), NFKB2(7), NFKBIA(1), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(11), PIK3R3(8), PIK3R5(8), RELA(5), RIPK1(2), SPP1(4), STAT1(10), TBK1(8), TICAM1(8), TIRAP(1), TLR1(6), TLR2(2), TLR3(6), TLR4(21), TLR5(10), TLR6(3), TLR7(5), TLR8(14), TLR9(15), TNF(3), TOLLIP(5), TRAF3(4), TRAF6(6) 36580761 427 143 406 148 114 97 14 95 104 3 0.604 1.000 1.000 227 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 121 ARAF(11), BID(2), BRAF(16), CASP3(2), CD244(2), CD247(3), FAS(3), FASLG(3), FCGR3A(4), FYN(10), GRB2(4), GZMB(3), HCST(1), HLA-C(6), HLA-E(5), HLA-G(5), ICAM1(2), ICAM2(3), IFNA1(1), IFNA10(4), IFNA13(1), IFNA16(4), IFNA2(1), IFNA4(1), IFNA5(2), IFNA6(3), IFNA7(4), IFNA8(1), IFNAR1(8), IFNAR2(6), IFNB1(3), IFNG(2), IFNGR1(6), IFNGR2(2), ITGAL(16), ITGB2(6), KIR2DL3(3), KIR3DL1(5), KIR3DL2(2), KLRC1(3), KLRC3(2), KLRD1(3), LAT(3), LCK(4), LCP2(7), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), MICB(3), NCR1(3), NCR2(3), NCR3(1), NFAT5(10), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), NRAS(3), PAK1(5), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(11), PIK3R3(8), PIK3R5(8), PLCG1(19), PLCG2(15), PPP3CA(10), PPP3CB(6), PPP3CC(5), PPP3R1(2), PRF1(8), PRKCA(5), PRKCG(17), PTK2B(16), PTPN11(6), PTPN6(4), RAC2(2), RAC3(4), RAF1(10), SH2D1A(1), SH2D1B(1), SH3BP2(5), SHC1(7), SHC2(2), SHC3(10), SHC4(4), SOS1(7), SOS2(19), SYK(7), TNF(3), TNFRSF10A(1), TNFRSF10B(2), TNFRSF10C(3), TNFRSF10D(3), TNFSF10(5), TYROBP(2), ULBP1(3), ULBP3(1), VAV1(9), VAV2(12), VAV3(10), ZAP70(14) 46789181 621 143 594 192 184 149 16 121 148 3 0.0349 1.000 1.000 228 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 106 A4GNT(1), ALG1(6), ALG10(11), ALG12(10), ALG13(8), ALG14(2), ALG2(2), ALG3(2), ALG6(2), ALG8(4), ALG9(2), B3GNT1(3), B3GNT2(3), B3GNT6(4), B3GNT7(5), B4GALT1(2), B4GALT2(7), B4GALT3(2), B4GALT4(5), B4GALT5(6), B4GALT7(5), C1GALT1(3), C1GALT1C1(7), CHPF(2), CHST1(14), CHST11(4), CHST12(5), CHST13(4), CHST14(1), CHST2(14), CHST3(3), CHST4(6), CHST6(11), CHST7(7), CHSY1(6), DPAGT1(4), EXT1(19), EXT2(5), EXTL1(8), EXTL2(2), EXTL3(10), FUT11(3), FUT8(7), GALNT1(4), GALNT10(7), GALNT11(6), GALNT12(3), GALNT13(8), GALNT14(10), GALNT2(5), GALNT3(4), GALNT4(5), GALNT5(12), GALNT6(6), GALNT7(2), GALNT8(6), GALNT9(3), GALNTL5(3), GANAB(12), GCNT3(3), GCNT4(4), HS2ST1(3), HS3ST1(3), HS3ST2(10), HS3ST3A1(2), HS3ST3B1(4), HS3ST5(8), HS6ST1(3), HS6ST2(7), HS6ST3(7), MAN1A1(2), MAN1A2(5), MAN1B1(6), MAN1C1(8), MAN2A1(5), MGAT1(3), MGAT2(2), MGAT3(8), MGAT4A(5), MGAT4B(3), MGAT5(10), MGAT5B(5), NDST1(11), NDST2(9), NDST3(13), NDST4(12), OGT(5), RPN1(3), RPN2(6), ST3GAL1(4), ST3GAL2(6), ST3GAL3(2), ST3GAL4(6), ST6GALNAC1(4), STT3B(5), UST(9), WBSCR17(25), XYLT1(12) 46223254 581 141 559 217 193 135 17 107 122 7 0.864 1.000 1.000 229 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 56 APC(43), AXIN1(9), CCND1(1), CCND2(3), CCND3(2), CSNK1E(8), CTNNB1(22), DVL1(7), DVL2(6), DVL3(12), FBXW2(3), FOSL1(1), FZD1(10), FZD10(18), FZD2(7), FZD3(11), FZD5(4), FZD6(9), FZD7(7), FZD8(10), FZD9(2), GSK3B(5), JUN(4), LDLR(10), MAPK10(5), MAPK9(3), MYC(5), PAFAH1B1(12), PPP2R5C(7), PPP2R5E(5), PRKCA(5), PRKCD(7), PRKCE(14), PRKCG(17), PRKCH(6), PRKCI(8), PRKCQ(10), PRKD1(20), SFRP4(5), TCF7(8), WNT1(8), WNT10A(5), WNT10B(2), WNT11(2), WNT2(4), WNT2B(10), WNT3(5), WNT4(2), WNT5A(6), WNT5B(4), WNT6(3), WNT7A(5), WNT7B(7) 25292624 414 141 391 139 128 79 14 79 103 11 0.256 1.000 1.000 230 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 51 ADORA3(5), ALG6(2), CCKBR(9), CCR2(6), CCR3(6), CCR5(4), CELSR1(39), CELSR2(31), CELSR3(47), CHRM2(17), CHRM3(11), CIDEB(2), CXCR3(1), DRD4(3), EDNRA(4), EMR2(9), EMR3(4), F2R(3), GHRHR(4), GNRHR(4), GPR116(13), GPR132(4), GPR133(13), GPR135(8), GPR143(4), GPR17(5), GPR18(3), GPR55(7), GPR56(6), GPR61(7), GPR84(2), GPR88(1), GRM1(31), GRPR(6), HRH4(3), LGR6(12), LPHN2(19), LPHN3(17), LTB4R2(4), NTSR1(7), OR2M4(5), P2RY13(4), PTGFR(5), SMO(13), SSTR2(4), TAAR5(6), TSHR(10), VN1R1(3) 27971269 433 139 421 139 141 108 22 95 64 3 0.0289 1.000 1.000 231 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 79 AGL(16), AMY2A(3), ASCC3(31), ATP13A2(13), DDX18(10), DDX19A(5), DDX23(8), DDX4(5), DDX41(8), DDX47(2), DDX50(11), DDX51(5), DDX52(3), DDX54(18), DDX55(5), DDX56(5), DHX58(9), ENPP1(7), ENPP3(8), ENTPD7(11), EP400(35), ERCC2(8), ERCC3(8), G6PC2(1), GAA(5), GANC(8), GBA(9), GBE1(5), GCK(4), GPI(5), GUSB(11), GYS1(6), GYS2(6), HK1(16), HK2(10), HK3(6), IFIH1(8), LYZL1(5), MGAM(15), MOV10L1(6), PGM1(2), PGM3(7), PYGB(10), PYGL(8), PYGM(14), RAD54B(3), RAD54L(5), RUVBL2(5), SETX(20), SI(27), SKIV2L2(8), SMARCA2(22), SMARCA5(7), TREH(1), UGDH(5), UGP2(7), UGT1A1(4), UGT1A10(1), UGT1A3(1), UGT1A4(3), UGT1A5(3), UGT1A6(6), UGT1A7(3), UGT1A9(3), UGT2A1(3), UGT2A3(6), UGT2B10(5), UGT2B11(1), UGT2B15(3), UGT2B17(2), UGT2B28(7), UGT2B4(4), UGT2B7(6), UXS1(5) 52505637 577 139 567 183 158 153 16 119 128 3 0.245 1.000 1.000 232 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 81 ANPEP(9), CD14(2), CD19(4), CD1B(7), CD1C(9), CD1D(8), CD1E(7), CD2(3), CD22(5), CD33(6), CD34(4), CD36(2), CD37(3), CD38(4), CD3E(2), CD3G(1), CD44(5), CD5(4), CD55(3), CD7(5), CD8A(4), CD8B(1), CD9(1), CR1(27), CR2(22), CSF1(2), CSF1R(15), CSF2RA(9), CSF3(2), CSF3R(13), DNTT(3), EPO(1), EPOR(3), FCER2(2), FLT3(10), FLT3LG(1), GP5(7), GP9(3), HLA-DRA(8), IL11(3), IL11RA(3), IL1A(2), IL1B(3), IL1R1(4), IL1R2(10), IL2RA(3), IL3(1), IL3RA(5), IL4(1), IL4R(3), IL5RA(4), IL6R(2), IL7(1), IL7R(9), IL9R(2), ITGA1(8), ITGA2(8), ITGA2B(9), ITGA3(11), ITGA4(12), ITGA5(5), ITGA6(6), ITGAM(9), ITGB3(7), KIT(12), KITLG(3), MME(8), MS4A1(1), TFRC(2), THPO(6), TNF(3), TPO(24) 34310749 417 139 391 136 109 94 17 92 101 4 0.285 1.000 1.000 233 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(5), BMP4(6), BMP5(11), BMP6(10), BMP7(7), BMP8A(1), BMP8B(2), BTRC(9), CSNK1A1(3), CSNK1A1L(6), CSNK1D(2), CSNK1E(8), CSNK1G1(6), CSNK1G2(5), CSNK1G3(8), DHH(2), FBXW11(10), GAS1(4), GLI1(20), GLI2(14), GLI3(47), GSK3B(5), HHIP(16), IHH(7), LRP2(59), PRKACA(4), PRKACB(4), PRKACG(8), PRKX(5), PTCH1(23), PTCH2(10), RAB23(2), SHH(4), SMO(13), STK36(11), SUFU(5), WNT1(8), WNT10A(5), WNT10B(2), WNT11(2), WNT2(4), WNT2B(10), WNT3(5), WNT3A(6), WNT4(2), WNT5A(6), WNT5B(4), WNT6(3), WNT7A(5), WNT7B(7), WNT8A(1), WNT8B(1), WNT9A(8), WNT9B(4), ZIC2(5) 25751704 450 138 424 137 157 94 16 85 91 7 0.0572 1.000 1.000 234 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 91 ACTB(8), BAD(3), BCL2(3), CABIN1(15), CALM1(2), CALM2(2), CAMK2B(4), CAMK4(8), CD3E(2), CD3G(1), CD69(3), CDKN1A(3), CNR1(11), CREBBP(40), CSNK2A1(5), CSNK2B(1), CTLA4(3), EGR2(8), EGR3(6), EP300(22), FCER1A(3), FCGR3A(4), FOS(1), FOSL1(1), GATA3(17), GATA4(4), GSK3A(3), GSK3B(5), ICOS(2), IFNA1(1), IFNB1(3), IFNG(2), IL10(2), IL13(2), IL1B(3), IL2RA(3), IL3(1), IL4(1), ITK(6), JUNB(3), KPNA5(6), MAPK14(1), MAPK8(5), MAPK9(3), MEF2A(2), MEF2B(5), MEF2D(7), MYF5(5), NCK2(5), NFAT5(10), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), NFKB2(7), NFKBIB(6), NPPB(2), NUP214(23), OPRD1(2), P2RX7(1), PAK1(5), PIN1(2), PPP3CB(6), PPP3CC(5), PPP3R1(2), PTPRC(19), RELA(5), RPL13A(4), SFN(1), SLA(4), SP1(6), SP3(3), TGFB1(3), TNF(3), TRAF2(4), TRPV6(9), VAV1(9), VAV2(12), VAV3(10), XPO5(4) 38827559 473 135 455 167 136 126 17 95 95 4 0.387 1.000 1.000 235 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(3), AKT1(3), BDKRB2(4), CALM1(2), CALM2(2), CAV1(4), CHRM1(4), CHRNA1(5), FLT1(16), FLT4(24), KDR(13), NOS3(10), PDE2A(15), PDE3A(14), PDE3B(20), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PRKG1(10), PRKG2(13), RYR2(82), SLC7A1(6), SYT1(4), TNNI1(2) 17362439 287 129 278 92 82 71 9 71 54 0 0.132 1.000 1.000 236 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 77 AIFM1(2), AKT1(3), AKT2(8), AKT3(6), APAF1(8), ATM(38), BAD(3), BAX(6), BCL2(3), BID(2), BIRC2(3), BIRC3(6), CAPN1(5), CAPN2(8), CASP10(6), CASP3(2), CASP6(1), CASP7(3), CASP9(3), CFLAR(1), CHUK(4), CSF2RB(9), DFFA(4), DFFB(3), FADD(1), FAS(3), FASLG(3), IKBKB(8), IL1A(2), IL1B(3), IL1R1(4), IL1RAP(7), IL3(1), IL3RA(5), IRAK1(6), IRAK2(7), IRAK3(6), IRAK4(3), MYD88(2), NFKB1(7), NFKB2(7), NFKBIA(1), NTRK1(10), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(11), PIK3R3(8), PIK3R5(8), PPP3CA(10), PPP3CB(6), PPP3CC(5), PPP3R1(2), PRKACA(4), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), RELA(5), RIPK1(2), TNF(3), TNFRSF10A(1), TNFRSF10B(2), TNFRSF10C(3), TNFRSF10D(3), TNFRSF1A(6), TNFSF10(5), TRADD(2), TRAF2(4) 33998710 400 128 372 104 113 82 10 70 118 7 0.0339 1.000 1.000 237 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 27 BRAF(16), CPEB1(5), EGFR(15), ERBB2(15), ERBB4(48), ETS1(8), ETS2(4), ETV6(7), ETV7(5), FMN2(38), GRB2(4), MAP2K1(5), MAPK1(3), MAPK3(1), NOTCH1(26), NOTCH2(25), NOTCH3(22), NOTCH4(16), PIWIL1(6), PIWIL2(8), PIWIL3(5), PIWIL4(7), RAF1(10), SOS1(7), SOS2(19), SPIRE1(6), SPIRE2(4) 22213947 335 128 311 111 101 71 12 83 66 2 0.422 1.000 1.000 238 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 66 AKT1(3), AKT2(8), AKT3(6), BAD(3), CASP9(3), CDC42(1), KDR(13), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK11(1), MAPK13(3), MAPK14(1), MAPK3(1), MAPKAPK2(1), MAPKAPK3(5), NFAT5(10), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), NOS3(10), NRAS(3), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(11), PIK3R3(8), PIK3R5(8), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6), PLCG1(19), PLCG2(15), PPP3CA(10), PPP3CB(6), PPP3CC(5), PPP3R1(2), PRKCA(5), PRKCG(17), PTGS2(7), PTK2(11), PXN(4), RAC2(2), RAC3(4), RAF1(10), SH2D2A(7), SHC2(2), SPHK1(6), SPHK2(3), SRC(3) 29609532 388 128 370 110 131 87 14 74 80 2 0.0108 1.000 1.000 239 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(35), ACSL1(3), ACSL3(8), ACSL4(4), ACSL5(7), ACSL6(6), ADIPOQ(3), ADIPOR1(5), ADIPOR2(4), AGRP(1), AKT1(3), AKT2(8), AKT3(6), CAMKK1(5), CAMKK2(2), CD36(2), CHUK(4), CPT1A(10), CPT1B(5), CPT1C(7), CPT2(5), G6PC2(1), IKBKB(8), IRS1(24), IRS2(6), IRS4(27), JAK1(12), JAK2(13), JAK3(13), LEP(2), LEPR(13), MAPK10(5), MAPK8(5), MAPK9(3), NFKB1(7), NFKB2(7), NFKBIA(1), NFKBIB(6), NPY(2), PCK1(11), PCK2(9), POMC(8), PPARA(4), PPARGC1A(10), PRKAA1(6), PRKAA2(7), PRKAB1(6), PRKAB2(4), PRKAG1(4), PRKAG2(5), PRKAG3(3), PRKCQ(10), PTPN11(6), RELA(5), RXRA(6), RXRB(4), RXRG(5), SLC2A1(6), SLC2A4(4), SOCS3(3), STAT3(7), STK11(3), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF2(4), TYK2(9) 35581356 451 128 432 139 138 87 11 96 111 8 0.184 1.000 1.000 240 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 42 ACTR2(2), ACTR3(2), AKT1(3), AKT2(8), AKT3(6), ANGPTL2(4), ARHGAP1(4), ARHGAP4(4), ARHGEF11(18), BTK(3), CDC42(1), CFL1(1), CFL2(1), GDI1(3), GDI2(4), INPPL1(24), ITPR1(24), ITPR2(30), ITPR3(36), LIMK1(5), MYLK(22), MYLK2(4), PAK1(5), PAK2(7), PAK3(5), PAK4(8), PAK6(9), PAK7(9), PDK1(3), PIK3CD(11), PIK3CG(21), PIK3R1(11), PITX2(6), PPP1R13B(11), RACGAP1(7), RHO(7), ROCK1(18), ROCK2(12), RPS4X(1), SAG(4), WASF1(5), WASL(3) 28795949 372 128 353 103 124 85 17 52 83 11 0.0274 1.000 1.000 241 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 47 ADCY4(9), ADCY6(14), ADCY8(31), CACNA1A(24), CACNA1B(24), GNAS(29), GNAT3(5), GNB1(1), GNB3(1), GNG13(2), GRM4(11), ITPR3(36), KCNB1(12), PDE1A(7), PLCB2(8), PRKACA(4), PRKACB(4), PRKACG(8), PRKX(5), SCNN1B(7), SCNN1G(4), TAS1R1(7), TAS1R2(10), TAS1R3(8), TAS2R1(3), TAS2R13(3), TAS2R14(5), TAS2R16(9), TAS2R3(2), TAS2R38(5), TAS2R39(1), TAS2R4(5), TAS2R40(3), TAS2R41(2), TAS2R42(4), TAS2R43(2), TAS2R5(3), TAS2R50(1), TAS2R60(3), TAS2R7(4), TAS2R8(3), TAS2R9(1), TRPM5(6) 24153466 336 127 327 117 124 82 14 69 45 2 0.235 1.000 1.000 242 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 62 ATM(38), CCNA1(6), CCNB1(3), CCND1(1), CCND2(3), CCND3(2), CCNE1(5), CCNE2(3), CCNH(2), CDC25A(6), CDK2(3), CDKN1A(3), CDKN2D(3), CREB3L1(4), CREB3L3(4), CREB3L4(2), E2F1(3), E2F2(4), E2F3(3), E2F5(1), E2F6(2), GBA2(4), MCM2(14), MCM3(6), MCM4(13), MCM5(8), MCM6(8), MCM7(7), MDM2(5), MNAT1(3), MYC(5), MYT1(19), NACA(3), PCNA(2), POLA2(4), POLE(24), POLE2(4), PRIM1(2), RB1(13), RBL1(11), RPA1(2), RPA2(2), RPA3(2), TFDP1(5), TFDP2(4), TNXB(43), WEE1(4) 32517517 318 124 303 104 99 75 11 58 71 4 0.267 1.000 1.000 243 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(39), ASH2L(5), CARM1(5), CTCFL(11), DOT1L(11), EED(5), EHMT1(14), EHMT2(12), EZH1(5), EZH2(6), FBXO11(11), HCFC1(17), HSF4(7), JMJD4(1), JMJD6(3), KDM6A(12), MEN1(8), NSD1(24), OGT(5), PAXIP1(5), PPP1CA(2), PPP1CB(1), PPP1CC(5), PRDM2(30), PRDM7(2), PRDM9(18), PRMT1(3), PRMT5(3), PRMT6(4), PRMT7(6), PRMT8(9), RBBP5(3), SATB1(16), SETD1A(18), SETD2(17), SETD7(2), SETDB1(18), SETDB2(10), SETMAR(2), SMYD3(3), STK38(7), SUV39H1(5), SUV39H2(2), SUV420H1(11), SUV420H2(3), SUZ12(3), WHSC1(16), WHSC1L1(17) 50987438 442 123 423 129 120 108 15 79 109 11 0.184 1.000 1.000 244 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 83 ATF2(3), BRAF(16), CHUK(4), CREB1(3), DAXX(10), ELK1(3), FOS(1), GRB2(4), IKBKB(8), JUN(4), MAP2K1(5), MAP2K2(3), MAP2K3(4), MAP2K4(8), MAP2K5(1), MAP2K6(1), MAP3K1(11), MAP3K10(8), MAP3K11(7), MAP3K12(15), MAP3K13(9), MAP3K2(4), MAP3K3(8), MAP3K4(21), MAP3K5(5), MAP3K6(8), MAP3K7(10), MAP3K9(3), MAP4K1(4), MAP4K2(8), MAP4K3(4), MAP4K4(10), MAP4K5(1), MAPK1(3), MAPK10(5), MAPK11(1), MAPK13(3), MAPK14(1), MAPK3(1), MAPK4(6), MAPK6(1), MAPK7(6), MAPK8(5), MAPK9(3), MAPKAPK2(1), MAPKAPK3(5), MAPKAPK5(3), MAX(3), MEF2A(2), MEF2B(5), MEF2C(4), MEF2D(7), MKNK1(3), MKNK2(7), MYC(5), NFKB1(7), NFKBIA(1), PAK1(5), PAK2(7), RAF1(10), RELA(5), RIPK1(2), RPS6KA1(9), RPS6KA2(9), RPS6KA3(4), RPS6KA4(6), RPS6KA5(3), RPS6KB1(5), RPS6KB2(4), SHC1(7), SP1(6), STAT1(10), TGFB1(3), TGFB2(6), TGFB3(8), TGFBR1(4), TRADD(2), TRAF2(4) 40455701 421 123 408 143 120 97 19 71 109 5 0.461 1.000 1.000 245 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 45 AKT1(3), AKT2(8), AKT3(6), BAD(3), BCL2(3), BCR(11), BLNK(4), BTK(3), CD19(4), CD22(5), CD81(6), CR2(22), CSK(7), DAG1(13), FLOT1(2), FLOT2(5), GRB2(4), GSK3A(3), GSK3B(5), INPP5D(4), ITPR1(24), ITPR2(30), ITPR3(36), LYN(5), MAP4K1(4), MAPK1(3), MAPK3(1), NFATC1(13), NFATC2(17), NR0B2(3), PDK1(3), PIK3CD(11), PIK3R1(11), PLCG2(15), PPP1R13B(11), PPP3CA(10), PPP3CB(6), PPP3CC(5), PTPRC(19), RAF1(10), SHC1(7), SOS1(7), SOS2(19), SYK(7), VAV1(9) 30816252 407 123 385 122 134 94 8 77 88 6 0.0579 1.000 1.000 246 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 60 AKT1(3), AKT2(8), AKT3(6), BCL10(2), BLNK(4), BTK(3), CARD11(20), CD19(4), CD22(5), CD72(1), CD79A(6), CD79B(2), CD81(6), CHUK(4), CR2(22), FCGR2B(1), FOS(1), GSK3B(5), IFITM1(1), IKBKB(8), INPP5D(4), JUN(4), LILRB3(2), LYN(5), MALT1(4), NFAT5(10), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), NFKB1(7), NFKB2(7), NFKBIA(1), NFKBIB(6), NRAS(3), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(11), PIK3R3(8), PIK3R5(8), PLCG2(15), PPP3CA(10), PPP3CB(6), PPP3CC(5), PPP3R1(2), PTPN6(4), RAC2(2), RAC3(4), RASGRP3(5), SYK(7), VAV1(9), VAV2(12), VAV3(10) 30829916 389 122 368 126 126 90 8 75 88 2 0.208 1.000 1.000 247 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 64 ADAM10(3), ADAM17(6), ATP6AP1(6), ATP6V0A1(5), ATP6V0A2(7), ATP6V0A4(10), ATP6V0B(4), ATP6V0D1(8), ATP6V0D2(2), ATP6V1A(6), ATP6V1B2(5), ATP6V1C1(2), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(2), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), CASP3(2), CCL5(2), CDC42(1), CHUK(4), CSK(7), EGFR(15), F11R(2), GIT1(3), HBEGF(1), IGSF5(3), IKBKB(8), JAM2(2), JAM3(7), JUN(4), LYN(5), MAP2K4(8), MAPK10(5), MAPK11(1), MAPK13(3), MAPK14(1), MAPK8(5), MAPK9(3), MET(8), NFKB1(7), NFKB2(7), NFKBIA(1), NOD1(11), PAK1(5), PLCG1(19), PLCG2(15), PTPN11(6), PTPRZ1(25), RELA(5), SRC(3), TCIRG1(7), TJP1(21) 29703045 325 121 315 113 84 74 10 75 80 2 0.597 1.000 1.000 248 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 70 AKT1(3), AKT2(8), AKT3(6), BTK(3), FCER1A(3), FYN(10), GAB2(3), GRB2(4), IL13(2), IL3(1), IL4(1), INPP5D(4), LAT(3), LCP2(7), LYN(5), MAP2K1(5), MAP2K2(3), MAP2K3(4), MAP2K4(8), MAP2K6(1), MAPK1(3), MAPK10(5), MAPK11(1), MAPK13(3), MAPK14(1), MAPK3(1), MAPK8(5), MAPK9(3), MS4A2(2), NRAS(3), PDK1(3), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(11), PIK3R3(8), PIK3R5(8), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6), PLCG1(19), PLCG2(15), PRKCA(5), PRKCD(7), PRKCE(14), RAC2(2), RAC3(4), RAF1(10), SOS1(7), SOS2(19), SYK(7), TNF(3), VAV1(9), VAV2(12), VAV3(10) 29353214 374 118 360 116 114 93 10 74 78 5 0.157 1.000 1.000 249 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 50 ACTA1(3), AGT(3), AKT1(3), CALM1(2), CALM2(2), CALR(5), CAMK1(3), CAMK1G(6), CAMK4(8), CREBBP(40), CSNK1A1(3), EDN1(3), ELSPBP1(3), F2(9), FGF2(2), FKBP1A(2), GATA4(4), GSK3B(5), HAND1(3), HAND2(2), IGF1(4), LIF(2), MAP2K1(5), MAPK1(3), MAPK14(1), MAPK3(1), MAPK8(5), MEF2C(4), MYH2(29), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), NKX2-5(4), NPPA(2), PIK3R1(11), PPP3CA(10), PPP3CB(6), PPP3CC(5), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), RAF1(10), RPS6KB1(5), SYT1(4) 20830824 303 118 291 90 103 66 11 52 69 2 0.0222 1.000 1.000 250 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(3), AKT2(8), AKT3(6), ANKRD6(6), APC(43), AXIN1(9), AXIN2(15), CER1(2), CSNK1A1(3), CTNNB1(22), DACT1(10), DKK1(9), DKK2(5), DKK3(3), DKK4(3), DVL1(7), FSTL1(3), GSK3A(3), GSK3B(5), LRP1(47), MVP(7), NKD1(10), NKD2(1), PIN1(2), PSEN1(3), PTPRA(12), SENP2(4), SFRP1(4), TSHB(3), WIF1(2) 17297677 260 118 238 80 78 60 4 44 62 12 0.357 1.000 1.000 251 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 60 APAF1(8), ATM(38), ATR(18), BAI1(14), BAX(6), BID(2), CASP3(2), CASP9(3), CCNB1(3), CCNB2(1), CCNB3(20), CCND1(1), CCND2(3), CCND3(2), CCNE1(5), CCNE2(3), CD82(3), CDK2(3), CDK6(4), CDKN1A(3), CHEK1(4), CHEK2(8), DDB2(2), EI24(1), FAS(3), GADD45B(1), GTSE1(3), IGF1(4), IGFBP3(6), MDM2(5), MDM4(4), PERP(3), PPM1D(9), RCHY1(1), RFWD2(7), RPRM(5), RRM2(4), RRM2B(4), SERPINB5(3), SERPINE1(3), SESN1(3), SESN2(2), SESN3(4), SFN(1), SIAH1(2), STEAP3(9), THBS1(16), TNFRSF10B(2), TP53I3(1), TP73(5), TSC2(12), ZMAT3(4) 26539030 283 116 268 87 76 76 4 55 67 5 0.265 1.000 1.000 252 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 49 ABL1(7), ACTB(8), ACTG1(1), ARHGEF2(11), ARPC5L(1), CD14(2), CDC42(1), CLDN1(3), CTNNB1(22), CTTN(7), EZR(6), FYN(10), HCLS1(3), ITGB1(10), KRT18(2), LY96(4), NCK1(6), NCK2(5), NCL(7), OCLN(6), PRKCA(5), ROCK1(18), ROCK2(12), TLR4(21), TLR5(10), TUBA1A(2), TUBA1B(1), TUBA1C(1), TUBA3C(8), TUBA3D(7), TUBA3E(8), TUBA4A(1), TUBA8(5), TUBAL3(5), TUBB1(5), TUBB2A(3), TUBB2B(3), TUBB3(7), TUBB6(7), TUBB8(2), WAS(3), WASL(3), YWHAQ(2), YWHAZ(3) 21655457 264 116 252 86 67 73 7 64 50 3 0.287 1.000 1.000 253 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 49 ABL1(7), ACTB(8), ACTG1(1), ARHGEF2(11), ARPC5L(1), CD14(2), CDC42(1), CLDN1(3), CTNNB1(22), CTTN(7), EZR(6), FYN(10), HCLS1(3), ITGB1(10), KRT18(2), LY96(4), NCK1(6), NCK2(5), NCL(7), OCLN(6), PRKCA(5), ROCK1(18), ROCK2(12), TLR4(21), TLR5(10), TUBA1A(2), TUBA1B(1), TUBA1C(1), TUBA3C(8), TUBA3D(7), TUBA3E(8), TUBA4A(1), TUBA8(5), TUBAL3(5), TUBB1(5), TUBB2A(3), TUBB2B(3), TUBB3(7), TUBB6(7), TUBB8(2), WAS(3), WASL(3), YWHAQ(2), YWHAZ(3) 21655457 264 116 252 86 67 73 7 64 50 3 0.287 1.000 1.000 254 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CD2BP2(3), CDC40(8), CLK2(11), CLK3(12), CLK4(4), COL2A1(16), CPSF1(18), CPSF2(4), CPSF3(3), CPSF4(3), CSTF1(8), CSTF2(5), CSTF2T(7), CSTF3(8), DDIT3(4), DDX1(7), DDX20(4), DHX15(10), DHX16(6), DHX38(16), DHX8(14), DHX9(7), DICER1(11), DNAJC8(4), GIPC1(4), NCBP1(5), NCBP2(3), NONO(4), NUDT21(2), NXF1(7), PABPN1(1), PAPOLA(5), PHF5A(1), POLR2A(19), PPM1G(4), PRPF18(2), PRPF3(6), PRPF4(6), PRPF4B(11), PRPF8(16), PSKH1(7), PTBP1(7), PTBP2(2), RBM17(2), RBM5(8), RNGTT(4), RNMT(9), SF3A1(3), SF3A2(2), SF3A3(3), SF3B1(6), SF3B2(17), SF3B4(6), SNRPA(8), SNRPA1(4), SNRPB(2), SNRPB2(2), SNRPD1(2), SNRPD2(5), SNRPD3(4), SNRPE(2), SNRPG(1), SNRPN(8), SPOP(3), SRPK1(3), SRPK2(8), SRRM1(12), SUPT5H(13), U2AF1(4), U2AF2(10), XRN2(15) 45433080 471 116 454 126 150 119 19 68 110 5 0.0422 1.000 1.000 255 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 64 AGTR1(2), AGTR2(4), ATP8A1(8), AVPR1A(14), AVPR1B(3), AVPR2(6), BDKRB1(2), BDKRB2(4), BRS3(3), C3AR1(8), CCKAR(5), CCKBR(9), CCR1(5), CCR10(1), CCR2(6), CCR3(6), CCR5(4), CCR6(1), CCR7(3), CCR8(3), CX3CR1(3), CXCR3(1), CXCR4(1), CXCR6(2), EDNRA(4), FPR1(6), GALR1(6), GALR2(10), GALR3(2), GALT(1), GHSR(9), GNB2L1(4), GNRHR(4), GRPR(6), LHCGR(11), MC1R(6), MC2R(2), MC3R(9), MC4R(5), MC5R(5), NMBR(4), NPY1R(4), NPY2R(6), NPY5R(4), NTSR1(7), NTSR2(4), OPRD1(2), OPRK1(14), OPRL1(6), OPRM1(4), OXTR(7), SSTR1(9), SSTR2(4), SSTR3(8), SSTR4(14), TAC4(3), TACR1(3), TACR2(1), TACR3(15), TRHR(5), TSHR(10) 21493599 328 116 316 129 127 88 9 55 48 1 0.291 1.000 1.000 256 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(5), APC(43), ATF2(3), AXIN1(9), BMP10(4), BMP2(5), BMP4(6), BMP5(11), BMP7(7), BMPR1A(5), BMPR2(16), CHRD(9), CTNNB1(22), DVL1(7), FZD1(10), GATA4(4), GSK3B(5), MAP3K7(10), MEF2C(4), MYL2(8), NKX2-5(4), NOG(1), NPPA(2), NPPB(2), RFC1(10), TGFB1(3), TGFB2(6), TGFB3(8), TGFBR1(4), TGFBR2(14), TGFBR3(7), WNT1(8) 15607883 262 115 251 75 64 62 9 44 72 11 0.186 1.000 1.000 257 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 55 ADH1A(4), ADH1B(4), ADH4(2), ADH5(3), ADH6(7), ADH7(1), ADHFE1(9), ALDH1A3(6), ALDH3A1(11), ALDH3B1(4), ALDH3B2(7), AOC2(6), AOC3(15), AOX1(12), CARM1(5), COMT(4), DBH(6), DCT(13), ECH1(2), ESCO1(7), ESCO2(8), FAH(8), GOT1(3), GOT2(2), GSTZ1(3), HEMK1(1), HGD(4), HPD(1), LCMT1(1), LCMT2(11), MAOA(2), MAOB(3), METTL6(3), MIF(1), NAT6(3), PNMT(8), PNPLA3(2), PRMT2(8), PRMT3(5), PRMT5(3), PRMT6(4), PRMT7(6), PRMT8(9), SH3GLB1(3), TAT(5), TH(3), TPO(24), TYR(9), TYRP1(4), WBSCR22(6) 25073677 281 115 257 86 74 57 6 63 75 6 0.380 1.000 1.000 258 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 45 FN3K(3), IMPA1(4), IMPA2(2), INPP1(1), INPP4A(6), INPP4B(7), INPP5A(8), INPP5B(7), INPP5E(6), INPPL1(24), IPMK(1), ISYNA1(3), ITPK1(4), ITPKA(2), ITPKB(11), MINPP1(5), MIOX(5), OCRL(9), PI4KA(14), PI4KB(5), PIK3C3(14), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIP4K2A(6), PIP4K2B(4), PIP4K2C(2), PIP5K1A(4), PIP5K1B(1), PIP5K1C(11), PLCB1(19), PLCB2(8), PLCB3(12), PLCB4(13), PLCD1(4), PLCD3(9), PLCD4(5), PLCE1(14), PLCG1(19), PLCG2(15), PLCZ1(6), PTPMT1(1), SYNJ1(10), SYNJ2(18) 30553150 367 115 344 110 129 87 7 67 76 1 0.0512 1.000 1.000 259 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 85 AICDA(3), AK3(5), CAD(17), CANT1(4), CTPS2(4), DCTD(1), DHODH(3), DPYD(16), DPYS(7), DUT(2), ENTPD1(5), ENTPD3(5), ENTPD4(8), ENTPD5(3), ENTPD6(4), ENTPD8(6), ITPA(1), NME2(3), NME6(3), NME7(1), NT5C(1), NT5C1A(5), NT5C1B(6), NT5C2(8), NT5E(2), NUDT2(4), PNPT1(5), POLA1(6), POLA2(4), POLD1(15), POLD2(4), POLD3(7), POLE(24), POLE2(4), POLE3(3), POLR1A(15), POLR1B(8), POLR1C(3), POLR1D(4), POLR2A(19), POLR2B(11), POLR2C(4), POLR2E(2), POLR2F(4), POLR2G(1), POLR2I(2), POLR2K(1), POLR3A(17), POLR3B(13), POLR3G(2), POLR3K(1), PRIM1(2), PRIM2(1), RFC5(1), RRM1(5), RRM2(4), RRM2B(4), TK1(1), TK2(3), TXNRD1(6), TXNRD2(3), TYMS(1), UCK1(5), UCK2(1), UMPS(4), UPB1(4), UPP1(1), UPP2(7), UPRT(6), ZNRD1(1) 34589561 366 113 359 108 125 87 12 64 75 3 0.0340 1.000 1.000 260 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 33 AKT1(3), AKT2(8), AKT3(6), ASAH1(4), BRAF(16), DAG1(13), DRD2(9), EGFR(15), EPHB2(12), GRB2(4), ITPKA(2), ITPKB(11), ITPR1(24), ITPR2(30), ITPR3(36), KCNJ5(5), KCNJ9(2), MAPK1(3), PI3(2), PIK3CB(13), PITX2(6), PLCB1(19), PLCB2(8), PLCB3(12), PLCB4(13), RAF1(10), RGS20(6), SHC1(7), SOS1(7), SOS2(19), SRC(3), STAT3(7), TERF2IP(5) 24667306 340 113 325 113 116 79 11 63 67 4 0.322 1.000 1.000 261 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 30 AKT1(3), AKT2(8), AKT3(6), BCR(11), BTK(3), CD19(4), DAPP1(1), FLOT1(2), FLOT2(5), GAB1(3), ITPR1(24), ITPR2(30), ITPR3(36), LYN(5), NR0B2(3), PDK1(3), PHF11(4), PITX2(6), PLCG2(15), PPP1R13B(11), PREX1(16), PTPRC(19), RPS6KA1(9), RPS6KA2(9), RPS6KA3(4), RPS6KB1(5), SAG(4), SYK(7), TEC(4), VAV1(9) 22141852 269 112 262 99 95 62 7 53 47 5 0.587 1.000 1.000 262 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(4), ADH1B(4), ADH4(2), ADH5(3), ADH6(7), ADH7(1), ADHFE1(9), AGK(6), AGPAT1(3), AGPAT2(2), AGPAT3(4), AGPAT4(5), AGPAT6(5), AKR1A1(1), AKR1B1(6), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), CEL(10), DAK(8), DGAT1(3), DGAT2(1), DGKA(7), DGKB(11), DGKD(6), DGKE(7), DGKG(4), DGKH(10), DGKI(16), DGKQ(2), DGKZ(8), GK(3), GK2(7), GLA(3), GLB1(5), GPAM(10), LCT(23), LIPA(3), LIPC(4), LIPF(5), LIPG(4), LPL(7), MGLL(1), PNLIP(4), PNLIPRP1(4), PNPLA3(2), PPAP2A(3), PPAP2B(1), PPAP2C(4) 25140442 293 111 282 98 79 77 9 58 68 2 0.309 1.000 1.000 263 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 43 AKT1(3), AKT2(8), AKT3(6), BRAF(16), CAB39(1), EIF4B(5), EIF4EBP1(2), FIGF(4), HIF1A(7), IGF1(4), MAPK1(3), MAPK3(1), PDPK1(2), PGF(1), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(11), PIK3R3(8), PIK3R5(8), PRKAA1(6), PRKAA2(7), RHEB(1), RICTOR(19), RPS6(1), RPS6KA1(9), RPS6KA2(9), RPS6KA3(4), RPS6KA6(15), RPS6KB1(5), RPS6KB2(4), STK11(3), TSC1(7), TSC2(12), ULK1(16), ULK2(11), VEGFB(1), VEGFC(9) 21801263 285 111 266 86 98 58 11 50 66 2 0.275 1.000 1.000 264 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(43), AXIN1(9), CREBBP(40), CTNNB1(22), DVL1(7), EP300(22), FZD1(10), GSK3B(5), HDAC1(5), LDB1(5), LEF1(8), PITX2(6), TRRAP(50), WNT1(8) 14224454 240 110 227 64 75 52 6 39 58 10 0.0334 1.000 1.000 265 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 49 ACOX1(5), APOA1(8), CD36(2), CITED2(3), CPT1B(5), CREBBP(40), DUSP1(2), DUT(2), EHHADH(7), EP300(22), HSD17B4(7), HSPA1A(2), JUN(4), LPL(7), MAPK1(3), MAPK3(1), ME1(2), MYC(5), NCOA1(17), NCOR1(26), NCOR2(30), NFKBIA(1), NR0B2(3), NR1H3(6), NR2F1(7), NRIP1(17), PDGFA(2), PIK3R1(11), PPARA(4), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PRKCA(5), PTGS2(7), RB1(13), RELA(5), RXRA(6), SP1(6), STAT5A(3), STAT5B(14), TNF(3) 26171716 344 110 331 103 88 90 9 64 90 3 0.104 1.000 1.000 266 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 63 ACHE(11), AGPAT1(3), AGPAT2(2), AGPAT3(4), AGPAT4(5), AGPAT6(5), CDIPT(1), CDS1(6), CDS2(2), CHAT(4), CHKA(2), CHKB(2), CHPT1(3), CRLS1(1), DGKA(7), DGKB(11), DGKD(6), DGKE(7), DGKG(4), DGKH(10), DGKI(16), DGKQ(2), DGKZ(8), ESCO1(7), ESCO2(8), ETNK1(2), ETNK2(1), GNPAT(1), GPAM(10), GPD1(7), GPD1L(4), GPD2(7), LCAT(4), LYPLA1(1), LYPLA2(2), NAT6(3), PCYT1A(9), PCYT1B(6), PEMT(1), PHOSPHO1(1), PISD(5), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6), PLD1(19), PLD2(16), PNPLA3(2), PPAP2A(3), PPAP2B(1), PPAP2C(4), PTDSS1(4), PTDSS2(3), SH3GLB1(3) 27922723 290 109 285 99 93 70 9 55 61 2 0.359 1.000 1.000 267 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(29), COL4A2(13), COL4A3(13), COL4A4(15), COL4A5(14), COL4A6(9), F10(7), F11(4), F12(3), F2(9), F2R(3), F5(21), F8(22), F9(9), FGA(9), FGB(4), FGG(3), KLKB1(7), PROC(3), PROS1(9), SERPINC1(4), SERPING1(7) 19074452 217 109 214 67 51 55 7 62 41 1 0.150 1.000 1.000 268 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 32 AKT1(3), APC(43), AR(14), ASAH1(4), BRAF(16), CAMP(2), CCL15(2), CCL16(1), DAG1(13), EGFR(15), GNA11(6), GNA15(3), GNAI1(1), GNAQ(4), ITPKA(2), ITPKB(11), ITPR1(24), ITPR2(30), ITPR3(36), KCNJ5(5), KCNJ9(2), MAPK1(3), MAPK10(5), MAPK14(1), PHKA2(10), PIK3CD(11), PIK3R1(11), PITX2(6), PTX3(2), RAF1(10), SRC(3) 21528829 299 109 284 95 96 64 14 52 61 12 0.155 1.000 1.000 269 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 43 CBL(3), CD28(1), CSK(7), CTLA4(3), DAG1(13), EPHB2(12), GRAP2(4), GRB2(4), ITK(6), ITPKA(2), ITPKB(11), LAT(3), LCK(4), LCP2(7), MAPK1(3), NCK1(6), NFAT5(10), NFKB1(7), NFKB2(7), NFKBIA(1), NFKBIB(6), NFKBIL1(4), PAK1(5), PAK2(7), PAK3(5), PAK4(8), PAK6(9), PAK7(9), PLCG1(19), PTPRC(19), RAF1(10), RASGRP1(8), RASGRP2(7), RASGRP3(5), RASGRP4(4), SOS1(7), SOS2(19), VAV1(9), ZAP70(14) 23227824 288 109 278 90 92 69 9 60 56 2 0.222 1.000 1.000 270 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(3), ACTN1(7), ACTN2(23), BCAR1(8), BCR(11), CAPN1(5), CAPNS1(2), CAPNS2(2), CAV1(4), CRKL(1), CSK(7), FYN(10), GRB2(4), ITGA1(8), ITGB1(10), JUN(4), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), MAPK8(5), PPP1R12B(15), PTK2(11), PXN(4), RAF1(10), RAP1A(2), ROCK1(18), SHC1(7), SOS1(7), SRC(3), TLN1(23), VCL(6), ZYX(7) 20180510 239 108 230 75 82 57 9 47 41 3 0.0922 1.000 1.000 271 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 22 ADRB1(7), AKT1(3), APC(43), ASAH1(4), CAMP(2), CAV3(2), DAG1(13), DLG4(3), EPHB2(12), GNAI1(1), GNAQ(4), ITPR1(24), ITPR2(30), ITPR3(36), KCNJ5(5), KCNJ9(2), MAPK1(3), PITX2(6), PTX3(2), RHO(7), RYR1(61) 19250329 270 108 263 93 98 56 9 47 48 12 0.243 1.000 1.000 272 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 50 ACTG1(1), APAF1(8), ARHGDIB(1), BAG4(2), BCL2(3), BID(2), BIRC2(3), BIRC3(6), CASP2(3), CASP3(2), CASP6(1), CASP7(3), CASP9(3), CFLAR(1), CHUK(4), CRADD(1), DAXX(10), DFFA(4), DFFB(3), FADD(1), GSN(11), LMNA(6), LMNB1(4), LMNB2(6), MAP3K1(11), MAP3K5(5), MAPK8(5), MDM2(5), NFKB1(7), NFKBIA(1), NUMA1(22), PAK2(7), PRKCD(7), PRKDC(40), PSEN1(3), PSEN2(2), PTK2(11), RASA1(17), RB1(13), RELA(5), RIPK1(2), SPTAN1(21), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF1(3), TRAF2(4) 28835914 294 107 286 97 81 76 15 46 73 3 0.415 1.000 1.000 273 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(13), AR(14), ESR1(9), ESR2(9), ESRRA(2), HNF4A(7), NR0B1(5), NR1D1(5), NR1D2(6), NR1H2(7), NR1H3(6), NR1I2(7), NR1I3(4), NR2C2(3), NR2E1(3), NR2F1(7), NR2F2(3), NR2F6(3), NR3C1(6), NR4A1(4), NR4A2(12), NR5A1(5), NR5A2(5), PGR(14), PPARA(4), PPARD(8), PPARG(4), RARA(3), RARB(7), RARG(1), ROR1(10), RORA(5), RORC(6), RXRA(6), RXRB(4), RXRG(5), THRA(6), THRB(9), VDR(2) 18034824 239 107 233 99 87 50 13 49 39 1 0.840 1.000 1.000 274 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 54 AK3(5), CAD(17), CANT1(4), CTPS2(4), DCTD(1), DHODH(3), DPYD(16), DPYS(7), DUT(2), ENTPD1(5), ITPA(1), NME2(3), NT5C(1), NT5E(2), NUDT2(4), POLB(4), POLD1(15), POLD2(4), POLE(24), POLG(8), POLL(3), POLQ(29), POLR1B(8), POLR2A(19), POLR2B(11), POLR2C(4), POLR2E(2), POLR2F(4), POLR2G(1), POLR2I(2), POLR2K(1), POLRMT(9), RRM1(5), RRM2(4), TK1(1), TK2(3), TXNRD1(6), TYMS(1), UCK1(5), UCK2(1), UMPS(4), UNG(2), UPB1(4), UPP1(1) 24438612 260 107 256 82 72 65 10 54 56 3 0.196 1.000 1.000 275 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 45 AKT1(3), AKT2(8), AKT3(6), BRD4(11), CAP1(2), CBL(3), CDC42(1), F2RL2(3), FLOT1(2), FLOT2(5), GRB2(4), GSK3A(3), GSK3B(5), INPPL1(24), IRS1(24), IRS2(6), IRS4(27), LNPEP(11), MAPK1(3), MAPK3(1), PARD3(11), PARD6A(1), PDK1(3), PIK3CD(11), PIK3R1(11), PTPN1(3), RAF1(10), RPS6KA1(9), RPS6KA2(9), RPS6KA3(4), RPS6KB1(5), SERPINB6(4), SFN(1), SHC1(7), SLC2A4(4), SORBS1(9), SOS1(7), SOS2(19), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(3), YWHAQ(2), YWHAZ(3) 23837686 293 107 274 87 105 65 3 41 75 4 0.135 1.000 1.000 276 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(1), ACTG2(9), ACTR2(2), ACTR3(2), AKT1(3), ANGPTL2(4), CDC42(1), CFL1(1), CFL2(1), FLNA(26), FLNC(26), FSCN1(5), FSCN3(11), GDI1(3), GDI2(4), LIMK1(5), MYH2(29), MYLK(22), MYLK2(4), PAK1(5), PAK2(7), PAK3(5), PAK4(8), PAK6(9), PAK7(9), PFN2(2), RHO(7), ROCK1(18), ROCK2(12), RPS4X(1), VASP(2), WASF1(5), WASL(3) 20534986 252 107 246 85 92 61 8 42 44 5 0.192 1.000 1.000 277 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(14), GABBR1(16), GPRC5B(8), GPRC5C(3), GPRC5D(2), GRM1(31), GRM2(23), GRM3(17), GRM4(11), GRM5(26), GRM7(20), GRM8(22) 9011198 193 105 184 75 82 30 11 42 28 0 0.481 1.000 1.000 278 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(6), ALPL(8), ALPP(7), ALPPL2(5), ASCC3(31), ATP13A2(13), DDX18(10), DDX19A(5), DDX23(8), DDX4(5), DDX41(8), DDX47(2), DDX50(11), DDX51(5), DDX52(3), DDX54(18), DDX55(5), DDX56(5), DHX58(9), ENTPD7(11), EP400(35), ERCC2(8), ERCC3(8), FPGS(4), GCH1(1), GGH(3), IFIH1(8), MOV10L1(6), QDPR(3), RAD54B(3), RAD54L(5), RUVBL2(5), SETX(20), SKIV2L2(8), SMARCA2(22), SMARCA5(7), SPR(2) 26941169 323 104 317 110 112 70 8 62 68 3 0.507 1.000 1.000 279 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 A4GALT(3), B3GALNT1(3), B3GALT1(3), B3GALT2(7), B3GALT4(7), B3GALT5(1), B3GNT1(3), B3GNT2(3), B3GNT3(5), B3GNT4(7), B3GNT5(10), B4GALNT1(5), B4GALT1(2), B4GALT2(7), B4GALT3(2), B4GALT4(5), B4GALT6(4), FUT1(3), FUT2(1), FUT3(3), FUT4(2), FUT5(3), FUT6(4), FUT7(2), FUT9(6), GBGT1(3), GCNT2(2), PIGA(3), PIGB(10), PIGC(6), PIGF(1), PIGG(12), PIGK(3), PIGL(4), PIGM(5), PIGN(7), PIGO(12), PIGP(1), PIGQ(7), PIGS(4), PIGT(8), PIGU(1), PIGV(7), PIGX(2), PIGZ(4), ST3GAL1(4), ST3GAL2(6), ST3GAL3(2), ST3GAL4(6), ST3GAL5(3), ST3GAL6(4), ST6GALNAC3(8), ST6GALNAC4(2), ST6GALNAC5(3), ST6GALNAC6(4), ST8SIA1(7), ST8SIA5(8), UGCG(3) 20790706 263 103 244 91 86 50 6 47 71 3 0.758 1.000 1.000 280 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(5), AASDHPPT(1), AASS(7), ACAT1(5), ACAT2(4), AKR1B10(6), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), BBOX1(4), DLST(4), DOT1L(11), EHHADH(7), EHMT1(14), EHMT2(12), GCDH(8), HADH(3), HADHA(4), HSD17B4(7), HSD3B7(6), NSD1(24), OGDH(11), OGDHL(16), PIPOX(3), PLOD1(7), PLOD2(12), PLOD3(16), RDH11(1), RDH12(3), RDH13(5), SETD1A(18), SETD7(2), SETDB1(18), SHMT1(2), SHMT2(9), SPCS1(2), SPCS3(2), SUV39H1(5), SUV39H2(2), TMLHE(5) 24889355 316 102 292 92 96 74 9 51 83 3 0.119 1.000 1.000 281 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 57 AADAT(5), AANAT(2), ACAT1(5), ACAT2(4), ACMSD(5), AFMID(3), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), AOC2(6), AOC3(15), AOX1(12), ASMT(3), CARM1(5), CAT(5), CYP1A1(5), CYP1A2(5), CYP1B1(2), EHHADH(7), GCDH(8), HAAO(1), HADH(3), HADHA(4), HEMK1(1), HSD17B4(7), INMT(3), KMO(4), KYNU(11), LCMT1(1), LCMT2(11), LNX1(3), MAOA(2), MAOB(3), METTL6(3), NFX1(5), OGDH(11), OGDHL(16), PRMT2(8), PRMT3(5), PRMT5(3), PRMT6(4), PRMT7(6), PRMT8(9), TDO2(7), TPH1(3), TPH2(7), WARS(5), WARS2(10), WBSCR22(6) 25538240 304 102 276 96 75 72 11 50 90 6 0.419 1.000 1.000 282 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 31 ACTR2(2), ACTR3(2), AKT1(3), ANGPTL2(4), DAG1(13), DGKA(7), ETFA(1), GCA(2), ITGA9(8), ITPKA(2), ITPKB(11), ITPR1(24), ITPR2(30), ITPR3(36), MAP2K1(5), MAPK1(3), MAPK3(1), NR1I3(4), PAK1(5), PDE3A(14), PDE3B(20), PI3(2), PIK3C2G(10), PIK3CD(11), PIK3R1(11), PSME1(3), RIPK3(5), RPS4X(1), SGCB(4), VASP(2) 19922709 246 102 236 73 77 60 9 46 50 4 0.0603 1.000 1.000 283 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 40 AKT1(3), ASAH1(4), BRAF(16), CAMP(2), CREB1(3), CREB5(5), CREBBP(40), CRKL(1), DAG1(13), EGR1(10), EGR2(8), EGR3(6), EGR4(6), ELK1(3), FRS2(4), GNAQ(4), JUN(4), MAP1B(20), MAP2K4(8), MAPK1(3), MAPK10(5), MAPK3(1), MAPK8(5), MAPK8IP1(4), MAPK8IP2(4), MAPK8IP3(13), MAPK9(3), NTRK1(10), OPN1LW(6), PIK3C2G(10), PIK3CD(11), PIK3R1(11), PTPN11(6), RPS6KA3(4), SHC1(7), SRC(3), TERF2IP(5), TH(3) 20776834 274 102 260 88 88 65 4 49 65 3 0.161 1.000 1.000 284 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 40 AGL(16), AMY2A(3), ENPP1(7), ENPP3(8), GAA(5), GANAB(12), GBE1(5), GCK(4), GPI(5), GUSB(11), GYS1(6), GYS2(6), HK1(16), HK2(10), HK3(6), MGAM(15), PGM1(2), PGM3(7), PYGB(10), PYGL(8), PYGM(14), SI(27), UCHL1(1), UCHL3(3), UGDH(5), UGT1A1(4), UGT1A10(1), UGT1A3(1), UGT1A4(3), UGT1A5(3), UGT1A6(6), UGT1A7(3), UGT1A9(3), UGT2B15(3), UGT2B4(4), UXS1(5) 23900373 248 102 244 83 63 71 6 50 58 0 0.362 1.000 1.000 285 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 41 CALM1(2), CALM2(2), CD3E(2), CD3G(1), ELK1(3), FOS(1), FYN(10), GRB2(4), JUN(4), LAT(3), LCK(4), MAP2K1(5), MAP2K4(8), MAP3K1(11), MAPK3(1), MAPK8(5), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), NFKB1(7), NFKBIA(1), PIK3R1(11), PLCG1(19), PPP3CA(10), PPP3CB(6), PPP3CC(5), PRKCA(5), PTPN7(7), RAF1(10), RASA1(17), RELA(5), SHC1(7), SOS1(7), SYT1(4), VAV1(9), ZAP70(14) 19599314 260 102 249 63 83 59 6 38 70 4 0.00531 1.000 1.000 286 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 53 AANAT(2), ACAT1(5), ACAT2(4), ACMSD(5), ALDH1A1(7), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), AOC2(6), AOC3(15), AOX1(12), ASMT(3), CAT(5), CYP19A1(13), CYP1A1(5), CYP1A2(5), CYP2A13(8), CYP2A6(7), CYP2A7(3), CYP2B6(6), CYP2C18(4), CYP2C19(7), CYP2C8(1), CYP2D6(9), CYP2E1(6), CYP2F1(4), CYP2J2(3), CYP3A4(4), CYP3A7(4), CYP4B1(9), CYP51A1(8), EHHADH(7), GCDH(8), HAAO(1), HADHA(4), KMO(4), KYNU(11), MAOA(2), MAOB(3), SDS(4), TDO2(7), TPH1(3), WARS(5), WARS2(10) 23202205 289 101 267 82 79 65 5 58 79 3 0.194 1.000 1.000 287 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 AGXT(1), AGXT2(8), AKR1B10(6), ALAS1(3), ALAS2(12), AMT(4), AOC2(6), AOC3(15), BHMT(5), CBS(6), CHDH(6), CHKA(2), CHKB(2), CTH(2), DAO(11), DLD(4), DMGDH(6), GAMT(1), GARS(4), GATM(3), GCAT(4), GLDC(8), GNMT(4), HSD3B7(6), MAOA(2), MAOB(3), PEMT(1), PHGDH(3), PIPOX(3), PISD(5), PSAT1(5), PSPH(2), RDH11(1), RDH12(3), RDH13(5), SARDH(13), SARS(8), SARS2(7), SDS(4), SHMT1(2), SHMT2(9), TARS(7), TARS2(7) 18301593 219 100 207 73 68 53 13 39 45 1 0.370 1.000 1.000 288 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACAA1(3), ACADL(2), ACADM(4), ACOX1(5), ACOX2(6), ACOX3(11), ACSL1(3), ACSL3(8), ACSL4(4), ACSL5(7), ACSL6(6), ADIPOQ(3), ANGPTL4(2), APOA1(8), APOA5(4), AQP7(2), CD36(2), CPT1A(10), CPT1B(5), CPT1C(7), CPT2(5), CYP27A1(5), CYP4A11(2), CYP4A22(2), CYP7A1(6), CYP8B1(7), EHHADH(7), FABP2(1), FABP3(1), FABP5(1), FABP6(3), FABP7(1), FADS2(5), GK(3), GK2(7), HMGCS2(3), ILK(8), LPL(7), ME1(2), MMP1(2), NR1H3(6), OLR1(2), PCK1(11), PCK2(9), PDPK1(2), PLTP(2), PPARA(4), PPARD(8), PPARG(4), RXRA(6), RXRB(4), RXRG(5), SCD(1), SCP2(5), SLC27A1(4), SLC27A2(6), SLC27A4(10), SLC27A5(5), SLC27A6(8), SORBS1(9), UBC(8), UCP1(2) 28118351 301 100 290 95 105 52 19 63 59 3 0.186 1.000 1.000 289 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(6), APH1A(1), CREBBP(40), CTBP1(3), CTBP2(8), DLL1(15), DLL3(7), DLL4(4), DTX1(14), DTX2(5), DTX3(2), DTX3L(2), DTX4(7), DVL1(7), DVL2(6), DVL3(12), EP300(22), HDAC1(5), HDAC2(2), JAG1(12), JAG2(8), MAML1(5), MAML2(7), MAML3(8), NCOR2(30), NCSTN(7), NOTCH1(26), NOTCH2(25), NOTCH3(22), NOTCH4(16), NUMB(3), NUMBL(4), PSEN1(3), PSEN2(2), PSENEN(2), PTCRA(2), RBPJ(7), RBPJL(6), RFNG(2), SNW1(6) 29602732 371 100 361 154 131 81 14 62 82 1 0.805 1.000 1.000 290 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 41 BCL2(3), CHUK(4), DAXX(10), EGF(10), EGFR(15), ETS1(8), ETS2(4), FOS(1), HOXA7(4), IKBKB(8), JUN(4), MAP2K1(5), MAP2K3(4), MAP2K4(8), MAP2K6(1), MAP3K1(11), MAP3K5(5), MAPK1(3), MAPK13(3), MAPK14(1), MAPK3(1), MAPK8(5), NFKB1(7), NFKBIA(1), PPP2CA(4), PRKCA(5), PRKCD(7), PRKCE(14), PRKCG(17), PRKCH(6), PRKCQ(10), RAF1(10), RELA(5), RIPK1(2), SP1(6), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TRAF2(4) 20786976 228 100 220 80 72 50 7 44 51 4 0.327 1.000 1.000 291 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(45), B3GALT4(7), CDR1(5), DGKI(16), IL6ST(6), PIGK(3), RPL10(5), RPL11(1), RPL12(3), RPL13A(4), RPL14(1), RPL15(1), RPL18(1), RPL19(2), RPL22(2), RPL23(1), RPL24(1), RPL26(1), RPL27(1), RPL28(2), RPL29(1), RPL3(3), RPL31(1), RPL34(2), RPL35A(1), RPL36(1), RPL37(1), RPL38(1), RPL3L(3), RPL4(1), RPL5(3), RPL6(2), RPL7(1), RPL7A(5), RPL8(2), RPL9(3), RPLP0(3), RPLP1(1), RPLP2(2), RPS11(2), RPS13(2), RPS14(2), RPS18(1), RPS20(1), RPS23(1), RPS24(1), RPS25(1), RPS27(1), RPS27A(2), RPS3(2), RPS3A(2), RPS4X(1), RPS4Y1(1), RPS5(4), RPS6(1), RPS6KA1(9), RPS6KA2(9), RPS6KA3(4), RPS6KA6(15), RPS6KB1(5), RPS6KB2(4), RPS7(1), RPS9(1), RPSA(2), SLC36A2(7), TBC1D10C(5), TSPAN9(2), UBA52(2), UBC(8) 22452226 244 100 236 76 60 64 11 49 58 2 0.493 1.000 1.000 292 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 38 AKT1(3), AKT2(8), AKT3(6), BAD(3), BCR(11), BLNK(4), BTK(3), CD19(4), CSK(7), DAG1(13), EPHB2(12), GRB2(4), ITPKA(2), ITPKB(11), LYN(5), MAP2K1(5), MAP2K2(3), MAPK1(3), NFAT5(10), NFKB1(7), NFKB2(7), NFKBIA(1), NFKBIB(6), NFKBIL1(4), PI3(2), PIK3CD(11), PIK3R1(11), PLCG2(15), PPP1R13B(11), RAF1(10), SERPINA4(2), SHC1(7), SOS1(7), SOS2(19), SYK(7), VAV1(9) 21686339 253 100 241 88 82 59 3 50 56 3 0.565 1.000 1.000 293 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(12), ACSS2(10), ACYP1(1), ACYP2(3), ADH1A(4), ADH1B(4), ADH4(2), ADH5(3), ADH6(7), ADH7(1), ADHFE1(9), AKR1A1(1), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH3B1(4), ALDH3B2(7), ALDH9A1(4), ALDOA(1), ALDOB(6), ALDOC(6), BPGM(5), DLAT(3), DLD(4), ENO1(3), ENO2(3), ENO3(4), FBP1(4), FBP2(5), G6PC2(1), GALM(4), GAPDH(2), GAPDHS(4), GCK(4), GPI(5), HK1(16), HK2(10), HK3(6), LDHA(3), LDHAL6B(5), LDHB(4), LDHC(1), PDHA1(1), PDHA2(6), PDHB(4), PFKL(5), PFKM(2), PFKP(14), PGAM2(5), PGAM4(2), PGK1(4), PGK2(3), PGM1(2), PGM3(7), PKLR(7), TPI1(1) 24964559 285 99 271 101 73 83 8 63 57 1 0.471 1.000 1.000 294 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(22), ACACB(35), ACAT1(5), ACAT2(4), ACOT12(5), ACSS1(12), ACSS2(10), ACYP1(1), ACYP2(3), AKR1B1(6), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), DLAT(3), DLD(4), GLO1(2), GRHPR(1), HAGH(3), HAGHL(1), LDHA(3), LDHAL6B(5), LDHB(4), LDHC(1), LDHD(3), MDH1(3), ME1(2), ME2(5), ME3(4), PC(15), PCK1(11), PCK2(9), PDHA1(1), PDHA2(6), PDHB(4), PKLR(7) 20067838 245 99 232 79 71 62 6 49 54 3 0.349 1.000 1.000 295 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 56 ALG2(2), BAK1(4), BAX(6), BFAR(5), BTK(3), CAD(17), CASP10(6), CASP3(2), CD7(5), CSNK1A1(3), DAXX(10), DEDD(2), DEDD2(1), DFFA(4), DIABLO(1), EGFR(15), EPHB2(12), FADD(1), FAF1(8), FAIM2(1), IL1A(2), MAP2K4(8), MAP3K1(11), MAP3K5(5), MAPK1(3), MAPK10(5), MAPK8(5), MAPK8IP1(4), MAPK8IP2(4), MAPK8IP3(13), MAPK9(3), MET(8), NFAT5(10), NFKB1(7), NFKB2(7), NFKBIA(1), NFKBIB(6), NFKBIL1(4), NR0B2(3), PFN2(2), PTPN13(24), RALBP1(8), RIPK1(2), ROCK1(18), SMPD1(6), TPX2(6), TRAF2(4) 30041275 287 99 274 106 80 70 5 51 75 6 0.781 1.000 1.000 296 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 31 ADH1A(4), ADH1B(4), ADH4(2), ADH6(7), ADH7(1), ADHFE1(9), ALDH1A3(6), ALDH3A1(11), ALDH3B1(4), ALDH3B2(7), AOC2(6), AOC3(15), AOX1(12), COMT(4), DBH(6), DCT(13), FAH(8), GOT1(3), GOT2(2), GSTZ1(3), HGD(4), HPD(1), MAOA(2), MAOB(3), PNMT(8), TAT(5), TH(3), TPO(24), TYR(9) 13167243 186 99 168 60 51 37 2 48 44 4 0.447 1.000 1.000 297 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 AGMAT(2), ALDH1A1(7), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH4A1(4), ALDH9A1(4), AMD1(5), AOC2(6), AOC3(15), ARG1(2), ARG2(2), ASL(6), CKB(2), CKM(1), CKMT1A(3), CKMT1B(1), CKMT2(6), CPS1(22), DAO(11), GAMT(1), GATM(3), GLUD1(2), GOT1(3), GOT2(2), MAOA(2), MAOB(3), NOS1(28), NOS3(10), OAT(2), ODC1(4), OTC(2), P4HA1(5), P4HA2(8), P4HA3(6), P4HB(4), PYCR1(1), RARS(5), SMS(5) 18952255 241 98 223 68 71 59 9 47 54 1 0.0923 1.000 1.000 298 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 35 BTK(3), CALM1(2), CALM2(2), ELK1(3), FCER1A(3), FOS(1), GRB2(4), JUN(4), LYN(5), MAP2K1(5), MAP2K4(8), MAP3K1(11), MAPK1(3), MAPK3(1), MAPK8(5), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), PAK2(7), PIK3R1(11), PLA2G4A(6), PLCG1(19), PPP3CA(10), PPP3CB(6), PPP3CC(5), RAF1(10), SHC1(7), SOS1(7), SYK(7), SYT1(4), VAV1(9) 17251998 218 98 209 53 72 53 7 31 50 5 0.00416 1.000 1.000 299 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(4), ADH1B(4), ADH4(2), ADH6(7), ADH7(1), ADHFE1(9), AGPAT1(3), AGPAT2(2), AGPAT3(4), AGPAT4(5), AKR1A1(1), AKR1B1(6), ALDH1A1(7), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), CEL(10), DGAT1(3), DGKA(7), DGKB(11), DGKD(6), DGKE(7), DGKG(4), DGKH(10), DGKQ(2), DGKZ(8), GK(3), GLA(3), GLB1(5), LCT(23), LIPC(4), LIPF(5), LIPG(4), LPL(7), PNLIP(4), PNLIPRP1(4), PPAP2A(3), PPAP2B(1), PPAP2C(4) 20656971 243 98 232 89 67 61 7 47 59 2 0.608 1.000 1.000 300 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(3), AKT2(8), AKT3(6), ARHGEF11(18), BCL2(3), CDC42(1), DLG4(3), GNA13(5), LPA(17), MAP2K4(8), MAP3K1(11), MAP3K5(5), MAPK8(5), NFKB1(7), NFKB2(7), NFKBIA(1), NFKBIB(6), NFKBIL1(4), PDK1(3), PHKA2(10), PI3(2), PIK3CB(13), PLD1(19), PLD2(16), PLD3(6), PTK2(11), RDX(7), ROCK1(18), ROCK2(12), SERPINA4(2), SRF(2), TBXA2R(8) 21046269 247 98 233 64 73 58 9 33 68 6 0.0533 1.000 1.000 301 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 63 APAF1(8), BAD(3), BAK1(4), BAX(6), BCL2(3), BCL2L11(1), BID(2), BIRC2(3), BIRC3(6), BIRC5(2), CASP1(4), CASP10(6), CASP2(3), CASP3(2), CASP4(8), CASP6(1), CASP7(3), CASP9(3), CHUK(4), DFFA(4), DFFB(3), FADD(1), FAS(3), FASLG(3), GZMB(3), HELLS(8), IKBKB(8), IRF1(5), IRF3(3), IRF4(7), IRF5(4), IRF6(5), IRF7(1), JUN(4), LTA(4), MAP2K4(8), MAP3K1(11), MAPK10(5), MDM2(5), MYC(5), NFKB1(7), NFKBIA(1), NFKBIB(6), PLEKHG5(7), PRF1(8), RELA(5), RIPK1(2), TNF(3), TNFRSF10B(2), TNFRSF1A(6), TNFRSF1B(3), TNFRSF21(5), TNFRSF25(4), TNFSF10(5), TP73(5), TRADD(2), TRAF1(3), TRAF2(4), TRAF3(4) 23443633 254 97 243 75 64 57 10 47 73 3 0.199 1.000 1.000 302 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(17), CARM1(5), CCND1(1), CREBBP(40), EP300(22), ERCC3(8), ESR1(9), GRIP1(20), GTF2A1(3), GTF2E1(6), GTF2F1(5), HDAC1(5), HDAC2(2), HDAC3(6), HDAC4(25), HDAC5(10), HDAC6(7), MEF2C(4), NCOR2(30), NR0B1(5), NRIP1(17), PELP1(6), POLR2A(19), TBP(3) 19723106 275 97 262 73 92 68 7 45 61 2 0.00825 1.000 1.000 303 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 ANKHD1(12), EEF1A2(5), EEF1B2(3), EEF1D(3), EEF1G(3), EEF2(9), EEF2K(10), EIF1AX(2), EIF1AY(1), EIF2AK1(5), EIF2AK2(5), EIF2AK3(15), EIF2B1(4), EIF2B2(3), EIF2B3(7), EIF2B4(9), EIF2B5(9), EIF2S1(2), EIF2S2(2), EIF4A1(3), EIF4A2(6), EIF4E(2), EIF4EBP1(2), EIF4EBP2(2), EIF4G1(23), EIF4G3(17), EIF5(6), EIF5A(5), EIF5B(20), ETF1(4), GSPT2(6), PABPC1(2), PABPC3(10), PAIP1(1), SLC35A4(6) 18741103 224 96 209 61 57 62 7 49 46 3 0.0921 1.000 1.000 304 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 48 ACHE(11), AGPAT1(3), AGPAT2(2), AGPAT3(4), AGPAT4(5), AGPS(2), CDIPT(1), CDS1(6), CDS2(2), CHAT(4), CHKA(2), CHKB(2), CLC(1), CPT1B(5), DGKA(7), DGKB(11), DGKD(6), DGKE(7), DGKG(4), DGKH(10), DGKQ(2), DGKZ(8), ETNK1(2), GNPAT(1), GPD1(7), GPD2(7), LCAT(4), LYPLA1(1), LYPLA2(2), PAFAH1B1(12), PAFAH2(3), PCYT1A(9), PCYT1B(6), PEMT(1), PISD(5), PLA2G2A(2), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6), PLCB2(8), PLCG1(19), PLCG2(15), PPAP2A(3), PPAP2B(1), PPAP2C(4) 21257977 243 95 233 88 77 60 8 45 51 2 0.560 1.000 1.000 305 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 AGXT(1), AGXT2(8), ALAS1(3), ALAS2(12), AMT(4), AOC2(6), AOC3(15), BHMT(5), CBS(6), CHDH(6), CHKA(2), CHKB(2), CPT1B(5), CTH(2), DAO(11), DLD(4), DMGDH(6), GAMT(1), GARS(4), GATM(3), GCAT(4), GLDC(8), MAOA(2), MAOB(3), PEMT(1), PISD(5), PLCB2(8), PLCG1(19), PLCG2(15), PSPH(2), SARDH(13), SARS(8), SHMT1(2), SHMT2(9), TARS(7) 18004346 212 95 200 69 61 46 10 44 50 1 0.440 1.000 1.000 306 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(19), CALM1(2), CALM2(2), CREB1(3), ELK1(3), FOS(1), GNAI1(1), GNAQ(4), GNAS(29), GNB1(1), GNGT1(3), JUN(4), MAP2K1(5), MAPK3(1), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), PLCG1(19), PPP3CA(10), PPP3CB(6), PPP3CC(5), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PRKCA(5), RAF1(10), RPS6KA3(4), SYT1(4) 15033057 222 95 211 67 89 52 4 33 44 0 0.0511 1.000 1.000 307 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(4), ADH1B(4), ADH4(2), ADH5(3), ADH6(7), ADH7(1), ADHFE1(9), AKR1C1(3), AKR1C2(1), AKR1C3(2), AKR1C4(6), ALDH1A3(6), ALDH3A1(11), ALDH3B1(4), ALDH3B2(7), CYP1A1(5), CYP1A2(5), CYP1B1(2), CYP2B6(6), CYP2C18(4), CYP2C19(7), CYP2C8(1), CYP2E1(6), CYP2F1(4), CYP2S1(6), CYP3A4(4), CYP3A43(4), CYP3A7(4), DHDH(5), EPHX1(9), GSTA1(3), GSTA2(2), GSTA3(1), GSTA4(2), GSTA5(2), GSTK1(1), GSTM2(1), GSTM3(2), GSTM4(3), GSTM5(2), GSTO2(3), GSTP1(1), GSTZ1(3), MGST1(3), MGST2(3), MGST3(3), UGT1A1(4), UGT1A10(1), UGT1A3(1), UGT1A4(3), UGT1A5(3), UGT1A6(6), UGT1A7(3), UGT1A9(3), UGT2A1(3), UGT2A3(6), UGT2B10(5), UGT2B11(1), UGT2B15(3), UGT2B17(2), UGT2B28(7), UGT2B4(4), UGT2B7(6) 24504533 238 95 228 66 54 64 3 60 56 1 0.112 1.000 1.000 308 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 33 ACTA1(3), CRKL(1), DOCK1(17), ELK1(3), FOS(1), GAB1(3), GRB2(4), HGF(15), ITGA1(8), ITGB1(10), JUN(4), MAP2K1(5), MAP2K2(3), MAP4K1(4), MAPK1(3), MAPK3(1), MAPK8(5), MET(8), PAK1(5), PIK3R1(11), PTK2(11), PTK2B(16), PTPN11(6), PXN(4), RAF1(10), RAP1A(2), RAP1B(6), RASA1(17), SOS1(7), SRC(3), STAT3(7) 17658832 203 95 191 64 51 45 9 46 49 3 0.271 1.000 1.000 309 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(16), ADRA1B(5), ADRA1D(4), ADRA2A(7), ADRA2C(5), ADRB1(7), ADRB2(8), ADRB3(5), CHRM1(4), CHRM2(17), CHRM3(11), CHRM4(2), CHRM5(2), DRD1(3), DRD2(9), DRD3(7), DRD4(3), DRD5(10), HRH1(5), HRH2(8), HTR1A(11), HTR1B(10), HTR1D(4), HTR1E(10), HTR1F(8), HTR2A(6), HTR2B(5), HTR2C(6), HTR4(5), HTR5A(9), HTR6(7), HTR7(10) 11062835 229 95 222 81 89 50 13 50 27 0 0.116 1.000 1.000 310 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 24 ATM(38), BMPR1B(7), CCND2(3), DMC1(8), EGR1(10), ESR2(9), GJA4(4), INHA(5), LHCGR(11), MLH1(6), MSH5(4), NCOR1(26), NR5A1(5), NRIP1(17), PGR(14), PRLR(4), PTGER2(5), SMPD1(6), VDR(2), ZP2(8) 14401287 192 95 179 55 45 55 8 32 48 4 0.151 1.000 1.000 311 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 112 ATP12A(18), ATP4A(17), ATP4B(4), ATP5A1(2), ATP5B(7), ATP5C1(3), ATP5F1(1), ATP5G2(1), ATP5G3(1), ATP5J(1), ATP5J2(1), ATP5L(2), ATP6AP1(6), ATP6V0A1(5), ATP6V0A2(7), ATP6V0A4(10), ATP6V0B(4), ATP6V0D1(8), ATP6V0D2(2), ATP6V1A(6), ATP6V1B2(5), ATP6V1C1(2), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(2), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), COX10(2), COX15(6), COX4I1(6), COX4I2(1), COX6B1(2), COX7A1(1), COX7A2(1), COX7B(2), COX7C(1), COX8C(4), CYC1(3), LHPP(4), NDUFA1(1), NDUFA10(4), NDUFA12(2), NDUFA3(1), NDUFA6(1), NDUFA8(5), NDUFA9(4), NDUFAB1(2), NDUFB11(2), NDUFB2(1), NDUFB3(2), NDUFB4(1), NDUFB5(1), NDUFB6(1), NDUFB7(1), NDUFB8(1), NDUFB9(2), NDUFC2(1), NDUFS1(7), NDUFS2(5), NDUFS3(2), NDUFS4(2), NDUFS5(3), NDUFS6(3), NDUFS7(3), NDUFS8(2), NDUFV1(5), PPA1(2), PPA2(3), SDHA(6), SDHB(4), SDHC(1), SDHD(1), TCIRG1(7), UQCRB(1), UQCRC1(2), UQCRC2(3), UQCRFS1(1), UQCRQ(1) 23452838 272 94 263 98 87 67 11 51 56 0 0.595 1.000 1.000 312 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 22 IMPA1(4), INPP1(1), INPP4A(6), INPP4B(7), INPP5A(8), INPPL1(24), ITPKA(2), ITPKB(11), MIOX(5), OCRL(9), PIK3C2A(14), PIK3C2B(19), PIK3C2G(10), PIK3CB(13), PIK3CG(21), PLCB1(19), PLCB2(8), PLCB3(12), PLCB4(13), PLCD1(4), PLCG1(19), PLCG2(15) 18252148 244 94 226 71 73 56 10 48 55 2 0.246 1.000 1.000 313 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 30 AKR1C3(2), ALOX12(6), ALOX15(7), ALOX5(10), CBR1(1), CBR3(2), CYP4F2(6), CYP4F3(11), EPX(9), GGT1(6), LPO(9), LTA4H(5), MPO(7), PLA2G2A(2), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6), PRDX1(1), PRDX2(2), PRDX5(1), PRDX6(2), PTGDS(1), PTGES2(3), PTGIS(6), PTGS1(12), PTGS2(7), TBXAS1(6), TPO(24) 11835282 174 94 170 48 62 29 9 42 31 1 0.0527 1.000 1.000 314 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 46 APAF1(8), BAD(3), BAX(6), BCL2(3), BCL2L2(4), BOK(1), CASP1(4), CASP10(6), CASP2(3), CASP3(2), CASP4(8), CASP6(1), CASP7(3), CASP9(3), CD40(3), CD40LG(5), CRADD(1), DAXX(10), DFFA(4), DFFB(3), FADD(1), FAS(3), FASLG(3), IKBKE(12), LTA(4), MCL1(1), NFKB1(7), NFKBIA(1), NGFR(4), NR3C1(6), NTRK1(10), PTPN13(24), RIPK1(2), TFG(1), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF1(3), TRAF2(4), TRAF3(4), TRAF6(6) 18099189 191 93 180 62 44 40 10 45 50 2 0.451 1.000 1.000 315 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(3), AGTR2(4), CALM1(2), CALM2(2), CAMK2A(3), CAMK2B(4), CAMK2D(3), CAMK2G(8), CDK5(2), F2(9), FYN(10), GNA11(6), GNAI1(1), GNB1(1), GNGT1(3), GRB2(4), JAK2(13), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK14(1), MAPK3(1), MAPK8(5), MAPT(7), MYLK(22), PLCG1(19), PRKCA(5), PTK2B(16), RAF1(10), SHC1(7), SOS1(7), STAT1(10), STAT3(7), STAT5A(3), SYT1(4) 17859302 213 93 209 73 69 56 7 41 37 3 0.306 1.000 1.000 316 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(7), F11(4), F12(3), F13B(16), F2(9), F5(21), F7(10), F8(22), F9(9), FGA(9), FGB(4), FGG(3), LPA(17), PLAT(7), PLG(14), SERPINB2(7), SERPINE1(3), SERPINF2(8), VWF(28) 15158900 201 93 197 51 51 44 9 56 40 1 0.0328 1.000 1.000 317 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(3), ALDH4A1(4), ALDH5A1(6), CAD(17), CPS1(22), EARS2(3), EPRS(11), GAD1(7), GAD2(9), GCLC(3), GCLM(3), GFPT1(4), GFPT2(5), GLS(10), GLS2(7), GLUD1(2), GLUD2(11), GLUL(5), GMPS(7), GNPNAT1(4), GOT1(3), GOT2(2), GPT(3), GPT2(5), GSR(5), GSS(3), NADSYN1(8), NAGK(2), PPAT(5), QARS(5) 16949877 184 93 181 67 48 49 7 41 39 0 0.574 1.000 1.000 318 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(6), APC(43), AXIN1(9), BTRC(9), CTNNB1(22), DLL1(15), DVL1(7), FZD1(10), GSK3B(5), NOTCH1(26), PSEN1(3), WNT1(8) 9169493 163 93 149 52 47 28 6 26 47 9 0.422 1.000 1.000 319 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(4), BTK(3), CALM1(2), CALM2(2), CD79A(6), CD79B(2), ELK1(3), FOS(1), GRB2(4), JUN(4), LYN(5), MAP2K1(5), MAP3K1(11), MAPK14(1), MAPK3(1), MAPK8(5), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), PLCG1(19), PPP3CA(10), PPP3CB(6), PPP3CC(5), PRKCA(5), RAF1(10), SHC1(7), SOS1(7), SYK(7), SYT1(4), VAV1(9) 16430692 198 92 190 56 75 48 5 30 38 2 0.0322 1.000 1.000 320 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(3), GTF2A1L(3), GTF2B(4), GTF2E1(6), GTF2E2(2), GTF2F1(5), GTF2F2(2), GTF2H1(2), GTF2H3(2), GTF2H4(7), GTF2I(4), GTF2IRD1(13), STON1(6), TAF1(20), TAF10(1), TAF13(1), TAF1L(29), TAF2(11), TAF4(12), TAF4B(3), TAF5(2), TAF5L(6), TAF6(12), TAF6L(5), TAF7(7), TAF7L(8), TAF9B(4), TBPL1(2), TBPL2(6) 15449868 188 92 181 48 48 44 8 37 51 0 0.0820 1.000 1.000 321 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(2), ACTR3(2), ARHGAP1(4), ARHGAP4(4), ARHGAP5(18), ARHGAP6(9), ARHGEF1(11), ARHGEF11(18), ARHGEF5(5), ARPC1A(3), ARPC2(3), ARPC4(2), BAIAP2(5), CFL1(1), DIAPH1(11), GSN(11), LIMK1(5), MYL2(8), MYLK(22), OPHN1(9), PIP5K1A(4), PIP5K1B(1), PPP1R12B(15), ROCK1(18), SRC(3), TLN1(23), VCL(6) 19475904 223 92 211 71 64 55 10 35 55 4 0.339 1.000 1.000 322 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(10), AKT1(3), AKT2(8), AKT3(6), DAG1(13), GNAQ(4), ITPKA(2), ITPKB(11), ITPR1(24), ITPR2(30), ITPR3(36), NFKB1(7), NFKB2(7), NFKBIA(1), NFKBIB(6), NFKBIL1(4), PDK1(3), PHKA2(10), PIK3CB(13), PITX2(6), PLD1(19), PLD2(16), PLD3(6), VN1R1(3) 19243480 248 92 240 65 86 56 12 44 47 3 0.0182 1.000 1.000 323 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 36 AKT1(3), ATF2(3), CDC42(1), DLD(4), DUSP10(8), DUSP4(1), DUSP8(1), GAB1(3), GCK(4), IL1R1(4), JUN(4), MAP2K4(8), MAP2K5(1), MAP3K1(11), MAP3K10(8), MAP3K11(7), MAP3K12(15), MAP3K13(9), MAP3K2(4), MAP3K3(8), MAP3K4(21), MAP3K5(5), MAP3K7(10), MAP3K9(3), MAPK10(5), MAPK7(6), MAPK8(5), MAPK9(3), MYEF2(9), NFATC3(4), NR2C2(3), PAPPA(25), SHC1(7), TRAF6(6), ZAK(9) 20962605 228 92 223 74 60 61 14 39 51 3 0.345 1.000 1.000 324 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 26 ARHGDIB(1), CASP10(6), CASP3(2), CASP6(1), CASP7(3), CFLAR(1), DAXX(10), DFFA(4), DFFB(3), FADD(1), FAF1(8), JUN(4), LMNA(6), LMNB1(4), LMNB2(6), MAP2K4(8), MAP3K1(11), MAP3K7(10), MAPK8(5), PAK1(5), PAK2(7), PRKDC(40), PTPN13(24), RB1(13), RIPK2(1), SPTAN1(21) 16909222 205 91 200 61 46 60 9 33 54 3 0.202 1.000 1.000 325 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 20 ATM(38), ATR(18), BRCA1(17), CCNB1(3), CDC25A(6), CDC25B(4), CDC34(2), CDKN1A(3), CDKN2D(3), CHEK1(4), CHEK2(8), EP300(22), MDM2(5), MYT1(19), PRKDC(40), RPS6KA1(9), WEE1(4), YWHAH(3), YWHAQ(2) 17173734 210 91 201 64 55 56 5 42 48 4 0.385 1.000 1.000 326 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM1(2), CALM2(2), CAMK1(3), CAMK1G(6), ELK1(3), FPR1(6), GNA15(3), GNB1(1), GNGT1(3), MAP2K1(5), MAP2K2(3), MAP2K3(4), MAP2K6(1), MAP3K1(11), MAPK1(3), MAPK14(1), MAPK3(1), NCF1(3), NCF2(4), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), NFKB1(7), NFKBIA(1), PAK1(5), PIK3C2G(10), PLCB1(19), PPP3CA(10), PPP3CB(6), PPP3CC(5), RAF1(10), RELA(5), SYT1(4) 16399444 197 90 187 65 67 44 4 34 48 0 0.280 1.000 1.000 327 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ACYP2(3), ADH1A(4), ADH1B(4), ADH4(2), ADH6(7), ADH7(1), ADHFE1(9), AKR1A1(1), ALDH1A1(7), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH3B1(4), ALDH3B2(7), ALDH9A1(4), ALDOA(1), ALDOB(6), ALDOC(6), BPGM(5), DLAT(3), DLD(4), ENO1(3), ENO2(3), ENO3(4), FBP1(4), FBP2(5), GAPDH(2), GCK(4), GPI(5), HK1(16), HK2(10), HK3(6), LDHA(3), LDHB(4), LDHC(1), PDHA1(1), PDHA2(6), PDHB(4), PFKM(2), PFKP(14), PGK1(4), PGM1(2), PGM3(7), PKLR(7), TPI1(1) 20976024 243 90 230 87 60 66 6 56 54 1 0.618 1.000 1.000 328 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ACYP2(3), ADH1A(4), ADH1B(4), ADH4(2), ADH6(7), ADH7(1), ADHFE1(9), AKR1A1(1), ALDH1A1(7), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH3B1(4), ALDH3B2(7), ALDH9A1(4), ALDOA(1), ALDOB(6), ALDOC(6), BPGM(5), DLAT(3), DLD(4), ENO1(3), ENO2(3), ENO3(4), FBP1(4), FBP2(5), GAPDH(2), GCK(4), GPI(5), HK1(16), HK2(10), HK3(6), LDHA(3), LDHB(4), LDHC(1), PDHA1(1), PDHA2(6), PDHB(4), PFKM(2), PFKP(14), PGK1(4), PGM1(2), PGM3(7), PKLR(7), TPI1(1) 20976024 243 90 230 87 60 66 6 56 54 1 0.618 1.000 1.000 329 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(7), CALCR(6), CALCRL(8), CD97(4), CRHR1(11), CRHR2(4), ELTD1(17), EMR1(13), EMR2(9), GHRHR(4), GIPR(4), GLP1R(1), GLP2R(8), GPR64(13), LPHN1(19), LPHN2(19), LPHN3(17), SCTR(3), VIPR1(3), VIPR2(3) 11421754 173 90 168 50 43 43 6 50 30 1 0.0573 1.000 1.000 330 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 27 ARHGDIB(1), BAG4(2), CASP2(3), CASP3(2), CRADD(1), DFFA(4), DFFB(3), FADD(1), JUN(4), LMNA(6), LMNB1(4), LMNB2(6), MADD(16), MAP2K4(8), MAP3K1(11), MAP3K7(10), MAPK8(5), PAK1(5), PAK2(7), PRKDC(40), RB1(13), RIPK1(2), SPTAN1(21), TNF(3), TNFRSF1A(6), TRADD(2), TRAF2(4) 16108101 190 90 187 62 52 50 10 28 46 4 0.393 1.000 1.000 331 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(8), CDC7(4), CDK2(3), CDT1(4), DIAPH2(7), GMNN(1), MCM10(10), MCM2(14), MCM3(6), MCM4(13), MCM5(8), MCM6(8), MCM7(7), NACA(3), PCNA(2), POLA2(4), POLD1(15), POLD2(4), POLD3(7), POLE(24), POLE2(4), PRIM1(2), RFC1(10), RFC2(1), RFC3(3), RFC4(1), RFC5(1), RPA1(2), RPA2(2), RPA3(2), RPA4(5), RPS27A(2), UBA52(2), UBC(8) 21753848 197 89 191 52 69 36 7 33 50 2 0.0923 1.000 1.000 332 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(3), ACAA1(3), ACAA2(5), ACADM(4), ACADS(4), ACAT1(5), ACAT2(4), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH6A1(6), ALDH9A1(4), AOX1(12), AUH(7), BCAT1(5), BCAT2(6), BCKDHA(11), BCKDHB(3), DBT(4), DLD(4), EHHADH(7), HADH(3), HADHA(4), HADHB(5), HIBADH(3), HMGCS1(2), HMGCS2(3), HSD17B4(7), IVD(4), MCCC1(3), MCCC2(3), MCEE(4), MUT(6), OXCT1(8), OXCT2(3), PCCA(8), PCCB(5) 18452974 209 89 193 68 45 55 4 37 65 3 0.589 1.000 1.000 333 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(9), AADAC(5), ABAT(3), ACADS(4), ACAT1(5), ACAT2(4), ACSM1(5), AKR1B10(6), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH5A1(6), ALDH9A1(4), BDH1(5), DDHD1(9), EHHADH(7), GAD1(7), GAD2(9), HADH(3), HADHA(4), HMGCS1(2), HMGCS2(3), HSD17B4(7), HSD3B7(6), ILVBL(5), L2HGDH(2), OXCT1(8), OXCT2(3), PDHA1(1), PDHA2(6), PDHB(4), PLA1A(2), PPME1(1), PRDX6(2), RDH11(1), RDH12(3), RDH13(5) 17394750 197 89 186 76 58 43 4 38 53 1 0.786 1.000 1.000 334 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 68 CALR(5), CANX(3), CD74(1), CD8A(4), CD8B(1), CIITA(17), CREB1(3), CTSB(3), CTSS(2), HLA-C(6), HLA-DMA(1), HLA-DMB(3), HLA-DOA(2), HLA-DOB(2), HLA-DPA1(2), HLA-DPB1(3), HLA-DQA1(1), HLA-DQA2(3), HLA-DQB1(1), HLA-DRA(8), HLA-E(5), HLA-F(7), HLA-G(5), HSP90AA1(11), HSP90AB1(6), HSPA5(2), IFI30(2), IFNA1(1), IFNA10(4), IFNA13(1), IFNA16(4), IFNA2(1), IFNA4(1), IFNA5(2), IFNA6(3), IFNA7(4), IFNA8(1), KIR2DL3(3), KIR3DL1(5), KIR3DL2(2), KLRC1(3), KLRC3(2), KLRD1(3), LGMN(6), LTA(4), NFYA(1), NFYC(2), PDIA3(3), PSME1(3), PSME2(1), RFX5(11), RFXANK(4), RFXAP(1), TAP1(4), TAP2(6), TAPBP(6) 18672597 201 89 199 53 35 58 15 46 45 2 0.0484 1.000 1.000 335 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(12), ADRBK2(5), ARRB2(1), CALM1(2), CALM2(2), CALML3(1), CAMK2A(3), CAMK2B(4), CAMK2D(3), CAMK2G(8), CLCA1(10), CLCA2(6), CLCA4(12), CNGA3(8), CNGA4(19), CNGB1(15), GNAL(2), GUCA1A(3), GUCA1B(2), GUCA1C(4), PDC(2), PDE1C(11), PRKACA(4), PRKACB(4), PRKACG(8), PRKG1(10), PRKG2(13), PRKX(5) 13099384 179 89 171 55 55 36 5 39 43 1 0.174 1.000 1.000 336 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(4), ARG1(2), ARG2(2), ASL(6), ASS1(9), CKB(2), CKM(1), CKMT1A(3), CKMT1B(1), CKMT2(6), CPS1(22), DAO(11), EPRS(11), GAMT(1), GATM(3), GLUD1(2), GLUD2(11), GOT1(3), GOT2(2), LAP3(2), NOS1(28), NOS3(10), OAT(2), OTC(2), P4HA1(5), P4HA2(8), P4HA3(6), PYCR1(1), PYCR2(3), PYCRL(2), RARS(5), RARS2(6) 15394352 182 88 178 52 59 45 10 41 27 0 0.0719 1.000 1.000 337 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(1), ACTG2(9), ADCY3(12), ADCY9(13), AK1(1), ARF1(5), ARF4(1), ARF5(1), ARL4D(1), ATP6V0A1(5), ATP6V0A2(7), ATP6V0A4(10), ATP6V0B(4), ATP6V0D1(8), ATP6V0D2(2), ATP6V1A(6), ATP6V1C1(2), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(2), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), ERO1L(1), GNAS(29), PDIA4(3), PLCG1(19), PLCG2(15), PRKCA(5), SEC61A1(5), SEC61A2(1), SEC61B(1), SEC61G(1), TRIM23(5) 15886250 202 88 192 67 78 37 6 39 42 0 0.386 1.000 1.000 338 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 21 ARHGAP5(18), DIAPH1(11), FYN(10), GSN(11), ITGA1(8), ITGB1(10), MAP2K1(5), MAPK1(3), MAPK3(1), MYL2(8), MYLK(22), PIK3R1(11), PTK2(11), PXN(4), RAF1(10), ROCK1(18), SHC1(7), SRC(3), TLN1(23) 15078096 194 87 181 47 52 46 8 37 46 5 0.0255 1.000 1.000 339 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 25 CSNK2A1(5), EGF(10), EGFR(15), ELK1(3), FOS(1), GRB2(4), JAK1(12), JUN(4), MAP2K1(5), MAP2K4(8), MAP3K1(11), MAPK3(1), MAPK8(5), PIK3R1(11), PLCG1(19), PRKCA(5), RAF1(10), RASA1(17), SHC1(7), SOS1(7), SRF(2), STAT1(10), STAT3(7), STAT5A(3) 15164766 182 87 173 50 49 46 5 27 52 3 0.0928 1.000 1.000 340 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(6), AKR1D1(3), ARSD(4), ARSE(5), CARM1(5), CYP11B1(12), CYP11B2(5), CYP19A1(13), HEMK1(1), HSD11B1(3), HSD11B2(3), HSD17B1(4), HSD17B12(3), HSD17B2(2), HSD17B3(1), HSD17B7(3), HSD3B1(4), HSD3B2(1), LCMT1(1), LCMT2(11), METTL6(3), PRMT2(8), PRMT3(5), PRMT5(3), PRMT6(4), PRMT7(6), PRMT8(9), SRD5A1(3), STS(6), SULT1E1(2), SULT2A1(3), UGT1A1(4), UGT1A10(1), UGT1A3(1), UGT1A4(3), UGT1A5(3), UGT1A6(6), UGT1A7(3), UGT1A9(3), UGT2A1(3), UGT2A3(6), UGT2B10(5), UGT2B11(1), UGT2B15(3), UGT2B17(2), UGT2B28(7), UGT2B4(4), UGT2B7(6), WBSCR22(6) 21453585 209 87 202 67 50 68 9 36 45 1 0.200 1.000 1.000 341 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(6), AARS2(10), CARS(5), CARS2(6), DARS(2), DARS2(3), EARS2(3), EPRS(11), FARS2(7), FARSA(3), FARSB(1), GARS(4), HARS(9), HARS2(4), IARS(10), IARS2(9), KARS(5), LARS(5), LARS2(8), MARS(4), MARS2(2), MTFMT(1), NARS(5), QARS(5), RARS(5), RARS2(6), SARS(8), SARS2(7), TARS(7), TARS2(7), VARS(16), VARS2(12), WARS(5), WARS2(10), YARS(6), YARS2(2) 23293919 219 87 215 65 69 58 9 40 43 0 0.175 1.000 1.000 342 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(6), ARSB(2), FUCA1(1), FUCA2(2), GALNS(1), GBA(9), GLB1(5), GNS(5), GUSB(11), HEXA(2), HEXB(3), HGSNAT(5), HPSE(8), HPSE2(5), HYAL1(6), HYAL2(5), IDS(4), IDUA(4), LCT(23), MAN2B1(17), MAN2B2(18), MAN2C1(11), MANBA(7), NAGLU(6), NEU1(3), NEU2(6), NEU3(5), NEU4(2), SPAM1(9) 14764926 191 87 187 59 59 52 8 31 40 1 0.190 1.000 1.000 343 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 25 CSNK2A1(5), ELK1(3), FOS(1), GRB2(4), JAK1(12), JUN(4), MAP2K1(5), MAP2K4(8), MAP3K1(11), MAPK3(1), MAPK8(5), PDGFA(2), PDGFRA(11), PIK3R1(11), PLCG1(19), PRKCA(5), RAF1(10), RASA1(17), SHC1(7), SOS1(7), SRF(2), STAT1(10), STAT3(7), STAT5A(3) 14061063 170 87 162 42 43 47 4 25 48 3 0.0301 1.000 1.000 344 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 24 ARNT(6), EIF1(1), EIF2B1(4), EIF2B2(3), EIF2B3(7), EIF2B4(9), EIF2B5(9), EIF2S1(2), EIF2S2(2), ELAVL1(9), FLT1(16), FLT4(24), HIF1A(7), KDR(13), NOS3(10), PIK3R1(11), PLCG1(19), PRKCA(5), PTK2(11), PXN(4), SHC1(7), VHL(2) 13639951 181 87 174 45 55 44 8 31 42 1 0.0234 1.000 1.000 345 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 50 AKR1C3(2), ALOX12(6), ALOX12B(10), ALOX15(7), ALOX15B(3), ALOX5(10), CBR1(1), CBR3(2), CYP2B6(6), CYP2C18(4), CYP2C19(7), CYP2C8(1), CYP2E1(6), CYP2J2(3), CYP2U1(6), CYP4A11(2), CYP4A22(2), CYP4F2(6), CYP4F3(11), DHRS4(1), EPHX2(4), GGT1(6), GPX2(3), GPX3(1), GPX5(2), GPX6(5), GPX7(3), LTA4H(5), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6), PTGDS(1), PTGES2(3), PTGIS(6), PTGS1(12), PTGS2(7), TBXAS1(6) 16563665 194 86 190 47 68 44 5 43 34 0 0.00361 1.000 1.000 346 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(8), AZIN1(2), CBX3(1), CLDN5(2), CLOCK(5), CRY1(3), CRY2(5), DAZAP2(4), DNAJA1(6), EIF4G2(7), ETV6(7), G0S2(2), GFRA1(9), GSTM3(2), GSTP1(1), HERPUD1(2), HSPA8(4), IDI1(2), KLF9(2), MYF6(5), NCKAP1(9), NCOA4(5), NR1D2(6), PER1(4), PER2(15), PIGF(1), PPP1R3C(4), PPP2CB(3), PSMA4(4), PURA(1), SF3A3(3), SUMO3(3), TOB1(1), TUBB3(7), UCP3(3), UGP2(7), VAPA(3), ZFR(13) 15664745 171 85 167 53 45 40 6 36 43 1 0.390 1.000 1.000 347 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(3), ALDH4A1(4), ALDH5A1(6), CAD(17), CPS1(22), EPRS(11), GAD1(7), GAD2(9), GCLC(3), GCLM(3), GFPT1(4), GLS(10), GLS2(7), GLUD1(2), GLUL(5), GMPS(7), GOT1(3), GOT2(2), GPT(3), GPT2(5), GSS(3), NADSYN1(8), PPAT(5), QARS(5) 14245065 154 85 153 53 41 43 5 32 33 0 0.476 1.000 1.000 348 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(3), ACAA2(5), ACADL(2), ACADM(4), ACADS(4), ACADSB(7), ACADVL(1), ACAT1(5), ACAT2(4), ACOX1(5), ACOX3(11), ACSL1(3), ACSL3(8), ACSL4(4), ACSL5(7), ACSL6(6), ADH1A(4), ADH1B(4), ADH4(2), ADH5(3), ADH6(7), ADH7(1), ADHFE1(9), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), CPT1A(10), CPT1B(5), CPT1C(7), CPT2(5), CYP4A11(2), CYP4A22(2), EHHADH(7), GCDH(8), HADH(3), HADHA(4), HADHB(5), HSD17B4(7) 21011347 219 85 204 58 47 59 7 42 62 2 0.0409 1.000 1.000 349 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(6), AARS2(10), ABAT(3), ACY3(1), ADSL(5), ADSS(5), ADSSL1(8), AGXT(1), AGXT2(8), ASL(6), ASNS(4), ASPA(1), ASRGL1(2), ASS1(9), CAD(17), CRAT(5), DARS(2), DARS2(3), DDO(6), DLAT(3), DLD(4), GAD1(7), GAD2(9), GOT1(3), GOT2(2), GPT(3), GPT2(5), NARS(5), PC(15), PDHA1(1), PDHA2(6), PDHB(4) 16218924 169 85 166 66 57 43 1 31 37 0 0.752 1.000 1.000 350 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 24 APC(43), ASAH1(4), CAMP(2), CASP3(2), CERK(6), CREB1(3), CREB5(5), CXCL2(2), DAG1(13), EPHB2(12), FOS(1), GNAQ(4), ITPKA(2), ITPKB(11), JUN(4), MAP2K4(8), MAPK1(3), MAPK10(5), MAPK8(5), MAPK8IP1(4), MAPK8IP2(4), MAPK8IP3(13), MAPK9(3) 11948394 159 85 155 42 43 38 3 26 39 10 0.0643 1.000 1.000 351 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(2), CHUK(4), ELK1(3), FOS(1), IKBKB(8), IRAK1(6), JUN(4), LY96(4), MAP2K3(4), MAP2K4(8), MAP2K6(1), MAP3K1(11), MAP3K7(10), MAPK14(1), MAPK8(5), MYD88(2), NFKB1(7), NFKBIA(1), PPARA(4), RELA(5), TIRAP(1), TLR10(7), TLR2(2), TLR3(6), TLR4(21), TLR6(3), TLR7(5), TLR9(15), TOLLIP(5), TRAF6(6) 15655244 162 85 155 53 42 34 7 37 40 2 0.376 1.000 1.000 352 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(1), ALDOB(6), ALDOC(6), DLAT(3), DLD(4), ENO1(3), ENO2(3), ENO3(4), FBP1(4), FBP2(5), GAPDH(2), GAPDHS(4), GCK(4), GOT1(3), GOT2(2), GPI(5), HK1(16), HK2(10), HK3(6), LDHA(3), LDHAL6B(5), LDHB(4), LDHC(1), MDH1(3), PC(15), PCK1(11), PDHA1(1), PDHA2(6), PDHB(4), PDHX(5), PFKL(5), PFKM(2), PFKP(14), PGAM2(5), PGK1(4), PGK2(3), PKLR(7), TNFAIP1(4), TPI1(1) 18230069 194 84 188 81 64 55 3 38 33 1 0.825 1.000 1.000 353 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 26 ALDH1A3(6), ALDH3A1(11), ALDH3B1(4), ALDH3B2(7), AOC2(6), AOC3(15), EPX(9), ESCO1(7), ESCO2(8), GOT1(3), GOT2(2), HPD(1), LPO(9), MAOA(2), MAOB(3), MIF(1), MPO(7), NAT6(3), PNPLA3(2), PRDX6(2), SH3GLB1(3), TAT(5), TPO(24) 14248371 140 84 127 41 40 22 3 36 37 2 0.536 1.000 1.000 354 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 21 ARFIP2(3), CDK5(2), CDK5R1(4), CFL1(1), CHN1(3), LIMK1(5), MAP3K1(11), MYL2(8), MYLK(22), NCF2(4), PAK1(5), PDGFRA(11), PIK3R1(11), PLD1(19), PPP1R12B(15), RALBP1(8), RPS6KB1(5), TRIO(39), VAV1(9), WASF1(5) 14051946 190 84 186 61 54 53 2 37 41 3 0.454 1.000 1.000 355 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(3), BCR(11), BLNK(4), ELK1(3), FOS(1), GRB2(4), JUN(4), LYN(5), MAP2K1(5), MAP3K1(11), MAPK1(3), MAPK3(1), MAPK8IP3(13), PAPPA(25), RPS6KA1(9), RPS6KA3(4), SHC1(7), SOS1(7), SYK(7), VAV1(9), VAV2(12), VAV3(10) 13738984 158 84 153 62 51 44 3 32 27 1 0.640 1.000 1.000 356 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(3), ACTN1(7), ACTN2(23), CAPN1(5), CAPNS1(2), CAPNS2(2), ITGA1(8), ITGB1(10), ITGB3(7), PTK2(11), PXN(4), SPTAN1(21), SRC(3), TLN1(23) 12238790 129 84 124 56 55 27 7 22 18 0 0.784 1.000 1.000 357 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 20 ADCY1(19), CD3E(2), CD3G(1), CREBBP(40), CSK(7), GNAS(29), GNB1(1), GNGT1(3), HLA-DRA(8), LCK(4), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PTPRC(19), ZAP70(14) 9488059 178 83 170 64 68 47 2 26 35 0 0.474 1.000 1.000 358 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 20 ADCY1(19), CD3E(2), CD3G(1), CREBBP(40), CSK(7), GNAS(29), GNB1(1), GNGT1(3), HLA-DRA(8), LCK(4), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PTPRC(19), ZAP70(14) 9488059 178 83 170 64 68 47 2 26 35 0 0.474 1.000 1.000 359 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 40 ACY3(1), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH3B1(4), ALDH3B2(7), ALDH9A1(4), AOC2(6), AOC3(15), ASPA(1), CARM1(5), CNDP1(6), FTCD(5), HAL(4), HARS(9), HARS2(4), HDC(8), HEMK1(1), HNMT(2), LCMT1(1), LCMT2(11), MAOA(2), MAOB(3), METTL6(3), PRMT2(8), PRMT3(5), PRMT5(3), PRMT6(4), PRMT7(6), PRMT8(9), PRPS1(3), PRPS2(3), UROC1(10), WBSCR22(6) 16550436 200 83 180 56 52 45 7 37 55 4 0.182 1.000 1.000 360 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM1(2), CALM2(2), DLG4(3), GRIN1(8), GRIN2A(16), GRIN2B(23), GRIN2C(6), GRIN2D(7), NOS1(28), PPP3CA(10), PPP3CB(6), PPP3CC(5), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PRKCA(5), SYT1(4) 10962140 156 83 152 59 55 35 5 30 31 0 0.491 1.000 1.000 361 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(22), ACAT1(5), ACAT2(4), ACYP1(1), ACYP2(3), ADH5(3), AKR1B1(6), ALDH1A1(7), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), DLAT(3), DLD(4), GLO1(2), GRHPR(1), HAGH(3), HAGHL(1), LDHA(3), LDHB(4), LDHC(1), LDHD(3), MDH1(3), ME1(2), ME2(5), ME3(4), PC(15), PCK1(11), PDHA1(1), PDHA2(6), PDHB(4), PKLR(7) 15844517 184 83 174 63 52 51 3 34 42 2 0.553 1.000 1.000 362 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(3), AGTR1(2), ATF2(3), CALM1(2), CALM2(2), EGFR(15), ELK1(3), GNAQ(4), GRB2(4), JUN(4), MAP2K1(5), MAP2K2(3), MAP2K4(8), MAP3K1(11), MAPK1(3), MAPK3(1), MAPK8(5), MEF2A(2), MEF2B(5), MEF2C(4), MEF2D(7), PAK1(5), PRKCA(5), PTK2(11), PTK2B(16), RAF1(10), SHC1(7), SOS1(7), SRC(3), SYT1(4) 14383282 164 82 157 53 51 34 9 25 43 2 0.305 1.000 1.000 363 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCL11(1), CCR3(6), CFL1(1), GNAQ(4), GNAS(29), GNB1(1), GNGT1(3), LIMK1(5), MAP2K1(5), MAPK1(3), MAPK3(1), MYL2(8), NOX1(6), PIK3C2G(10), PLCB1(19), PPP1R12B(15), PRKCA(5), PTK2(11), RAF1(10), ROCK2(12) 10800778 155 82 147 38 58 27 4 30 35 1 0.103 1.000 1.000 364 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 29 AKT1(3), AVP(3), CABIN1(15), CALM1(2), CALM2(2), CAMK1(3), CAMK1G(6), HDAC5(10), IGF1(4), IGF1R(16), INSR(14), MAP2K6(1), MAPK14(1), MAPK7(6), MEF2A(2), MEF2B(5), MEF2C(4), MEF2D(7), MYOD1(6), NFATC1(13), NFATC2(17), PIK3R1(11), PPP3CA(10), PPP3CB(6), PPP3CC(5), SYT1(4), YWHAH(3) 13979056 179 82 173 64 61 43 6 29 39 1 0.270 1.000 1.000 365 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(6), AKR1B10(6), ALDOA(1), ALDOB(6), ALDOC(6), FBP1(4), FBP2(5), FPGT(5), FUK(5), GMDS(2), GMPPA(6), GMPPB(5), HK1(16), HK2(10), HK3(6), HSD3B7(6), KHK(2), LHPP(4), MPI(3), MTMR1(8), MTMR2(5), MTMR6(7), PFKFB1(6), PFKFB2(6), PFKFB3(7), PFKFB4(4), PFKL(5), PFKM(2), PFKP(14), PGM2(1), PHPT1(3), PMM1(2), PMM2(2), RDH11(1), RDH12(3), RDH13(5), SORD(2), TPI1(1), TSTA3(8) 15931702 196 82 190 59 73 55 5 27 36 0 0.0354 1.000 1.000 366 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(3), ACACA(22), ACACB(35), ACADM(4), ACAT1(5), ACAT2(4), ACSS1(12), ACSS2(10), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH6A1(6), ALDH9A1(4), EHHADH(7), HADHA(4), LDHA(3), LDHAL6B(5), LDHB(4), LDHC(1), MCEE(4), MLYCD(5), MUT(6), PCCA(8), PCCB(5), SUCLA2(4), SUCLG1(2), SUCLG2(5) 17041403 209 82 192 57 49 53 5 44 54 4 0.158 1.000 1.000 367 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(3), CAPN1(5), CAPN2(8), CAPNS1(2), CAPNS2(2), CXCR3(1), EGF(10), EGFR(15), ITGA1(8), ITGB1(10), MAPK1(3), MAPK3(1), MYL2(8), MYLK(22), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PTK2(11), PXN(4), TLN1(23) 14031620 167 82 159 64 59 39 8 27 32 2 0.520 1.000 1.000 368 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(15), ELK1(3), GNAS(29), GNB1(1), GNGT1(3), GRB2(4), IGF1R(16), ITGB1(10), KLK2(1), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), MKNK1(3), MKNK2(7), MYC(5), NGFR(4), PDGFRA(11), PPP2CA(4), PTPRR(11), RAF1(10), RPS6KA1(9), RPS6KA5(3), SHC1(7), SOS1(7), SRC(3), STAT3(7) 14218333 185 81 174 77 69 45 0 43 27 1 0.844 1.000 1.000 369 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(5), AASDH(7), AASDHPPT(1), AASS(7), ACAT1(5), ACAT2(4), ALDH1A1(7), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), BBOX1(4), DLST(4), DOT1L(11), EHHADH(7), EHMT1(14), EHMT2(12), GCDH(8), HADHA(4), PLOD1(7), PLOD2(12), PLOD3(16), SDS(4), SHMT1(2), SHMT2(9), TMLHE(5) 15854463 205 81 185 62 54 53 3 30 64 1 0.219 1.000 1.000 370 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 26 AKT1(3), AKT2(8), AKT3(6), BAD(3), BCL2(3), GRB2(4), GSK3A(3), GSK3B(5), IL4R(3), IRS1(24), IRS2(6), JAK1(12), JAK3(13), MAP4K1(4), MAPK1(3), MAPK3(1), PDK1(3), PIK3CD(11), PIK3R1(11), PPP1R13B(11), RAF1(10), SHC1(7), SOCS1(1), SOS1(7), SOS2(19), STAT6(3) 14742335 184 81 173 48 61 39 3 24 54 3 0.121 1.000 1.000 371 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 59 ATP12A(18), ATP4B(4), ATP6AP1(6), ATP6V0A1(5), ATP6V0A4(10), ATP6V0B(4), ATP6V0D1(8), ATP6V1A(6), ATP6V1B2(5), ATP6V1C1(2), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(2), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), ATP7A(12), ATP7B(12), COX10(2), COX4I1(6), COX6B1(2), COX7A1(1), COX7A2(1), COX7B(2), COX7C(1), NDUFA1(1), NDUFA10(4), NDUFA8(5), NDUFB2(1), NDUFB4(1), NDUFB5(1), NDUFB6(1), NDUFB7(1), NDUFS1(7), NDUFS2(5), NDUFV1(5), PPA2(3), SDHA(6), SDHB(4), SHMT1(2), UQCRB(1), UQCRC1(2), UQCRFS1(1) 15912824 187 80 180 63 58 45 8 35 40 1 0.454 1.000 1.000 372 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 BAD(3), BRAF(16), CREB1(3), CREB5(5), DUSP4(1), DUSP6(3), DUSP9(5), EEF2K(10), EIF4E(2), GRB2(4), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), MKNK1(3), MKNK2(7), MOS(11), NFKB1(7), RAP1A(2), RPS6KA1(9), RPS6KA2(9), RPS6KA3(4), SHC1(7), SOS1(7), SOS2(19), TRAF3(4) 12642981 153 80 143 60 40 34 3 33 41 2 0.878 1.000 1.000 373 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(3), CAMK2B(4), CAMK2D(3), CAMK2G(8), DAG1(13), ITPKA(2), ITPKB(11), ITPR1(24), ITPR2(30), ITPR3(36), NFAT5(10), PDE6A(4), PDE6B(10), PDE6C(4), PDE6D(1), PDE6G(1), SLC6A13(8), TF(15) 15339132 187 80 183 67 67 44 11 30 32 3 0.297 1.000 1.000 374 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM1(2), CALM2(2), CHUK(4), EGR2(8), EGR3(6), GNAQ(4), MAP3K1(11), MYC(5), NFATC1(13), NFATC2(17), NFKB1(7), NFKBIA(1), PLCG1(19), PPP3CA(10), PPP3CB(6), PPP3CC(5), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), RELA(5), SYT1(4), VIP(5), VIPR2(3) 12007552 168 80 159 48 59 35 3 31 40 0 0.0648 1.000 1.000 375 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(3), ACAA2(5), ACAD8(4), ACAD9(6), ADH1A(4), ADH1B(4), ADH4(2), ADH5(3), ADH6(7), ADH7(1), ADHFE1(9), AKR1B10(6), AKR1C4(6), AKR1D1(3), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), BAAT(4), CEL(10), CYP27A1(5), CYP7A1(6), HADHB(5), HSD3B7(6), LIPA(3), RDH11(1), RDH12(3), RDH13(5), SLC27A5(5), SOAT1(7), SOAT2(2), SRD5A1(3) 13577969 173 79 161 50 36 56 9 35 36 1 0.107 1.000 1.000 376 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 18 ADCY1(19), ARHGEF1(11), F2(9), F2R(3), F2RL3(3), GNA12(1), GNA13(5), GNAI1(1), GNAQ(4), GNB1(1), GNGT1(3), MAP3K7(10), PIK3R1(11), PLCB1(19), PPP1R12B(15), PRKCA(5), PTK2B(16), ROCK1(18) 10149452 154 79 151 50 46 39 2 27 37 3 0.401 1.000 1.000 377 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(8), CALM1(2), CALM2(2), CRKL(1), GNAQ(4), GRB2(4), JUN(4), MAP2K1(5), MAP2K2(3), MAP2K3(4), MAP2K4(8), MAP3K1(11), MAPK1(3), MAPK14(1), MAPK3(1), MAPK8(5), PAK1(5), PLCG1(19), PRKCA(5), PTK2B(16), RAF1(10), SHC1(7), SOS1(7), SRC(3), SYT1(4) 12217945 142 79 136 38 47 31 4 23 35 2 0.103 1.000 1.000 378 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(10), DYRK1B(12), GLI2(14), GLI3(47), GSK3B(5), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), SHH(4), SMO(13), SUFU(5) 7134953 141 79 134 52 51 25 5 30 28 2 0.426 1.000 1.000 379 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(3), DLG4(3), EPHB2(12), F2(9), F2RL1(2), F2RL2(3), F2RL3(3), JUN(4), MAP2K5(1), MAPK1(3), MAPK7(6), MAPK8(5), MYEF2(9), PLD1(19), PLD2(16), PLD3(6), PTK2(11), RAF1(10), RASAL1(7), SRC(3), TEC(4), VAV1(9) 11762632 148 79 147 43 51 35 6 24 30 2 0.124 1.000 1.000 380 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 25 AKT1(3), AKT2(8), AKT3(6), CISH(3), GRB2(4), IARS(10), IL13RA1(4), IL2RG(6), IL4(1), IL4R(3), INPP5D(4), JAK1(12), JAK2(13), JAK3(13), NR0B2(3), PI3(2), PPP1R13B(11), RPS6KB1(5), SERPINA4(2), SHC1(7), SOS1(7), SOS2(19), SRC(3), STAT6(3), TYK2(9) 14883760 161 79 153 48 38 39 2 30 50 2 0.561 1.000 1.000 381 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 39 APAF1(8), BAK1(4), BAX(6), BCL2(3), BID(2), BIRC2(3), BIRC3(6), CASP2(3), CASP3(2), CASP6(1), CASP7(3), CASP9(3), FADD(1), FAS(3), FASLG(3), GZMB(3), JUN(4), MAP2K4(8), MAP3K1(11), MAPK10(5), MCL1(1), MDM2(5), MYC(5), NFKB1(7), NFKBIA(1), PARP1(10), PRF1(8), RELA(5), RIPK1(2), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TNFSF10(5), TRADD(2), TRAF1(3), TRAF2(4) 15184336 152 78 143 43 40 33 3 31 42 3 0.213 1.000 1.000 382 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(3), ACADL(2), ACADM(4), ACADSB(7), ALDH1A1(7), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), AOC2(6), AOC3(15), CNDP1(6), DPYD(16), DPYS(7), EHHADH(7), GAD1(7), GAD2(9), HADHA(4), MLYCD(5), SDS(4), SMS(5), UPB1(4) 12474673 168 78 151 47 35 41 2 35 54 1 0.168 1.000 1.000 383 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 39 ALG1(6), ALG10(11), ALG12(10), ALG13(8), ALG14(2), ALG2(2), ALG3(2), ALG5(3), ALG6(2), ALG8(4), ALG9(2), B4GALT1(2), B4GALT2(7), B4GALT3(2), DHDDS(4), DPAGT1(4), DPM1(1), FUT8(7), GANAB(12), MAN1A1(2), MAN1A2(5), MAN1B1(6), MAN1C1(8), MAN2A1(5), MGAT1(3), MGAT2(2), MGAT3(8), MGAT4A(5), MGAT4B(3), MGAT5(10), MGAT5B(5), RFT1(4), RPN1(3), RPN2(6), STT3B(5) 17534770 171 78 162 70 39 40 6 27 55 4 0.975 1.000 1.000 384 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(4), B4GALT5(6), C1GALT1(3), C1GALT1C1(7), GALNT1(4), GALNT10(7), GALNT11(6), GALNT12(3), GALNT13(8), GALNT14(10), GALNT2(5), GALNT3(4), GALNT4(5), GALNT5(12), GALNT6(6), GALNT7(2), GALNT8(6), GALNT9(3), GALNTL5(3), GCNT3(3), GCNT4(4), OGT(5), ST3GAL1(4), ST3GAL2(6), ST6GALNAC1(4), WBSCR17(25) 13869210 155 78 151 58 53 34 5 28 34 1 0.836 1.000 1.000 385 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(4), ALAS1(3), ALAS2(12), BLVRA(4), BLVRB(1), COX10(2), COX15(6), CP(10), CPOX(2), EARS2(3), EPRS(11), FECH(6), FTH1(4), FTMT(6), GUSB(11), HCCS(3), HMBS(3), HMOX1(5), HMOX2(1), MMAB(2), PPOX(5), UGT1A1(4), UGT1A10(1), UGT1A3(1), UGT1A4(3), UGT1A5(3), UGT1A6(6), UGT1A7(3), UGT1A9(3), UGT2A1(3), UGT2A3(6), UGT2B10(5), UGT2B11(1), UGT2B15(3), UGT2B17(2), UGT2B28(7), UGT2B4(4), UGT2B7(6), UROD(1), UROS(4) 18014594 170 78 169 58 35 48 8 43 36 0 0.574 1.000 1.000 386 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 23 POLA1(6), POLA2(4), POLB(4), POLD1(15), POLD2(4), POLD3(7), POLE(24), POLE2(4), POLE3(3), POLG(8), POLG2(5), POLH(6), POLI(2), POLK(8), POLL(3), POLQ(29), PRIM1(2), PRIM2(1), REV1(8), REV3L(38), RFC5(1) 17037861 182 78 179 57 48 41 4 29 58 2 0.594 1.000 1.000 387 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(2), ERCC3(8), GTF2B(4), GTF2E1(6), GTF2E2(2), GTF2F2(2), GTF2H1(2), GTF2H4(7), ILK(8), MNAT1(3), POLR1A(15), POLR1B(8), POLR2A(19), POLR2B(11), POLR2C(4), POLR2E(2), POLR2F(4), POLR2G(1), POLR2I(2), POLR2K(1), POLR3B(13), POLR3D(6), POLR3E(6), POLR3K(1), TAF13(1), TAF5(2), TAF6(12), TAF7(7), TBP(3) 15030146 162 78 159 44 56 41 2 23 39 1 0.0827 1.000 1.000 388 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 20 ATM(38), ATR(18), BRCA1(17), BRCA2(34), CHEK1(4), CHEK2(8), FANCA(7), FANCC(5), FANCD2(12), FANCE(7), FANCG(4), HUS1(2), MRE11A(5), RAD1(3), RAD17(6), RAD50(8), RAD51(1), RAD9A(4), TREX1(3) 18565736 186 77 174 43 32 44 3 35 67 5 0.292 1.000 1.000 389 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(19), EXT2(5), EXTL1(8), EXTL2(2), EXTL3(10), GLCE(5), HS2ST1(3), HS3ST1(3), HS3ST2(10), HS3ST3A1(2), HS3ST3B1(4), HS3ST5(8), HS6ST1(3), HS6ST2(7), HS6ST3(7), NDST1(11), NDST2(9), NDST3(13), NDST4(12) 8890710 141 77 136 47 43 35 4 38 18 3 0.454 1.000 1.000 390 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(3), ACAA2(5), ACADL(2), ACADM(4), ACADS(4), ACADSB(7), ACAT1(5), ACAT2(4), ALDH1A1(7), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH6A1(6), ALDH9A1(4), AOX1(12), BCAT1(5), BCKDHA(11), BCKDHB(3), EHHADH(7), HADHA(4), HADHB(5), HIBADH(3), IVD(4), MCCC1(3), MCCC2(3), MCEE(4), MUT(6), OXCT1(8), PCCA(8), PCCB(5), SDS(4) 15440430 192 77 176 64 37 58 3 33 58 3 0.663 1.000 1.000 391 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 23 ABL1(7), ATM(38), ATR(18), CCNA1(6), CCND1(1), CCNE1(5), CDC25A(6), CDK2(3), CDK6(4), CDKN1A(3), E2F1(3), GSK3B(5), HDAC1(5), RB1(13), SKP2(5), TFDP1(5), TGFB1(3), TGFB2(6), TGFB3(8) 12359948 144 76 138 47 31 39 3 27 41 3 0.608 1.000 1.000 392 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(5), ACP2(4), ACP5(2), ACPP(3), ACPT(4), ALPI(6), ALPL(8), ALPP(7), ALPPL2(5), CYP19A1(13), CYP1A1(5), CYP1A2(5), CYP2A13(8), CYP2A6(7), CYP2A7(3), CYP2B6(6), CYP2C18(4), CYP2C19(7), CYP2C8(1), CYP2D6(9), CYP2E1(6), CYP2F1(4), CYP2J2(3), CYP3A4(4), CYP3A7(4), CYP4B1(9), CYP51A1(8), PON1(2) 12601131 152 76 148 50 63 30 4 25 30 0 0.250 1.000 1.000 393 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 24 GH1(2), GHR(6), GRB2(4), INSR(14), IRS1(24), JAK2(13), MAP2K1(5), MAPK1(3), MAPK3(1), PIK3R1(11), PLCG1(19), PRKCA(5), PTPN6(4), RAF1(10), RPS6KA1(9), SHC1(7), SLC2A4(4), SOCS1(1), SOS1(7), SRF(2), STAT5A(3), STAT5B(14) 13260386 168 76 159 45 46 48 4 23 44 3 0.0740 1.000 1.000 394 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(6), AKR1B10(6), B4GALT1(2), B4GALT2(7), G6PC2(1), GAA(5), GALE(1), GALK1(4), GALK2(2), GALT(1), GANC(8), GCK(4), GLA(3), GLB1(5), HK1(16), HK2(10), HK3(6), HSD3B7(6), LALBA(1), LCT(23), MGAM(15), PFKL(5), PFKM(2), PFKP(14), PGM1(2), PGM3(7), RDH11(1), RDH12(3), RDH13(5), UGP2(7) 16536364 178 76 168 78 65 46 5 24 38 0 0.914 1.000 1.000 395 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(3), ACADM(4), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), AOC2(6), AOC3(15), CNDP1(6), DPYD(16), DPYS(7), EHHADH(7), GAD1(7), GAD2(9), HADHA(4), MLYCD(5), SMS(5), SRM(1), UPB1(4) 11585589 144 76 127 40 30 32 2 30 49 1 0.191 1.000 1.000 396 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(3), ARSD(4), ARSE(5), ASAH1(4), B4GALT6(4), CERK(6), DEGS1(1), DEGS2(1), ENPP7(4), GAL3ST1(8), GALC(5), GBA(9), GLA(3), GLB1(5), LCT(23), NEU1(3), NEU2(6), NEU3(5), NEU4(2), PPAP2A(3), PPAP2B(1), PPAP2C(4), SGMS1(3), SGMS2(3), SGPP1(2), SGPP2(1), SMPD1(6), SMPD2(3), SMPD3(9), SMPD4(4), SPHK1(6), SPHK2(3), SPTLC1(2), SPTLC2(3), UGCG(3), UGT8(5) 15329572 162 76 161 61 55 42 8 22 34 1 0.567 1.000 1.000 397 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 14 ATN1(8), BAIAP2(5), CASP1(4), CASP3(2), CASP7(3), GAPDH(2), INSR(14), ITCH(4), MAGI1(20), MAGI2(27), RERE(27), WWP1(12), WWP2(14) 9790586 142 76 134 38 38 33 6 21 43 1 0.119 1.000 1.000 398 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(3), CDC42(1), CREB1(3), DAXX(10), DDIT3(4), ELK1(3), GRB2(4), HMGN1(2), HSPB2(1), MAP2K4(8), MAP2K6(1), MAP3K1(11), MAP3K5(5), MAP3K7(10), MAP3K9(3), MAPK14(1), MAPKAPK2(1), MAPKAPK5(3), MAX(3), MEF2A(2), MEF2B(5), MEF2C(4), MEF2D(7), MKNK1(3), MYC(5), PLA2G4A(6), RIPK1(2), RPS6KA5(3), SHC1(7), STAT1(10), TGFB1(3), TGFB2(6), TGFB3(8), TGFBR1(4), TRADD(2), TRAF2(4) 15731666 158 76 154 50 41 40 6 22 46 3 0.349 1.000 1.000 399 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 29 A1BG(1), AKT1(3), AKT2(8), AKT3(6), BAD(3), BTK(3), DAPP1(1), GRB2(4), GSK3A(3), GSK3B(5), IARS(10), INPP5D(4), PDK1(3), PPP1R13B(11), RPS6KA1(9), RPS6KA2(9), RPS6KA3(4), RPS6KB1(5), SFN(1), SHC1(7), SOS1(7), SOS2(19), TEC(4), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(3), YWHAQ(2), YWHAZ(3) 13753909 143 76 140 49 39 37 2 27 35 3 0.671 1.000 1.000 400 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 25 ADCY1(19), AKT1(3), CAMK2A(3), CAMK2B(4), CAMK2D(3), CAMK2G(8), CREB1(3), GNAS(29), GRB2(4), MAPK1(3), MAPK14(1), MAPK3(1), PIK3R1(11), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PRKCA(5), RPS6KA1(9), RPS6KA5(3), SOS1(7) 11573022 147 75 141 49 53 38 1 19 34 2 0.462 1.000 1.000 401 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(18), ARHGEF1(11), GNA12(1), GNA13(5), GNAQ(4), GNB1(1), GNGT1(3), MYL2(8), MYLK(22), PLCB1(19), PPP1R12B(15), PRKCA(5), ROCK1(18) 8871982 130 75 122 39 33 30 2 25 36 4 0.480 1.000 1.000 402 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(38), MAP2(34), PPP1CA(2), PPP2CA(4), PRKACB(4), PRKACG(8), PRKAG1(4), PRKAR2A(2), PRKAR2B(8), PRKCE(14) 7793931 118 74 113 40 20 32 2 35 25 4 0.740 1.000 1.000 403 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(7), ACTN2(23), BCAR1(8), CSK(7), CTNNA1(15), CTNNA2(19), CTNNB1(22), PTK2(11), PXN(4), SRC(3), VCL(6) 8205698 125 74 120 48 36 26 8 26 26 3 0.732 1.000 1.000 404 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 38 ANAPC1(13), ANAPC10(2), ANAPC11(1), ANAPC2(7), ANAPC5(4), ANAPC7(6), BTRC(9), CDC16(7), CDC20(5), CDC23(6), CDC26(1), CDC27(3), CUL1(22), CUL2(6), CUL3(6), FBXW11(10), FZR1(7), ITCH(4), RBX1(1), SKP2(5), SMURF1(6), SMURF2(5), TCEB1(1), UBA1(4), UBE2D3(1), UBE2E3(3), VHL(2), WWP1(12), WWP2(14) 16490181 173 74 164 38 53 46 2 26 45 1 0.00749 1.000 1.000 405 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(4), CREBBP(40), DUSP1(2), EP300(22), IKBKB(8), IL1B(3), MAP2K3(4), MAP2K6(1), MAP3K7(10), MAPK11(1), MAPK14(1), MYD88(2), NFKB1(7), NFKBIA(1), NR3C1(6), RELA(5), TGFBR1(4), TGFBR2(14), TLR2(2), TNF(3) 12711671 140 74 138 37 35 34 7 27 36 1 0.0903 1.000 1.000 406 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(8), GTF2A1(3), GTF2B(4), GTF2E1(6), GTF2F1(5), HDAC3(6), NCOA1(17), NCOA2(22), NCOA3(16), NCOR2(30), POLR2A(19), RARA(3), RXRA(6), TBP(3) 10675277 148 74 144 48 44 47 4 25 28 0 0.285 1.000 1.000 407 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(9), ABAT(3), ACADS(4), ACAT1(5), ACAT2(4), ALDH1A1(7), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH5A1(6), ALDH9A1(4), EHHADH(7), GAD1(7), GAD2(9), HADHA(4), L2HGDH(2), OXCT1(8), PDHA1(1), PDHA2(6), PDHB(4), SDHB(4), SDS(4) 11064699 144 73 135 54 37 34 0 28 44 1 0.752 1.000 1.000 408 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(9), ACO1(8), ACO2(9), CLYBL(3), CS(3), DLD(4), DLST(4), FH(3), IDH1(2), IDH2(4), IDH3A(2), IDH3B(2), IDH3G(3), MDH1(3), OGDH(11), OGDHL(16), PC(15), PCK1(11), PCK2(9), SDHA(6), SDHB(4), SDHC(1), SDHD(1), SUCLA2(4), SUCLG1(2), SUCLG2(5) 12830038 144 73 137 46 52 32 6 19 30 5 0.296 1.000 1.000 409 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 21 ALDH1A3(6), ALDH3A1(11), ALDH3B1(4), ALDH3B2(7), AOC2(6), AOC3(15), EPX(9), GOT1(3), GOT2(2), HPD(1), LPO(9), MAOA(2), MAOB(3), MPO(7), PRDX1(1), PRDX2(2), PRDX5(1), PRDX6(2), TAT(5), TPO(24) 8992015 120 73 108 40 35 19 4 33 27 2 0.649 1.000 1.000 410 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 12 CREBBP(40), DAXX(10), PAX3(11), PML(12), RARA(3), RB1(13), SIRT1(6), SP100(15), TNF(3), TNFRSF1A(6), TNFRSF1B(3) 7805750 122 73 119 31 41 34 2 16 29 0 0.0344 1.000 1.000 411 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(3), CDC42(1), CREB1(3), CREB5(5), DUSP1(2), DUSP10(8), EEF2K(10), EIF4E(2), ELK1(3), IL1R1(4), MAP2K3(4), MAP2K4(8), MAP2K6(1), MAP3K10(8), MAP3K4(21), MAP3K5(5), MAP3K7(10), MAPK1(3), MAPK11(1), MAPK13(3), MAPK14(1), MAPKAPK2(1), MAPKAPK5(3), MKNK1(3), MKNK2(7), MYEF2(9), NFKB1(7), NR2C2(3), SRF(2), TRAF6(6) 14301914 147 73 145 47 36 43 9 25 33 1 0.217 1.000 1.000 412 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(29), COL4A2(13), COL4A3(13), COL4A4(15), COL4A5(14), COL4A6(9), P4HB(4), SLC23A1(5), SLC23A2(11), SLC2A1(6), SLC2A3(8) 10760945 127 73 124 48 37 36 3 25 25 1 0.396 1.000 1.000 413 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 18 ABL1(7), ATM(38), BRCA1(17), CDKN1A(3), CHEK1(4), CHEK2(8), JUN(4), MAPK8(5), MDM2(5), MRE11A(5), NFKB1(7), NFKBIA(1), RAD50(8), RAD51(1), RBBP8(7), RELA(5), TP73(5) 12429810 130 72 122 35 23 28 4 27 44 4 0.436 1.000 1.000 414 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 21 ADCY1(19), AKT1(3), ASAH1(4), GNAI1(1), GNB1(1), GNGT1(3), ITGAV(13), ITGB3(7), MAPK1(3), MAPK3(1), PDGFA(2), PDGFRA(11), PIK3R1(11), PLCB1(19), PRKCA(5), PTK2(11), SMPD1(6), SMPD2(3), SPHK1(6), SRC(3) 10836767 132 72 127 51 37 41 4 15 34 1 0.647 1.000 1.000 415 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(6), B4GALT1(2), B4GALT2(7), FBP2(5), GAA(5), GALE(1), GALK1(4), GALK2(2), GALT(1), GANAB(12), GCK(4), GLA(3), GLB1(5), HK1(16), HK2(10), HK3(6), LALBA(1), LCT(23), MGAM(15), PFKM(2), PFKP(14), PGM1(2), PGM3(7) 13947676 153 72 144 64 57 38 4 19 35 0 0.831 1.000 1.000 416 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 21 AKT1(3), BCL2(3), BCR(11), CRKL(1), FOS(1), GRB2(4), JAK2(13), JUN(4), MAP2K1(5), MAP2K4(8), MAP3K1(11), MAPK3(1), MAPK8(5), MYC(5), PIK3R1(11), RAF1(10), SOS1(7), STAT1(10), STAT5A(3), STAT5B(14) 11116734 130 72 121 33 27 36 1 23 39 4 0.0908 1.000 1.000 417 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(4), CHIA(4), CHIT1(4), CMAS(7), CTBS(3), CYB5R1(3), CYB5R3(4), GFPT1(4), GFPT2(5), GNE(7), GNPDA1(4), GNPDA2(6), GNPNAT1(4), HEXA(2), HEXB(3), HK1(16), HK2(10), HK3(6), LHPP(4), MTMR1(8), MTMR2(5), MTMR6(7), NAGK(2), NANS(3), NPL(3), PGM3(7), PHPT1(3), RENBP(2), UAP1(5) 12309781 145 72 143 40 38 41 6 27 33 0 0.0517 1.000 1.000 418 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(8), AGT(3), AGTR1(2), AGTR2(4), CMA1(1), COL4A1(29), COL4A2(13), COL4A3(13), COL4A4(15), COL4A5(14), COL4A6(9), REN(4) 10842746 115 71 113 37 31 30 4 25 24 1 0.221 1.000 1.000 419 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM1(2), CALM2(2), CDKN1A(3), GNAQ(4), MARCKS(3), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), PLCG1(19), PPP3CA(10), PPP3CB(6), PPP3CC(5), PRKCA(5), SP1(6), SP3(3), SYT1(4) 9006258 122 71 117 37 44 31 3 16 28 0 0.0992 1.000 1.000 420 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(2), CDK5R1(4), CSNK1D(2), DRD1(3), DRD2(9), GRM1(31), PLCB1(19), PPP1CA(2), PPP1R1B(1), PPP2CA(4), PPP3CA(10), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8) 6867076 118 71 113 42 40 29 1 18 30 0 0.490 1.000 1.000 421 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(6), ALDOA(1), ALDOB(6), ALDOC(6), FBP1(4), FBP2(5), FPGT(5), GCK(4), GMDS(2), GMPPA(6), GMPPB(5), HK1(16), HK2(10), HK3(6), KHK(2), MPI(3), PFKFB1(6), PFKFB3(7), PFKFB4(4), PFKM(2), PFKP(14), PMM1(2), PMM2(2), SORD(2), TPI1(1) 10274441 127 71 122 38 51 33 3 18 22 0 0.0670 1.000 1.000 422 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ACY1(3), AGMAT(2), ALDH18A1(7), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), AMD1(5), AOC2(6), AOC3(15), ARG1(2), ARG2(2), ASL(6), ASS1(9), CPS1(22), GATM(3), MAOA(2), MAOB(3), NAGS(1), ODC1(4), OTC(2), SAT1(1), SMS(5), SRM(1) 12641840 146 71 131 35 35 36 4 32 38 1 0.0739 1.000 1.000 423 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 33 AKT1(3), BAD(3), BCL2(3), CBL(3), CFLAR(1), CRKL(1), E2F1(3), FOS(1), GRB2(4), IL2RA(3), IL2RB(2), IL2RG(6), IRS1(24), JAK1(12), JAK3(13), MAPK1(3), MAPK3(1), MYC(5), NMI(1), PIK3R1(11), PTPN6(4), RAF1(10), RPS6KB1(5), SHC1(7), SOCS1(1), SOCS3(3), SOS1(7), STAT5A(3), STAT5B(14), SYK(7) 14558500 164 71 154 47 40 46 2 25 49 2 0.296 1.000 1.000 424 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(9), F2R(3), F2RL3(3), GNAI1(1), GNB1(1), GNGT1(3), ITGA1(8), ITGB1(10), MAP2K1(5), MAPK1(3), MAPK3(1), PLA2G4A(6), PLCB1(19), PRKCA(5), PTGS1(12), PTK2(11), RAF1(10), SRC(3), SYK(7), TBXAS1(6) 10447613 126 71 120 47 46 25 6 25 24 0 0.521 1.000 1.000 425 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 31 APAF1(8), BCL2(3), BID(2), BIRC2(3), BIRC3(6), CASP10(6), CASP3(2), CASP6(1), CASP7(3), CASP9(3), CFLAR(1), CHUK(4), DFFA(4), DFFB(3), FADD(1), GAS2(2), LMNA(6), NFKB1(7), NFKBIA(1), RELA(5), RIPK1(2), SPTAN1(21), TNFRSF10A(1), TNFRSF10B(2), TNFRSF25(4), TNFSF10(5), TRADD(2), TRAF2(4) 13818875 112 70 109 33 29 26 2 26 28 1 0.406 1.000 1.000 426 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(3), EPHA4(17), EPHB1(23), FYN(10), ITGA1(8), ITGB1(10), L1CAM(16), LYN(5), RAP1B(6), SELP(10) 6780295 108 70 103 37 38 19 8 31 11 1 0.269 1.000 1.000 427 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 21 ACTA1(3), ADCY1(19), CAP1(2), CCNB1(3), GNAI1(1), GNAS(29), GNB1(1), GNGT1(3), MAPK1(3), MAPK3(1), MYT1(19), PIN1(2), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), RPS6KA1(9), SRC(3) 8428380 129 70 123 53 50 31 1 25 22 0 0.771 1.000 1.000 428 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(4), ASNS(4), ASRGL1(2), CA1(1), CA12(1), CA13(5), CA14(5), CA2(5), CA3(5), CA4(5), CA5A(1), CA5B(1), CA6(3), CA7(4), CA8(4), CA9(6), CPS1(22), CTH(2), GLS(10), GLS2(7), GLUD1(2), GLUD2(11), GLUL(5), HAL(4) 9110531 119 69 114 40 27 36 4 29 23 0 0.470 1.000 1.000 429 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 19 CSNK2A1(5), ELK1(3), FOS(1), GRB2(4), IGF1(4), IGF1R(16), IRS1(24), JUN(4), MAP2K1(5), MAPK3(1), MAPK8(5), PIK3R1(11), PTPN11(6), RAF1(10), RASA1(17), SHC1(7), SOS1(7), SRF(2) 9709668 132 69 124 36 34 31 3 24 37 3 0.161 1.000 1.000 430 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(4), IFNA1(1), IFNB1(3), IKBKB(8), IL1A(2), IL1B(3), IL1R1(4), IL1RAP(7), IL1RN(2), IRAK1(6), IRAK2(7), IRAK3(6), JUN(4), MAP2K3(4), MAP2K6(1), MAP3K1(11), MAP3K7(10), MAPK14(1), MAPK8(5), MYD88(2), NFKB1(7), NFKBIA(1), RELA(5), TGFB1(3), TGFB2(6), TGFB3(8), TNF(3), TOLLIP(5), TRAF6(6) 12735275 135 69 132 34 35 28 4 29 37 2 0.0855 1.000 1.000 431 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(4), FADD(1), IKBKB(8), IL1A(2), IL1R1(4), IRAK1(6), MAP3K1(11), MAP3K7(10), MYD88(2), NFKB1(7), NFKBIA(1), RELA(5), RIPK1(2), TLR4(21), TNF(3), TNFAIP3(10), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF6(6) 10426604 114 69 109 31 27 22 5 30 30 0 0.210 1.000 1.000 432 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(3), EGF(10), EGFR(15), GRB2(4), MAP2K1(5), MAPK1(3), MAPK3(1), PTPRB(21), RAF1(10), RASA1(17), SHC1(7), SOS1(7), SPRY1(3), SPRY3(6), SPRY4(5), SRC(3) 10713395 120 69 115 39 32 25 3 31 29 0 0.552 1.000 1.000 433 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 14 AKT1(3), BCL2(3), EGFR(15), IGF1R(16), MYC(5), POLR2A(19), PPP2CA(4), PRKCA(5), RB1(13), TEP1(29), TERF1(5), TERT(4), TNKS(19), XRCC5(10) 11763574 150 69 145 61 36 48 5 27 34 0 0.777 1.000 1.000 434 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(5), GPLD1(11), PGAP1(8), PIGA(3), PIGB(10), PIGC(6), PIGF(1), PIGG(12), PIGK(3), PIGL(4), PIGM(5), PIGN(7), PIGO(12), PIGP(1), PIGQ(7), PIGS(4), PIGT(8), PIGU(1), PIGV(7), PIGW(3), PIGX(2), PIGZ(4) 10172108 124 68 111 35 29 29 2 25 36 3 0.352 1.000 1.000 435 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(30), C5(11), C6(12), C7(3), ICAM1(2), IL1A(2), ITGA4(12), ITGAL(16), ITGB1(10), ITGB2(6), SELP(10), SELPLG(7), TNF(3), VCAM1(10) 10638910 134 68 126 43 44 29 3 34 24 0 0.162 1.000 1.000 436 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 19 AKT1(3), EIF4A1(3), EIF4A2(6), EIF4B(5), EIF4E(2), EIF4EBP1(2), EIF4G1(23), EIF4G2(7), EIF4G3(17), FKBP1A(2), MKNK1(3), PDPK1(2), PIK3R1(11), PPP2CA(4), RPS6(1), RPS6KB1(5), TSC1(7), TSC2(12) 10558822 115 68 110 29 32 28 4 22 28 1 0.173 1.000 1.000 437 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(3), ACACA(22), ACADL(2), ACADM(4), ACADSB(7), ACAT1(5), ACAT2(4), ALDH1A1(7), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH6A1(6), ALDH9A1(4), EHHADH(7), HADHA(4), LDHA(3), LDHB(4), LDHC(1), MCEE(4), MLYCD(5), MUT(6), PCCA(8), PCCB(5), SDS(4), SUCLA2(4), SUCLG1(2), SUCLG2(5) 14214282 172 68 158 49 36 53 2 33 45 3 0.302 1.000 1.000 438 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 21 ADCY1(19), AKT1(3), BAD(3), BAX(6), BCL2(3), CSF2RB(9), IGF1(4), IGF1R(16), IL3(1), IL3RA(5), KIT(12), KITLG(3), PIK3R1(11), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), YWHAH(3) 8479948 129 67 121 52 36 38 3 22 29 1 0.703 1.000 1.000 439 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(9), CS(3), DLAT(3), DLD(4), DLST(4), FH(3), IDH2(4), IDH3A(2), IDH3B(2), IDH3G(3), MDH1(3), OGDH(11), PC(15), PDHA1(1), PDHA2(6), PDHB(4), PDHX(5), PDK1(3), PDK3(4), PDK4(2), PDP2(4), SDHA(6), SDHB(4), SDHC(1), SDHD(1), SUCLA2(4), SUCLG1(2), SUCLG2(5) 12176274 118 67 113 50 33 31 4 21 26 3 0.915 1.000 1.000 440 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 30 DUSP1(2), GORASP1(4), MAP2K4(8), MAPK1(3), MAPK10(5), MAPK11(1), MAPK13(3), MAPK14(1), MAPK3(1), MAPK8(5), MAPK8IP1(4), MAPK8IP2(4), MAPK8IP3(13), MAPK9(3), MAPKAPK5(3), NFKB1(7), NFKB2(7), NFKBIA(1), NFKBIB(6), NFKBIL1(4), PIK3CD(11), PIK3R1(11), SYT1(4), TRAF2(4), TRAF3(4), TRAF5(1), TRAF6(6) 13169944 126 67 122 34 42 28 2 18 31 5 0.0985 1.000 1.000 441 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(3), ACAA2(5), ADH1A(4), ADH1B(4), ADH4(2), ADH6(7), ADH7(1), ADHFE1(9), AKR1C4(6), AKR1D1(3), ALDH1A1(7), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), BAAT(4), CEL(10), CYP27A1(5), CYP7A1(6), HADHB(5), SOAT2(2), SRD5A1(3) 9967366 136 66 127 41 26 40 5 29 35 1 0.251 1.000 1.000 442 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(19), GNAS(29), GNB1(1), GNGT1(3), PPP2CA(4), PRKAA1(6), PRKAA2(7), PRKAB1(6), PRKAB2(4), PRKACB(4), PRKACG(8), PRKAG1(4), PRKAG2(5), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8) 6605217 119 66 112 38 46 24 1 18 28 2 0.537 1.000 1.000 443 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 28 ATG12(1), ATG5(3), ATG7(5), BECN1(7), GABARAPL1(5), IFNA1(1), IFNA10(4), IFNA13(1), IFNA16(4), IFNA2(1), IFNA4(1), IFNA5(2), IFNA6(3), IFNA7(4), IFNA8(1), IFNG(2), PIK3C3(14), PIK3R4(11), PRKAA1(6), PRKAA2(7), ULK1(16), ULK2(11) 8880754 110 66 105 30 23 21 7 30 28 1 0.323 1.000 1.000 444 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(15), CALM1(2), CALM2(2), CAPN2(8), CAPNS1(2), CAPNS2(2), EP300(22), HDAC1(5), HDAC2(2), MEF2D(7), NFATC1(13), NFATC2(17), PPP3CA(10), PPP3CB(6), PPP3CC(5), PRKCA(5), SYT1(4) 10479130 127 65 121 34 49 27 3 21 26 1 0.0404 1.000 1.000 445 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 26 ANXA1(2), ANXA2(3), ANXA3(1), ANXA4(3), ANXA5(3), ANXA6(2), CYP11A1(5), EDN1(3), EDNRA(4), HSD11B1(3), HSD11B2(3), PLA2G4A(6), PRL(1), PTGDR(7), PTGDS(1), PTGER2(5), PTGER4(8), PTGFR(5), PTGIS(6), PTGS1(12), PTGS2(7), S100A6(1), SCGB1A1(2), TBXAS1(6) 8457480 99 65 98 39 27 25 7 23 17 0 0.744 1.000 1.000 446 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(5), CREB1(3), CREBBP(40), EP300(22), NCOA3(16), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), RARA(3), RXRA(6) 8872206 126 64 121 37 39 34 2 16 33 2 0.165 1.000 1.000 447 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 23 ALDH1A1(7), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH3B1(4), ALDH3B2(7), ALDH9A1(4), AOC2(6), AOC3(15), ASPA(1), CNDP1(6), HAL(4), HARS(9), HDC(8), HNMT(2), MAOA(2), MAOB(3), PRPS1(3), PRPS2(3) 10050972 130 64 115 36 37 25 3 25 38 2 0.314 1.000 1.000 448 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(5), CARM1(5), CBS(6), CTH(2), GGT1(6), HEMK1(1), LCMT1(1), LCMT2(11), MARS(4), MARS2(2), MAT1A(4), MAT2B(3), METTL6(3), PAPSS1(6), PAPSS2(5), PRMT2(8), PRMT3(5), PRMT5(3), PRMT6(4), PRMT7(6), PRMT8(9), SCLY(2), SEPHS1(4), SEPHS2(2), WBSCR22(6) 10696394 113 64 106 43 31 26 6 16 33 1 0.650 1.000 1.000 449 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(2), GALNS(1), GLB1(5), GNS(5), GUSB(11), HEXA(2), HEXB(3), HGSNAT(5), HPSE(8), HPSE2(5), HYAL1(6), HYAL2(5), IDS(4), IDUA(4), LCT(23), NAGLU(6), SPAM1(9) 8767957 104 64 103 36 33 31 4 17 18 1 0.427 1.000 1.000 450 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(3), B3GNT2(3), B3GNT7(5), B4GALT1(2), B4GALT2(7), B4GALT3(2), B4GALT4(5), CHST1(14), CHST2(14), CHST4(6), CHST6(11), FUT8(7), ST3GAL1(4), ST3GAL2(6), ST3GAL3(2), ST3GAL4(6) 5365973 97 64 94 33 50 18 1 12 16 0 0.348 1.000 1.000 451 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 21 AOX1(12), BST1(3), CD38(4), ENPP1(7), ENPP3(8), NADK(10), NADSYN1(8), NMNAT1(3), NMNAT2(1), NMNAT3(2), NNMT(1), NNT(12), NT5C(1), NT5C1A(5), NT5C1B(6), NT5C2(8), NT5E(2), NUDT12(4) 9071950 97 64 92 39 24 26 5 16 25 1 0.776 1.000 1.000 452 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(3), AP2A1(9), AP2M1(7), ARF1(5), BAD(3), BTK(3), EEA1(13), GRASP(1), GSK3A(3), GSK3B(5), LYN(5), PDPK1(2), PFKL(5), PFKM(2), PFKP(14), PLCG1(19), PRKCE(14), RAB5A(2), RPS6KB1(5), VAV2(12) 10720354 132 64 125 39 41 32 7 21 29 2 0.168 1.000 1.000 453 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(6), ABAT(3), ADSL(5), ADSS(5), AGXT(1), AGXT2(8), ASL(6), ASNS(4), ASPA(1), CAD(17), CRAT(5), DARS(2), DDO(6), GAD1(7), GAD2(9), GOT1(3), GOT2(2), GPT(3), GPT2(5), NARS(5), PC(15) 11174678 118 63 115 49 41 30 0 21 26 0 0.776 1.000 1.000 454 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(9), CD2(3), CD33(6), CD5(4), CD7(5), IFNA1(1), IFNB1(3), IFNG(2), IL10(2), IL12A(2), IL12B(2), IL13(2), IL3(1), IL4(1), ITGAX(14), TLR2(2), TLR4(21), TLR7(5), TLR9(15) 7990479 100 63 94 46 28 21 5 33 13 0 0.907 1.000 1.000 455 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(6), FUCA1(1), FUCA2(2), GLB1(5), HEXA(2), HEXB(3), LCT(23), MAN2B1(17), MAN2B2(18), MAN2C1(11), MANBA(7), NEU1(3), NEU2(6), NEU3(5), NEU4(2) 8731153 111 63 108 35 36 24 4 19 28 0 0.375 1.000 1.000 456 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(40), EP300(22), LPL(7), NCOA1(17), NCOA2(22), PPARG(4), RXRA(6) 7927613 118 63 114 30 35 32 5 23 22 1 0.0490 1.000 1.000 457 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(4), CREBBP(40), EP300(22), FADD(1), HDAC3(6), IKBKB(8), NFKB1(7), NFKBIA(1), RELA(5), RIPK1(2), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF6(6) 9586705 116 63 114 33 35 29 3 19 29 1 0.147 1.000 1.000 458 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(18), APOA1(8), APOA4(5), APOC2(2), APOE(2), CETP(5), CYP7A1(6), DGAT1(3), HMGCR(7), LCAT(4), LDLR(10), LIPC(4), LPL(7), LRP1(47), SCARB1(4), SOAT1(7) 11773166 139 63 129 51 50 25 10 26 24 4 0.591 1.000 1.000 459 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(6), CARS(5), DARS(2), EPRS(11), FARS2(7), GARS(4), HARS(9), IARS(10), KARS(5), LARS(5), LARS2(8), MARS(4), MARS2(2), NARS(5), QARS(5), RARS(5), SARS(8), TARS(7), WARS(5), WARS2(10), YARS(6) 13750028 129 62 126 34 39 36 4 23 27 0 0.0959 1.000 1.000 460 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 30 AKR1B10(6), ALOX15(7), ALOX5(10), CYP1A2(5), CYP2C18(4), CYP2C19(7), CYP2C8(1), CYP2E1(6), CYP2J2(3), CYP3A4(4), CYP3A43(4), CYP3A7(4), HSD3B7(6), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6), RDH11(1), RDH12(3), RDH13(5) 10139132 110 62 109 36 36 34 4 21 15 0 0.245 1.000 1.000 461 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(4), ASNS(4), CA1(1), CA12(1), CA14(5), CA2(5), CA3(5), CA4(5), CA5A(1), CA5B(1), CA6(3), CA7(4), CA8(4), CA9(6), CPS1(22), CTH(2), GLS(10), GLS2(7), GLUD1(2), GLUL(5), HAL(4) 8154405 101 62 96 37 21 32 3 22 23 0 0.690 1.000 1.000 462 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 14 AANAT(2), ACHE(11), CHAT(4), COMT(4), DBH(6), GAD1(7), GAD2(9), HDC(8), MAOA(2), PAH(6), PNMT(8), SLC18A3(13), TH(3), TPH1(3) 5744224 86 61 85 43 32 14 2 20 17 1 0.888 1.000 1.000 463 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(7), B4GALNT1(5), GLB1(5), HEXA(2), HEXB(3), LCT(23), SLC33A1(5), ST3GAL1(4), ST3GAL2(6), ST3GAL5(3), ST6GALNAC3(8), ST6GALNAC4(2), ST6GALNAC5(3), ST6GALNAC6(4), ST8SIA1(7), ST8SIA5(8) 7066627 95 61 93 39 38 16 5 18 18 0 0.801 1.000 1.000 464 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CSNK2A1(5), ELK1(3), FOS(1), GRB2(4), IL6R(2), IL6ST(6), JAK1(12), JAK2(13), JAK3(13), JUN(4), MAP2K1(5), MAPK3(1), PTPN11(6), RAF1(10), SHC1(7), SOS1(7), SRF(2), STAT3(7) 10248426 108 61 104 39 25 33 1 29 19 1 0.593 1.000 1.000 465 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 26 BAG4(2), BIRC2(3), BIRC3(6), CASP3(2), CFLAR(1), FADD(1), JUN(4), MAP2K4(8), MAP3K3(8), MAP3K7(10), NFKB1(7), NFKB2(7), NFKBIA(1), NFKBIB(6), NFKBIL1(4), NR2C2(3), RALBP1(8), RIPK1(2), TNF(3), TNFAIP3(10), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF2(4) 11182344 111 61 109 34 33 23 5 19 29 2 0.422 1.000 1.000 466 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(19), ADRB2(8), CFTR(14), GNAS(29), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8) 5625929 101 60 96 38 40 23 0 18 20 0 0.758 1.000 1.000 467 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(3), ARSB(2), ARSD(4), ARSE(5), ASAH1(4), GAL3ST1(8), GALC(5), GBA(9), GLA(3), GLB1(5), LCT(23), NEU1(3), NEU2(6), NEU3(5), NEU4(2), PPAP2A(3), PPAP2B(1), PPAP2C(4), SMPD1(6), SMPD2(3), SPTLC1(2), SPTLC2(3), UGCG(3) 10372839 112 60 111 41 37 32 6 14 23 0 0.528 1.000 1.000 468 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(9), G6PD(5), GCLC(3), GCLM(3), GGT1(6), GPX2(3), GPX3(1), GPX5(2), GPX6(5), GPX7(3), GSR(5), GSS(3), GSTA1(3), GSTA2(2), GSTA3(1), GSTA4(2), GSTA5(2), GSTK1(1), GSTM2(1), GSTM3(2), GSTM4(3), GSTM5(2), GSTO2(3), GSTP1(1), GSTZ1(3), IDH1(2), IDH2(4), MGST1(3), MGST2(3), MGST3(3), OPLAH(15), TXNDC12(1) 9412179 105 60 97 33 27 23 2 23 30 0 0.521 1.000 1.000 469 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(15), POLR1B(8), POLR1C(3), POLR1D(4), POLR2A(19), POLR2B(11), POLR2C(4), POLR2E(2), POLR2F(4), POLR2G(1), POLR2I(2), POLR2K(1), POLR3A(17), POLR3B(13), POLR3G(2), POLR3K(1), ZNRD1(1) 10075177 108 60 106 30 40 30 1 21 16 0 0.0846 1.000 1.000 470 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(10), ACE2(8), AGT(3), AGTR1(2), AGTR2(4), ANPEP(9), CMA1(1), CPA3(1), CTSA(4), CTSG(3), ENPEP(12), LNPEP(11), MAS1(2), MME(8), NLN(6), REN(4), THOP1(4) 9073726 92 60 88 37 27 23 4 17 21 0 0.752 1.000 1.000 471 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(5), ELK1(3), FOS(1), GRB2(4), IL2RA(3), IL2RB(2), IL2RG(6), JAK1(12), JAK3(13), JUN(4), LCK(4), MAP2K1(5), MAPK3(1), MAPK8(5), RAF1(10), SHC1(7), SOS1(7), STAT5A(3), STAT5B(14), SYK(7) 9999634 116 60 108 30 28 33 1 25 28 1 0.138 1.000 1.000 472 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(19), ADRB2(8), GNAS(29), PLCE1(14), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8) 6367978 101 60 96 44 44 25 0 15 17 0 0.848 1.000 1.000 473 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(3), CSF1R(15), EGF(10), EGFR(15), GRB2(4), MET(8), PDGFRA(11), PRKCA(5), SH3GLB1(3), SH3GLB2(7), SH3KBP1(15), SRC(3) 8346713 99 59 92 44 28 22 3 17 29 0 0.929 1.000 1.000 474 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(2), CSF1R(15), DDX20(4), E2F1(3), ETS1(8), ETS2(4), FOS(1), HDAC2(2), HDAC5(10), JUN(4), NCOR2(30), RBL1(11), RBL2(8), SIN3A(14), SIN3B(12) 11107755 128 59 124 44 35 22 5 29 37 0 0.717 1.000 1.000 475 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(17), IL13(2), IL4(1), JUNB(3), MAF(3), MAP2K3(4), MAPK14(1), NFATC1(13), NFATC2(17), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8) 5203055 92 59 85 31 36 21 1 11 23 0 0.193 1.000 1.000 476 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(5), BCAT2(6), IARS(10), IARS2(9), ILVBL(5), LARS(5), LARS2(8), PDHA1(1), PDHA2(6), PDHB(4), VARS(16), VARS2(12) 7978229 87 58 87 30 27 21 2 21 16 0 0.533 1.000 1.000 477 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(11), AMT(4), ATIC(6), FTCD(5), GART(9), MTFMT(1), MTHFD1(5), MTHFD1L(6), MTHFD2(1), MTHFR(9), MTHFS(3), MTR(13), SHMT1(2), SHMT2(9), TYMS(1) 8109297 85 58 82 29 23 18 3 15 24 2 0.339 1.000 1.000 478 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(1), ALDOB(6), ALDOC(6), FBP1(4), FBP2(5), GOT1(3), GOT2(2), GPT(3), GPT2(5), MDH1(3), ME1(2), ME3(4), PGK1(4), PGK2(3), PKLR(7), RPE(5), RPIA(2), TKT(4), TKTL1(10), TKTL2(12), TPI1(1) 8666919 92 58 90 37 29 25 4 19 15 0 0.647 1.000 1.000 479 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(6), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), CYP2C19(7), DHRS1(2), DHRS3(2), DHRS7(6), DHRSX(5), EHHADH(7), ESCO1(7), ESCO2(8), HADHA(4), NAT6(3), PNPLA3(2), SH3GLB1(3), YOD1(2) 13265815 109 58 99 30 26 28 1 17 36 1 0.317 1.000 1.000 480 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(5), IL22(1), IL22RA1(2), IL22RA2(1), JAK1(12), JAK2(13), JAK3(13), SOCS3(3), STAT1(10), STAT3(7), STAT5A(3), STAT5B(14), TYK2(9) 7875134 93 58 89 30 20 25 1 20 26 1 0.564 1.000 1.000 481 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(16), ABCC2(12), ABCG2(6), BCHE(18), CES1(7), CES2(8), CYP3A4(4), UGT1A1(4), UGT1A10(1), UGT1A3(1), UGT1A4(3), UGT1A5(3), UGT1A6(6), UGT1A7(3), UGT1A9(3) 9818652 95 58 93 34 21 26 2 26 19 1 0.634 1.000 1.000 482 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 CASP2(3), CHUK(4), CRADD(1), IKBKB(8), JUN(4), LTA(4), MAP2K3(4), MAP2K4(8), MAP2K6(1), MAP3K1(11), MAP4K2(8), MAPK14(1), MAPK8(5), NFKB1(7), NFKBIA(1), RELA(5), RIPK1(2), TANK(3), TNF(3), TNFRSF1A(6), TRADD(2), TRAF2(4) 10323491 95 58 93 28 22 19 5 14 32 3 0.401 1.000 1.000 483 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(8), ACO2(9), CS(3), DLD(4), DLST(4), FH(3), IDH1(2), IDH2(4), IDH3A(2), IDH3B(2), IDH3G(3), MDH1(3), PC(15), PCK1(11), SDHA(6), SDHB(4), SUCLA2(4), SUCLG1(2), SUCLG2(5) 8846734 94 57 88 31 36 21 2 14 19 2 0.360 1.000 1.000 484 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(4), POLD1(15), POLD2(4), POLE(24), POLG(8), POLL(3), POLQ(29) 7187553 87 57 85 34 27 16 3 16 24 1 0.831 1.000 1.000 485 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(7), F2(9), F2R(3), F3(1), F5(21), F7(10), FGA(9), FGB(4), FGG(3), PROC(3), PROS1(9), SERPINC1(4), TFPI(4) 7040319 87 57 87 27 25 20 4 27 11 0 0.369 1.000 1.000 486 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(1), ALDOB(6), ALDOC(6), FBP1(4), FBP2(5), G6PD(5), GPI(5), H6PD(6), PFKL(5), PFKM(2), PFKP(14), PGD(6), PGLS(2), PGM1(2), PGM3(7), PRPS1(3), PRPS1L1(2), PRPS2(3), RBKS(3), RPE(5), RPIA(2), TALDO1(5), TKT(4), TKTL1(10), TKTL2(12) 10417105 125 57 119 39 31 38 6 21 29 0 0.157 1.000 1.000 487 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(6), DCXR(1), GUSB(11), RPE(5), UGDH(5), UGP2(7), UGT1A1(4), UGT1A10(1), UGT1A3(1), UGT1A4(3), UGT1A5(3), UGT1A6(6), UGT1A7(3), UGT1A9(3), UGT2A1(3), UGT2A3(6), UGT2B10(5), UGT2B11(1), UGT2B15(3), UGT2B17(2), UGT2B28(7), UGT2B4(4), UGT2B7(6), XYLB(7) 11603295 103 57 100 26 17 31 3 27 25 0 0.160 1.000 1.000 488 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(3), CAT(5), EPX(9), LPO(9), MPO(7), PRDX1(1), PRDX2(2), PRDX5(1), PRDX6(2), SHMT1(2), SHMT2(9), TPO(24) 5046162 74 57 72 25 23 10 5 18 17 1 0.543 1.000 1.000 489 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(4), BLVRA(4), BLVRB(1), CP(10), CPOX(2), EPRS(11), FECH(6), GUSB(11), HCCS(3), HMBS(3), HMOX1(5), HMOX2(1), PPOX(5), UGT1A1(4), UGT1A10(1), UGT1A3(1), UGT1A4(3), UGT1A5(3), UGT1A6(6), UGT1A7(3), UGT1A9(3), UGT2B15(3), UGT2B4(4), UROD(1), UROS(4) 11715149 102 56 102 36 23 31 2 24 22 0 0.581 1.000 1.000 490 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 12 AKT1(3), BAD(3), CHRNB1(4), CHRNG(4), MUSK(13), PIK3R1(11), PTK2(11), PTK2B(16), RAPSN(4), SRC(3), TERT(4), YWHAH(3) 6077439 79 55 78 28 26 16 5 14 17 1 0.528 1.000 1.000 491 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(6), AKR1D1(3), ARSB(2), ARSD(4), ARSE(5), CYP11B1(12), CYP11B2(5), HSD11B1(3), HSD11B2(3), HSD17B2(2), HSD17B3(1), HSD3B1(4), HSD3B2(1), SRD5A1(3), STS(6), SULT1E1(2), SULT2A1(3), UGT1A1(4), UGT1A10(1), UGT1A3(1), UGT1A4(3), UGT1A5(3), UGT1A6(6), UGT1A7(3), UGT1A9(3), UGT2B15(3), UGT2B4(4) 11676971 96 55 95 36 29 36 3 15 13 0 0.392 1.000 1.000 492 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT1(3), B3GNT2(3), B3GNT3(5), B3GNT4(7), B3GNT5(10), B4GALT1(2), B4GALT2(7), B4GALT3(2), B4GALT4(5), FUT1(3), FUT2(1), FUT3(3), FUT4(2), FUT5(3), FUT6(4), FUT7(2), FUT9(6), GCNT2(2), ST3GAL6(4), ST8SIA1(7) 6941063 81 55 76 28 25 19 3 13 21 0 0.647 1.000 1.000 493 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 17 DNAJA3(4), HSPA1A(2), IFNG(2), IFNGR1(6), IFNGR2(2), IKBKB(8), JAK2(13), LIN7A(9), NFKB1(7), NFKBIA(1), RB1(13), RELA(5), TNF(3), TNFRSF1A(6), TNFRSF1B(3), USH1C(4), WT1(3) 7437068 91 55 88 33 18 24 1 23 24 1 0.657 1.000 1.000 494 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(5), C1QB(1), C1R(5), C1S(7), C2(1), C3(30), C5(11), C6(12), C7(3), C8A(5), C8B(14), C9(7), MASP1(1) 8920652 102 54 93 28 30 20 3 22 26 1 0.284 1.000 1.000 495 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 14 AKT1(3), BAD(3), GRB2(4), IGF1R(16), IRS1(24), MAP2K1(5), MAPK1(3), MAPK3(1), PIK3R1(11), RAF1(10), SHC1(7), SOS1(7), YWHAH(3) 7208112 97 54 92 31 28 27 2 13 25 2 0.417 1.000 1.000 496 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(5), ICAM1(2), ITGA4(12), ITGAL(16), ITGAM(9), ITGB1(10), ITGB2(6), SELE(5), SELL(4), SELP(10) 6840070 79 54 75 39 29 15 1 19 15 0 0.890 1.000 1.000 497 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(1), ALDOB(6), ALDOC(6), FBP1(4), FBP2(5), G6PD(5), GPI(5), H6PD(6), PFKM(2), PFKP(14), PGD(6), PGLS(2), PGM1(2), PGM3(7), PRPS1(3), PRPS1L1(2), PRPS2(3), RBKS(3), RPE(5), RPIA(2), TAL1(5), TALDO1(5), TKT(4) 8776582 103 54 98 32 24 30 4 18 27 0 0.215 1.000 1.000 498 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(3), IL6R(2), JAK1(12), JAK2(13), JAK3(13), PIAS3(7), PTPRU(25), REG1A(4), SRC(3), STAT3(7) 6536837 89 54 85 30 24 23 0 17 24 1 0.602 1.000 1.000 499 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(5), ARFGAP1(2), ARFGAP3(5), ARFGEF2(28), CLTA(2), CLTB(1), COPA(9), GBF1(18), GPLD1(11), KDELR1(2), KDELR2(1), KDELR3(3) 6976993 87 53 86 26 27 29 1 13 17 0 0.165 1.000 1.000 500 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 20 APAF1(8), ARHGDIB(1), BIRC2(3), BIRC3(6), CASP1(4), CASP10(6), CASP2(3), CASP3(2), CASP4(8), CASP6(1), CASP7(3), CASP9(3), DFFA(4), DFFB(3), GZMB(3), LMNA(6), LMNB1(4), LMNB2(6), PRF1(8) 7772192 82 53 79 23 21 19 5 14 23 0 0.357 1.000 1.000 501 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(5), AMD1(5), BHMT(5), CBS(6), CTH(2), DNMT1(13), DNMT3A(8), DNMT3B(15), MARS(4), MARS2(2), MAT1A(4), MAT2B(3), MTAP(1), MTFMT(1), MTR(13), SRM(1), TAT(5) 8894699 93 53 90 49 28 29 2 16 18 0 0.964 1.000 1.000 502 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(11), AMT(4), ATIC(6), GART(9), MTHFD1(5), MTHFD1L(6), MTHFD2(1), MTHFR(9), MTHFS(3), MTR(13), SHMT1(2), SHMT2(9), TYMS(1) 7669366 79 53 76 25 21 18 3 12 24 1 0.216 1.000 1.000 503 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(4), DUSP1(2), IKBKAP(14), IKBKB(8), LTA(4), MAP3K1(11), NFKB1(7), NFKBIA(1), RELA(5), RIPK1(2), TANK(3), TNFAIP3(10), TNFRSF1B(3), TRAF1(3), TRAF2(4), TRAF3(4) 9635897 85 53 82 28 24 15 3 14 28 1 0.595 1.000 1.000 504 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(1), ALDOB(6), ALDOC(6), FBP1(4), FBP2(5), GOT1(3), GOT2(2), GPT(3), GPT2(5), MDH1(3), ME1(2), ME2(5), ME3(4), PGK1(4), PKLR(7), RPE(5), RPIA(2), TKT(4), TPI1(1) 7747581 72 52 72 29 21 21 2 15 13 0 0.635 1.000 1.000 505 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(5), C1QB(1), C1R(5), C1S(7), C2(1), C3(30), C5(11), C6(12), C7(3), C8A(5), C9(7), MASP1(1), MASP2(6), MBL2(4) 9135788 98 52 89 30 29 20 3 16 29 1 0.455 1.000 1.000 506 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(10), EGFR(15), MAP2K1(5), MAP3K1(11), MAPK14(1), NCOR2(30), RARA(3), RXRA(6), THRA(6), THRB(9) 7391765 96 52 89 40 39 20 2 15 20 0 0.776 1.000 1.000 507 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(5), ACAT2(4), ACOT11(6), ACYP1(1), ACYP2(3), DHRS1(2), DHRS3(2), DHRS7(6), DHRSX(5), EHHADH(7), ESCO1(7), ESCO2(8), FN3K(3), GCDH(8), HADHA(4), NAT6(3), PNPLA3(2), SH3GLB1(3), YOD1(2) 11150538 81 51 77 17 19 25 3 7 25 2 0.0525 1.000 1.000 508 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(8), CLOCK(5), CRY1(3), CRY2(5), CSNK1D(2), CSNK1E(8), NPAS2(11), NR1D1(5), PER1(4), PER2(15), PER3(12) 7294432 78 51 76 25 22 15 5 18 17 1 0.370 1.000 1.000 509 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(2), ALG5(3), B4GALT1(2), B4GALT2(7), B4GALT3(2), B4GALT5(6), DPAGT1(4), DPM1(1), FUT8(7), MAN1A1(2), MAN1B1(6), MGAT1(3), MGAT2(2), MGAT3(8), MGAT4A(5), MGAT4B(3), MGAT5(10), RPN1(3), RPN2(6) 8554570 82 51 80 42 24 18 4 17 19 0 0.975 1.000 1.000 510 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(6), FUCA1(1), FUCA2(2), GLB1(5), HEXA(2), HEXB(3), LCT(23), MAN2C1(11), MANBA(7), NEU1(3), NEU2(6), NEU3(5), NEU4(2) 7079699 76 51 76 27 23 16 3 13 21 0 0.670 1.000 1.000 511 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(9), ESR2(9), ITPKA(2), PDE1A(7), PDE1B(6), PLCB1(19), PLCB2(8), PRL(1), TRH(4), VIP(5) 4767984 70 51 67 25 23 14 4 15 14 0 0.604 1.000 1.000 512 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 14 AKT1(3), AKT2(8), AKT3(6), BPNT1(4), GRB2(4), ILK(8), MAPK1(3), MAPK3(1), PDK1(3), PIK3CD(11), PTK2B(16), RBL2(8), SHC1(7), SOS1(7) 7470757 89 51 86 23 34 20 0 13 21 1 0.272 1.000 1.000 513 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 14 AKT1(3), AKT2(8), AKT3(6), CDKN1A(3), ELK1(3), GRB2(4), MAP2K1(5), MAP2K2(3), NGFR(4), NTRK1(10), PIK3CD(11), SHC1(7), SOS1(7) 5976990 74 51 71 29 28 18 1 17 10 0 0.636 1.000 1.000 514 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(9), LPO(9), MPO(7), PRDX1(1), PRDX2(2), PRDX5(1), PRDX6(2), TPO(24), TYR(9) 4127047 64 51 62 24 18 12 5 19 9 1 0.678 1.000 1.000 515 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 13 ABL1(7), E2F1(3), MDM2(5), MYC(5), PIK3R1(11), POLR1A(15), POLR1B(8), POLR1C(3), POLR1D(4), RB1(13), TBX2(6), TWIST1(2) 7159385 82 50 78 30 21 22 1 10 27 1 0.633 1.000 1.000 516 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 15 ADAM12(6), AGT(3), AGTR2(4), EDN1(3), EDNRA(4), EGF(10), EGFR(15), FOS(1), JUN(4), MYC(5), NFKB1(7), PLCG1(19), PRKCA(5), RELA(5) 8444319 91 50 89 32 26 18 7 21 19 0 0.474 1.000 1.000 517 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 21 CCNA1(6), CCNB1(3), CCND1(1), CCND2(3), CCND3(2), CCNE1(5), CCNH(2), CDC25A(6), CDK2(3), CDK6(4), CDKN1A(3), CDKN2D(3), E2F1(3), RB1(13), RBL1(11), TFDP1(5) 6638746 73 50 70 28 14 27 2 15 15 0 0.611 1.000 1.000 518 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 27 CCL3(1), CCR1(5), CCR2(6), CCR3(6), CCR5(4), CCR7(3), CD28(1), CXCR3(1), CXCR4(1), IFNG(2), IFNGR1(6), IFNGR2(2), IL12A(2), IL12B(2), IL12RB1(5), IL12RB2(11), IL18R1(4), IL4(1), IL4R(3), TGFB1(3), TGFB2(6), TGFB3(8) 8207664 83 50 83 32 20 19 3 21 19 1 0.643 1.000 1.000 519 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(11), DNMT1(13), MTNR1A(5), MTNR1B(6), PTAFR(5), PTGDR(7), PTGER2(5), PTGER4(8), PTGFR(5), TBXA2R(8) 4774797 73 50 71 39 30 20 4 14 5 0 0.834 1.000 1.000 520 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(5), C1QB(1), C1R(5), C1S(7), C2(1), C3(30), C5(11), C6(12), C7(3), C8A(5), C9(7) 7502145 87 49 79 28 26 18 3 16 23 1 0.565 1.000 1.000 521 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(2), GALNS(1), GLB1(5), GNS(5), GUSB(11), HEXA(2), HEXB(3), IDS(4), IDUA(4), LCT(23), NAGLU(6) 6152305 66 49 66 29 20 18 1 13 14 0 0.806 1.000 1.000 522 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 21 AKT1(3), CCND1(1), CCNE1(5), CDK2(3), CDK6(4), CDKN1A(3), E2F1(3), MAPK1(3), MAPK3(1), NFKB1(7), NFKBIA(1), PAK1(5), PIK3R1(11), RAF1(10), RB1(13), RELA(5), TFDP1(5) 7743062 83 49 80 21 16 28 2 13 23 1 0.113 1.000 1.000 523 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(5), ACP2(4), ACP5(2), ACP6(3), ACPP(3), ACPT(4), ALPI(6), ALPL(8), ALPP(7), ALPPL2(5), CYP3A4(4), CYP3A43(4), CYP3A7(4), DHRS1(2), DHRS3(2), DHRS7(6), DHRSX(5), PON1(2), PON2(3), PON3(2) 7742962 81 48 77 39 30 17 1 12 20 1 0.913 1.000 1.000 524 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(3), ALDH18A1(7), ARG1(2), ARG2(2), ASL(6), CKB(2), CKM(1), CKMT1A(3), CKMT1B(1), CKMT2(6), CPS1(22), GAMT(1), GATM(3), GLUD1(2), NAGS(1), OAT(2), ODC1(4), OTC(2), PYCR1(1), SMS(5) 7505559 76 48 76 22 24 20 3 21 8 0 0.149 1.000 1.000 525 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(3), ACTR2(2), ACTR3(2), ARPC1A(3), ARPC2(3), ARPC4(2), NCK1(6), NCKAP1(9), NTRK1(10), PIR(1), PSMA7(4), WASF1(5), WASF2(5), WASF3(13), WASL(3) 6535402 71 47 67 30 24 17 2 9 18 1 0.804 1.000 1.000 526 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(4), DUSP1(2), IKBKAP(14), IKBKB(8), MAP3K1(11), NFKB1(7), NFKBIA(1), RELA(5), TNFAIP3(10), TRAF3(4), TRAF6(6) 7779939 72 47 69 19 20 12 2 12 26 0 0.373 1.000 1.000 527 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(9), FOS(1), GRB2(4), IL3(1), IL3RA(5), JAK2(13), MAP2K1(5), MAPK3(1), PTPN6(4), RAF1(10), SHC1(7), SOS1(7), STAT5A(3), STAT5B(14) 7591736 84 47 78 28 23 26 1 17 16 1 0.466 1.000 1.000 528 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 66 MRPL13(1), MRPS7(1), RPL10A(2), RPL11(1), RPL12(3), RPL13A(4), RPL14(1), RPL18(1), RPL19(2), RPL22L1(1), RPL23A(2), RPL24(1), RPL26(1), RPL27(1), RPL28(2), RPL29(1), RPL3(3), RPL31(1), RPL34(2), RPL35A(1), RPL36A(1), RPL37(1), RPL38(1), RPL3L(3), RPL6(2), RPL7(1), RPL8(2), RPL9(3), RPS11(2), RPS13(2), RPS18(1), RPS20(1), RPS23(1), RPS24(1), RPS25(1), RPS27(1), RPS3(2), RPS3A(2), RPS4Y1(1), RPS5(4), RPS6(1), RPS7(1), RPS9(1), RPSA(2) 9510507 70 46 68 27 17 23 2 10 18 0 0.799 1.000 1.000 529 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(4), CD3E(2), CD3G(1), CXCR3(1), ETV5(5), IFNG(2), IL12A(2), IL12B(2), IL12RB1(5), IL12RB2(11), IL18(1), IL18R1(4), JAK2(13), JUN(4), MAP2K6(1), MAPK14(1), MAPK8(5), STAT4(6), TYK2(9) 7995959 79 46 79 30 10 23 5 16 22 3 0.749 1.000 1.000 530 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(3), GRB2(4), IL2RG(6), IL4(1), IL4R(3), IRS1(24), JAK1(12), JAK3(13), RPS6KB1(5), SHC1(7), STAT6(3) 6338702 81 46 75 24 22 20 1 7 30 1 0.612 1.000 1.000 531 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(5), BHMT(5), CBS(6), CTH(2), DNMT1(13), DNMT3A(8), DNMT3B(15), MARS(4), MARS2(2), MAT1A(4), MAT2B(3), MTR(13) 7458581 80 46 77 43 26 23 2 12 17 0 0.959 1.000 1.000 532 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 12 AOX1(12), CD38(4), ENPP1(7), ENPP3(8), NADSYN1(8), NMNAT1(3), NMNAT2(1), NNMT(1), NNT(12), NT5C(1), NT5E(2) 6080969 59 46 57 27 7 15 4 15 17 1 0.928 1.000 1.000 533 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 6 AKT1(3), PIK3R1(11), PLCB1(19), PLCG1(19), PRKCA(5), VAV1(9) 4574941 66 46 63 20 19 16 2 8 20 1 0.419 1.000 1.000 534 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 5 ATM(38), ATR(18), CHEK1(4), CHEK2(8), YWHAH(3) 6076602 71 46 66 19 15 15 1 14 23 3 0.702 1.000 1.000 535 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(3), FUT1(3), FUT2(1), FUT9(6), GBGT1(3), GLA(3), HEXA(2), HEXB(3), NAGA(5), ST3GAL1(4), ST3GAL2(6), ST3GAL4(6), ST8SIA1(7) 4353526 52 44 50 20 26 7 1 12 6 0 0.566 1.000 1.000 536 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(4), HK1(16), HK2(10), HK3(6), IMPA1(4), IMPA2(2), ISYNA1(3), PGM1(2), PGM3(7), TGDS(4) 5006454 58 44 57 25 21 20 2 11 4 0 0.507 1.000 1.000 537 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(10), CD44(5), CSF1(2), FCGR3A(4), IL1B(3), IL6R(2), SELL(4), SPN(4), TGFB1(3), TGFB2(6), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TNFRSF8(4), TNFSF8(3) 5649037 62 44 61 30 20 14 0 12 15 1 0.865 1.000 1.000 538 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(1), CTSD(7), ESR1(9), GREB1(22), HSPB2(1), MTA1(8), MTA3(2), PDZK1(2), TUBA8(5) 4688945 57 43 55 24 21 17 3 5 11 0 0.593 1.000 1.000 539 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(3), CD28(1), CD3E(2), CD3G(1), CD8A(4), ICAM1(2), ITGAL(16), ITGB2(6), PTPRC(19), THY1(1) 4615326 55 43 52 25 13 16 2 14 10 0 0.817 1.000 1.000 540 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(3), B3GALNT1(3), B3GALT5(1), FUT1(3), FUT2(1), FUT9(6), GBGT1(3), GLA(3), HEXA(2), HEXB(3), NAGA(5), ST3GAL1(4), ST3GAL2(6), ST8SIA1(7) 4620674 50 42 48 23 23 6 2 12 7 0 0.806 1.000 1.000 541 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(3), ACOX1(5), ACOX3(11), ELOVL2(7), ELOVL5(2), ELOVL6(1), FADS1(3), FADS2(5), FASN(19), HADHA(4), HSD17B12(3), PECR(1), SCD(1) 6118413 65 42 59 28 24 12 5 8 16 0 0.779 1.000 1.000 542 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(4), BLVRB(1), HMOX1(5), IL10(2), IL10RA(5), IL10RB(3), IL1A(2), JAK1(12), STAT1(10), STAT3(7), STAT5A(3), TNF(3) 5236591 57 42 57 19 11 16 0 15 15 0 0.556 1.000 1.000 543 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 9 CD3E(2), CD3G(1), FYN(10), HLA-DRA(8), LCK(4), PTPRC(19), ZAP70(14) 3489064 58 42 56 22 18 20 1 13 6 0 0.566 1.000 1.000 544 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(13), EGF(10), EGFR(15), HGS(4), RAB5A(2), TF(15), TFRC(2) 5503496 61 41 58 27 16 12 2 16 13 2 0.872 1.000 1.000 545 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 23 CYP27B1(5), CYP51A1(8), DHCR24(4), DHCR7(6), EBP(1), FDFT1(2), FDPS(9), GGCX(4), GGPS1(1), HMGCR(7), HSD17B7(3), IDI1(2), IDI2(1), LSS(9), MVD(2), NQO1(3), NSDHL(3), PMVK(1), SQLE(5), TM7SF2(2), VKORC1(1) 7905200 79 41 75 25 21 17 2 17 21 1 0.548 1.000 1.000 546 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(6), DLL1(15), FURIN(5), NOTCH1(26), PSEN1(3) 3968173 55 41 53 28 20 10 4 11 10 0 0.826 1.000 1.000 547 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(8), POLR2A(19), POLR2B(11), POLR2C(4), POLR2E(2), POLR2F(4), POLR2G(1), POLR2I(2), POLR2K(1), POLRMT(9) 5766212 61 41 60 18 20 20 0 11 10 0 0.172 1.000 1.000 548 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(4), HK1(16), HK2(10), HK3(6), IMPA1(4), PGM1(2), PGM3(7), TGDS(4) 4393173 53 41 53 22 18 20 2 9 4 0 0.484 1.000 1.000 549 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 6 ADCY1(19), CREM(4), FHL5(3), FSHB(1), GNAS(29), XPO1(7) 3521065 63 40 59 23 30 13 0 15 5 0 0.779 1.000 1.000 550 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(6), DCXR(1), GUSB(11), RPE(5), UCHL1(1), UCHL3(3), UGDH(5), UGT1A1(4), UGT1A10(1), UGT1A3(1), UGT1A4(3), UGT1A5(3), UGT1A6(6), UGT1A7(3), UGT1A9(3), UGT2B15(3), UGT2B4(4) 7488405 63 40 63 19 16 21 1 14 11 0 0.245 1.000 1.000 551 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(12), JAK2(13), JAK3(13), MAPK1(3), MAPK3(1), STAT3(7), TYK2(9) 5011880 58 40 57 22 12 20 0 12 13 1 0.729 1.000 1.000 552 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 10 CD2(3), CD28(1), CD3E(2), CD3G(1), ICAM1(2), ITGAL(16), ITGB2(6), PTPRC(19), THY1(1) 4453020 51 40 48 25 12 15 1 13 10 0 0.895 1.000 1.000 553 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(19), GNAS(29), GNB1(1), GNGT1(3), PRKACA(4), PRKAR1A(3) 2861889 59 39 56 22 30 10 0 11 8 0 0.725 1.000 1.000 554 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(5), ICAM1(2), ITGA4(12), ITGAL(16), ITGB1(10), ITGB2(6), SELE(5), SELL(4) 5201509 60 39 56 29 22 14 1 12 11 0 0.770 1.000 1.000 555 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(11), CHAT(4), CHKA(2), PCYT1A(9), PDHA1(1), PDHA2(6), PEMT(1), SLC18A3(13) 2990888 47 38 47 26 18 10 0 14 5 0 0.914 1.000 1.000 556 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 12 AKT1(3), CAT(5), GH1(2), GHR(6), IGF1(4), IGF1R(16), PIK3R1(11), SHC1(7), SOD2(1) 4771973 55 38 54 20 10 17 2 13 12 1 0.640 1.000 1.000 557 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(3), PSMA2(1), PSMA3(3), PSMA4(4), PSMA6(5), PSMA7(4), PSMB1(2), PSMB2(2), PSMB3(2), PSMB4(3), PSMB5(1), PSMB6(3), PSMC3(8), PSMD14(1), RPN1(3), RPN2(6), UBE2A(1), UBE3A(5) 5531848 57 38 56 21 15 17 5 9 11 0 0.541 1.000 1.000 558 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(1), RANBP1(1), RANBP2(33), RANGAP1(12) 3622899 47 38 47 19 6 15 3 10 11 2 0.791 1.000 1.000 559 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(6), AKR1D1(3), CYP11A1(5), CYP11B1(12), CYP11B2(5), CYP17A1(6), CYP21A2(5), HSD11B1(3), HSD11B2(3), HSD3B1(4), HSD3B2(1) 3982377 53 37 52 18 20 15 4 9 5 0 0.358 1.000 1.000 560 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(6), AKR1D1(3), CYP11A1(5), CYP11B1(12), CYP11B2(5), CYP17A1(6), CYP21A2(5), HSD11B1(3), HSD11B2(3), HSD3B1(4), HSD3B2(1) 3982377 53 37 52 18 20 15 4 9 5 0 0.358 1.000 1.000 561 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 14 CCR5(4), CD2(3), CD3E(2), CD3G(1), CXCR3(1), IFNG(2), IL12A(2), IL12B(2), IL12RB1(5), IL12RB2(11), JAK2(13), STAT4(6), TYK2(9) 5910953 61 37 61 27 7 19 4 13 16 2 0.892 1.000 1.000 562 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(10), AGT(3), AGTR1(2), AGTR2(4), BDKRB2(4), KNG1(9), NOS3(10), REN(4) 4226077 46 36 43 17 12 9 3 6 15 1 0.636 1.000 1.000 563 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 14 CYP51A1(8), DHCR7(6), FDFT1(2), FDPS(9), HMGCR(7), HMGCS1(2), IDI1(2), LSS(9), MVD(2), NSDHL(3), PMVK(1), SQLE(5) 5286772 56 36 53 19 15 10 1 14 16 0 0.624 1.000 1.000 564 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(5), CBS(6), CTH(2), GGT1(6), MARS(4), MARS2(2), MAT1A(4), MAT2B(3), PAPSS1(6), PAPSS2(5), SCLY(2), SEPHS1(4) 5307074 49 36 47 23 16 10 2 7 14 0 0.819 1.000 1.000 565 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(2), IL13RA1(4), IL13RA2(6), IL4R(3), JAK1(12), JAK2(13), TYK2(9) 4493030 49 36 49 22 10 15 2 8 13 1 0.895 1.000 1.000 566 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(2), IL13RA1(4), IL13RA2(6), IL4R(3), JAK1(12), JAK2(13), TYK2(9) 4493030 49 36 49 22 10 15 2 8 13 1 0.895 1.000 1.000 567 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(5), CYP2A13(8), CYP2A6(7), CYP2A7(3), NAT1(2), NAT2(5), XDH(14) 3428046 44 35 44 16 11 14 1 13 5 0 0.570 1.000 1.000 568 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(8), ACO2(9), AFMID(3), CS(3), GRHPR(1), HAO1(3), HAO2(5), HYI(2), MDH1(3), MTHFD1(5), MTHFD1L(6), MTHFD2(1) 5751981 49 35 48 21 19 17 2 4 7 0 0.587 1.000 1.000 569 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(5), ICAM1(2), ITGAL(16), ITGAM(9), ITGB2(6), SELE(5), SELL(4) 4455983 47 35 46 30 18 10 1 8 10 0 0.985 1.000 1.000 570 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(9), CAPN1(5), CAPNS1(2), CAPNS2(2), CDK5(2), CDK5R1(4), CSNK1A1(3), CSNK1D(2), GSK3B(5), MAPT(7), PPP2CA(4) 3947928 45 35 44 24 17 14 0 7 6 1 0.914 1.000 1.000 571 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 4 EGF(10), EGFR(15), NRG1(14) 3214486 39 34 38 21 14 11 3 6 5 0 0.868 1.000 1.000 572 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(8), ACO2(9), CS(3), GRHPR(1), HAO1(3), HAO2(5), HYI(2), MDH1(3), MTHFD1(5), MTHFD1L(6), MTHFD2(1) 5492669 46 34 45 21 17 16 2 4 7 0 0.696 1.000 1.000 573 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(5), CARS2(6), CDO1(1), CTH(2), GOT1(3), GOT2(2), LDHA(3), LDHAL6B(5), LDHB(4), LDHC(1), MPST(2), SDS(4), SULT1B1(4), SULT1C2(2), SULT1C4(2), SULT4A1(2) 5375393 48 34 48 19 17 14 1 8 8 0 0.619 1.000 1.000 574 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(6), DHRS1(2), DHRS3(2), DHRS7(6), DHRSX(5), HSD3B7(6), PON1(2), PON2(3), PON3(2), RDH11(1), RDH12(3), RDH13(5) 3863797 43 34 42 22 15 11 2 9 5 1 0.909 1.000 1.000 575 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(3), ANKRD1(5), ATF3(1), CYR61(1), DUSP14(3), EIF4E(2), EIF4EBP1(2), HBEGF(1), IFNG(2), IFRD1(8), IL18(1), IL1A(2), IL1R1(4), JUND(2), MYOG(4), NR4A3(5), WDR1(2) 4571364 48 34 45 17 17 6 4 10 11 0 0.597 1.000 1.000 576 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(9), CS(3), FH(3), IDH2(4), MDH1(3), OGDH(11), SDHA(6), SUCLA2(4) 4045241 43 34 40 17 14 10 2 4 11 2 0.763 1.000 1.000 577 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 8 CD3E(2), CD3G(1), GZMB(3), ICAM1(2), ITGAL(16), ITGB2(6), PRF1(8) 3328004 38 33 37 16 13 8 1 6 10 0 0.694 1.000 1.000 578 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(5), ADSS(5), IMPDH1(5), MTHFD2(1), NME2(3), POLB(4), POLD1(15), POLG(8), PRPS2(3), RRM1(5), SRM(1) 5356739 55 33 55 19 19 16 2 8 10 0 0.466 1.000 1.000 579 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 MMP14(6), MMP2(6), MMP9(17), RECK(8), TIMP2(2), TIMP3(6), TIMP4(1) 3229191 46 33 45 21 18 11 0 4 12 1 0.798 1.000 1.000 580 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(3), APAF1(8), BCL2(3), CASP3(2), CASP9(3), DAXX(10), FAS(3), FASLG(3), HSPB2(1), IL1A(2), MAPKAPK2(1), MAPKAPK3(5), TNF(3) 4861076 47 32 46 23 15 9 0 12 10 1 0.924 1.000 1.000 581 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(4), GNAQ(4), GNB1(1), GNGT1(3), HTR2C(6), PLCB1(19), TUB(5) 3071122 42 32 41 18 12 8 1 9 12 0 0.826 1.000 1.000 582 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(2), CDK5R1(4), EGR1(10), KLK2(1), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), NGFR(4), RAF1(10) 3504293 43 31 38 19 14 12 0 8 9 0 0.724 1.000 1.000 583 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(2), IFNGR1(6), IFNGR2(2), JAK1(12), JAK2(13), STAT1(10) 3519636 45 31 45 17 6 15 1 8 14 1 0.774 1.000 1.000 584 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(5), IARS(10), LARS(5), LARS2(8), PDHA1(1), PDHA2(6), PDHB(4) 4295125 39 31 39 17 6 13 1 10 9 0 0.865 1.000 1.000 585 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(1), IFNB1(3), IFNG(2), IL10(2), IL12A(2), IL12B(2), IL13(2), IL16(13), IL18(1), IL1A(2), IL3(1), IL4(1), LTA(4), TNF(3) 4262673 39 30 39 20 8 10 2 10 9 0 0.948 1.000 1.000 586 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(6), ALPL(8), ALPP(7), ALPPL2(5), FPGS(4), GCH1(1), GGH(3), SPR(2) 2800342 36 30 35 17 21 4 0 5 6 0 0.585 1.000 1.000 587 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT1(3), B3GALT2(7), B3GALT5(1), B3GNT5(10), FUT1(3), FUT2(1), FUT3(3), ST3GAL3(2), ST3GAL4(6) 3103013 36 30 33 15 15 5 0 4 12 0 0.877 1.000 1.000 588 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(6), GAD1(7), HDC(8), PNMT(8), TH(3), TPH1(3) 2587177 35 30 34 17 14 7 2 5 6 1 0.815 1.000 1.000 589 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 13 ACTR2(2), ACTR3(2), ARPC1A(3), ARPC2(3), ARPC4(2), CDC42(1), PAK1(5), PDGFRA(11), PIK3R1(11), WASL(3) 4806501 43 29 42 19 4 17 1 6 14 1 0.894 1.000 1.000 590 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(9), CKM(1), EIF4E(2), FBL(5), GPT(3), LDHA(3), LDHB(4), LDHC(1), MAPK14(1), NCL(7) 3852606 36 29 35 15 7 9 0 11 9 0 0.907 1.000 1.000 591 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(5), CYP2E1(6), NR1I3(4), PTGS1(12), PTGS2(7) 2297060 34 27 34 13 12 9 1 5 7 0 0.654 1.000 1.000 592 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(7), FARSA(3), FARSB(1), GOT1(3), GOT2(2), PAH(6), TAT(5), YARS(6), YARS2(2) 3735417 35 27 35 13 10 11 0 8 6 0 0.656 1.000 1.000 593 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(9), CS(3), MDH1(3), ME1(2), PC(15), PDHA1(1), SLC25A1(1), SLC25A11(2) 3977681 36 27 35 15 13 9 2 5 7 0 0.742 1.000 1.000 594 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 12 CCNA1(6), CCNA2(1), CCND1(1), CCNE1(5), CCNE2(3), CDK2(3), E2F1(3), E2F2(4), PRB1(4) 3596037 30 27 30 14 5 14 1 6 4 0 0.718 1.000 1.000 595 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(3), LDLR(10), NR0B2(3), NR1H3(6), NR1H4(5), RXRA(6) 2341435 33 26 31 15 15 4 0 5 9 0 0.732 1.000 1.000 596 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(5), ACAT2(4), BDH1(5), HMGCS1(2), HMGCS2(3), OXCT1(8), OXCT2(3) 3087523 30 26 30 13 8 8 1 6 6 1 0.842 1.000 1.000 597 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(2), NRF1(6), TAX1BP3(1), UBE2A(1), UBE2D3(1), UBE2E3(3), UBE2G2(2), UBE2H(1), UBE2I(1), UBE2J1(1), UBE2J2(6), UBE2L3(1), UBE2L6(1), UBE2M(1), UBE2N(1), UBE2S(1), UBE3A(5) 4508860 35 26 35 16 15 9 0 3 8 0 0.634 1.000 1.000 598 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(5), CYP11A1(5), CYP11B2(5), CYP17A1(6), HSD11B1(3), HSD11B2(3), HSD3B1(4), HSD3B2(1) 2971693 32 25 32 14 10 6 5 6 5 0 0.745 1.000 1.000 599 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(5), ADORA2A(1), ADORA2B(1), ADORA3(5), LTB4R(2), P2RY1(3), P2RY2(5), P2RY6(8) 2559650 30 25 30 12 16 3 1 6 3 1 0.489 1.000 1.000 600 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(8), CLOCK(5), CRY1(3), CRY2(5), CSNK1E(8), PER1(4) 3629150 33 24 32 15 10 7 2 5 8 1 0.895 1.000 1.000 601 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 9 BAG4(2), BIRC3(6), FADD(1), RIPK1(2), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF2(4) 3080991 29 24 29 14 7 7 1 4 9 1 0.899 1.000 1.000 602 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 HDAC1(5), MAX(3), MYC(5), SP1(6), SP3(3), WT1(3) 2677771 25 23 25 14 6 8 0 6 5 0 0.895 1.000 1.000 603 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(6), EPHX2(4), HSD3B7(6), RDH11(1), RDH12(3), RDH13(5) 2060797 25 22 24 13 8 8 1 4 4 0 0.865 1.000 1.000 604 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(5), PLCD1(4), PRKCA(5), TGM2(12) 2138229 26 22 26 10 14 3 0 5 4 0 0.533 1.000 1.000 605 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(6), CDC25B(4), CDKN1A(3), CHEK1(4), NEK1(4), WEE1(4) 2941216 25 22 25 10 5 9 0 6 5 0 0.852 1.000 1.000 606 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(5), AASDH(7), AASDHPPT(1), AASS(7), KARS(5) 2983556 25 21 25 10 5 10 1 5 4 0 0.705 1.000 1.000 607 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 B3GNT1(3), FUT1(3), FUT2(1), FUT9(6), GCNT2(2), ST8SIA1(7) 2635353 22 20 21 10 8 3 1 8 2 0 0.777 1.000 1.000 608 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(2), GPD2(7), NDUFA1(1), SDHA(6), SDHB(4), SDHC(1), SDHD(1), UQCRC1(2) 2840593 24 19 24 10 9 6 2 4 3 0 0.590 1.000 1.000 609 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(3), ACTR2(2), ACTR3(2), ARPC1A(3), ARPC2(3), ARPC4(2), CDC42(1), WASF1(5), WASL(3) 3482292 24 19 24 20 5 7 1 3 8 0 0.999 1.000 1.000 610 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(5), CTH(2), GOT1(3), GOT2(2), LDHA(3), LDHB(4), LDHC(1), MPST(2) 2935234 22 18 22 10 7 8 1 2 4 0 0.754 1.000 1.000 611 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 4 GOT1(3), GOT2(2), TAT(5), TYR(9) 1590256 19 18 18 11 4 6 1 6 2 0 0.931 1.000 1.000 612 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT1(3), FUT2(1), FUT3(3), FUT5(3), FUT6(4), ST3GAL3(2) 2191676 16 13 16 10 9 3 0 1 3 0 0.893 1.000 1.000 613 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(3), RAB11A(4), RAB27A(4), RAB4A(2), RAB5A(2), RAB6A(1) 1819759 16 11 16 13 4 5 0 2 5 0 0.967 1.000 1.000 614 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(5), PGLYRP2(3) 778402 8 7 8 6 4 3 0 1 0 0 0.917 1.000 1.000 615 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(7) 870608 7 5 7 3 3 2 0 2 0 0 0.736 1.000 1.000 616 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 218932 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000